심근경색의 위험인자로서 Thrombomodulin유전자변이의 의의

박현영,김영미,권혁문,지선하,조승연,정남식,심원흠,장양수 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

忍冬덩굴의 揷木繁殖에 관한 硏究

沈慶久,安永熙,柳美先 成均館大學校 科學技術硏究所 1983 論文集 Vol.34 No.2

The honeysuckles constitute a sturdy group of semievergreen vines, some which can be grown in everywhere of the native mountains. As a group, they are not susceptible to serve disease troubles, which are easily grown and will usually produce a wealth of foliage, flower and fruit with very little care. They are perenial and deciduous climbing plants with strong vines, and flowered from June to September that are considerd as a good ornamental plants for Landscaping. Plants of honeysuckle are ordinarily able to be rooted from softwood or hardwood cuttings, the cutting itself being about 4-5cm long. This study was carried out to determine the effectiveness. of various rate of IBA and NAA treatment on rooting of honeysuckles (Lonicera japonica, Lonicera japonica var. aureoreticulata, Lonicera sempervirens) in the mist room and closed moist chamber. And the results obtained were as follows. Treatment of IBA and NAA increase! in the rooting percentage, rootlet number and length of root on the rooting of honeysuckle cuttings. The rooting percentage of honeysuckle cuttings with IBA 2000pprn 10 sec dip are higher than other rooting hormone treatment. IBA showed more promoting .effect than NAA treatment on the rooting of leafy softwood cuttings. Rooting percentage and number of root tended to have the hightest root system in the closed moist chamber than the mist room.

노인의료서비스정책의 발전방안에 관한 연구

심민수,정희선,심미연 원광대학교 대학원 2007 論文集 Vol.38 No.-

The population of the Aged in Korea is more rapidly growing, as compared with that of other countries, which raises serious intricacies in every walk of life, including politics, economy, society, and so forth. In particular, old-age medical service may be said to be one of the largest variables that produce a direct effect upon the good quality of old-age life. Furthermore, it functions as one of the most difficult impedi-ments in building an integration in society. The republic of Korea has made a great deal of efforts for old-age medical service but is now in an early stage. With this n view, this study puts its principal objective on groping for measures for the development of old-age medical service, and suggests some of them, as follows: First, from an environmental perspective, the Republic of Korea is greatly affected by its political influencing power, and so politics and economy need to be grow to a higher stage. And this study suggests changes in the overall age-group social structure and the eradication of a negative image of the aged, on a sociocultural side Second, it is recommended to boldly correct unreal or irrational laws and systems if any, on a legal system dimension. And this study suggests some strategies to establish old-age hospitals, to expand professional personnel, and to extend the range of medical allowances. Thirds, this study suggests measures to pay medical allowances for old-age health diagnoses for disease prevention is the national medical insurance system, to reduce the cost bearing in the use of high-priced medical equipments, to extend the application of administration of Oriental medicine and dental treatment in the old-age medical allowances. Fourth, this study suggests how to objectify the selection of subjects of the underprivileged, how to rationally calculate the amount of properties according to the standards of income, and how to reduce supporting obli-gators for beneficiaries of medical allowances for the underprivileged. Fifth, this study suggests the diversification and specialization of sanatoriums, the generation of subjects of home old-age welfare, and methods of rational fund-raising for long-term medical care. Sixth, this suggests the establishment of an old-age welfare police-making organization in the government, proper personnel allotment, the reestablishment of administrative functions among local governments, and the securement of officeholders in charge of social welfare. Finally, it is absolutely needed to augment the budget to expand the substrata of old-age medical services. In addition to it, to secure a budget on a proper scale for old-age medical services in consideration of the growing population of the aged.

Mycosis Fungoides 1예 보고

지미경,양기화,김병기,심상인,김선무 大韓血液學會 1984 大韓血液學會誌 Vol.19 No.1

일개 대학 병원 종사자의 직종별 직무스트레스 수준

심미선,이강숙,홍현숙,이경숙 가톨릭대학교 산업의학센터 2000 韓國의 産業醫學 Vol.39 No.4

This study was carried out to find out the job stress factors, coping skill, stress symptom, stress results at a university hospital workers and to develop the goal of health promotion including stress management program. The data for job stress were collected from 61 doctors, 141 nurses, and 84 assistant-nurses in a university from March, 2000 to April, 2000. The results of the study were summarized as follows; 1.The stress scores from job internal factors were highest in doctor group for variety, in nurse group for significance, and assistant-nurse group for identity. 2.The hospital workers felt high stress from promotion and salary but there was no difference from professional groups. There were significant differences in interpersonal relation and organizational norm between nurse and assistant-nurse group and in job-home conflict between doctor and assistant-nurse group. 3.The stress symptoms such as anxiety, depression, and physical symptom were highest in assistant-nurse group. 4.The coping skill was highest in nurse group. 5.The result of stress such as work performance, job involvement and organization commitment was highest in nurse group. The intention to change the job was highest in doctor group. 6.The stress scores had positive correlations with various symptoms. In conclusion, the hospital workers felt high stress from job, interpersonal relation, and organizational norm. In order to relive the stress, the stress management program including to improve coping skill and strategy would be necessary.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

Inhibition of Pathogenic Bacterial Adhesion by Acidic Polysaccharide from Green Tea (Camellia sinensis)

Shim, Jin-Sun,Lee, Ji-Hye,Lee, Jung-Sun,Chung, Mi-Sook,Kim, Kyung-Hyun 덕성여자대학교 대학원 2006 덕성여자대학교 대학원 논문집 Vol.8 No.-

An acidic polysaccharide CS-F2 from Camellia sinensis was examined to characterize its anti-adhesive effects against pathogenic bacteria, most notably Helicobacter pylori, Propionibacterium acnes, and Staphylococcus aureus. CS-F2 showed marked inhibitory activity against the pathogen-mediated hemagglutination with a minimum inhibitory concentration (MIC) between 0.01 and 0.1 mg/mL, which is lower than the previously reported MIC values for Panax ginseng and Artemisia capillaris. The inhibitory effects of CS-F2 on the adhesion of H. pylori to AGS adenocarcinoma gastric epithelial cells, or P. acnes and S. aureus to NIH 3T3 fibroblast cells, were further assessed resulting in MIC values between 0.063 and 0.13 mg/mL. Importantly, CS-F2 showed no inhibitory effects against Lactobacillus acidophilus, Escherichia coli, or Staphylococcus epidermidis. Our results suggest that CS-F2, which is a pectin-type polysaccharide with a molecular weight of approximately 8.0×10^(4) Da, may exert a selective anti-adhesive effect against certain pathogenic bacteria, while exerting no effects against beneficial and commensal bacteria.

Server-Aided Delegation in Ubiquitous Computing Environment

Mi Sun Shim,Jong-Phil Yang,Kyung Hyune Rhee 대한전자공학회 2004 International Conference on Electronics, Informati Vol.2004 No.8

Significant Change of Stress-related Proteins and Gene Profile in the Liver of Long-term Ground Transported Animals

Sun Bo Shim,Se Hyun Lee,Dae Youn Hwang,Chuel Kyu Kim,Bung Guk Kim,Yong Kyu Kim,Seung Wan Jee,Su Hae Lee,Ji Soon Sin,Chang Jun Bae,Byoung Chun Lee,Mi Kyong Jang,Min Sun Kim,Su Youn Yim,Jung Sik Cho,Kab 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.1

The transportation stress cause rise in the levels of many hormones and proteins to maintain homeostasis in the laboratory animals. In order to study whether the stress induced by long-term ground transport could contribute to change in the stress-related protein and profile of stress-regulated gene expression, these factors were detected in the animals between before and after the ground transportation. Herein, it is concluded that; ⅰ) the transported mice significantly exhibited the increase of corticosterone concentration in serum. ⅱ) the heat shock protein 70 (HSP70) in the liver were significantly decreased in the transported animals. ⅲ) 372 and 272 genes were up- and down-regulated, respectively, by stress in the long-term ground transported mice compare to the controls. ⅳ) genes encoding for immunity, signal transduction response and response to protein metabolism were significantly over-represented in the up-regulated group. ⅴ) among the down-regulated transcripts, those encoding for protein metabolism were dramatically over-represented, followed by those related to lipid metabolism and development process. These results suggested that the stress induced by ground transportation could significantly changed the level of stress-indicator hormone, proteins and gene profile in the mice. Therefor, the animal transported a long distance should be had the adaptation period to recover the normal physical state.

Protein Expression Analysis in Hematopoietic Stem Cells during Osteopontin-Induced Differentiation of Natural Killer Cells

( Mi Sun Kim ),( Kil Soo Bae ),( Hye Jin Kim ),( Suk Ran Yoon ),( Doo Byung Oh ),( Kwang Woo Hwang ),( Woo Jin Jun ),( Sang In Shim ),( Kwang Dong Kim ),( Yong Woo Jung ),( So Young Park ),( Ki Sun Kw 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.2

Natural Killer (NK) cells are the lymphocytes that are derived from hematopoietic stem cells, developed in the bone marrow from hematopoietic stem cells (HSC) by sequential acquisition of functional surface receptors, and express the repertoire of inhibitory and activating receptors. Recently, Osteopontin (OPN) has been identified as a critical factor for differentiation of natural killer cells. However, the detailed mechanism of OPN-induced NK differentiation has been still to be elucidated. Here, we determined the signaling pathway and possible receptor for OPN in NK differentiation. OPN induced expression of Bcl-2 and activation of Erk kinase. Inhibition of Erk pathway decreased the effect of OPN on NK differentiation. In addition, the expression of integrin α9 was significantly increased by OPN during NK differentiation, suggesting the possible role of a major signaling molecule for OPN-induced NK differentiation.