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Bupivacaine과 ropivacaine이 Xenopus oocyte에 발현된 HERG 전류에 미치는 영향
김국성,이규승,김효신,손숙진,이상도,김광진,전병화,김윤희,박진봉 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1
Bupivacaine is an amide-type local anesthetic widely used for regional anesthesia. Ropivacaine is developed as a less cardiotoxic alternatives to bupivacaine. In the present study, we have analyzed the effects of bupivacaine and ropivacaine on HERG currents expressed in Xenopus oocytes. Bupivacaine and ropivacaine(3∼1,000μM) blocked HERG currents in a concentration dependent manner. EC_(50) was 26.1±3.1μM(n_(R) 0.65±0.04) and 43.5±7.9μM(n_(H) 0.99±0.13) in bupivacaine and ropivacaine, respectively. Bupivacaine and ropivacaine did not affect the activation and deactivation kinetics of HERG channels. However, the drugs decreased the slope conductance measured from fully activated current-voltage relationship curves. These results suggest that bupivacaine and ropivacaine have a similarinhibitory effect on HERG channels, which could be a possible cellular mechanism of LQT or ventricular arrythmia by the drugs.
안성훈 ( Seong Hun Ahn ),김민수 ( Min Su Kim ),이상훈 ( Sang Hun Lee ),권오상 ( O Sang Kwon ),김재효 ( Jae Hyo Kim ),소광섭 ( Kwang Sup Soh ),손인철 ( In Chul Sohn ) 대한경락경혈학회 2009 Korean Journal of Acupuncture Vol.26 No.1
Objective: In 1960`s Bonghan Kim`s team found BongHan(BH) ducts which were presumed as acupuncture meridians and BH corpuscles. They asserted Bonghan theory and SanAl theory which was involved in cell division and cell restoration. However, many other experiments which had been operated to demonstrate and find the existence of BH ducts had failed because of the secret of blue stain drugs. During the last several years, BongHan theory has been revived through experimental researches to find the anatomical structures of BH ducts and corpuscles by Soh`s Biomedical Physics Lab. Soh`s research team used the staining with Janus Green B, Alcian blue, nanoparticles and Acridine Orange. We used DAPI staining to find the existence of BH ducts and the corpuscles and to observe nuclear arrangement. Methods: We used japan white rabbits as experimental animals. BH ducts and corpuscles were stained with DAPI. The nucleus configuration in BH ducts stained with DAPI were observed with microscope. Results: In this study, we found thread like structures in silver white color distinguished from the blood vessels, nerves and lymph vessels. These thread like vessels in the linear duct shape were connected to same colored mass in the ball shape. Thread like structures we found could be separated easily from the surrounding other organ mass. The nuclei of the thread like structure in DAPI staining, are about 10~20㎛ length, in rod shape and linear arrangement. Conclusion: We concluded that the thread like structure we found was same vessel reported by Soh`s research team, BongHan ducts and corpuscle.
강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-
과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.
國內飼育 犬에 있어서 心臟絲狀蟲의 感染率에 관한 調査 硏究
Ji Hee Seong(成知禧),Hwa Joong Yoon(尹和重),Won Chang Lee(李元暢),Kwang Ho Kim(金光浩),Seung Won Kang(姜承遠) 한국예방수의학회 1996 예방수의학회지 Vol.20 No.2
The purpose of this study was carried out an epidemiological survey on the prevalence rate of the canine heartworms in Seoul City and the districts of Pa-Ju, Seong-Nam and Po-Chon in Kyonggi province of Korea from September 1994 to the end of September 1995. The blood samples from 292 male and 193 female dogs (pet, 363 ; fighting dogs, 60 ; working dogs, 62) were examined for the adult heartworms cuticle antibodies using the enzyme-linked immunosorbent assay (ELSA) kits. The test was designed to detect the antibodies of the host against the specific cuticle antigens produced with the adult heartworms.
난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화
이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3
Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.
페놀을 포함하는 여러 자리 리간드 구리(II)착물의 용매추출 및 분석적 응용
김선덕,김준광,박정은,김성윤 대구대학교 기초과학연구소 1998 基礎科學硏究 Vol.15 No.2
The extraction of aqueous Cu(II) ion into chloroform were conducted by using N,N-bis(2-hydroxybenzyl)-propylenediamine(BHPD), N,N-bis(2-hydroxybenzyl)-diethylenetriamine(BHDT), N,N-bis(2-hydroxybenzyl)-triethylenetetraamine(BHTT), and N,N-bis(2-hydroxybenzyl)-tetraethylenepentaamine (BHDP) as ligands. The method is based on the formation of Cu(ll)- ligand complex, which is extractable into chloroform from an aqueous solution at pH 8 over by shaking for 1h. The absorbance were measured at 614nm Cu(ll)-BHPD, 599nm Cu(ll)-BHDT, 605nm Cu(ll)-BHTT, and 626nm Cu(ll)-BHTP. The Iigand-to-Cu(ll) ion ratio, the relationship between extractability and pH of the aqueous phase were examined.
Al-8.7Zn-2.8Mg-2.6Cu+0.1wt.%Sc Al 합금 압출재의 시효 거동 및 기계적 성질
김광삼,심성용,임수근,이상용 慶尙大學校 經營行政大學院 2004 工學硏究院論文集 Vol.20 No.-
7000계 알루미늄 합금은 시효경화에 의해 기계적 성질이 크게 향상됨으로 항공기 등 수송기기의 구조재료로서 이용되고 있으며, 합금이 개발된 이후 지속적인 성능향상을 위한 연구가 진행중이다. Al 합금에 있어 Sc 첨가는 Al_(3)Sc 상의 생성에 의한 결정립 미세화 및 분산 강화에 의해 효과적으로 강도를 향상 시킬 수 있다. 따라서 본 연구에서는 Al-8.7Zn-2.8Mg-2.6Cu+0.1wt.%Sc 합금 압출제를 이용하여 시효 열처리를 실시하여 시효 거동과 기계적 성질을 조사하였으며, 열처리에 따른 기계적 성질을 조사하였다. 압출재의 미세 조직 관찰 결과 Al_(3)Sc상이 기지 전반에 압출 방향으로 분포되어 있음을 알 수 있었고, 시효 거동 관찰 결과 최대경도 지점이 2400분에서 나타났으며, 시효 경화성 또한 기존의 Al7075 합금 보다 우수하였으며, 강도 증가에 있어서도 T6 처리한 경우 인장강도 657MPa로 나타났으며, 연신율의 경우 5%이었다.