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Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1
Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.
1920년대 초 '開闢' 誌에 등장하는 주택개량론의 성격
김명선,심우갑 대한건축학회 2002 대한건축학회논문집 Vol.18 No.10
This study investigates the discourses of "Housing Improvement" in 「KaeByeok」 from 1920, June to 1926, August. They are produced by "Culture Movement" advocates, whose main concern was in improvement of housing as a social residence from traditional to modern style, rather than spacial improvement of housing itself. So the discourses dealt with housing as a installation or a supplement for modernization of family life, and insisted on improving traditional housing to support modern life style. These situation are understood as unique character of housing improvement discourses of early 1920s as well as distinguished property from those produced by architects after mid 1920s.
정상인과 혈액질환 환자에서의 혈소판 평균용적치에 관한 연구
김학현,구선회,박종우 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1
Molphologic study of platelet have been done by many authors for the past years, they investigated that the heterogeneity of platelet size was shown even in normal person and various hematologic disorder. In the past the platelet size was not utilized in clinical medicine because of its technical difficulties of measuring. Recently, and automated blood cell counter, Coulter counter Model Splus Ⅱ®, was introduced and platelet size could be easily gained, which expressed by mean platelet volume(MPV). Therefore, this study was planned to evaluated the clinical significance of MPV in health person and various hematologic disease. The following results were obtained: 1. In healthy person, MPV was decreased along with increasing the platelet number. 2. In thrombocytopenic patients, MPV was decreased more than normal. 3. In various hematologic disease, MPV was decreased in acute leukemia, marrow failure and aplastic anemia, normal in iron deficiency. anemia, increased in reactive marrow, MPV was varied by platelet number in various hematologic disease. This disclosed that MPV was related with marrow function and production of megakaryocytes. From these results, MPV could be used as a valuable parameter in the evaluation of platelet together with measuring the platelet number. Particular relation-ship between MPV and various hematologic disease were not observed. We should be more study for MPV.
김문규,남선우,정현철 동아대학교 건설기술연구소 1997 硏究報告 Vol.21 No.2
Usually, Many Engineers have used predicting the settlement and displacement using linear elastic modulus(E_(50) calculated by the conventional triaxial test results. But it is results are very diffemt from those of field, which follows deffent stress path and nonlinear behaviour. Therefore, to investigate the dependence of stress path with the variation of confining pressure and relative density on Sum-Jin River sand, local strain triaxial tests are preformed. It is showed as follows ; For the same stress path condition, the stiffness increased with increasing confining pressure and relative density, especially it is more affected by confining pressure. From the relations between Young's modulus and axial strain showed all nonlinear-elastic behaviour and independent on testing conditions, such as, confining pressure, relative density and stress path, etc. The mount of stiffness at very small strain range showed very high value and linear elastic behaviour. And compression results are rather overestimated than that of extention.
김인택,정선우 7개 국립대학교 환경연구 논문집 공동발행 위원회 2001 환경연구논문집 Vol.1 No.1
The flora and insect fauna of Mt. Waryong was surveyed. The flora was surveyed from 1998 to 2001 and insect fauna was done from spring to autumn of 2000. The vascular plants collected from this region are 815 taxa: 41 orders, 133 families, 476 genera, 702 species, 1 subspecies, 96 varieties, and 16 forma. In the area, Korean endemic plants were 18 taxa(2.2% among total 815 taxa); cultivated plants were 154 taxa (18.9% among total 815 taxa). Also the naturalized plants were 48 taxa(5.9% among total 815 taxa and 26.7% among the total naturalized plants in Korea): 19 families, 40 genera, and 8 species. The total insect specimens were classified into 6 orders, 53 families, and 239 species. In hemiptera, 11 families and 25 species were classified, and 8 families and 28 species were contained in homoptera. diptera held 6 families and 11 species, hymenoptera had 4 families and 9 species, and coleoptera had 4 families 35 species. And we could classified 20 families and 131 species in lepidoptera.
사무공간의 통합유니트 구축을 위한 조명유니트 도출에 관한 연구
김선숙,신선준,김지현,양인호,김광우 대한건축학회 2005 대한건축학회논문집 Vol.21 No.1
The purpose of this study is to develop the lighting units for workspace and to propose their application method at the architectural design stage The lighting unit is one of the components of a workspace integrated unit, which can be defined as the planning unit satisfying the environmental comfort criteria of workspace According to the survey of current domestic and foreign office buildings, the luminaire layout types could be classified into the line, spot and square type Various simulation cases were set up considering these layout types, architectural modules, and luminaire types Finally, forty-four lighting units were developed by RADIANCE simulation With these lighting units, the designer would be able to easily predict how his decision about architectural modules influences the lighting design, and can consider other alternatives
유산소 리듬 운동프로그램이 노인의 혈압, 심박수 및 생활만족도에 미치는 효과
우선혜,김효정,박영숙 대한보건협회 2001 대한보건연구 Vol.27 No.3
The purpose of this study was to test the effects of aerobic rhythmical exercise program on blood pressure, pulse and the life satisfaction of the elderly. This quai-experimental study was designed as a non-equivalent control group pretest-posttest study. The subjects were 36 subjects(experimental group: 19 subjects, control group: 17 subjects), aged between 65 and 73 years who have normal cognition, sensory function and cerebellum function. Aerobic rhythmical exercise program was developed on the basis of aerobic exercise, Korean tradititional dance and music by the author. The blood pressure, pulse rate and life satisfaction were measured prior to and following the experimental treatment. Data were analyzed with x^2-test, t-test, mean, standard deviation, percentage of change and ANCOVA test using SAS program. The results were as follows. 1. There was no significant difference of systolic blood pressure between experimental and control group following the aerobic rhythmical exercise program(F=1.39, P=0.247). 2. The diastolic blood pressure of the experimental group was significantly lower than that of control group following the aerobic rhythmical exercise program(F=2.96, p<0.1). 3. There was no significant difference of resting heart rate between experimental and control group following the aerobic rhythmical exercise program(F=0.07, P=0.793). 4. The life satisfaction of the experimental group was significantly higher than that of control group following the aerobic rhythmical exercise program(F=9.94, p<0.01). On the basis of the above findings, aerobic rhythmical exercise program is effective in reducing diastolic blood pressure and promoting life satisfaction of the elderly. Thus, this program can be recommended as an effective nursing intervention for the elderly.