자동측정망 데이터를 이용한 국내 항공기소음 실태 조사

이주엽,전지현,이태강,김선우 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

Currently domestic criteria for the aircraft noise is being adapted WECPNL(weighted equivalent continuous perceived noise level), while internationally preferred method is L_(dn) which is originated from L_(eq) and can evaluate even environmental noise. WECPNL used in domestic as a evaluation method is only for the aircraft noise. It is, therefore, not adequate for the evaluation of residents' injury, moreover, it is very difficult to measure the aircraft noise with WECPNL due to the complicated calculating procedures as long as automatic measuring system is not used This study aims to propose alternative evaluation method for the aircraft noise. To achieve this purpose, the data measured by automatic measuring system in 5 places among domestic airports from 1998 to 2002 were gathered and calculated with three evaluation method ; WECPNL, L_(eq) and L_(dn) and the results calculated from different methods were compared and analyzed. At the same time, it was investigated problems generated from the actual operating of the automatic measuring system and that remedy was presented.

Ranitidine, Sucralfate, Bismuth Subcitrate 복합제의 흰쥐 위궤양에 대한 치료효과

조태순,조광재,주일로,이선미,유영효 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.1

Gastric ulcer disease results when there is an imbalance between aggressive factors(acid secretion) and protective factors(mucosal defence). H_2-receptor antagonists are the most frequently used agents for treatment of gastric ulcer disease. However, use of these products should be determined by potential for adverse effects, drug interactions and cost. Ranitidine, H_2 - receptor antagonist, competitively block the H_Z-receptor on the parietal cell, causing inhibition of gastric acid secretion. Sucralfate and bismuth subcitrate coat ulcer craters and then enhance mucosal defence. Bismuth subcitrate also causes detachment of Helicobacter pylori from the gastric epithelium with subsequent lysis of the bacteria. To estimate effects of the mixture of ranitidine 20mg/kg, bismuth subcitrate 40mg/kg and sucralfate 120mg/kg on aspirin - HCl induced gastric ulcer in rats, gastric ulceration, pH, gastric secretion, free and total acidity, pepsin activity, gastric mucosal hemorrhage were investigated. Results obtained were as follow : 1) The mixture showed remarkable suppression of gastric ulceration, pH, gastric secretion, free and total acidity, pepsin activity, gastric mucosal hemorrhage compared with ranitidine alone. 2) With elapse of time, the mixture showed more increasing inhibitory effects on gastric ulceration, pH, gastric secretion, pepsin activity, gastric mucosal hemorrhage than sucralfate and bismuth subcitrate.

파스칼 삼각형의 대화식 시각화

송태성,이순주 부산대학교 사범대학 과학교육연구소 2006 科學敎育硏究報 Vol.33 No.-

Pascal's triangle is a number triangle with numbers arranged in staggered rows such that the elements of nth row are the binomial coefficients ◁수식 삽입▷ (원문을 참조하세요) , where κ=0, 1, …, n. The rows and columns that make up the Pascal's triangle contain many number patterns. In this paper, we construct various interactive Pascal Triangle Movies using Adobe Flash drawing API. The interactive Pascal Triangle Movies provide the opportunity for students to easily investigate various number patterns contained in the Pascal's triangle.

심실 조기 수축의 발생 부위 및 연결 간격의 차이에 따른 혈역학적 변화

진승원,김재형,노태호,조은주,김희열,이만영,김종진,박준철,채장성,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.7

개의 심낭내 투여한 Quinidine이 삼장 유효불응기에 미치는 영향

한명철,김재형,노태호,김희열,김종진,조은주,진승원,유기동,이만영,채장성,홍순조,최규보 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

Case Reports : Treatment of Intractable Hiccups With an Oral Agent Monotherapy of Baclofen

( Ju Hwan Lee ),( Tai Yo Kim ),( Hyun Wook Lee ),( Yu Sun Choi ),( Seo Young Moon ),( Yong Kwan Cheng ) 대한통증학회 2010 The Korean Journal of Pain Vol.23 No.1

Treatment of Intractable Hiccups With an Oral Agent Monotherapy of Baclofen -A Case Report-

Lee, Ju-Hwan,Kim, Tai-Yo,Lee, Hyun-Wook,Choi, Yu-Sun,Moon, Seo-Young,Cheong, Yong-Kwan The Korean Pain Society 2010 The Korean Journal of Pain Vol.23 No.1

Hiccups are an involuntarily powerful spasm of the diaphragm, followed by a sudden inspiration with a closure of the glottis. Hiccups that are caused by gastric distention, spicy foods and neural dysfunction can resolve themselves without any treatment. Some hiccups are associated with certain diseases or they occur postsurgically, and life-restricting intractable hiccups should be treated. The cause of hiccups should be quickly determined so as to administer the proper treatment. Hiccups often remit spontaneously within a short period of time, but they may also occur without remission for a prolonged period in some cases. We report here on a 36-year-old man who suffered with intractable hiccups for 5 years. We administered a single oral dose of baclofen, and then the hiccups disappeared. We conclude that a single dose of baclofen is a good treatment for intractable hiccups.

만성골수성백혈병에서의 동종골수이식 : 국내 경험의 후향적 분석 Retrospective Analysis of Korean Experience

이규형,이제환,이정신,김상희,김우건,김춘추,이종욱,김병국,박선양,이홍기,윤성수,김효철,남동기,한지숙,민유홍,현명수,황태주,정익주,박영석,이정애 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.2

연구방법: 국내에서 시행된 만성골수백혈병의 치료를 위한 가족간 동종골수이식의 임상적 특징을 후향적으로 분석하였다. 9개의 병원에서 1986년 9월부터 1997년 6월까지 시행한 137예의 가족간 동종골수이식을 보고하였다. 결과: 전체 환자 중 62%인 85예가 남자였고 연령은 15세에서 50세까지 분포하였다(중앙치 30세). 95예(71%)의 환자는 이식 당시 만성골수성백혈병 만성기의 상태였고 38예(28%)는 가속기 또는 모세포성발증기의 상태였다. 70예(51%)의 환자는 이식전처치로 busulfan+cyclophosphamide (BuCy) 치료를 받았고 42예(31%)의 환자는 cyclophosphamide+전신방사선 조사(Cy-TBI)를 받았다. 환자에게 이식된 단핵구의 수는 0.06-9.5×10^(8)/kg(중앙치 1.2×10^*/kg)였다. 1 예를 제외한 모든 환자에서 이식 후 8-100일(중앙치 17일)에 중성구 500/㎕ 이상의 착상이 관찰되었다. 급성 및 만성이식편대숙주질환은 각각 46%와 43%의 환자에서 관찰되었다. 중앙추적기간 20개월(범위 3-135개월) 경과 후 137예의 환자 중 52예의 환자가 사망하였다. 사망 원인은 감염(27%), 백혈병의 지속 또는 재발(23%), 이식편대숙주질환(21%), 치료독성(15%), 그리고 이식편거부(8%) 등이었다. 환자들의 event-free survival에 영향을 주는 인자로는 이식전 병의 상태(p<0.001)와 환자의 혈청 HBsAg 양성여부(p=0.012)가 중요하였다. Overall survival에 영향을 주는 인자도 이식전 병의 상태와 환자 혈청 HBsAg 양성여부로 나타났다. 결론: 본 연구에서 국내 만성골수성백혈병에 대한 동종골수이식술은 그 시행 예가 급격히 증가하고 있음을 보여주었다. 환자들의 임상 특성과 생존 성적은 외국의 성적과 유사하였다. B형 간염 감염환자의 경우 예후가 유의하게 불량하였고, 이는 추후의 임상연구에서 확인이 필요한 소견으로 사료된다. Background and Methods: Clinical features of allogeneic bone marrow transplantation (BMT) performed for patients with chronic myelocytic leukemia (CML) in Korea were analyzed retrospectively. Nine hospitals reported a total of 137 cases of allogeneic BMT performed between September, 1986 and June, 1997. Results: There were 85 male (62%) and 52 female patients with median age of 30 years (range 15-50). Ninety five patients (71%) were in chronic phase and 38 patients (28 %) were in accelerated/blastic phase of the disease. Seventy patients (51%) received busulfan-cyclophosphamide (BuCy) regimen for preparation and 42 patients (31%) received cyclophosphamide-total body irradiation (Cy-TBI) regimen. The median mononuclear cell dose given to patients was 1.2×10^(8)/kg (range, 0.06-9.5×10^(8)/kg). All but one patient achieved absolute neutrophil count of 500/μl after median 17 days after BMT (range, 8-100 days). Acute and chronic graft-versus-host disease (GVHD) were reported in 61/133 (46%) and in 57/134 (43%) patients, respectively. The median follow-up time of survivors was 20 months (range, 3-135 months). There were 52 deaths (38%). The causes of death were infection (14 patients, 27%), recurrent/persistent disease (12 patients, 23%), GVHD (11 patients, 21%), regimen related toxicity (8 patients, 15%), graft rejection/failure (4 patients, 8%), and unknown (3 patients, 6%). The factors influencing event free survival of the patients were disease status before BMT (p<0.001, by log-rank test) and serum hepatitis B surface antigen status (p=0.012). Longer duration of disease before BMT showed poorer outcome but the difference did not reach statistical significance. The factors affecting overall survival of the patients were disease status before BMT (p=0.009) and hepatitis B surface antigen status (p=0.036). The donor hepatitis B antigen status did not influence event free survival or overall survival of the patients. Conclusion: Clinical features and survival patterns of patients with CML treated with allogeneic BMT in Korea were similar to historical data from other countries. Further data analyses are warranted for the role of hepatitis B virus infection influencing the outcome of allogeneic BMT for CML.

Anti-wrinkle Compounds Isolated from the Seeds of Arctium lappa L.

Ju-Young Hwang(황주영),Tae-Soon Park(박태순),Dong-Hee Kim(김동희),Eun-Young Hwang(황은영),Jung-Noh Lee(이정노),Ji young Lee(이지영),Ghang-Tai Lee(이강태),Kunkook Lee(이건국),Jun-Ho Son(손준호) 한국생명과학회 2012 생명과학회지 Vol.22 No.8

본 연구에서는 우방자를 70% 에탄올로 추출하여 얻어진 추출물을 n-hexane, methylene chloride, ethyl acetate로 순차용매 분획하였다. 각 분획물에 대해 activity-guided isolation을 수행하여 활성물질의 분리 정제를 실시하였다. 활성을 나타내는 물질은 silica gel chromatography (230 mesh), sephadex LH 20, recrystallization method를 이용하여 분리하였다. 각 화합물의 화학구조는 NMR 스펙트럼 데이터 해석하였고 arctiin, arctigenin, diarctigenin, matairesinol 으로 동정하였다. 이들을 human dermal fibroblast HS68 세포에 처리하여 얻어진 상등액은 ELISA kit를 활용하여 procollagen type Ⅰ생합성과 MMP-1 저해활성을 측정하였다. 측정결과 procollagen type Ⅰ생합성과 MMP-1 저해활성 결과 모두 arctiin이 가장 우수한 결과를 보였다. 이와 같은 결과를 통해 우방자에서 분리한 리그난 화합물들을 이용하여 주름개선 소재로 개발할 수 있을 것으로 사료 된다. This study was carried out to discover the skin wrinkle reducing components in the seeds of Arctium lappa. The isolation of a methylene chloride-soluble fraction of 70% ethanol extract from the seeds of Arctium lappa using a procollagen type-1 synthesis and MMP-1 activity resulted in the isolation and identification of four lignin compounds: arctiin, arctigenin, matairesinol, and diarctigenin. All structures were confirmed via NMR and MS spectroscopic data. To determine cell viability and procollagen type-1 synthesis, human dermal fibroblasts were treated with 10-100 μM. As a result, none of the four compounds showed cytotoxicity up to 50 μM. We also investigated their procollagen type-1 synthesis and MMP-1 inhibition activity and found that arctiin had the highest activity in terms of both procollagen synthesis and MMP-1 inhibition among all four compounds. Putting all the data together, we suggest that arctiin be used in cosmetics as an anti-wrinkle material.

High Prevalence of Opisthorchis viverrini Infection in a Riparian Population in Takeo Province, Cambodia

Tai-Soon Yong,Eun-Hee Shin,Jong-Yil Chai,Woon-Mok Sohn,Keeseon S. Eom,Dong-Min Lee,Keunhee Park,Hoo-Gn Jeoung,Eui-Hyug Hoang,Yoon-Hee Lee,Hyun-Ju Woo,Ji-Hwa Lee,Sin-Il Kang,Jae-Ku Cha,Keon-Hoon Lee,Ch 대한기생충학열대의학회 2012 The Korean Journal of Parasitology Vol.50 No.2

Opisthorchis viverrini infection was found to be highly prevalent in 3 riverside villages (Ang Svay Chek A, B, and C) of the Prey Kabas District, Takeo Province. This area is located in the southern part of Cambodia, where the recovery of adult O. viverrini worms was recently reported. From May 2006 until May 2010, fecal examinations were performed on a total of 1,799 villagers using the Kato-Katz thick smear technique. In the 3 villages, the overall positive rate for helminth eggs ranged from 51.7 to 59.0% (av. 57.4%), and the percentage positive for O. viverrini was 46.4-50.6% (47.5%). Other helminths detected included hookworms (13.2%), echinostomes (2.9%), Trichuris trichiura (1.3%), Ascaris lumbricoides (0.6%), and Taenia spp. (0.06%). The prevalence of O. viverrini eggs appeared to reflect a lower infection in younger individuals (<20 years) than in the adult population (>20 years). Men (50.4%) revealed a significantly higher (P=0.02) prevalence than women (44.3%). The Ang Svay Chek villages of the Prey Kabas District, Takeo Province, Cambodia have been confirmed to be a highly endemic area for human O. viverrini infection.