Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

Baclofen 投與에 따른 精神分裂症 患者의 血淸 成長호르몬의 反應

李圭煥,白仁浩,高孝進,李正杓,咸雄,李奎恒 서울醫大 1990 精神醫學 Vol.15 No.1

논문 : 동북아지역(東北亞地域)에서의 다뉴경(多뉴鏡) 부장묘(副葬墓)의 전개(展開)

이청규 ( Chung Kyu Lee ) 단국사학회 2012 史學志 Vol.44 No.-

청동기는 생업도구의 수준에서 벗어나 전쟁무기와 종교의기로 제작·보급되었다. 이논문은 종교의기이자 무구(巫具)로서 제사장들이 보유했던 청동거울, 그 가운데서도 다뉴경을 중심으로 다뉴경이 부장된 무덤들의 역사문화적 의미를 고찰한다. 다뉴경은 대릉하유역부터 한반도를 거쳐 일본 구주(九州)지역에 이르는 범(汎) 십이대영 자문화권(十二臺營子文化圈)을 나타내는 유물이다. 다뉴경 부장묘는 이 문화권에 속한 고조선, 부여, 한 왜(倭)의 범주에 속하는 소국(小國)들의 수장들의 무덤으로서, 다뉴경뿐만 아니라 다른 청동기 및 토기부장품들이 부장되어 있다. 이 부장품들은 당시의 chiefdom 사회의 수장들을 중심으로 한 정치상황뿐만 아니라 범 대영자문화권 내의 기술교류를 반영한다. 다뉴경은 중국 동북지역에서 한반도와 일본열도에 걸쳐 당시 엘리트들이 제사장의 신분과 지위를 과시하는 위세품인데, 전파과정에 따라 대릉하지역의 A형 다뉴경, 요동과 길림지역의 B형 다뉴경, 한반도 서남부와 일본 구주지역의 C형 다뉴경으로 발전되어갔다. A형 다뉴경으로부터 B형 다뉴경의 등장은 연(燕)나라의 동진으로 고조선의 강역이 이동한 것에 기인한다. C형 다뉴경은 중국 동북지역에서는 발견되지 않고 한반도 서북한과 서남한 지역, 일본 구주(九州)지역에서 발견된다. 이는 다뉴경을 최고 위세품으로 채용하는 계층이 상위급 수장(首長)에서 차상급 이하의 엘리트로 내려갔음과 일본 구주 지역의 소국들이 한반도 서남부지역의 마한(馬韓)지역과 교류하고 있었음을 보여준다. The geometric-design bronze mirrors of which numbers about 80, are assumed to be as ritual tools and political symbols of priest-king during the 8th~2nd century BCE. Those are classified into three types, that are A, B, and C, and each of them is assumed to be made and used in 800~400BCE, 400~200BCE, and 200~50BCE. The distributional range of three types were changed under the historical conditions, which includes Yen(燕)`s advance toward the northeastern China and Wiman(衛滿) becoming a king of Gojoseon(古朝鮮). The first A type mirrors were distributed mainly in northeastern China, B type ones in the geographical range from northeastern China to the Korean peninsular, and C type ones from the Korean peninsular to the Japanese archipelago. The size and numbers of mirrors are reflective of the social position of the person with whom are buried in the grave, and so the graves with mirrors in each type are those of the most unfluential leaders of ``Kuk(國)``―the political and regional groups at the time. In A type mirror stage, the graves with most abundant artefacts are located in Liaoning pronince(遼寧省); the graves with most abundant artefacts in B type mirror stage are in Chung-nam(忠南) province; and the graves with C type mirrors in Cheon-nam(全南) province. Each region with those burials was the trade-center in Korea connecting China and Japan, and is assumed to be the location of the most influential ``Kuk(國)`` in old Korea.

Infliximab으로 호전된 장관 증상없이 발생한 구강-안면 크론병

정보용 ( Bo Yong Jung ),이석호 ( Suck Ho Lee ),정승규 ( Seung Kyu Chung ),이창균 ( Chang Kyun Lee1 ),이태훈 ( Tae Hoon Lee ),정일권 ( Il Kwun Chung ),김선주 ( Sun Joo Kim ),조현득 ( Hyun Deuk Cho ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.6

Crohn`s disease is a chronic inflammatory bowel disease that can involve the whole gastrointestinal tract. The orofacial manifestation of Crohn`s disease, which is rare, can develop irrespective of intestinal involvement. These orofacial lesions are often misdiagnosed as simple oral ulcers. Corticosteroids are the mainstay of therapy for orofacial Crohn`s disease. However, infliximab, the chimeric monoclonal antibody to tumor necrosis factor-α, is now considered as a primary treatment because of the disease`s relatively high rate of steroid resistance. We present a case of deep oral ulcer and periorbital swelling in a 65-year-old woman. She was diagnosed with intestinal Crohn`s disease 7 years ago, which was in remission after treatment with an immunosuppressive agent (azathioprine). The patient was given the diagnosed with orofacial Crohn`s disease and successfully treated with infliximab. (Korean J Gastroenterol 2012;59:437-440)

Methotrexate가 Mouse 간세포의 미세구조에 미치는 영향

정호삼,장혁순,이규식 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.2

Methotrexate (MTX), folic acid analog, has been widely used in the therapy of psoriasis and also used in the chorionic adenoma and acute lymphatic leukemia. Methotrexate inhibits not only DNA synthesis but also RNA and protein synthesis. It has been reported that during the therapy, its cytotoxicity leads to necrosis of the epithelium of the renal tubules, hair loss and hepatic fibrosis. So the author undertook the present study to pursue the effect of methotrexate on the cytoplasmic organelles of hepatic cells. Albino mice, ICR strains, weighing 20gm were used experimental animals. The experimental animals were killed at 24, 48, 72 and 96 hours after administrations of 15 mg/kg of MTX. The specimens obtained from liver were prefixed in Millonig's solution and post-fixed in the 1% osmic acid. After specimens were dehydrated and embedded in the Epon 812, ultrathin sections were made and double stained with uranyl acetate and lead citrate. And these preparations were observed with the electron microscope. The results were as follows. 1. The majority of mitochondria was hypertrophied and some mitochondria were irregular shaped, its double membrane and crests disappeared in the mouse liver of the 24 hours-MTX treated group. 2. Golgi complexes were atrophied in the 48 hours-MTX treated group and cisternae of the Golgi apparatus were hypertrophied and vesicular formation was observed in the 72 hours-MTX treated group. 3. The cisternae of the rough endoplsmic reticulum wer dilated and sacculated, but the detachment of membrane bound ribosomes was observed. 4. Lysosomes and autophagic vacuoles were increased in number with time. Consequently, it is suggested that MTX would induced the damge of the organelles of the hepatic parenchymal cells in mice.

正常및 異常分娩中 母體와 臍帶血漿의 β-endorphin 및 ACTH値의 變動에 關한 硏究

鄭求烈,李揆玩,李珉載,洪性鳳 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1

β-endorphin and adrenocorticotrophic hormone (ACTH) are derived from the same precursor protein and they have been implicated as the modulators of pain during the labor process. To investigate their possible role during labor this study was undertaken to determine the levels of β-endorphin and ACTH during labor and delivery in healthy term pregnant women and their neonates after delivery. β-endorphin and ACTH were measured by radioimmunoassay in 22 spontaneous labors, 14 elective cesarean sections and 7 emergency cesarean sections during early and late labor, and after delivery. The results obtained are as follows: 1. In cases of spontaneous vaginal delivery and emergency cesarean section, maternal plasma β-endorphin and ACTH levels were significantly increased during late labor and remained and continuously elevated during the first postpartum hour. 2. In cases of elective cesarean sections, maternal mean plasma levels of β-endorphin and ACTH were significantly lower than levels in spontaneous vaginal deliveries and emergency cesarean sections. 3. There was a significant correlation between meternal plasma β-endorphin and ACTH levels during labor. 4. Umbilical arterial β-endorphin levels in newborn infants after spontaneous vaginal delivery and emergency cesarean section were significantly higher than levels in infants born by elective cesarean section, but only spontaneous vaginal deliveries showed higher umbilical arterial ACTH levels in newborn infants than infants born by elective cesarean section. 5. There was no relationship between meternal and umbilical cord plasma β-endorphin and ACTH. There was not significant correlation between umblical cord plasma β-endorphin and ACTH levels, and fetal weight and placental weight. 6. There was no correlation betwen umbilical arterial pH and Apgar score by mode of delivery, but statistical significance was found to exist in the umbilical arterial pH of emergency cesarean sections and elective cesarean sections. Present studies suggest that β-endorphin and ACTH are significantly increased during late labor due to stress and pain, and hypoxia may be important physiologic stiumuli controlling the release of β-endorphin and ACTH in the human fetus.

Mitomycin이 Mouse 간장의 인산염분해 효소에 미치는 영향

정호삼,신규석,이군자,이규식 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1

Mitomycin (MC), a wide spectrum antibiotic and anticancer drug, is isolated from streptomyces caespitosus. MC decomposes DNA in cancer cell by forming a complex with DNA and inhibits division of cancer cells by interfering with the biosynthesis of DNA. In the normal cell, MC cross linkes with DNA and inhibits synthesis of RNA and protein. Therefore MC causes many complication in the MC treated patient. The authers have investigated the effect of MC on the mouse liver histochemically observing the change in the activities of alkaline phosphatase and ATPaes. Male mouse, DDY strain, weighing about 20 grams was used as experimental animals. The experimental animals were divided into the control and MC treated group and given food and water unlimited. The animals treated with 4mg of MC per kilogram of body weight were sacrificed at 6, 12, 24, 36 and 48 hour after administration. The animals of control groups were administered only water for injection. The liver specimens were fixed in 10% formalin solution at 4℃ and sliced at 14㎛ thickness in a frozen cryostat. The activities of alkaline phosphatase were observed by the Gormori's method and those of ATPase were observed by the Wachstein-Meisel's method for histochemical study. The result are as follows. 1. As the time passed, the activity of alkaline phosphatase activity was decreased in the hepatic lobule. Negative reactions were showed in the central and intermediate zone of the lobule of 36 hours of MC treated group. Trace activities of the enzyme were observed in the whole hepatic lobule of 48 hours of MC treated group. 2. As the time goes by, the activity of adenosine triphosphatase was decreased in the hepatic lobule. Negative reactions were observed in the entire hepatic lobule of 36 hours of MC treated group. Weak activity of the enzyme were observed in the whole hepatic lobule of 48 hours of MC treated group. Consequently, it is suggested that MC causes decrease in activities of hepatic alkaline phosphatase and ATPase due to live damage by cross linking of DNA with the drug in the hepatocyte and destructive change of organelles of the cell.

아토피 피부염 환자에서 혈청내 Cu와 Zn치 및 Cu/Zn비에 관한 연구

이성열,정현,이종석,황규왕 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

아연과 구리는 피부를 포함하는 인체의 거의 모든 기관에서 일어나는 대사과정에 작용하는 metallonenzyme의 보조인자로 상당히 중요한 역할을 수행한다. 저자들은 정상대조군 10명, 전신성 아토피성 피부염 환자 16명을 대상으로 atomic absorption spectrometry를 사용하여 혈청 아연과 구리치를 측정하였고 그결과로 혈청 구리/아연 비를 구하였다. 그 결과 혈청 구리치는 대조군에 비하여 아토피성피부염 환자에서 통계적으로 의의있게 높게 나타났다. 이는 아마도 아토피성 피부염에 의한 염증반응으로 이차적으로 ceruloplasmin이 증가되어 나타난 것으로 생각되나 이 것이 명확히 규명된 것은 아니다. 혈청 아연치는 약간 감소하였으나 통계적인 유의성은 없었고 혈청 구리/아연 비의 값은 약간 증가되었으나 역시 통계적 유의성을 찾을 수는 없었다.

제1소구치 발치 증례와 비발치 증례에서 하악 제3대구치 맹출에 관한 연구

정규림,박영국,이정민 대한치과교정학회 1993 대한치과교정학회지 Vol.23 No.4

It is the aim of this study to determine the impacts of radicular development of lower third molars on its eruption/impaction and to grope the prediction for eruption and/or impaction in advance. Three hundred and thirty cases of orthopantomogram were employed and classified as mesial root-dominant group, distal root-dominant group and identical group according to the radicular development of lower third molars. This presentation has carried out the incipient mesial inclination, radicular development, impaction/eruption rate and changes of mesial inclination of the very teeth. Consequently the following summary and conclusions were drawn; Radicular development dominated mesial root than the distal and dominant mesial root invited higher potentialities for normal eruption. The mesial or horizontal impactions were detected on the distal root-dominant group. This analysis han been suggested the potential eruption/impaction of lower third molars were dependent upon the radicular development and the incipient mesial inclination.

경유돌공 부위에서 전기신경자극기를 이용한 안면경련 환자의 치료

정창우,민진혜,이규탁 관동대학교 의과학연구소 2000 關東醫大學術誌 Vol.4 No.1

Facial spasm is the most common in middle aged women, which is a distressing condition characterized by involuntary, intermittent, unilateral twitching of the muscles innervated by the facial nerve. There are various treatments for facial spam, such as neurovascular decompression, local injection of botulinum, facial nerve compression at stylomastoid foramen and facial nerve block with O'Brien method. There are the same clinical problems associated with the reported procedure in pain clinic, such as severe pain and recurrence of spasm. In this paper, we report the modified facial nerve block using electric nerve stimulator at the stylomastoid foramen. This new technique will be able to reduce the pain and the discomfort during facial nerve block, and reduced the recurrence of facial spasm.