부정교합 아동의 성장에 따른 연조직 측모의 변화

권오원,경희문,장병천,성재현,김정민 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.3

This investigation was undertaken to know how soft tissue facial profile could changed with age. The 3 serial lateral cephalometric roentgenograms of the twenty nine boys and twenty six girls between 9 and 13 years of age were studied and the findings seemed to warrant the following conclusions. 1. The author made the tables of means, standard deviations in each item, sex, age. 2. Soft tissue facial angle, soft tissue facial convexity including the nose tended to increase, but others tended to remain relatively stable. 3. Facial soft tissue thickness increased with age and the growth of facial soft tissue in the middle rgion (point A, LS, LI)was greater than others in the facial region. 4. In the soft tissue vertical proportions, GI'-Sn/Sn-Me' was 1.1, Sn-St/St-Me' was 0.51:1, Sn-LI/LI-Me' was 0.82.1 and those were stable with age.

Effect of Fertilizer Levels on Growth Characters, Dry Matter Yield and Nutrient Quality of Forage Rape in Spring Sowing

Kwon,Byung-Sun,Shin,Jeong-Sik,Shin,Dong-Young,Hyun,Kyu-Hwan,Park,Hee-Jin,Sin,Jong-Sup,Seong-Kyu 한국자원식물학회 2003 Plant Resources Vol.6 No.2

To find out the optimum fertilizer level for high yielding variety, Velox, experiment was conducted with 15 compositions of fertilizer levels at the experiment field of forage crop in Sunchon National University from Mar. 2000 to Aug. 2000. The effects of nitrogen fertilizer on plant growth were significant but increasing rate of application in potassium and phosphate fertilizers above 6 kg/a had negligible effects on plant growth. The optimum nitrogen application level of fertilizers turned out to be 16-6-6 kg/l0a of N-P2O5-K5O. Content of crude protein was highest and that of crude fiber such as NDF, ADF, cellulose and lignin were lowest at this rate of fertilizer application. Furthermore, IVDMD was high and dry matter yield were highest at the optimum raterate

직장암에서 수술 전 방사선-화학요법 후 발생한 후기 합병증

이승현,이철민,안병권,백승언 고신대학교 의과대학 2011 고신대학교 의과대학 학술지 Vol.26 No.1

OBJECTIVES: To compare the late complications after operations for rectal cancers with and without preoperative chemoradiation. METHODS: From January 2003 to December 2005, 55 patients underwent operation after preoperative chemoradiation for adenocarcinoma of the rectum. All of them received the full scheduled dose of radiation with concurrent chemotherapy. The interval between preoperative chemoradiation and surgery was 4-6 weeks. 47 patients who had tumors below 8 cm from the anal verge were enrolled into the study group (CRT group). During same period, we selected 153 patients who had adenocarcinoma of the rectum below 8cm from the anal verge, underwent surgery alone without postoperative radiotherapy non-CRT group). We compared the early and the late postoperative complications between the CRT group and the non-CRT group. RESULTS: Of the late complications, the incidence of anastomotic stricture was significantly higher in the CRT group (P = 0.018). The incidence of anal stricture was higher in the CRT group (P = 0.164). In the CRT group, 3 cases (17.6%) had failed to preserve the anal function due to moderate or severe anal stricture. Of the 3 cases, protective ileostomy was persistent in 2 cases, colostomy was performed in one case. Otherwise, the late complications of the CRT group were intestinal obstruction in 2 cases (4.3%), lymph edema in 2 cases (4.3%). CONCLUSION: In CRT group, failure of anal function preservation due to anastomotic stricture or anal stricture was more common and serious than non-CRT group. We emphasize the need for careful management for postoperative anal stricture after preoperative chemoradiation.

직장암 절제 수술 후에 발생하는 문합부 누출의 위험 인자

이승현,안병권,배승언 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Background: Anastomotic leakages are one of the most serious complications after rectal cancer resection. The aim of this study was to identify the relevant risk factors of anastomotic leakage after low anterior resection for rectal cancer. Methods: We reviewed retrospectively the medical records of 251 patients, who underwent low anterior resection for rectal cancers between January, 2001 and December, 2004. All patients underwent a tumor-specific mesorectal excision. We excluded the patients underwent emergent surgery, protective stoma formation and used pelvic drainage. Results: The mean distance of the tumor from the anal verge was 8.0 cm (3-16 cm). Lower anterior resection was performed in 214 patients and ultra-low anterior resection in 37 patients. Fifteen patients had preoperativechemoradiation for rectal cancer. The anastomotic leakage was identified in 10 patients (4.0%). Seven patients with anastomotic leakage underwent corrective surgery.Other postoperative complications included 5 rectovaginal fistula (2.0%) and 4 intra-abdominal abscess (1.6%). The incidences of anastomotic leakage were significantly different according to preoperative chemoradiation (13.3% vs. 3.4%, p=0.05) and rectal obstruction (33.3% vs. 3.3%, p=0.00). Conclusions: In patients with history of preoperative chemoradiation and rectal obstruction, the careful management for anastomotic leakage is necessary

당뇨병성 신경병증에서 근위부 비골신경전도 검사를 이용한 병태생리학적 접근

김동현,이강건,박종원,박태환,안병철,권오상 대한신경과학회 1998 대한신경과학회지 Vol.16 No.2

Cyclodextrin Glucanotransferase와 Cyclodextrinase를 생산하는 Bacillus 속 세균의 분리와 그 효소들의 특성

권현주,남수완,김광현,곽영규,김병우 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.3

토양으로부터 CGTase와 CDase를 함께 분비·생산하는 내열성 세균을 분리하였으며, 동정결과 Bacillus stearothermophilus로 판명되어 KJ16으로 명명하였다. Bacillus stearothermophilus KJ16 균주는 회분배양할 경우 2단계 성장을 하며 일차증식기에 CGTase를 생산하고 이차증식기에 CDase를 생산하는 양상을 보였다. 배치 pH를 7.0으로 조절하면서 배양할 경우, CGTase는 균의 증식에 따라 증가하고 CDase는 CGTase보다 뒤에 생산되었다. 그 생산양은 pH 비조절 배양에 비해 CGTase는 최대 12배(1300 mU/ml)까지, CDase는 2배(225 mU/ml)정도 증가되었다. 분리균주가 생산하는 CGTase는 분자량이 65,000 dalton으로 pH 6.0, 60℃에서 최적활성을 보이며 HPLC 분석을 통해 α-, β-, γ-CD를 42: 46: 12의 비율로 생산하는 α/β 혼합형 CGTase였다. 또한 CDase는 분자량이 68,000 dalton으로 pH 6.0, 55℃에서 최적활성을 보이며 최적기질은 γ-CD였다. A bacterium named as Bacillus stearothermophilus KJ16. The growth of the isolated strain occurred in two steps, and syntheses of CGTase and CDase were dependent on the growth cycle of the cell. CGTase was constitutively synthesized during the 1st growing phase, while CDase was synthesized inducibly during the 2nd growing phase. When the medium pH was controlled at 7.0, the maximun enzyme activities of CGTase and CDase were increased by 12-fold(1300 mU/ml) and 2-fold (225 mU/ml), respectively, compared with the pH-uncontrolled batch culture. The CGTase of the isolate converted soluble starch to CDs with the ratio of α-CD: β-CD: γ-CD=42:46:12 at 55℃. The optimal pH and temperature of CGTase were 6.0 and 60℃, respectively and the optimal pH and temperature of CDase were 6.0 and 55℃. The molecular weights of the purified CGTase and CDase were estimated to be 65,000 and 68,000 dalton, respectively. Among serveral substrates, γ-CD was most rapidly hydrolyzed by the purified CDase.

LC-MS/MS를 이용한 S.D. Rat 혈장 중 Arctiin 분석법 개발

송병정,채정우,백현문,권광일 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

KIOM-MA128 is a novel oriental herbal medicine which is for atopic dermatitis and asthma. The purpose of this study was to develop on analytical method of arctiin in rat plasma after oral administration of KIOM-MA128. Analyte was separated on a Atlantis dC18 reverse phase column, using gradient mobile phase (A:B = acetonitrile: 0.1% formic acid in water) at a flow rate of 0.3 mL/min. Detection was performed by electrospray positive ionization mass spectrometry using multiple reaction monitoring of the transitions of arctiin at m/z 552.4 → 372.8 and internal standard (carbamazepine) at m/z 237.0 → 194.5. The limit of quantification was 1 ng/mL for arctiin. The precisions were lower than 15% and the accuracy was between – 12.21 and 3.2%. The maximum concentration found in plasma samples was 4.1 ng/mL. The present method was successfully developed for detecting arctiin in plasma and this results would be utilized to the further study.

Relationship between Meteorological Elements and Yield of Hot Pepper in Yeosu Area of Korea

Kwon,Byung-Sun,Choi,Seong-Kyu,Shin,Jeong-Sik,Shin,Jong-Sup,Shin,Dong-Young,Hwan,Kyu-Hyun,Kim,Hak-Jin,Kuk,Yong-In,Choi,Kyong-Ju 한국자원식물학회 2003 Plant Resources Vol.6 No.1

This study was conducted to investigate the relationships between yearly variations of meteorological elements and yearly variations of productivity in hot pepper. In addition, correlation coefficients among the yields and yield components were used to find out the relationships between meteorological elements and productivity. Yearly variation of the mean air temperature in May and July showed large with coefficients of variation(C.V.) of 25.0,8.9%, respectively, but the variation of the duration of sunshine in May were relative small. Yield and plant height was greatly with C.V. of 7.14,11.6%, respectively, diameter of fruit showed more or less C.V. of 2.28% and length of fruit showed less variation. Correlation coefficients between maximum temperature in period of cultivation from May and yield are positively significant at the level of 1 %. Correlation Coefficients between precipitation in period of cultivation from May to August and yield are negative significant at the level of 5 and 1 %, respectively. Correlation coefficients amount the plant height, length of fruit, diameter of fruit per plant, and seed yield were positively significant at the level of 1 %, respectively.

일부 도시지역 노인의 건강관련 실천과 신체활동기능에 관한 연구

권순범,김공현,김병성,박형종 대한보건협회 1994 대한보건연구 Vol.20 No.2

본 연구는 65세이상 노인들의 보건 관련 행태와 일상생활 활동능력을 파악하고, 이들의 일상생활 활동능력과 관련된 요인들을 규명하여 노인들의 건강의 유지와 증진에 도움이 될 수 있는 보건사업을 개발하고 시행할 때 필요한 기초자료를 제공할 목적으로 실시되었다. 연구대상은 경상남도 마산시 합포구 월영 1동에 거주하는 65세 이상의 노인 가운데서 보건소에서 실시하는 순회진료에 응했거나 보건요원의 가정방문시 면담에 응해준 182명의 노인들이었다. 연구는 1994년 3월 2일부터 4월 8일까지 현지조사가 실시되었으며, 구조화된 설문지를 가지고 시행된 면담과 방사선촬영검사 및 이학적 검사, 그리고 의사외 진찰 등이 병행 실시되었다. 수집된 자료는 SPSS/PC^+ Program을 이용하여 각 변수의 도수와 상대도수를 산출하였고, Chi-square로 검증하였다. 연구결과에 의하면 노인들의 건강 관련 행태, 주관적 건강평가 수준, 일상생활 활동능력, 그리고 앓고있는 질환등에 차이가 많이 있었다. 따라서 노인보건사업을 개발하거나 시행할 경우에는 이러한 것들에 기초를 두어야 할 것으로 판단되었고, 또한 노인의 건강 관련 행태나 일상생활 활동능력에 관한 연구도 이같은 횡단면적 연구만으로 그칠 것이 아니라 코호트 연구를 통하여 보다 심층적 부분에 대하여 연구가 이루어져야 할 필요가 있을 것으로 사료되었다. This study was carried out to find out general characteristics and health-related behaviors of elders aged 65 or over and factors related to their activities of daily living, and thus to contribute to their health maintenance and promotion. The subjects were 182 elders who had resided at Woelyoung-1 dong, Masan-city and participated in this study voluntarily. To collect data for the study, the field survey was conducted from March 2 to April 8, 1994 with a structured questionnaire by trained nurses and the investigator, and physical, clinical and radiological examinations for most of subjects were made of. Univariate and multiple regression methods were employed for data analyses by use of SPSS/PC^+ program. The major findings were as follows: 1. 74.2% of the subjects were 65-74 years old, while 25.8% were 75 years old or over. 40.7% of them were illterate, 27.5% could read and write Korean, 26.9% graduated from elementary school, and 4.8% middle school or higher level. 2. 1.7% of men and 7.3% of women perceived their current health status as excellent, 44.8% of men and 17.7% of women as good, 51.7% of men and 72.6% of women as fair, and 1.7% of men and 2.4% of women as poor. In genral elderly men perceived their health status better than elderly women. Among the subjects, 55.2% of men and 70.2% of women reported that they experienced one or more illnesses during the last year. 3. 55.2% of men and 30.6% of women were current smokers. 53.1% of current male smokers smoked 11-20 cigarettes per day and 60.5% of current female smokers smoked less than 10 cigarettes per day. 4. 58.6% of men and 25% of women drank alcohol currently. 79.4% of current male drinkers and 38.7% of current female drinkers drank once or more per week. 5. 46.6% of men and 25.8% of women practiced regular excercises for their health maintenance and promotion. 6. In general, 39.6% of the subjects needed other's assistance for doing one or more activities such as doing heavy home work, walking up and down stairs or walking half a mile. And 13.2% of them needed other's assistance for doing one or more activities such as walking across a small room, bathing, grooming, dressing, eating and getting up. It showed that the more elders' age incresed, the more they needed others' assistance. 7. Common diseases of the subjects were hypertension, degenerative arthritis, chronic pulmonary disease, diabetes mellitus, chronic renal disease, and cerebrovascular accident in order. 8. Among the factors influencing activities of daily living of the subjects, age, diastolic blood pressure, and serum uric acid, as independent variables, explained 24.7%, 4.0% and 2.2% of required assistances, as a dependent variable, in activites of daily living, respectively. In conclusion, it is suggested that when health services for elders are planned, it is necessary to consider the findings of this study. And it is also desirable to conduct this type of studies in-depth with a sample cohort.

Cyclodextrin Glucanotransferase와 Cyclodextrinase를 생산하는 Bacillus 속 세균의 분리와 그 효소들의 특성

권현주,남수완,김광현,곽영규,김병우 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1

A bacterium producing Cyclodextrin Glucanotransferase (CGTase) and Cyclodextrinase (CDase) was isolated from soil, and named as Bacillus stearothermophilus KJ16 . The growth of the isolated strain occurred in two steps, and syntheses of CGTase and CDase were dependent on the growth cycle of the cell. CGTase was constitutively synthesized during the 1st growing phase. while CDase was synthesized inducibly during the 2nd growing phase. When the medium pH was controlled at 7.0, the maximun enzyme activities of CGTase and CDase were increased by 12-fold (1300 mU/ml) and 2-fold (225 mU/ml), respectively, compared with the pH-uncontrolled batch culture. The CGTase of the isolate converted soluble starch to CDs with the ratio of α-CD:β-CD:γ-CD=42:46:12 at 55℃. The optimal pH and temperature of CGTase were 6.0 and 60℃,respectively and the optimal pH and temperature of CDase were 6.0 and 55℃. The molecular weights of the purified CGTase and CDase were estimated to be 65,000 and 68,000 dalton, respectively, Among serveral substrates, γ-CD was most rapidly hydrolyzed by the purified CDase.