원통 연삭에서 가공 능률 향상을 위한 연삭 저항의 측정에 관한 연구

김원일,이진,이윤경,왕덕현,이상복,이관철,문원길 경남대학교 공업기술연구소 2000 硏究論文集 Vol.18 No.-

본 연구에서는 원통 연삭 가공에서 가공 능률 향상을 위한 연삭 저항을 측정하고자 연삭 가공 중에 발생하는 연삭 저항의 추이를 확인하였고 다음과 같은 결과를 얻었다. 숫돌과 공작물간의 연삭 강성은 공작 속도의 증가에 따라 지지계의 강성이 높은 경우 증가하였고 절삭 깊이와 연삭 숫돌의 속도에는 연삭 강성이 감소하는 경향을 보였다. 또한 총합 강성은 공작 속도, 절삭 깊이 및 연삭 숫돌의 속도 증가에 따라 지지계의 강성이 높을 수록 증가하였다. 연삭기의 강성 변형과 가공 능률에 영향을 주는 값으로 연삭 강성비는 지지계의 강성이 높을 수록 감소하였다. In this study, the measurement of grinding resistance to improve grinding efficiency in cylindrical grinding was studied and the following conclusions could be obtained. Relation grinding wheel and workpiece, grinding stiffness increases according to increase of work speed for high machine stiffness and decreases depth of cut and grinding wheel speed. Also, resultant stiffness increases high machine stiffness according to increase work speed, depth of cut and grinding wheel speed. The values of the effect stiffness deflection in grinding machine, grinding stiffness ratio decrease according to high machine stiffness.

한우의 간이물질 대사효소의 활성도

이관복,박승춘,한경오,윤호인 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.1 No.-

It is important to study the activity of drug biotransformation enzymes, because from a pharmacological and therapeutic point of view these enzymes are resposible for eliminating most drugs. Their level is ciritical when deciding the dose regimen. (From a toxicological perspective, the role of these enzymes varies, with some of them being directly responsible for activation of certain chemicals to reactive intermediates with deleterious consequence to the animal.) Experiments were designed to measure in vitro, the activity of drug metabolizing enzymes in liver of Korean native cattle. The microsomal monooxygenase activities were evaluated utilizing specific substrates. The activities of BPDM and TST 6β-hydroxylase were seemed to be high level relatively to other monooxygenzses such as ECOD, EROD and AH. Interestingly, TST 16α-hydroxylase which is a maker enzyme for CYP ⅠLA was not detected in Korean native cattle. These results sugest that Korean native cattle have high contents of CYP IIB1 and CYP IIIA.

충주시 농촌지역 주민들에 대한 보건교육 평가

권복규,양준호,송진범,이건세,이원진,장성훈 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

The aim of this study was to evaluate the effect of health education program in Choongju rural area which had conducted by Public Health Doctor during winter in 1994 and 1995. We used two step sampling method for a household survey. First, six were selected from 12 Myuns, which were stratified by the level of health education activity. Second, we applied convenient sample method. Of the 307 respondents, most of them knew Health-subcenter's existence in their region. However, only 149 persons(45%) visited it during last year. They visited Health-subcenter because it was easy to travel and convenient. Some of them thought that Health-subcenter had very poorly equipped and supplied. About 32∼34% of respondents participated the health education program for hypertension and diabetes mellitus which was done last winter, and 59∼70% of participants of the program answered that it was very, moderately helpful. 82∼83% of participants recognized complications of hypertension and diabetes mellitus, and 18∼20% of them did not know that medications of hypertension and diabetes mellitus should be continued one's whole life. The respondents want to receive health educations for cancer, arthritis, viral hepatitis and AIDS in orders. Many of rural residents utilize Health-subcenters because health clinics in Choongju rural area are very few.

대게 Chionoecetes opilio (O. Fabricius)의 난발생 및 부화 유생의 형태

이복규,임영수,이종관,허성범 동의대학교 기초과학연구소 1999 基礎科學硏究論文集 Vol.9 No.1

This paper documented mophological changes of embryonic development and first zoea larvae of snow crab, Chionoecetes opilio. Female crabs were sampled by the Danish seine fishery at the depth about 200m in Sep. 1997 in the eastern coast of Korea. Female with newly berried eggs was reared at the water temperature of 5℃ till the time of hatching. The results obtained are as follows. Embryonic development : According to morphogenesis of fertilized eggs, the developmental process of the embryo was classified into the following seven stages : First stage (cleavage and blastula stage, 24 days) Second stage (gastrula stage, 72 days) Third stage (nauplius stage, 22 days) Fourth stage (metanauplius stage, 57 days) Fifth stage (stage of a pigmentary deposit in the compound eye, 30 days) Sixth stage (chromatophore appearance stage in maxillipede, 56 days) Seventh stage (hatching stage, 36 days) Larvae hatched as prezoeas and they molted to first zoea in about an hour. The first zoea is 4.6 to 5.1 ㎜ in length, 3.2∼3.6 ㎜ in width. The abdomen consists of five segments and a bifurcate telson.

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in management of peritoneal carcinomatosis: Single center experience in Korea

Hee Ju Lee1,HyungJoo Baik1,박요한,서상혁,김광희,Ki Beom Bae,Kwan Hee Hong,김기향,변정미,Dae Hoon Jeong,Kyung Bok Lee,오민경,조광래,안민성 대한종양외과학회 2019 Korean Journal of Clinical Oncology Vol.15 No.2

Purpose: Peritoneal carcinomatosis (PC) has been considered a terminal condition and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIEPC) is regarded as an alternative therapeutic option. This study aimed to evaluate the 30-day clinical outcomes of CRS/HIPEC and the feasibility of the surgery by investigating the morbidity and mortality in Inje University Hospital. Methods: Data were retrospectively collected from 19 patients with PC who underwent CRS/HIPEC at Inje University Hospital in 2018. We evaluated pre-, intra-operative parameters and postoperative clinical outcomes and early complications. Results: The mean operating time was 506.95 minutes and the mean blood loss was 837.11 mL. Six cases (31.58%) had morbidity of grade III or above. A longer operating time (≥560 minutes, P=0.038) and large blood loss (≥700 mL, P=0.060) were positively correlated with grade III or worse postoperative complications. Conclusion: Our early experience with CRS/HIPEC resulted in a 31.58% morbidity rate of grade III and above, with risk factors being longer operating time and greater intraoperative blood loss. As the surgical team’s skills improve, a shorter operating time with less intraoperative blood loss could result in better short-term outcomes of CRS/HIPEC.

경주마에서 Naproxen 및 대사산물의 검출

윤효인,박승춘,이관복,김창식 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.1 No.-

Naproxen(NPX) was administrered to a throrougbred mare in a single oral does. Plasma and urine samples were collected from 1 hour to 144 hours after administration, at varying intervals. The alkali hydrolysis was used for the seperation of glucuronide from the conjugated naproxen and its metabolite in urine. Naproxen and its metabolite desmethylnaproxen (DesNPX) were extracted at pH 4.0 with DCM/ETHETR/HEXAN(1/1/1, v/v/v) and quantitated by HPLC with diode-array-detector. The wavelength of ultraviolet was 235, 254 and 264 nm. The qulification of NPX and DesNPX was performed by gas-chromatograph-mass spectrometry using DB-1 column. Silylation (BSTFA including 1% TMCS) before the analysis of the extracted residue with GC/MSD was carried out for the detection of this drug and its metabolite. The characteristic ions (m/e) of trimethyl Silyated NPX and DesNPX were 73, 185, 302 and 73, 243, 360, respectively.

Direct observation of microfracture process in metallic-continuous-fiber-reinforced amorphous matrix composites fabricated by liquid pressing process

Lee, Kyuhong,Son, Chang-Young,Lee, Sang-Bok,Lee, Sang-Kwan,Lee, Sunghak Elsevier 2010 Materials science & engineering. properties, micro Vol.527 No.4

<P><B>Abstract</B></P><P>Zr-based amorphous matrix composites reinforced with metallic continuous fibers were fabricated by liquid pressing process, and their fracture property improvement was explained by directly observing microfracture processes. About 60vol.% of metallic fibers were homogeneously distributed inside the amorphous matrix. Apparent fracture toughness of the tungsten-fiber-reinforced composites was lower than that of monolithic amorphous alloy, while that of the tantalum-fiber-reinforced composite was higher. According to the microfracture observation, shear bands or cracks were initiated at the amorphous matrix, and the propagation of the initiated shear bands or cracks was effectively blocked by fibers, thereby resulting in stable crack growth which could be confirmed by the fracture resistance curve (R-curve) behavior. This increase in fracture resistance with increasing crack length improved fracture properties of the fiber-reinforced composites, and could be explained by the formation of multiple shear bands or multiple cracks at the amorphous matrix, blocking of crack or shear band propagation, and multiple necking at metallic fibers.</P>

Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2

Lee, Young-Kwan,Lee, Hoon Bok,Shin, Dong-Mi,Kang, Min Jueng,Yi, Eugene C,Noh, Seungjoo,Lee, Jaewoo,Lee, Chulbom,Min, Chang-Ki,Choi, Eun Young Nature Publishing Group 2014 Experimental and molecular medicine Vol.46 No.11

<P>Indoleamine 2,3-dioxygenases (IDOs) are tryptophan-catabolizing enzymes with immunomodulatory functions. However, the biological role of IDO2 and its relationship with IDO1 are unknown. To assess the relationship between IDO2 and IDO1, we investigated the effects of co-expression of human (h) IDO2 on hIDO1 activity. Cells co-expressing hIDO1 and hIDO2 showed reduced tryptophan metabolic activity compared with those expressing hIDO1 only. In a proteomic analysis, hIDO1-expressing cells exhibited enhanced expression of proteins related to the cell cycle and amino acid metabolism, and decreased expression of proteins related to cell survival. However, cells co-expressing hIDO1 and hIDO2 showed enhanced expression of negative regulators of cell apoptosis compared with those expressing hIDO1 only. Co-expression of hIDO1 and hIDO2 rescued the cell death induced by tryptophan-depletion through hIDO1 activity. Cells expressing only hIDO2 exhibited no marked differences in proteome profiles or cell growth compared with mock-transfectants. Cellular tryptophan metabolic activity and cell death were restored by co-expressing the hIDO2 mutant substituting the histidine 360 residue for alanine. These results demonstrate that hIDO2 plays a novel role as a negative regulator of hIDO1 by competing for heme-binding with hIDO1, and provide information useful for development of therapeutic strategies to control cancer and immunological disorders that target IDO molecules.</P>

Identification and characterization of an indazole-3-carboxamide class synthetic cannabinoid: 2-[1-(cyclohexylmethyl)-1<i>H</i>-indazole-3-carboxamido]-3,3-dimethylbutanoic acid (DMBA-CHMINACA)

Lee, Ji Hyun,Jung, Aeran,Park, Han Na,Lee, Changhee,Mandava, Suresh,Lim, Sung-jun,Lim, Byoung-bok,Park, Sung-Kwan,Lee, Jongkook,Kang, Hoil Elsevier 2018 Forensic science international Vol.291 No.-

<P><B>Abstract</B></P> <P>Illicit psychoactive substances have threatened public health worldwide. An active metabolite of ADB-CHMINACA and MDMB-CHMINACA was identified for the first time in a powder-type product found in an airmail package. The structure of compound 1 was elucidated by a combination of gas chromatography-mass spectrometry (GC–MS), liquid chromatography-high resolution mass spectrometry (LC-HRMS), infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy. Compound 1 was proven to be an analogue of MDMB-CHMINACA, an indazole-based synthetic cannabinoid. The methyl ester group in MDMB-CHMINACA was replaced with a carboxylic acid group in compound 1. Compound 1 was determined as 2-[1-(cyclohexylmethyl)-1<I>H</I>-indazole-3-carboxamido]-3,3-dimethylbutanoic acid and named as DMBA-CHMINACA.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new indazole-3-carboxamide class synthetic cannabinoid was identified. </LI> <LI> Compound 1 was named as DMBA-CHMINACA according to the EMCDDA guideline. </LI> <LI> DMBA-CHMINACA is a hydrolysed form of MDMB-CHMINACA. </LI> <LI> DMBA-CHMINACA is a potential CB1 and CB2 agonist. </LI> <LI> DMBA-CHMINACA can work as a synthetic precursor of several synthetic cannabinoids. </LI> </UL> </P>

Treatment of Brainstem Cavernous Malformation: Treatment Indication, Technical Consideration, and Results

Lee, Sang-Bok,Lee, Jung-Il,Kim, Jong-Soo,Hong, Seung-Chyul,Park, Kwan The Korean Neurosurgical Society 2005 Journal of Korean neurosurgical society Vol.37 No.3

Objective: The goal of this study is to provide the clinical data of patients with brainstem cavernous hemangiomas after treatment with microsurgery or radiosurgery after conducting a retrospective analysis of 21 patients at one institution. Methods: Twenty one patients with brainstem cavernous hemangiomas were treated at the authors' institution between 1995 and 2004 and clinical analysis was performed by retrospective review of medical records and neuroimaging examinations. Thirteen patients underwent microsurgical resection and radiosurgery was performed as an initial treatment in 9 patients. Results: Radical excision was achieved in 12 among 13 patients and transitory neurological deterioration or new neurological deficit developed during the immediate postoperative period in 7 (54%). The final outcomes at 5 - 70 months after surgery were improved in 11 patients (85%) and worsened in 2 patients (15%) compared with the preoperative state. Radiosurgery was performed in 9 patients. During the follow up period from 5 to 70 months there was neurological improvement in 3 patients, no significant change in 3 and deterioration in 3 patients. Two patients developed rebleeding at 5 months, 60 months respectively after radiosurgery. Conclusion: Microsurgery for symptomatic cavernous hemangioma of brainstem can be performed with acceptable morbidity. Fatal complication is rare with careful selection of the optimal operative approach in well selected patients. Radiosurgery is an effective alternative for the lesions which are not accessible by surgical approach, however, there is still a possibility of rebleeding over a long period after radiosurgical treatment and microsurgery should be considered as a treatment with priority for the majority of cases.