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Clinical trial: Inhibitory effect of revaprazan on gastric acid secretion in healthy male subjects
Kim, Hyung‐,Keun,Park, Soox2010,Heon,Cheung, Daex2010,Young,Cho, Youngx2010,Seok,Kim, Jinx2010,Il,Kim, Sungx2010,Soo,Chae, Hiunx2010,Suk,Kim, Jaex2010,Kwang,Chung, Inx2010,Sik Blackwell Publishing Asia 2010 Journal of gastroenterology and hepatology Vol.25 No.10
<P><B>Abstract</B></P><P><B>Background and Aim: </B> Revaprazan is a novel acid pump antagonist. The aim of this study was to investigate the inhibitory effect of revaprazan on gastric acid secretion in healthy male subjects.</P><P><B>Methods: </B> In a double‐blind, three‐way cross‐over study, 30 healthy male volunteers were randomized to 100, 150 or 200 mg of oral revaprazan daily for 7 days. Serum gastrin concentration was measured, and 24‐h intragastric pH was recorded at baseline and on days 1 and 7 of each administration period. Serial blood samples were processed for pharmacokinetics.</P><P><B>Results: </B> Median intragastric pH over 24 h and mean percentage time that pH was > 4 increased in a dose‐dependent manner and were significantly higher on days 1 and 7 compared with baseline in all groups (<I>P</I> < 0.05). The antisecretory effect of revaprazan was rapid and nearly maximal on day 1 in all groups. Serum gastrin levels were rapidly normalized by 100 and 150 mg/day of revaprazan on days 1 and 7, but were significantly higher in the 200 mg/day revaprazan group. The pharmacokinetic effect was rapidly absorbed and eliminated on days 1 and 7 in all groups.</P><P><B>Conclusions: </B> Revaprazan rapidly and effectively inhibits gastric acid secretion in healthy male subjects. Therefore, revaprazan can be used as an effective drug for acid‐related disease.</P>
Nogo‐A expression in oligodendroglial tumors
Jung, Taex2010,Young,Jung, Shin,Lee, Kyungx2010,Hwa,Cao, Van Thang,Jin, Shux2010,Guang,Moon, Kyungx2010,Sub,Kim, Inx2010,Young,Kang, Samx2010,Suk,Kim, Hyung‐,Seok,Lee, Minx2010,Che Blackwell Publishing Asia 2011 Neuropathology Vol.31 No.1
<P>Nogo‐A belongs to the reticulon protein family and is expressed in the inner and outer loops of myelin sheaths of oligodendrocytes. We analyzed the patterns of Nogo‐A expression in human gliomas in an effort to identify a useful marker for the characterization of oligodendroglial tumors. We determined the expression of Nogo‐A in a panel of 58 astrocytic and oligodendroglial tumors using immunohistochemistry and compared the expression of Nogo‐A with Olig‐2, a recently identified marker for oligodendrogliomas. To localize Nogo‐A expression, immunofluorescent staining was performed using other glial markers (MAP‐2 and GFAP). We also confirmed the overexpression of the Nogo‐A protein in 53 astrocytic and oligodendroglial tumors using Western blot analysis. Based on immunohistochemical analysis, Nogo‐A and Olig‐2 had specificity in the detection of oligodendroglial tumors from astrocytic tumors (<I>P</I> = 0.001). The level of Nogo‐A staining was highly correlated with Olig‐2 (<I>P</I> = 0.001). The sensitivity and specificity of Nogo‐A for oligodendroglial tumors was 86.9% and 57.1%, respectively. Nogo‐A expression overlapped that of other oligodendroglial markers, but with different patterns of expression. Western blot analysis revealed that Nogo‐A is predominantly expressed in 85.7% of oligodendroglioma cells and 93.7% of anaplastic oligodendroglioma cells. Like other oligodendroglial markers, Nogo‐A is highly expressed in oligodendroglial tumors; however, it does not serve as a definite marker specific for oligodendroglial tumors.</P>
Kim, Soox2010,Jin,Pham, Thux2010,Huyen,Bak, Yesol,Ryu, Hyung‐,Won,Oh, Seix2010,Ryang,Yoon, Dox2010,Young John Wiley Sons, Inc. 2018 Environmental toxicology Vol.33 No.11
<P><B>Abstract</B></P><P>7‐Methoxy‐luteolin‐8‐C‐<I>β</I>‐6‐deoxy‐xylo‐pyranos‐3‐uloside (mLU8C‐PU) is a glycosylflavone of luteolin isolated from <I>Arthraxon hispidus</I> (Thunb.). Luteolin is known to exert anti‐migratory and anti‐invasive effects on tumor cells. However, there are no reports on the effects of mLU8C‐PU on tumor invasiveness and associated signaling pathways. In this study, we demonstrated the anti‐migratory and anti‐invasive effects of mLU8C‐PU in 12‐<I>O</I>‐tetradecanoylphorbol‐13‐acetate (TPA)‐treated MCF‐7 breast cancer cells. We also investigated the effect of mLU8C‐PU on invasion‐ related signal transducers, including protein kinase Cα (PKCα), c‐Jun N terminal kinase (JNK), activator protein‐1 (AP‐1), and nuclear factor‐kappa B (NF‐ĸB). TPA‐induced membrane translocation of PKCα, phosphorylation of JNK, and the nuclear translocations of AP‐1 and NF‐κB were downregulated by mLU8C‐PU in MCF‐7 cells. In addition, mLU8C‐PU also inhibited matrix metalloproteinase‐9 (MMP‐9) and interleukin‐8 (IL‐8) expression. These results indicate that mLU8C‐PU inhibits migratory and invasive responses in MCF‐7 breast cancer cells by suppressing MMP‐9 and IL‐8 expression through mitigating TPA‐induced PKCα, JNK activation, and the nuclear translocation of AP‐1 and NF‐κB. These results suggest that mLU8C‐PU may be used as an anti‐metastatic agent.</P>
Yun, Jinx2010,Mun,Yeo, Junx2010,Seok,Kim, Juhwan,Jeong, Hyung‐,Gu,Kim, Dongx2010,Yu,Noh, Yongx2010,Jin,Kim, Seokx2010,Soon,Ku, Bonx2010,Cheol,Na, Seokx2010,In WILEY‐VCH Verlag 2011 Advanced Materials Vol.23 No.42
<P><B>The preparation of a reduced graphene oxide (pr‐Go) is with a novel p‐TosNHNH2 reductant</B> is demonstrated for use as an efficient anode interfacial layer for high‐performance and highstability organic solar cells (OSCs). The efficiency of the cells with pr‐GO is highly comparable to those of the PEDOT:PSSbased devices. Furthermore, the pr‐GO based OSCs show a much longer cell life time in air stability tests in comparison with PEDOT:PSS‐based cells.</P>
Ko, Youngx2010,Ho,Kim, Jex2010,Hyung,Jin, Lix2010,Hua,Ko, Sukx2010,Min,Kwon, Bongx2010,Joon,Kim, Joosung,Kim, Taek,Cho, Yongx2010,Hoon WILEY‐VCH Verlag 2011 ADVANCED MATERIALS Vol.23 No.45
<P>Electrically driven hybrid light‐emitting diodes (LEDs) consisting of quantum dots, wires, and wells based on the nanometer‐sized pyramid GaN structure are reported by Taek Kim, Yong‐Hoon Cho, and co‐workers on page 5364. The LEDs exhibit mixed emissions from InGaN quantum dots, wires, and wells formed at the tops, edges, and sidewalls of the pyramids, respectively. The hybrid LEDs containing low‐dimensional quantum structures provide a broad‐band, highly efficient visible lighting source. </P>
Park, Jung Kyu,Shim, Jinx2010,Hyung,Kang, Kyung Shin,Yeom, Junseok,Jung, Ho Sang,Kim, Jong Young,Lee, Keum Hong,Kim, Taex2010,Ho,Kim, Shinx2010,Yoon,Cho, Dongx2010,Woo,Hahn, Sei Kwang WILEY‐VCH Verlag 2011 Advanced Functional Materials Vol.21 No.15
<P><B>Abstract</B></P><P>Despite wide applications of bone morphogenetic protein–2 (BMP‐2), there are few methods to incorporate BPM‐2 within polymeric scaffolds while maintaining biological activity. Solid free‐form fabrication (SFF) of tissue‐engineering scaffold is successfully carried out with poly(lactic‐<I>co</I>‐glycolic acid) grafted hyaluronic acid (HA‐PLGA) encapsulating intact BMP‐2/poly(ethylene glycol) (PEG) complex. HA‐PLGA conjugate is synthesized in dimethyl sulfoxide (DMSO) by the conjugation reaction of adipic acid dihydrazide modified HA (HA‐ADH) and PLGA activated with <I>N</I>,<I>N</I>′‐dicyclohexylcarbodiimide (DCC) and <I>N</I>‐hydroxysuccinimide (NHS). BMP‐2 is complexed with PEG, which is encapsulated within the PLGA domain of the HA‐PLGA conjugate by SFF to prepare tissue‐engineering scaffolds. In vitro release tests confirm the sustained release of intact BMP‐2 from the scaffolds for up to a month. After confirmation of the enhanced osteoblast cell growth, and high gene‐expression levels of alkaline phosphatase (ALP), osteocalcin (OC), and osterix (OSX) in the cells, the HA‐PLGA/PEG/BMP‐2 scaffolds are implanted into calvarial bone defects of Sprague Dawley (SD) rats. Microcomputed tomography (μCT) and histological analyses with Masson's trichrome, and hematoxylin and eosin (H&E) staining reveal effective bone regeneration on the scaffolds of HA‐PLGA/PEG/BMP‐2 blends.</P>
Yun, Jinx2010,Mun,Yeo, Junx2010,Seok,Kim, Juhwan,Jeong, Hyung‐,Gu,Kim, Dongx2010,Yu,Noh, Yongx2010,Jin,Kim, Seokx2010,Soon,Ku, Bonx2010,Cheol,Na, Seokx2010,In WILEY‐VCH Verlag 2011 Advanced Materials Vol.23 No.42
<P>Solution‐processable reduced graphene oxide as a hole‐transporting layer for highly efficient and stable organic solar cells is reported on page 4923 by Dong‐Yu Kim, Seok‐In Na, and co‐workers. Introduction of a newly reduced graphene oxide by simple solution processing into solar cells dramatically raises the cell efficiency and cell life‐time. The results will allow full use of chemically reduced graphene and will advance the realization of carbon‐based printable optoelectronic devices. </P>
Jeong, Hyung‐,Gu,Lim, Bogyu,Na, Seokx2010,In,Baeg, Kangx2010,Jun,Kim, Juhwan,Yun, Jinx2010,Mun,Kim, Dongx2010,Yu WILEY‐VCH Verlag 2011 Macromolecular Chemistry and Physics Vol.212 No.21
<P><B>Abstract</B></P><P>A series of conjugated polymers (PDTP, PDTPT, PDTPTT) based on dithieno[3,2‐<I>b</I>:2′,3′‐<I>d</I>]pyrrole (DTP) containing branched side‐chains is synthesized. The synthesized polymers show good solubility due to branched side‐chains in the organic solvent in the absence of heat treatment. To increase the oxidation potential, unsubstituted thiophene units are introduced into the polymer backbone. The introduction of unsubstituted thiophene units increases the oxidation potential, elevates degradation temperature, and enhances electronic properties. The PDTPTT FETs show the highest charge‐carrier mobility among the three polymers. These polymers are used as a donor material in bulk heterojunction solar cells, and the PDTPTT photovoltaic cells exhibit high performance.</P>
Yi, Junx2010,Koo,Kim, Heix2010,Jung,Yu, Dongx2010,Hoon,Park, Seox2010,Jin,Shin, Mix2010,Jung,Yuh, Hyung‐,Soo,Bae, Kix2010,Beom,Ji, Youngx2010,Rae,Kim, Nax2010,Ri,Park, Six2010 Wiley Subscription Services, Inc., A Wiley Company 2012 Vol.64 No.7
<P><B>Abstract</B></P><P><B>Objective</B></P><P>Calcineurin‐binding protein 1 (CABIN‐1) regulates calcineurin phosphatase activity as well as the activation, apoptosis, and inflammatory responses of fibroblast‐like synoviocytes (FLS), which actively participate in the chronic inflammatory responses in rheumatoid arthritis (RA). However, the mechanism of action of CABIN‐1 in FLS apoptosis is not clear. This study was undertaken to define the regulatory role of CABIN‐1 in FLS from mice with collagen‐induced arthritis (CIA).</P><P><B>Methods</B></P><P>Transgenic mice overexpressing human CABIN‐1 in joint tissue under the control of a type II collagen promoter were generated. Expression of human CABIN‐1 (hCABIN‐1) in joints and FLS was determined by reverse transcription–polymerase chain reaction (RT‐PCR) and Western blot analysis. The expression of cytokines, matrix metalloproteinases (MMPs), and apoptosis‐related genes in FLS was determined by enzyme‐linked immunosorbent assay, gelatin zymography, and RT‐PCR, respectively. Joints were stained with hematoxylin and eosin and with tartrate‐resistant acid phosphatase for histologic analysis.</P><P><B>Results</B></P><P>Human CABIN‐1–transgenic mice with CIA had less severe arthritis than wild‐type mice with CIA, as assessed according to hind paw thickness and histologic features. The milder arthritis was accompanied by significantly enhanced apoptosis in transgenic mice, evidenced by a significantly greater number of TUNEL‐positive cells in synovial tissue. Expression of inflammatory cytokines and MMPs in the transgenic mice with CIA was reduced, and they exhibited decreased Akt activation and increased expression of p53, caspase 3, caspase 9, and Bax.</P><P><B>Conclusion</B></P><P>Our findings demonstrate that hCABIN‐1 plays a critical role in promoting apoptosis of FLS and in attenuating inflammation and cartilage and bone destruction in RA. These results help elucidate the pathogenic mechanisms of RA and suggest that CABIN‐1 is a potential target for treatment of this disease.</P>
Relaxin is up‐regulated in the rat ovary by orthodontic tooth movement
Yang, Sox2010,Young,Ko, Hyunx2010,Mi,Kang, Jeex2010,Hae,Moon, Yeonx2010,Hee,Yoo, Hongx2010,Il,Jung, Nax2010,Ri,Kim, Minx2010,Seok,Cho, Jinx2010,Hyung,Oh, Wonx2010,Mann,Kim, Sunx201 Blackwell Publishing Ltd 2011 European journal of oral sciences Vol.119 No.2
<P> <I>Yang S‐Y, Ko H‐M, Kang J‐H, Moon Y‐H, Yoo H‐I, Jung N‐R, Kim M‐S, Cho J‐H, Oh W‐M, Kim S‐H. Relaxin is up‐regulated in the rat ovary by orthodontic tooth movement.</I> <I>Eur J Oral Sci 2011; 119: 115–120. © 2011 Eur J Oral Sci</I> </P><P>Relaxin (Rln) is an ovarian hormone that stimulates osteoclastic and osteoblastic activities and connective tissue turnover. To investigate the expression of Rln during orthodontic tooth movement, rats were implanted with orthodontic appliances that connected a spring from the upper incisors to the first molar with a 70 cN force. Rats in each group were killed 6, 48, and 144 h after activating the appliance, and the levels of <I>Rln1</I> and <I>Rln3</I> expression in the ovary were determined by real‐time RT‐PCR, northern blots, western blots, and immunofluorescence analyses. The amount of tooth movement induced by the orthodontic force increased in a time‐dependent manner. The levels of <I>Rln1</I> mRNA increased by 12‐, 41‐, and 263‐fold at 6, 48, and 144 h, respectively, after orthodontic tooth movement. The time‐dependent increase in the concentration of Rln 1 protein in the ovary was also confirmed by western blotting. Rln 1 was localized in the granulosa cells of the ovarian follicles, and the immunoreactivity against Rln 1 was increased by the movement. In contrast, the concentration of Rln 3 was below the level of detection. The results of this study suggest that local changes in periodontal tissues induced by orthodontic tooth movement may affect <I>Rln1</I> expression in the ovary. However, further studies are needed to decipher the mechanisms involved and the possible contribution of the increased level of expression of Rln 1 to the tooth movement.</P>