개에서 이중 결찰법을 통한 동맥관 개존증의 완치 예

윤헌영,정순욱,박희명,박철,정만복,김준영,한현정,황민,노병국,박상혁,장하영,박정윤 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.1

A ten months old, female Yorkshire terrier weighing 2.88 kg referred to veterinary teaching hospital of college of veterinary medicine, Konkuk University because of syncope, cough and dyspnea. First hematological and serum chemical test revealed thrombocytopenia, mild anemia, and increase of concentration of ALP (195 U/L). On 57 days later, second hematological and serum chemical test revealed polycythemia, increase of concentration of ALP (211 U/L), and Tchol (387 mg/dl). Right atrium enlargement, main pulmonary artery bulge and cardiomegaly (VHS = 11.5) were observed in radiographic findings. Ultrasonographic images showed both right and left ventricular dilation and turbulent flow between the descending aorta and the main pulmonary artery in color Doppler imaging. ECG showed left ventricular enlargement, SA block, and electrical alternant. Thoracotomy was performed through left fourth intercostal incision under isoflurane anesthesia. Patent ductus arteriosus was double ligated with 1-0 silk. Cough and dyspnea disappeared on 5 days after operation. Turbulent flow was not found in color doppler imaging of ultrasonography on 10 days after operation. Ten months later after the operation, syncope could not exist any more.

NiTi-형상기억합금 차동식 액츄에이터의 동특성연구

정상화,김현욱,장우양,김경석,차경래,나윤철 朝鮮大學校 機械技術硏究所 2001 機械技術硏究 Vol.4 No.2

최근 전 세계적으로 초소형 정밀 기계 기술에 관한 연구 및 개발이 활발하게 이루어지면서 형상기억합금(Shape Memory Alloy : SMA)을 이용한 초소형 액츄에이터(Micro Actuator)에 관한 관심이 증대되고 있다. 형상기억합금을 액츄에이터에 응용하기 위해서는 동적 특성의 분석이 필수적이지만 지금까지의 연구에서는 형상기억합금의 물질 및 재료적 특성은 많이 보고되고 있으나 동적 특성에 대한 연구는 매우 부족한 실정이다. 본 논문에서는 비저항(resistivity)이 큰 NiTi합금 와이어(wire)를 이용하여 나선형 스프링(helical spring)을 제작하여 디지털 힘 측정기(Digital force gauge)와 적외선 온도센서(Infrared themometer) 그리고 레이저 변위 센서(Laser displacement sensor)를 이용하여 이 NiTi 스프링의 힘의 크기와 반응속도, 온도와 변위를 측정하여 형상기억합금의 동적 특성을 분석하였다. 또한 형상기억합금을 이용하여 차동식 액츄에이터를 제작하여 그 동적 성능을 실험하였다. In the recent years, as the research and the development of micro and precision machinery become active, the interest of micro actuators using SMA(Shape Memory Alloy) has been increased. The dynamic characteristic analysis of SMA is necessary for actuator application and many common researches report the material characteristics of SMA sufficiently. However, the research on dynamic characteristics is very deficient. In this paper, the helical spring are fabricated with NiTi SMA wire of high resistivity. The force, response speed, temperature, and displacement are measured by digital force gauge, infrared thermometer, and laser displacement sensor so that the dynamic characteristics of this SMA is analyzed. Also, bidirectional actuator was fabricated and experimented for its performance.

개 대뇌겉질에서 Platelet-Derived Growth Factor α-Receptor의 출생 후 발달에 관한 면역조직화학적 연구

윤영,안병수,김인정,양경철,박선홍,김기훈,박도영,김장만,문정석,장인엽,조하영 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background and Objectives : The localization of platelet-derived growth factor-α receptor (PDGF-α R) was commonly restricted to oligodendrocyte progenitors during late embryonic and postnatal development. However, several studies recently demonstrated that mature neurons could also synthesize PDGF-α, Materials and Methods : In the present study, to analyze the distributional pattern of PDGF-αR during postnatal development of the canine cerebral cortex, we used immunohistochemistry on sections of canine brain tissue. Results : We found that neurons of various regions of cerebral cortex exhibited the immunoreactivity to PDGF-αR as early as postnatal day 0, and slightly decreased after postnatal day 14. Whereas neuronal PDGF-αR were maintained at all ages, the oligodendroglia-like expression of PDGF-αR could not be confirmed. Conclusion : The localization of PDGF-αR in immature and mature neurons supports the several roles of PDGF during development, protection and survival of neurons.

수직축 블레이드를 적용한 소형 풍력발전시스템에 관한 연구

윤정필,최장균,차인수 동신대학교 2004 論文集 Vol.14 No.-

Need developments of substitute energy to solve problem of global warming by excess use of fossil energy, excess discharge of carbon dioxide. Wind Generation is all-important energy in next generation as clean energy. Environmental pollution of wind force development is not exhausted entirely. And, electric-power production unit cost is cheap than other energy. Wind Generation system that is supplied much present is most horizontality style blade structure. But, Horizontal style structure is serious noise and there is problem in stability of blade. We designed special blade aiming to this problem. And, manufactured vertical axis wind force development system because using blade. Also, developed assistance power generator to heighten driving efficiency ago wind generation. We expect this devices that is such cover shortcoming of wind force development.

청소년의 인터넷 중독 정도에 따른 인적자원의 차이

장윤옥,정서린 경북대학교 사범대학 부속 중등교육연구소 2005 중등교육연구 Vol.53 No.2

본 연구의 목적은 청소년의 인터넷 중독 정도에 따른 이들의 인적자원의 차이를 알아보는 것이다. 본 연구는 396명의 중학교 2년생들을 대상으로 하였으며 연구방법으로는 질문지법을 이용하였다. 청소년들은 자신의 인터넷 중독 정도에 따라 인터넷 중독 집단, 인터넷 중독위험 집단, 인터넷 비중독 집단으로 나뉘어졌으며, 이러한 중독 정도에 따라 개인적 자원인 자기통제력, 시간관리, 문제해결능력과 대인적 자원인 부모 · 또래 · 교사지지에 차이가 있는지를 알아보았다. 본 연구결과 인터넷 중독 정도에 따라 개인적 자원에 유의한 차이가 있었는데 구체적으로는 인터넷 중독 청소년들이 비중독 청소년들보다 자기통제력과 문제해결능력이 통계적으로 유의하게 낮았으며, 시간관리능력도 차이가 있는 것으로 나타났으나 집단간 구체적인 차이는 통계적으로 유의하지 않았다. 또한 인터넷 중독 정도에 따라 대인적 자원에도 유의한 차이가 있었는데 구체적으로는 인터넷 중독 청소년들은 비중독 청소년들에 비해 부모, 또래, 교사로부터 지지를 더 적게 받는 것으로 지각하고 있었다. The purpose of this study was to investigate differences in human resource according to the degree of internet addiction of adolescents. The survey study administered 396 questionnaires to middle school students in Daegu. The adolescents were divided into three group - internet addiction group, internet mid-addiction group, and internet non-addiction group - by the degree of internet addiction. The data were processed using one-way ANOVA and Scheffe test for post-hoc analysis. The main findings of this study were as follows. First, The internet addiction adolescents were lower self-control and problem solving ability than internet non-addiction adolescents. Second, The internet addiction adolescents perceived lower support from parents, peers, and teachers than internet non-addiction adolescents.

일개 대학병원에서 항생제 사용량과 분리 균주의 항생제 내성률에 관한 시계열 분석

윤영경,김민자,손장욱,박대원,김정연,천병철 대한감염학회 2008 감염과 화학요법 Vol.40 No.2

배경 :항생제 사용이 내성 균주를 유발하는 것으로 알려져 있다. 그러나, 항생제 사용량과 분리 균주들의 항생제 내성률의 관련성에 관한 연구는 매우 드물다. 본 연구는 일정 기간 동안의 항생제 사용량과 분리 균주의 항생제 내성률의 추이를 확인하고, 시계열 분석을 통해 사용된 항생제 양에 따른 내성률의 정도를 예측할 수 있는 모델링 방법을 확인하고자 하였다. 방법 : 전산화 항생제 처방 시스템이 갖춰진 750 병상의 대학 병원에서 2004년 1월부터 2007년 3월까지 분리된 전체 임상 분리 균주를 대상으로 항생제 내성률을 조사하였다. 항생제 사용량은 12가지 계열별로 분류하여 월별 항생제 사용 밀도(antimicrobial use density; AUD={총량 /(DDDX연환자수)}x1,000)를 구하였다. 선택된 항생제들의 월별 사용량과 특정 분리 균주들의 항생제 내성률의 변동과의 연관성을 SAS/ETS를 이용하여 상관 분석과 시계열 분석을 실시하였다. 결과 : 39개월의 연구 기간 동안 총 15,522개의 균주가 분리되었고, 항생제 사용량은 총 1,926.07 DDD/1,000명/일 이었다. 계열별 항생제의 월별 총 사용량은 연구 기간 중 큰 변화가 없었다. 항생제 내성률은 ciprofloxacin 내성 Escherichia coli는 32.46%±14.0, imipenem 내성 Pseudomonas aureginosa는 11.44%±8.1, methicillin 내성 Staphylococcaus aureus (MRSA)는 78.60%±6.9였으며, van-comycin 내성 Enterococcus faecium은 7.43%±4.5 이었다. 12개의 항생제 계열 중 월별 AUD의 평균은 aminoglycosides는 156.16±6.49, 3세대 cephalosporins은 145.67±5.95, 2세대 cephasporins은 90.95±7.47의 순서로 확인되었다. 시계열 분석에서, E. coli ciprofloxacin 내성률은 2개월 전의 E. coli CFX 내성률과 2개월 전의 ciprofloxacin 사용량(52.98±2.12)과 유의한 연관성이 있음을 확인하였다. 또한, MRSA 비율은 2개월과 4개월 전의 MRSA 비율과 3개월 전의 oxacillin 사용량(4.69±0.67)과 유의한 연관성이 있음을 확인하였다. 결론 : 연구 기간 동안의 항생제 사용량과 분리 균주의 항생제 내성률의 안정적 추이를 확인하였다. 또한 항생제 사용과 항생제 내성 사이의 일시적 관계를 나타내는 데에 시계열 분석의 유용함을 확인하였고, 이를 통하여 특정 항생제의 사용량과 관련된 항생제 내성률을 예측할 수 있었다. Background : The purpose of this study was to investigate the relationship between antimicrobial consumption and antimicrobial resistance and to predict for the level of antimicrobial resistance by a time series analysis. Materials and Methods : In a 750-bed medical center, antimicrobial consumption data of 12 classes of antimicrobials and surveillance of resistant profiles from all microbial isolates were collected from 1/2004 through 3/2007 by database from the hospital's computerized order system. World Health Organization 2004 definition of defined daily doses per 1,000 patient days were used to express the antimicrobial use density (AUD). The monthly proportion of resistant isolates (PR) of selected pathogens and monthly AUD were analyzed by time series analysis with transfer function model by using the SAS/ETS software. Results : The microbial surveillance data covered 15,522 isolates. PR of ciprofloxacin-resistant E.coli (EC-CFX), imipenem-resistant P. aureginosa, and methicillin-resistant S. aureus (MRSA) were 32.5%±14.0 11.4%±8.1, and 78.6%±6.9. The two highest monthly AUD of 12 class antimicrobials were 156.2±6.5 AUD for aminoglycosides and 145.7±6.0 AUD for 3rd-generation cephalosporins. By using time series analysis, we verified a significant correlation between the monthly CFX use and the PR of EC-CFX, and between the monthly penicillin use and the PR of MRSA. Conclusion : Antibiotic consumption and PR of antimicrobial resistant pathogens remained stable over the period of study. Furthermore, we could confirm the usefulness of a time series analysis to demonstrate a temporal relationship between antimicrobial use and resistance, to predict the effect of antibiotics use on antimicrobial resistance.

위암의 근치절제술 후 생존율과 예후인자

차윤정,박진영,장정환,김성환,김권천,조현진,민영돈 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Background and Objectives: Gastric cancer is still the leading cause of cancer death in Korea, and surgery remains the only method of treatment that offers the potential for a cure. Purpose: The aims of this study are to examine the outcome of the patients with gastric adenocarcinoma who underwent curative resection and to identify the prognostic factors leading to improved survival rates in these patients. Materials and Methods: The medical records of 278 patients with gastric adenocarcinoma, treated curatively at the Chosun University Hospital between January 1990 and December 1994, were reviewed retrospectively from January 2000 to March 2000. Follow-up was obtained for 250 patients(89.9%). The survival rates were calculated by the Kaplan-Meier method, and the significance of differences between patient factors(age and sex), tumor factors(location, size, gross type, tumor depth, lymph node metastasis, and stage) and treatment factors(operation method and reconstruction type) were evaluated statistically by the log-rank test. Results: The overall five-year survival probability was 59.6%. There was no survival difference according to age and sex. The 5-year survival rates according to the tumor depth were 97.0% for Tl, 74.5% for T2, 39.6% for T3, and 23.1% for T4(p=0.0000); to the lymph node metastasis were 81,4% for N0, 51.9% for N1, and 21.2% for N2(p=0.0000); to the TNM stage were 96.7% for stage I a, 79.5% for stage I b, 68.8% for stage II, 52.9% for stage III a, 25.9% for stage III b, and 7.5% for stage IV(p=0.0000). Other statistically significant differences were shown in tumor location, size, gross type, operation method, and reconstruction type after subtotal gastrectomy. Conclusion: The most definitive prognostic factors affecting the survival rate of gastric adenocarcinoma were tumor depth, lymph node metastasis, and tumor stage. The keys to successful outcome includes early diagnosis and curative resection with radical lymph node dissection at early stage as possible.

풍력발전기 원격모니터링 시스템 구축 및 개발

차장현,이정완,유능수,남윤수 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.B

In this paper, remote monitoring system for wind turbine is developed. The developed system consists of data acquisition for wind sensor, and monitoring for site environment. In order to accomplish effective monitoring, the system uses Datasocket, SMB, FTP, Web Server, and G Web Server. Two computer system - one is data acquisition computer using Windows-XP and the other is monitoring computer using UNIX - constraint the distribute system with individual tasks. By using this system, one can perform various monitoring and control tasks in Wind-Turbine application, efficiently.

방향족 화합물의 할로 메칠화 반응

박정서,김신종,백운필,이현주,송윤석,장정민 明知大學校 自然科學硏究所 1997 자연과학논문집 Vol.15 No.-

Biphenyl의 para position에 methylene group을 도입 시키는 방법으로 paraformaldehyde와 dimethylamine을 반응시켜 Mannich Base인 (1,1'-biphenyl-4,4'-dimethyl)-dimethli amine을 합성해 보았으나, 전혀 반응이 진행되지 않았다. 즉 , Biphenyl에 강한 activating group이 없으므로 Mannich Base을 사용한 방법은 효과적이 못된다. 따라서, 다른 방법으로 biphenyl에 bromomethylation을 진행 시켜서, 두 개의 methylene group을 도입시켰다. Bromomethylation은 다음과 같이 사용하는 시약 및 실험 방법 등을 고려하여 3가지 방법으로 시도 하였다. 1)1,3,5-trioxane + HBr in AcOH + paraformaldehyde 사용법, 2)Hbr in AcOH + paraformaldehyde 사용법, 3) NaBr + H₂SO₄+paraformaldehyde 사용법, 이상의 3가지 방법 중에서 NaBr+ H₂SO₄+ paraformaldehyde 사용법이 가장 좋은 결과를 얻었다. 이러한 system에서 반응을 진행시킨 결과 69% 의 높은 수율 (87%의 purity)로 4,4'-dibromomethylbiphenyl 합성에 성공할 수 있었다. The synthetic method for the induction of methylene group on the para position of arenes is of importance. Since the weak activation effect of phenyl group on the electrophilic substitution reaction, the induction of methylene group by way of Mannich base using paraformaldehyde and dimethylamine was unsuccessful. It was found that halomethylation of byphenyl is only the way for the preparation of di-p-methylenebiphenyl. Especially, bromomethylation was turn out to be more reliable synthetic method than chloromethylation. Herein, we developed 3 protocols for the synthesis of 4,4'-dibromomethylbiphenyl. In addition, the best result was obtained using NaBr + H₂SO₄paraformaldehyde protocol in 69% yield.

풍력발전기 원격모니터링 시스템 구축 및 개발

차장현,이정완,유능수,남윤수 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.A

In this paper, remote monitoring system for wind turbine is developed. The developed system consists of data acquisition for wind sensor, and monitoring for site environment. In order to accomplish effective monitoring, the system uses Datasocket, SMB, FTP, Web Server, and G Web Server. Two computer system - one is data acquisition computer using Windows-XP and the other is monitoring computer using UNIX - constraint the distribute system with individual tasks. By using this system, one can perform various monitoring and control tasks in Wind-Turbine application, efficiently.