프로그램화 된 신체운동이 ADHD 아동의 주의산만행동과 과잉행동에 미치는 효과

최재원(Jae Won Choi),강경두(Kyoung Doo Kang),정혜연(Hye Yeon Jung) 한국사회체육학회 2012 한국사회체육학회지 Vol.0 No.47

The purpose of this study is to deeply analyze a change of the programmed physical exercise in attentiondeficient behavior and hyperactivity of children with ADHD, through the single-subject research design method. The research subjects were 4 elementary school students who are under being cured due to being judged to be ADHD at Child Psychiatric Clinic for C University Hospital where is located in Seoul at that time of beginning experiment in order to be conformed with the objective of research. For visual observation, the attention-deficient behavior was used the frequency-typed case sampling method(Shin So-yeon, Park Jaeguk, Kim Yeong-mi, Lee Hwa-eun, 2007). Observation of hyperactivity was used the contents, which Carlson and Hotfield(1991) defined, by referring to the contents by Mun Jae-gyeong(1998). The following are the results that were elicited through the research procedure of this study. First, the programmed physical exercise was indicated to reduce attention-deficient behavior in children with ADHD. Second, the programmed physical exercise was indicated to reduce hyperactivity in children with ADHD.

지능형 전자상거래를 위한 적응형 에이전트 기반 교섭 모델에 관한 연구

강재연,이은석 成均館大學校 科學技術硏究所 1998 論文集 Vol.49 No.2

With the growth of EC(Electronic Commerce) on the Internet and the increase of interests in software agents, researches for the automated negotiation are proceeding rapidly. We divide the present EC into two types - EC without a negotiation process and EC with a negotiation process - in the light of a negotiation process and look into characteristics and problems of them. We propose a flexible negotiation model for agent-based EC systems, and present the use of ontology to be open and shared as an expressive knowledge representation and strategy to be environment-adaptive as a function for the best transactions. The proposed negotiation model make it possible to negotiate for diverse attributes simultaneously and grip the progressive process of a negotiation via BB(Black Board), one that used in learning strategy. Finally, we evaluate the proposed negotiation model qualitatively.

최대하 운동부하검사가 노인 허혈성 뇌졸중환자의 혈관탄성·운동유발성 고혈압 및 허혈성 심장질환진단에 미치는 영향 : 사례연구

강동연,차재관,허재택,박정준,양점홍 釜山大學校 附設 體育科學硏究所 2009 體育科學硏究所 論文集 Vol.25 No.2

Purpose: The purpose of this study was to observe the blood pressure response during exercise test and to investigate baPWV and ABI and potentiality of the cardiovascular disease of three ischemic stroke elderly in submaximal exercise test. Method: It measured the blood pressure, ECG during submaximal exercise test and baPWV, ABI before and after exercise test. Results: It discovered low blood vessel elasticity, exercise induced hypertension, ST segment depression ≥ 1 mm through exercise test. Conclusion: Exercise test have a diagnosis valuable to decide a cardiac disorders. Moreover, It increases a sensibility of baPWV and ABI test and heighten a reliability of potential diagnosis of high blood pressure by submaximal exercise test. 뇌졸중(stroke)은 가령(加齡)과 함께 증가하며 크게 허혈성과 출혈성 형태로 니누고 근래에는 허혈성 뇌졸중의 발생빈도가 증가하고 있는 추세로 뇌졸중 환자의 혈류역학에 대한 연구는 순환기학 분야에서 뿐만 아니라 운동이 고혈압의 주요 개선 중재방법의 하나라는 관점에서 운동처방 분야에서도 심도 있는 연구가 요구된다. 그러므로 이 연구에서는 60세 이상의 허혈성 뇌졸중환자 3명에게 최대하 운동부하검사를 실시하여 각각의 사례에서 안정시에는 발견되지 않았던 혈관폐색의 높은 가능성, 운동유발성 고혈압 및 허혈성 심장질환의 정후인 ST분절≥1.0 mm 하강을 발견하였다. 이러한 점에서 운동부하검사는 심장질환을 판단하는 진단적 가치뿐만 아니라 baPWV와 ABI검사의 민감성을 증가시키며 고혈압 잠재성 진단에 유용하게 활용될 수 있다.

흰쥐 경동맥 손상 모형에서 체외 방사선조사에 의한 신내막 과증식억제 : Intercellular Adhesion Molecule-1과 Vascular cell Adhesion Molecule-1의 역할 The Possible Role of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1

강동헌,승기배,장기육,임상현,정해억,임효영,김연실,채장성,김재형,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

모세관 전기영동법을 이용한 1,2,4-트리메틸벤젠 대사체의 분석

강종성,홍정희,임정미,이용문,장재연 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

방향족 탄화수소인 tnmethylbenzene (TMB)은 그 사용량이 늘어갈 뿐 아니라 직업적으로 폭로되는 양도 증가하고 있으므로 생물학적 모니터링 및 흡수, 대사, 배설에 관한 연구가 중요시되고 있다. 일반적으로 TMB는 간의 산화효소에 의해 하나의 메틸기가 산화되고 이것은 glycine과 포합되어 배설되는 것으로알려져 있다. 본 연구에서는 1,2,4-TMB의 대사체를 합성하고, 모세관의 전기영동법으로 분석할 수 있는 방법을 개발하였다. 모세관 전기영동법으로 흰쥐의 뇨 중에서 1,2,4-TMB의 대사체인 3,4, 2,4, 2,5-dimethylbenzoic acid 및 3,4 2,4 2,5-dimethylhippuric acid를 분석하기 위하여 내경 75㎛, 총길이 35cm (검출기까지 29cm)인 용융실리카 모세관을 15℃로 유지하면서 양단에 10kV의 전압을 걸어주고, 전해질로는 15mM β-CD, 3% 2-프로판올을 포함하는 01m 인산완충액 (pH 7)을 사용하였으며, 검출신호는 UV 210nm와 254nm에서 동시에 모니터링하였다. 뇨 시료의 분석 결과 배설된 1,2,4-TMB의 대사체의 상대량은 3,4-이성질체가 56.&%, 2,4-이성질체가 30.5%, 2,5-이성질체가 12.8%였다. 이 방법은 노동자의 뇨 분석에도 적용될 수 있을 것으로 생각된다. The metabolites of 1,2,4-trimethylbenzene (TMB) were synthesized and determined by capillary electrophoresis (CE). The optimum conditions of CE for the separation and determination of 3,4-, 2,4-, 2,5-dimethylbenzoic acid and 3,4-, 2,4-, 2,5-dimethylhippuric acid from the rat wine were as following: the fused silica capillary(75μm i.d. X 36 cm length, 29 cm to detector) was used and kept at 15℃ The applied voltage was 10kV and compounds were detected at UV 210 nm and 254 nm. The running electrolyte was 0.1 M phosphate buffer (pH 7) contalI1ing 15 mM of β -CD and 3% of 2-propanol. The relative amount of the metabolite of 1,2.4-TMB in the rat urine was 56.7% of 3,4-isomer, 30.5% of 2,4-lsomer and 12.8% of 2,5-isomer. This method can be applied to the analysis of TMB-metabolites in human wine.

2000학년도 안산캠퍼스 신입생들의 심리적 특성

강재연,조윤희,박효서 한양대학교 학생생활상담연구소 2000 大學生活硏究 Vol.18 No.-

낙동강 물 관개논의 농업환경 특성과 질소, 인산 요구량

강위금,이재생,고지연,박창영,정기열 한국환경농학회 2004 한국환경농학회지 Vol.23 No.3

낙동강 물을 관개하여 벼를 재배하는 강 상류의 안동 풍산에서부터 하류의 부산 구포까지 7개 지역 논토양의 농업환경 특성을 1999년부터 2년간 비교 분석하였다. 토양의 중금속 함량은 자연함량 안팎이었으며 가장 높았던 곳은 부산 강서 지역이었고 다음으로는 고령 성산 지역이었다. 그러나 현미중의 중금속은 자연함량 이하를 보였다. 토양의 화학성은 고령 성산지역과 부산 강서지역에서 높았는데, 1999~2000년도의 영농 후 토양에서 고령은 pH (5.9~6.1), EC(0.8~0.9 dS/m), 유효인산(155~201 mg/kg), 치환성 칼슘(6.7~7.4 cmol^(+)//kg), 치환성 마그네슘(1.92~2.50 cmol^(+)/kg), 치환성 칼리(0.18~0.21 cmol^(+)//kg )가 가장 높았고 부산에서는 유기물(23.0~29.1 g/kg), 총질소(1.6~l.8 mg/kg)가 가장 높았다. 낙동강 물의 관개수질과 토양화학성을 고러한 벼의 진단시비량은 질소의 경우 110 kg/ha를 기준으로 안동 21.4%, 상주 11.85, 구미지역에서 8.8% 정도 증시할 필요가 있었으나, 고령에서는 14.9%, 창녕은 4.6%, 밀양 하남은 4.55, 부산 강서지역은 11.5% 내외로 줄일 수 있을 것으로 분석되었다. 그리고 인산질 비료는 45 kg/ha 기준으로 창녕 도천에서만 18.9% 줄여 주고 다른 지역에서는 기본시비량인 30 kg/ha만 시용하여도 무방할 것으로 판단되었다. 논토양에 분포하는 세균과 사상균, 방선균, 중온성 Bacillus, 형광성 Pseudomonas, Biomass C는 유기물과 총 질소, 인산 등의 양분함유량이 많았던 고령 성산과 그 하류지역에서 높았다. Agroenvironmental characteristics in paddy fields irrigated with the water of Nagdong river were analyzed along the river watershed for two years from 1999. The sites monitored from upper reaches of the river were Andong, Sangju, Gumi, Goryeong, Changnyeong, Milyang and Pusan. In paddy soils, the contents of heavy metals such as Cd, Cr, Cu, Pb, Ni, Zn and As were around natural values showing the highest values in Pusan followed by Goryeong. In brown rice, the contents of heavy metals were lower than natural values. Soil chemical properties appeared higher values in the lower reaches including Goryeong than the upper ones. The highest parameters in Goryeong were pH (5.9~6.1), EC (0.8~0.9 dS/m), Av.P₂O_(5) (155~201 mg/kg), exchangeable Ca (6.7~7.4 cmol^(+)/kg), Mg (1.92~2.50 cmol^(+)/kg), K (0.18~0.21 cmol^(+)/kg) and those in Pusan were organic matter (23.0~29.1 g/kg) and T-N (1.6~1.8 mg/kg). In conclusion, the recommended rates of N fertilizer for rice cropping were 21.4%, 11.8% and 8.8% high for Andong, Sangju and Gumi, respectively and 14.9%, 4.6%, 4.5% and 11.5% low for Goryeong, Changnyeong, Milyang and Pusan, respectively reflecting the chemical properties of soils and the quality of irrigation water on the basis of 110 kgN/ha. In the case of phosphorous, the rates were 18.9% and 33.3% low for Changnyeong and others, respectively on the basis of 45 kgP₂O_(5)/ha. The populations of bacteria, fungi, actinomycetes, Bacillus, fluorescent Pseudomonas and Biomass C were high at the lower reaches including Goryeong, which showed relatively much nutrient contents of organic matter, total N and phosphorous etc..

우리나라 카드뮴 폭로 근로자들의 혈중, 요중 카드뮴과 누적폭로 추정량에 따른 신장장해 평가

강성규,양정선,김기웅,장재연,정호근 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

88 workers exposed to cadmium were examined at the 12 factories using or producing cadmium in order to know the present state of cadmium exposure and renal dysfunction in 1992. Cadmium in blood and in urine were measured and compared by the 3 exposure level of cadmium in air. Cadmium in blood of low, moderate and high exposure group were 2.5, 3.8 and 7.6 ㎍/L, respectively. Cadmium in urine were 1.8(1.3), 3.8(2.6) and 7.9 ㎍/L(6.1 ㎍/g creatinine), respectively. However, there was no relationship between urinary cadmium and β₂-microglobulin. Cumulative exposure estimate(CEE) was calculated by multiplying the mean ambient cadmium level of the factory and working duration. CEE has a high correlation with cadmium in blood and urine, but no relation to β₂-microglobulin. Because working durations were relatively shorter than European workers', the highest CEE was just 300 ㎍·year/m³, which was not enough to induce renal tubular dysfunction. This study, however, suggested the possibility that renal tubular dysfunction caused by cadmium could be happened in Korea in the near future.

독성물질의 세포사 기전 및 세포사 유발물질의 검색법 개발에 관한 연구(Ⅰ) : 독성물질로 인한 파킨슨병 모델에서의 세포사 기전 연구 Study on the cell-death mechanisms of toxin-induced parkinsonism

강태석,김종민,서경원,김영옥,김준규,오재호,이윤동,김규봉,오정자,송연정,임종준,전범석,문전옥,최광식 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

MPTP 독성물질이 도파민성 신경세포에 선택적으로 작용하여 산화성 손상에 의한 신경세포사를 일으키는 것을 이용하여 파킨슨병의 동물모델을 만들고, 이를 통해서 아폼토시스를 비롯한 포사의 기전에 대한 연구 및 너코틴의 신경세포 보호효과 여부를 판정하는 실험을 병행하고자 하였다. 파킨슨꾐의 동물모델을 MPTf 독성 물질을 이용하여 확립하였으며, MPTP(30mgag, i.p.)를 투여한 후 1, 2,3, 4, 5일째 흑질 조직을 채춰하여 tarm로 박걸하여 tyrosine hydroxylase 면역조직화학염색을 수행하여 cell countif우한 결과, control은 57.635ce11s, 1일째 친.OfDells,2일째 57.9±6cells,3일릴 없.3±죠ells, 4일째 49.0츠3cells, 5일째 39.4±Scells료 4, 3일째 뚜렷한 신경세포 수의 감소를 보였다. 신경세포사 기전 규명을 위한 아폼토시스 분걱에서는 벼PTP 투여 후 1, 2, 3, 4, 5일째 조직을 채취하여 Hoechst staining, TUNEL staining을 수곡하였는데 양성 반응을 보인 신경세포는 관찰되지 않아. 아폼토시스로 인한 세포사가 관찰되지 않았다. bIPTP 파킨슨병 동물모델에서 nicotine 보호효과 탐색에 관한 실험은 nicat푸e 0.2mgAg을 5일 퐁안 투여 후 리『fP(30mgag)를 CS7Bt/6 마은스에 복강 내주사로 nicotine과 병용 투여한 후 1, 2, 3, 4, 5일째 뇌를 적출하땄다. 신경세포사가 뚜렷이 관찰되기 시작하는 4, 5일째의 신경세포 수의 감소 정도를 20. 30% 정도 약화시키는 경향을 보였으나, nicotine 보호효과에 대한 추가 실헝이 현재 수행 중에 있다. The cause of Parkinson's disease (PD) is largely unknown. However, free radical toxicit? may plaf a role ip. the degeneration of substantia nigra, which is the Hajorfocus of pathological damages in PD. Recently, a neuroprotective effect of nicotine in PD has been suggested. Therefore, the mechanism of neurodegenerafion and protective potential o( nicotine in PD were investigated in the experimental modeB of Pll using a neurotoxin, C57BL/6mice were administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg,j.p.). The degree of neurodegenerafion was determined by immunohistochemical stainiHB oftyrosine hydroxylase (TH). TH-positive cells on nigral sections were found 56.0 ±4, 57.9 ±6,52.315ce11s, 49.0±3cells, and 39,4±Scells at days 1, 2, 3, 4, 5, respectively (controls : 57.6±Scells). Hoechst and TUNEL staining showed no evidence of apoptosis. The exandnation on themice co-adrunistered with nicotine(0.2mgAg) and MPTP(30mgag) revealed a tendency ofnicotine protective effects. At days 4 and 5, the degree of TH-positive cells was decreased by20-30%, In corclusiffn, the role of apoptosis was not evidenced in this MPTP modeB of PB.The possible proteccon by nicotine should be elucidated with further studies.

사무직 근로자의 수면의 질 및 직무스트레스와 우울과의 관련성

강미나,강수영,권수정,김현주,배재원,이보연,이예진,임의롬,정다영,조한솔 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47

Purpose: The purpose of this study was to understand the degree of depression, sleep quality, job stress and their association among office workers. Method: A self-administered questionnaire was distributed to 147 workers employed in 5 big enterprises, and 5 small and medium enterprises from October 21 to November 21, 2012. The questionnaires included socio-demographic and health-related characteristics, job-related characteristics, sleep quality, job stress (KOSS) and depression (CES-D). Result: Among all subjects, 23.1% was in the depression group (21 points and over in the CES-D score). Depressive level was positively correlated with job stress and quality of sleep. The adjusted odd ratio for the effects of sleep quality and job stress on depression significantly increased in the depression group compared to that of the normal group. Multiple regression analysis revealed that the following factors of influence had combined explanatory powers on depression: BMI, life satisfaction, quality of sleep, and job stress. Conclusion: The study revealed that complicated influences were exerted on the level of depression by variable factors, as well as socio-demographic characteristics, health-related characteristics, quality of sleep, and job stress. Specifically, the level of depression was influenced by the quality of sleep and job stress.