한약과 양약의 약물상호작용에 관한 연구(제1보) : Nicardipine과 청혈단의 상호작용 Effects of CHUNGHYULDAN on the Pharmacokinetics and Pharmacodydnamics of Nicardipine in Rats

김남재,진성민,최혁재,주수만,송보완,김종우 한국병원약사회 2002 병원약사회지 Vol.19 No.4

The influence of single and repeated oral pretreatment of CHUNG-HYUL-DAN(CHD). a widely used Korean traditional herbal medicines prescribed for hypertension and hyperlipidemia, on the pharmacokinetics and pharmacodynamics of a calcium channel blocker, nicardipine after oral administration of nicardipine was investigated in rats. The single pretreatment of CHD significantly increased area under the plasma concentration-time curve(AUC_(0-8h), but did not influence the time to reach the maximum peak plasma concentration(T_(max)), the maximum peak plasma concentration(C_(max)), terminal elimination half-life(t_(1/2) or the elimination rate constant(λ) for nicardipine. And, C_(max) and AUC_(0-8h) for nicardipine were significantly increased by with 1-week repeated pretreatment with CHD, but the other parameters were not significantly different from those of control. Also, the extent of the lowering effect of nicardipine on blood pressure in rats was significantly increased after oral administration of nicardipine with single and repeated oral pretreatment with CHD. These results indicated that single and 1-week repeated oral pretreatment with CHD should inhibit the metabolism of nicardipine in rats.

치성낭종으로부터 유래된 편평상피세포암종 : Report of a Case & Review of Literatures

권혁진,현재훈,박형국,김용각 大韓顎顔面成形再建外科學會 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.2

Odontogenic cysts are relatively common pathologic lesions found in the oral and perioral structures, but the case of squamous cell carcinoma arising from those cysts are very uncommon. After first reported of that case in 1889 by Herman, Schwimmer collected 56 cases of previously reported squamous cell carcinoma arising in residual odontogenic cyst during about past one century. More than 60% of cases of carcinoma developing in odontogenic cysts arising in inflammatory periapical or residual cyst, and these tumors are usually well-differentiated with relatively good prognosis, and often are diagnosed as benign lesion in radiographic or clinical examination, therefore definitive diagnosis must be made by histologic examintation. We report a case and review the literatures, in our case, 78-year old woman were clinically and radiographically diagnosed as residual odontogenic cyst. But in histologic examination after enucleation of lesion, mass of squamous cell carinoma were observed, but in other area, typical cyst wall and lining epithelium were observed. And in some area, carcinoma in situ and invading squamous cell carcinoma into the lining epithlium were also observed.

ATM망 트래픽 제어 알고리즘 연구

유진호,손준영,안재환,박성우,김명수,장혁수 明知大學校 産業技術硏究所 1996 産業技術硏究所論文集 Vol.15 No.-

ATM(Asynchronous Transfer Mode) is a transmission technique for the B-lSDN(Broadband Integrated Service Digital Network). Congestion problems are unavoidable in the ATM networks, since various traffic typos coexist in the networks. The preventive congestion control algorithm is widely used for the real time traffics such as voice and video. The reactive congestion control algorithm works well for the non-real time traffic within a short distance. A mixed traffic control algorithm is proposed, which works either preventively or reactively based on traffic types. The proposed algorithm sets a high and low threshold value at the output buffers and modifies the EPRCA(Enhanced Proportion Rate Control Algorithm) to control loss-sensitive cells. Delay-sensitive cells are handled by the priority control and the UPC(Usage Parameter Control) algorithm. The performance analysis shows that the proposed traffic control algorithm works well for both the VBR(Variab1e Bit Rate) and ABR(Available Bit Rate) traffic with small buffers

동일한 환자에서 조혈모세포이식 전후의 호중구감소 기간 중 감염양상에 대한 비교연구 : 중심정맥관 관련 패혈증을 중심으로 Based on Central Venous Catheter Related Septicemia

류재호,노규태,이영석,이영호,권혁찬,김재석,김효진,이영민,박혜원,박근희 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.1

연구배경: 동일한 환자를 대상으로 조혈모세포이식 전 일반 병실에서의 관해유도 항암제치료 및 강화요법으로 인한 호중구감소 기간의 감염양상과 고용량 항암제치료 후 무균실에서의 조혈모세포이식 시 호중구감소 기간의 감염양상을 중심정맥관 관련 패혈증을 중심으로 비교 연구함으로써 효율적인 감염관리지침을 마련하고자 하였다. 대상 및 방법: 1999년 1월부터 2001년 7월까지 2년 7개월간 동아대학교병원 일반병실에서 악성혈액질환으로 항암제 치료를 받다가 조혈모세포이식을 시행받았던 22명을 대상으로 중심정맥관 관련 패혈증의 형태를 비교분석하였다. 결과: 대상 환자들의 일반병실과 무균실에서의 입원기간은 각각 32±13일, 33±19일, 호중구 감소기간은 15±12일, 17±18일, 호중구 감소기간의 발열 횟수는 14회, 14회로서 입원병실의 종류에 따른 차이는 없었다. 환자들의 중심정맥관 사용일수는 일반병실에서 29일(7~545일), 무균실에서 100.5일(25~606일)이었으며, 총 사용일수는 각각 1,515일, 3,250일로서 무균실에서의 중심정맥관 사용일수가 의미 있게 길었다(P=0.001). 중심정맥관 사용 일수에 대한 감염률은 각각 5.28/1,000일, 3.08/1,000일로서 일반병실에서 그 빈도가 높았으나 통계적 유의성은 보이지 않았다(P=0.141). 결론: 중심정맥관 삽입 후 일반병실에서 항암제 치료를 받던 환자가 조혈모세포이식을 위하여 무균실에 입원하는 경우, 중심정맥관을 교체하는 것이 감염관리를 위하여 바람직할 것으로 생각된다. Background: We compared the incidence of central venous catheter (CVC) related septicemia during neutropenic period in the same patient, which developed following chemotherapy for remission induction and consolidation, or hematopoietic stem cell transplantation (HSCT). Methods: We retrospectively reviewed the medical records and laboratory data of 22 patients with hematologic malignancies who received anticancer chemotherapy followed by HSCT at Dong-A University Hospital between January, 1999 and July, 2001. We investigated the duration of hospitalization, duration of neutropenic period, duration of catheterization, microbiologically documented organisms and incidence of CVC related septicemia. Results: The data in general ward (before HSCT) and laminar air flow room (after HSCT) were as follows: duration of hospitalization was 32±13 days and 33±19 days, duration of neutropenic period was 15±12 days and 17±18 days, median duration of catheterization was 29 days (7~545 days) and 100.5 days (25~606 days) (P=0.001), and incidence of CVC related septicemia was 5.28/1000 days and 3.08/1000 days, respectively. In the CVC related septicemia, the most common etiologic organism was coagulase negative staphylococcus. Conclusion: We suggest that the exchange of CVC before admission to laminar air flow room could decrease the incidence of CVC related septicemia in HSCT recipients.

ELASTIC BAND 운동과 스트레칭 운동이 노인 당뇨환자의 혈당, 중성지질 및 근지구력에 미치는 영향

조재혁,이승훈,진종현 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

The purpose of this study s to find the effects of elastic band exercise and stretching exercise on glucose level, triglyceride and muscle endurance in elderly patient with NDDM. The subjects consisted of elderly patient(n=20) with NlDDM dstributed into resstance training group(n=10) and stretching exercise group(n=10). Both groups participated in resstance training and stretching exercise program respectively, 3times per wear during 9weeks. Repeated measures ANOVA was used for statstical analysis. The results of this study are following. 1. Glucose level of both groups decreased significantly after 9 weeks training. There was significant differences between groups in FBS and no significant differences between groups in PP2 after training. There was significant differences in PP2 at time and no significant differences in FBS at times. 2. There was significant decreases in triglyceride level of both groups after 9 weeks training, however no significant differences showed between goups. There was no significant differences between groups at time. 3. Muscle endurance of both groups increased after 9weeks training, however no significant differences showed between groups. There was no significant differences between groups at time.

이동 애드 혹 네트워크에서의 환경적응형 QoS AODV 라우팅 프로토콜에 관한 연구

裵振勝,宋東勳,吳世德,鄭燦赫,金玄郁,李光培,文泰洙,郭承郁,河載承 明知大學校 産業技術硏究所 2004 産業技術硏究所論文集 Vol.23 No.-

In this paper, we propose a bidirectional mobile Ad Hoc routing protocol based on AODV(ad-hoc on-demand distance vector routing) with QoS(quality of service) support. At presence, wireless mobile communication focuses on how to efficiently support mobility of users more than QoS guarantee. However, in order to satisfy requirement of various applications which have been or will be served, QoS guarantee between end points is a very important issue. The existing AODV routing protocol is implemented to use only BE (Best Effort) service. However, actual wireless mobile environment requires to reduce a waste of communication resources and meet with the real-time change of data paths by setting up routes with QoS support, considering available communication resources at each node in advance. Therefore, in this thesis, we propose an adaptive QoS support method using hello message in order to rapidly meet with the change of available communication resources and to smoothly perform route maintenance. For performance evaluation, we analyzed the average data reception rate. At that time, we used evaluation parameters such as node's mobility-stop time, hello message period, and packet priority, considering the node's mobility and the number of best effort/QoS data flows. As results, we found that with our proposed method the average data reception rate was increased 16.293%, 15.914%, 17.238% for 300 mobility-stop second case and 4.809%, 4.264%, 2.956% for 300 mobility-stop second case.

GMAHN 환경에 적응하는 에러 복구기능을 이용한 AODV 라우팅 프로토콜

정찬혁,오세덕,배진승,이기원,장양근,이광배,김현욱,유충렬,하재승 明知大學校 産業技術硏究所 2006 産業技術硏究所論文集 Vol.25 No.-

Mobile nodes in ad hoc mobile networks typically communicate over wireless channels and are capable of movement. These are networks that support multihop communication and can be formed on a temporary basis. This paper proposes a solution that allows mobile nodes to access the wired Internet and to roam from base station to base station. And we also develop the efficient method that adapts in Global MANET which can be changed over time. It is observed that we can reduce not only error detection time but also network load, thus increasing the data reception rate in Global MANET Environment.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

주택용 환기시스템의 덕트설계를 위한 분배기 적용성 검토

이정재,최진혁,주성용 東亞大學校 建設技術硏究所 2007 硏究論文集 Vol.31 No.1

Although these days application of heat recovery ventilation and improved kitchen ventilation system came into wide use in mixed-use residential Buildings and exclusive residences, there are not enough ventilation systems except the local ventilation of kitchens and rest rooms. It is very important part to regulate and distribute correct air flow rate for controlling air change rate. The purpose of this study is to investigate the application of distributor at house ventilation system by comparing a duct system without distributor and with distributor. The results of this study are as follows. (1) When using distributor though the size of duct diameter is reduced rapidly, the pressure loss doesn’t rise largely. The pressure loss without distributor is 4.08 mmAq, the pressure loss with distributor 4.10 mmAq. (2) To use distributor can reduce materials of duct and secure enough ceiling space by reducing duct diameter. (3) Diameters and air flow paths of distributor on the design stage are important part for accurate air flow rate. 21 세기는 환경에 대한 고려 없이는 쾌적한 삶과 지속가능한 경제발전이 불가능한 시대 이다. 특히 요즘 건축물에서 고기밀, 고단열 을 강조하고 있으며,근래 건축기술의 발달과 토지이용의 효율화에 따라 20층 이상의 초고층 공동주택의 건설이 늘어나고 있으나 (Moon, J.S, 2004), 고충부분에서는 환기의 어려움이 발생하는 실정이다. 동시에 새 건축물의 자재나 도료에서 발생되어 호흡계 증상 및 신체의 부조화를 일으키는 새집증후군의 원인물질인 포름알데히드, 휘발성 유기 화합물질 등에 대해서는 대책이 미비한 실정이다. 때문에 국내 건축법의 환기기준이 강화되어 기존의 자연환기에만 의존했던 것과는 달리 2006년 l 월부터 건축법령에서 정한 신축되는 공동주택의 필요환기횟수는 0.7회이며, 이 기준을 충족하지 못할 경우 기계 환기 설비의 설치가 필요하게 되었다. 기존의 공동주택에서 환기시스템이 적극적으로 도입되기 어려웠던 이유는 설치비용의 경제성 문제뿐만 아니라 천장부분의 공간 부족으로 덕트 설치의 어려움이 있었으나 2005 년 l 월부터 시행되어진 소방법에 의해 11 층 이상의 공동주택에서는 전층에 스프링클러를 설치해야함에 따라 천장공간이 확보되어 덕트 설치 또한 가능하게 되었다. 환기시스템이 공동주택에 적용될 경우, 일반적으로 환기유나트 본체에서 각 실까지는 덕트를 통하여 신선한 공기가 공급된다. 주택환기시스템 덕트 설계의 경우, 소 풍량 으로 운전되므로 정확한 치수의 덕트 설계가 요구되며 24시간 가동을 전제로 하기 때문에 덕트내의 압력손실감소와 적절한 팬의 선정은 에너지 손실방지를 위해 반드시 고려되어야 할 부분이다.

내측회장동맥에 의해 형성된 척수경막동정맥루로 인한 척수병증 1예

이일형,배재천,이상무,김진혁,권기한,이병철 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3