Alkylhalide가 Mouse의 LDH isozyme 분포에 미치는 영향 : Cellulose Acetate Electrophoresis Method

권미경,김영옥,박은주,이동화,이명미,이문희,이양자 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-

The effect of Carbontetrachloride administration on Lactatedehydrogenase isozyme patterns were analyzed by cellulose acetate electrophoresis for the brain, heart, kidney, lung, liver and mouse muscle. Each other tissue was found to have a characteristic distribution of these isozymes. At normal condition, aerobic tissue such as brain, heart, kidney, and lung were found to have all five isozymes from LDH_1 to LDH_5, while anaerobic tissues such as liver and muscle were found to have superiorly LDH_5 The toxicity of Carbontetrachloride administration was most prominence in the liver, and lung toxicity was occured also.

장기기증 희망자의 의사결정 경험

권영미,윤은자 성인간호학회 2003 성인간호학회지 Vol.15 No.2

The aim of this study was to identify the process of experience toward decision making to donate organs. Method: Eleven subjects who registered at the Association for Organ Sharing in Korea were recruited. Using in-depth interviews and tape-recordings. Data was collected from Jun. 2001 to Feb. 2002 and the contents of these were analyzed by Glaser's grounded theory analysis method. Result: Basic Social- Psychological Problem(BSPP) of subjects were 'attachment to body' and the core theme, that is Basic Socialization Progress(BSP) were discovered to 'find out what is the meaning of life' Also it consisted of four steps: 1st 'hesitate' 2nd 'look into self'. 3rd 'realize the tie up to self' and last 're-find the meaning of life'. Conclusion: These findings indicate the Korean's Basic Socialization Progress of decision making regarding organ donation, so possible development of promoting decision making is necessary strategies for people who is having his/her potential of organ donation in mind.

간호학생의 간호전문직관과 전공만족, 사회성, 자아존중감간의 관계

권영미,윤은자 대한간호학회 간호행정학회 2007 간호행정학회지 Vol.13 No.3

Purpose: The purpose of this study was to identify the factors influencing the nursing professional values(NPV) of college nursing students. Methods: A convenience sample of 274 subjects was recruited from the department of nursing at a college. The survey was conducted from May 29 to Jun 20 2006. The data was analyzed using descriptive statistics, Pearson correlation coefficients, and stepwise multiple regression with SPSS/WIN 10.1. Results: The average item score of NPV, satisfaction, socialization, self-esteem were 3.60, 3.00, 2.74, and 2.71. The NPV of nursing students showed a significantly positive correlation to speciality satisfaction(r=.28-.46), socialization(r=.13-.46), and self-esteem(r=.12-.15). The significant factors influencing NPV of nursing students were service, curriculum satisfaction, social perception satisfaction, leadership & popularity, and sociability, which explained about 37.5%. Conclusions: Therefore, on the basis of this study's result, when nursing educational programs are developed to make positive NPV, these factors need to be considered.

젖산탈수소효소에 의한 탈수소 반응에 관한 연구

권순자,고영옥 慶熙大學校 1990 論文集 Vol.19 No.-

The kinetics and inhibiton of LDH-catalyzed dehydrogenation of lactic acid were studied to evalute Michaelis constant, Km, maximal velocity, V_max, and inhibition constant, Ki by means of spectrophotofluorometer. The assay condition of reaction mixture was as follows : Lineweaver-Burke plot and found to be 3.4×10^4M and 5.75×10^7M/sec respectively. Reaction medium ◁표삽입▷(원문을 참조하세요) The Dixon and Lineweaver-Burke plot were done to study the effect on LDH of oxalic acid as an inhibitor, whose inhibition constant was found to be 1.26×10^-4M.

노인단독가구의 지역사회 건강관리 프로그램 개발

권영숙,이선자 노인간호학회 2005 노인간호학회지 Vol.7 No.2

Purpose: As a preparation for the increase in the number of the aged families, this study was carried out to present health care programs in accordance with the level of self care need of the old of the aged families in one city. Methods: The home visiting survey to the aged families and the documents analysis of the elderly health service of public health centers were investigated. Results: With respect to the self care requisites, the programs were identified to be necessary which are for the improvement of family function, cognitive capability, eyesight and for the control of depression and pain, health education. Conclusion: The developed programs were divided to 'wholly intervention programs', 'partially intervention programs', 'educative-supportive programs'. They are 'expert program'(health visiting program, dementia program) 'self-help program'(senior center supporting program, religious facilities supporting program) and 'health-promoting self-care program (self care program)'.

병원진료 및 서비스에 대한 환자의 만족도 조사연구

權秀子,李英子 서라벌대학 1991 논문집 Vol.5 No.-

The purpose of this study was to investigate the patient satisfaction about curative service in clinical setting. The subjects of this study were 665 patients who were 228 inpatients and 437 outpatients. The data were collected from 10th to 16th, April, 1990 using questionnaire and analized by spss program(percentage, mean score). The results were as follows : A. Inpatients 1. Information & Communication The item which showed the highest level of the patient satisfaction was "number of nursing care" (mean score : 3,32) 2. Hospital Diet The subjects were not satisfied with hospital diet relatively. The item which showed the highest level of the patient satisfaction was "attitude of the hospital diet supplier" (mean score : 3,02). 3. Explanation of the medical or nursing procedure The subjects were not satisfied with explanation of medical or nursing procedure relatively. The item which showed the highest level of the patient satisfaction was "explanation of the received treatment and therapy (mean score : 2.86). 4. Hospital personal attitude The item which showed the highest level of the patient satisfaction was "attitude of the guard" (mean score : 3.33). 5. Hospital facilities The subjects were not satisfied with hospital facilities. The item which showed the highest level of the patient satisfaction was "temperature and humidity" (mean score : 2.60). 6. Regular hour of the curative service The item which showed the highest level of the patient satisfaction was "accuracy of medication timing" (mean score : 3.54). 7. Care of the patient comfort The item which showed the highest level of the patient satisfaction was "explanation of action and side effect received drug" (mean score : 2.92). 8. Cleaning & cleaner The item which showed the highest level of the patient satisfaction was "attitude of the cleaner" (mean score : 3.14). 9. Explanation of follow up care The item of "Explanation of follow up care" was low(mean score : 2.89). B. Outpatients 1. Attitude of the staff with sincerity The item which showed the highest level was "attitude of respction a patient's personality" (mean score : 3.45). 2. Explanation of the curative service The item which showed the highest level was "Explanation of matters that demand special attention" (mean score : 3.25). 3. OPD facilities The item which showed the highest level was "facilities of the telephone booth" (mean score : 3.27). 4. Spending time of the curative service The item which showed the highest level was "spending time of the receipt (mean score : 2.91). 5. Cost of curative service The item which showed the highest level was "cost of drug and therapy" (mean score : 2.78) 6. Guidance of the facilities The item which showed the hughest level was "department of medical treatment" (mean score : 3.46). 7. Incidental facilities The item which showed the highest level was "number of the bench" (mean score : 2.72) 8. Guidance of the receipt and the store The item which showed the highest level was "guidance of the consultation room and the laboratory" (mean score : 3.17).

염모제 사용에 의한 인체림프구의 DNA 손상 변화

김영철,심미자,권정숙 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.1

To ascertain the effects of hair dyeing application on the DNA damage in human lymphocytes, a mixture of permanent black colored hair dye with the same amount of oxidant containing 6% hydrogen peroxide was used. A hair dyeing with contacting the scalp(conventional dyeing) and a hair dyeing with 3 to 4mm away from the scalp(alternative dyeing) were applied to each 15 young healthy women. Blood was taken from the brachial vein at two sampling times, just before and 6 hours after the hair dyeing, and tail extent moment(TEM) and tail length(TL) were measured by using a comet assay. After dyeing, TL was significantly increased in both conventional dyeing group and alternative dyeing group compared with before dyeing as an average of 47% and 28%, respectively, and TL for conventional dyeing group was higher than alternative dyeing group as an average of 1.2 fold. After dyeing, TEM was significantly increased in both conventional dyeing group and alternative dyeing group compared with before dyeing as an average of 192% and 76% respectively, and TEM for conventional dyeing group was significantly higher than alternative dyeing group as an average of 1.7 fold. Therefore, alternative dyeing application was induced to lower lymphocyte DNA damage than conventional dyeing application, and TEM was appeared to be a more sensitive tool for the measurement of lymphocyte DNA damage than TL in this study.

염모제 도포방법에 따른 인체 적혈구의 산화스트레스 비교

김영철,심미자,권정숙 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.2

To ascertain the effects of hair dyeing application on oxidative stress in human, a mixture of permanent black colored hair dye with the same amount of oxidant containing 6% hydrogen peroxide was used. A hair dyeing with contacting the scalp(conventional dyeing) and a hair dyeing with 3 to 4mm away from the scalp(alternative dyeing) were applied to each 15 young healthy women. Blood was taken from the brachial vein at two sampling times, just before and 6 hours after the hair dyeing, and antioxidant enzyme activities and antioxidant contents were measured in red blood cells. After increased, malondialdehyde(MDA) contents for conventional dyeing group was shown to a tendence for more increased than alternative dyeing group. After dyeing, reduced glutathione(GSH) contents for conventional dyeing group was shown to a tendence of more decreased than alternative dyeing group. After dyeing, superoxide dismutase(SOD) and catalase(CAT) activities were significantly decreased in conventional dyeing group(p<0.01), however, SOD and CAT activities were not significantly decreased in alternative dyeing group. After dyeing, there was no significant decrease in glutathione peroxidase(GPX) activity both for conventional dyeing group and alternative dyeing group. Therefore, after dyeing, the degree of oxidative stress in red blood cells for alternative dyeing group was appeared to be lower than conventional dyeing group.

새로운 백금착체의 설계와 그 항암활성

황규자,이근임,권영이 숙명여자대학교 약학연구소 1996 약학논문집-숙명여자대학교 Vol.12 No.-

Pt(Ⅱ) and Pt(Ⅳ) complexes having six-membered chelate rings with N,N'-bis(2-chloroethyl)propanediamine (2-CePn) as carrier ligand have been prepared and characterized by IR and ^1H NMR. These complexes were examined for their in vitro cytotoxicity against leukemia L1210 and P388 cell lines. The cytotoxicity of platinum complexes with 1,3-propanediamine were improved by introduction of 2-chloroethyl group which nitrogen mustard, and alkylating agent, contains. The Pt(Ⅱ) complex showed more effective cytotoxicity than Pt(Ⅳ) complex.

간호사의 임상 실무 경험

서문자,손행미,강현숙,권성복,김주현,박영숙,이은희,임난영,조경숙,지성애 성인간호학회 2002 성인간호학회지 Vol.14 No.4

purpose: This study was conducted to describe qualitatively the entities of nurse's experiences in general hospitals and to suggest basic data guiding research on developing Standards of clinical nursing practice in Korea. Method: Fourteen nurses working at general hospitals with over 300 beds in Seoul were interviewed in-depth until saturation using tape-recorders and transcription. Result: The central theme of clinical nursing practice experienced by subjects was "being with clients" that means accepting client's personal character, solving client's needs and providing client-centered nursing. A also "being with clients" was felt to be the responsibility of nurses which was learned from their nursing schools. The nursing strategies performed in order to be with patients were proving skillful nursing techniques, accepting, educating, emotional support, advocating, and self-reflecting, the subjects experienced somewhat problematic affects such as difficulties in interpersonal relationship, work overload, negative image of nursing, deficit of self-confidence for nursing actions, poor working conditions, and unfair treatment. Nurses at the hospital practiced with pride when they felt that they were accepted by clients. Conclusion: Further research is needed to analysis problems in clinical practice and the comparison of nurses' experiences of clinical practice, with nurses' experiences in various settings.