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청열약 추출물들의 아세틸콜린에스테라제 저해와베타아밀로이드 펩티드 응집 억제 효능
권영이 한국생약학회 2007 생약학회지 Vol.38 No.4
’s disease ther-apeutics. Among the twenty enthusiasm reducing herbals, the 70% methanol extracts (1 mg/ml) of Moutan Radicis Cortex andForsythiae Fructus showed 91.5% and 85.3% about acethylcholinesterase inhibition, respectively. The extracts (1 mg/ml) ofCoptidis Rhizoma and Paeoniae Radix Rubra showed more than 85% inhibition rate against amyloid beta (1-42) peptide aggre-gation. The neuroprotective effect of the extracts (1 mg/ml) of Moutan Radicis Cortex, Forsythiae Fructus and Paeoniae RadixRubra showed 90.0%, 87.4% and 85.1% to compare with amyloid beta (1-42) peptide treated cells (IMR-32), respectively.Three herbs, Moutan Radicis Cortex, Forsythiae Fructus and Paeoniae Radix Rubra are promising candidates from naturalproducts for development of Alzheimer's disease therapeutics.Key words ’s disease, acetylcholinesterase, amyloid beta(1-42), Moutan Radicis Cortex, Gardeniae Fructus... ....... . , .... , .... .. ..... . .. ... .... , 85. .. ... . 47%
베타아밀로이드응집 억제제 도출을 위한 새로운 벤질피페리디닐에터 유도체의 합성
권영이,Kwon, Young-Ee 대한약학회 2006 약학회지 Vol.50 No.5
We designed and synthesized new benzylpiperidinyl ether derivatives as beta-amyloid aggregation inhibitors for the development of novel anti-Alzheimer's disease agents. As starting material, 4-hydroxypiperidine was used. For protection of the amine group in piperidine (2), di-tert-butyl dicarbonate was reacted with 4-hydroxypiperidine in the presence of triethylamine. For introduction of benzyl group, benzylbromide was treated with compound 2 in dioxane. After deprotection of Boc group on amine in compound 3, ester (5) was synthesized by addition of ethyl-4-chlorobutyrate. The alcohol 6 was synthesized by hydride reduction of 5 using $LiAlH_4$. To obtain final products (7-14), the alcohol 6 was condensed with each of substituted benzoic acids. To screen beta-amyloid aggregation inhibition of the products, thioflavinT assay was performed using $A{\beta}1-42\;at\;37^{\circ}C$ for 26 h incubation, in vitro. From the result of screening, compound 8, 9, 11 and 12 showed effective activity about $65{\sim}85\;{\mu}M\;as\;IC_{50}$ value. Among the prepared compounds, 4-[4-(benzyloxy)piperidino]butyl-4-chlorobenzoate (8) was the most effective inhibitor having $IC_{50}\;of\;65.4{\mu}M$.
동맥류 결찰술 시행군과 GDC색전술 시행군에서 지주막하 출혈 후 만성 션트-의존성 수두증의 발생빈도
권영이,조맹기,박봉진,성정남,김영준,Kwon, Young-Yi,Cho, Maeng Ki,Park, Bong-Jin,Sung, Jung-Nam,Kim, Young-Joon 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1
Objective : The goal of this study was to document the influence of the treatment modality(surgery versus endovascular treatment) on the development of chronic shunt-dependent hydrocephalus in a series of 296 patients treated after aneurysmal subarachnoid hemorrhage(SAH). Methods : The following parameters were retrospectively analyzed for association with chronic shunt-dependent hydrocephalus : 1) Age and Sex, 2) Hunt and Hess grade, 3) Fisher computed tomographic grade, 4) aneurysm location, and 5) treatment modality(surgery versus endovascular treatment). Results : Thirty-six of 251 patients(14.3%) who survived the SAH and its neurological and/or medical sequelae underwent definitive shunting for treatment of chronic hydrocephalus. The rate of shunt dependency was positively correlated with a higher age, a higher Hunt and Hess grade, a higher Fisher computed tomographic grade, and aneurysms arising at the anterior communicating artery(p<0.05). Conclusion : The results of the present study indicate that the treatment modality used does not affect the risk of the later development of chronic shunt-dependent hydrocephalus(surgery, 16.2% [25 of 154] ; endovascular treatment, 11.3% [11 of 97] ; p=0.45).
권영이,박봉진,성정남,김영준,조맹기,Kwon, Young-Yi,Park, Bong-Jin,Sung, Jung-Nam,Kim, Young-Joon,Cho, Maeng Ki 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.10
Germinomas of the central nervous system are rare embryonal tumors(accounting for less than 1% of intracranial neoplasms) that may be located in the pineal region, in the floor of the third ventricle, or in the suprasellar area. We report a case of germinoma developed in periventricular deep white matter without pineal region tumors or suprasellar masses. The 19-year-old male patient presented with slowly progressing headache, dizziness, photophobia, and dysarthria. Initial brain MRI revealed a irregular and dense enhancement from lateral ventricles to 4th ventricle. The stereotactic biopsy of tumor and histologic examination revealed the germinoma. Craniospinal axis radiation therapy was performed. After radiation therapy patient was improved and no neurologic sequelae was seen at discharge. Periventricular germinomas without pineal or suprasellar lesion are very rare. The radiation therapy, as in our case, is beneficial as with other intracranial germinomas. Stereotactic biopsy of periventricular germinoma provides precise pathologic diagnosis and thus allows more specific management.
가상 검색 및 시험관 시험을 이용한 총명탕 중 주성분들에 대한 약물작용 및 대사 예측
권영이,Kwon, Young-Ee 대한약학회 2007 약학회지 Vol.51 No.6
Chong Myung Tang is consisted of three medicinal herbs (Acori Graminei Rhizoma, Polygalae Radix and Hoelen cum Radix). It has been used as a medicine for the purpose of learning and memory improvement. In this paper, Chong Myung Tang was screened the biological activities for Alzheimer's disease. The extract (70% ethanol) of Acari Graminei Rhizoma (1 mg/ml) showed that acetylcholinesterase (AChE) and amyloid beta ($A{\beta}$) peptide aggregation inhibitory potency are 43.1% and 76.5%, respectively. The extract of Polygalae Radix showed inhibitory activity against $A{\beta}_{1-42}$ peptide aggregation (51.5%). To predict the drug-likeness, oral absorption ability; blood-brain barrier (BBB) penetraion rate, mutagenecity and carcinogenicity; in silico screening was performed against 16 compounds in the three medicinal herbs. According to the results, all compounds have appropriate chemical structures as medicines. The six compounds in Acori Graminei Rhizoma and the five compounds in Hoelen cum Radix showed excellent oral absorption rate and BBB penetration rate. The four compounds in Polygalae Radix showed excellent oral absorption rate, but their BBB penetration was presented low rate. And, the extract of Hoelen cum Radix didn't show AChE and $A{\beta}_{1-42}$ peptide aggregation inhibitory activities in vitro. Therefore, their activity in brain may be other mechanism. According to all of the results, in silico prediction technology is convenient and effective to determine biological active compounds in medicinal herbs.
교사 내부마케팅 요인이 조직신뢰 및 고객지향성에 미치는 영향
권영인 ( Young-in Kwon ),원미란 ( Ran-mi Won ) 한국유통경영학회(구 한국유통정보학회) 2021 유통경영학회지 Vol.24 No.3
Purpose: The main purpose of this research is to analyze that how internal marketing factors implemented on teachers can have an effect on organizational trust and customer orientation. The various supporting systems to teachers must take precedence in order to obtain educational competitiveness in educational institutions. Research design, data, and methodology: This research has been initiated and completed on 245 questionnaires of the elementary and junior high school teachers for about a month in October, 2019, by utilizing for frequency analysis, technical analysis, exploratory factor analysis, cronbach’s alpha, covariance analysis to verify its hypothesis by SPSS 23.0 & AMOS tool. Results: First of all, 5 major factors(management support, education & training, authority delegation, reward system, and internal communication) were selected among various internal marketing factors of teachers. Secondly, imposing internal marketing factors have been proven to display positive effects in terms of above 5 major factors for improving on organizational trust. Thirdly, above 5 major factors have been lead to positive influences on the development of the internal customer orientation, too. Lastly, organizational trust also are appeared to yield positive effects on customer orientation. Conclusions: This research has verified that implementation of internal marketing factors could potentially lead to enhance teacher’s organizational trust, and also lead to positive effects on customer orientation to students. In comparison with existing research contents, internal marketing factors might have different effects on organizational trust among occupational differences. More objective measurement tools must need to be developed and lead to further research which are prepared for the effects on teacher’s internal marketing factors.