3단계 테스트 -지적재산권제도의 표준화인가 흠결 있는 국제규범인가?-

이일호 ( Ii Ho Lee ) 연세대학교 법학연구원 2011 法學硏究 Vol.21 No.4

Der Dreistufentest ist bekanntlich in den volkerrechtlichen Vertragen geregelt; daher ist er als volkervertragsrechtliche Norm in den volkerrechtlichen Rahmenbedingungen zu interpretieren und anzuwenden. Die Volkerrechtsordnung stellt ein vollig anderes Rechtsgebiet als die nationale Rechtsordnung dar. Die bisherigen Diskussionen uber den Test haben die volkerrechtlichen MaBgaben und Methoden als Anhaltspunkt der Analyse anerkannt, trotzdem beschrankt sich diese Berucksichtigung entweder in der Anfangsphase oder nur in gewissen Aspekten. In beiden Fallen ist der Test durch die bestimmten Rechtsdogmatiken der einzelnen Autoren angeschaut und subjektiv analysiert worden. Diese Arbeit hat sich zum Ziel gesetzt, zu uberprufen, in welchen Rahmenbedingungen die weiteren Diskussionen uber den Dreistufentest durchgefuhrt werden sollten. Dafur ist erstens die Feststellung der volkerrechtlichen Lage des Tests notwendig (II.). Daruber hinaus sind zweitens die Besonderheiten des internationalen Immaterialguterrechts zu berucksichtigen und einzuschatzen, ob die hier gefundenen Besonderheiten auf die Auslegung oder die Anwendung des Dreistufentests tatsachlich einen gewissen Einfluss entfalten konnen (III.). SchlieBlich liefert die Arbeit einen neuen Blickwinkel auf den Dreistufentest (IV.). Vermutlich mussten wir unsere Pramisse aufgeben, dass der Dreistufentest ein materielles Wesen enthalt, das wir durch die wissenschaftliche Analyse herausfinden konnen. Wir brauchen zu diesem Zeitpunkt die materiellen Lucken im Dreistufentest nicht zu schlieBen, sondern lediglich zu feststellen, bis sich die Rechtslage weiterhin durch die Auslegungshilfe, die Erlauterung oder moglicherweise die (nachtragliche) Vertragsanderung noch geklart wurde . Die Generalklausel konnte die Delegation des Normgebers an die Rechtsprechung sein, aber auch an den zukunftigen Normgeber. Um den Dreistufentest ins lebendiges Recht zu wandeln, ist entscheidend die internationale Runde, in der die Mitglieder der Volkergemeinschaft die bis heute gestellten Fragen in der Umgebung des Dreistufentests selbst zu losen versuchen. Die Unbestimmtheit des Dreistufentests ware nicht stets negativ, sondern stellt eine Chance dar, momentane oder zukunftige Herausforderungen angemessen zu bewaltigen.

Planck Cold Clumps in the <i>λ</i> Orionis Complex. II. Environmental Effects on Core Formation

Yi, Hee-Weon,Lee, Jeong-Eun,Liu, Tie,Kim, Kee-Tae,Choi, Minho,Eden, David,II, Neal J. Evans,Francesco, James Di,Fuller, Gary,Hirano, N.,Juvela, Mika,Kang, Sung-ju,Kim, Gwanjeong,M. Koch, Patrick,Lee, American Astronomical Society 2018 The Astrophysical journal, Supplement series Vol.236 No.2

<P>Based on the 850 mu m dust continuum data from SCUBA-2 at James Clerk Maxwell Telescope (JCMT), we compare overall properties of Planck Galactic Cold Clumps (PGCCs) in the lambda Orionis cloud to those of PGCCs in the Orion A and B clouds. The Orion A and B clouds are well-known active star-forming regions, while the A Orionis cloud has a different environment as a consequence of the interaction with a prominent OB association and a giant H-II region. PGCCs in the lambda Orionis cloud have higher dust temperatures (T-d = 16.13 +/- 0.15 K) and lower values of dust emissivity spectral index (beta = 1.65 +/- 0.02) than PGCCs in the Orion A (T-d = 13.79 +/- 0.21 K, beta = 2.07 +/- 0.03) and Orion B (T-d = 13.82 +/- 0.19 K, beta =1.96 +/- 0.02) clouds. We find 119 substructures within the 40 detected PGCCs and identify them as cores. Out of a total of 119 cores, 15 cores are discovered in the lambda Orionis cloud, while 74 and 30 cores are found in the Orion A and B clouds, respectively. The cores in the lambda Orionis cloud show much lower mean values of size R = 0.08 pc, column density N(H-2) (9.5 +/- 1.2) x 10(22)cm(-2) , number density n(H-2) - (2.9 +/- 0.4) x 10 5 CM -3 , and mass M-core = 1.0 +/- 0.3 M(circle dot)compared to the cores in the Orion A [R = 0.11 pc, N(H-2) = (2.3 +/- 0.3) x 10(23) cm(-2), n(H-2) = (3.8 +/- 0.5) x 10(5)cm(-3) , and M-core = 2.4 +/- 0.3 M-circle dot] and Orion B [R = 0.16 pc, N(H-2) (3.8 +/- 0.4) x 10(23) cm(-2), n(H-2) = (15.6 +/- 1.8) x 10(5) cm(-3) , and M-core = 2.7 +/- 0.3 M-circle dot] clouds. These core properties in the A Orionis cloud can be attributed to the photodissociation and external heating by the nearby H rr region, which may prevent the PGCCs from forming gravitationally bound structures and eventually disperse them. These results support the idea of negative stellar feedback on core formation.</P>

복합 관동맥병변에서의 Rotational Atherectomy : 초기결과

김진우,박성욱,홍명기,이상곤,이일수,이철환,최기준,강덕현,송재관,김재중,박승정 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

Pulsed ECR PECVD를 이용한 SiOx박막의 성장 및 특성분석

이주현,정일채,채상훈,서영준,이영백 선문대학교 1998 공과대학논문집 Vol.1 No.1

일반적으로 TFT(thin film transistor)의 유전체막으로 실리콘 실화막(Si_(3)N_(4))이나 실리콘 산화막(SiO_(2)) 을 200 - 300℃의 온도에서 증착을 하게되는데 본 연구에서는 비정질 실리콘과 유전체막사이의 계면 특성 특히 계면의 거칠기를 향상시키기 위해서 기존의 증착법이 아니라 비정질 실리콘(a-Si:H)과 산소 ECR 플라즈마의 반응 에 의한 산화막의 성장법을 시도했는데, 이 때 기판은 의도적으로 가열하지 않았으며 특히 본 연구에서는 기존의 시도와는 달리 ECR 플라즈마를 형성할 때 마이크로파 전력에 pulse콜 가하는 방법을 최초로 시도했고, 계면에 불 순물의 혼입을 최대한으로 줄이기 위해서 진공을 파괴하지 않은 상태로 산화막을 연속적으로 성장시키는 방법을 이용했다. Pulse를 가했을 경우에는 pulse를 가하지 않은 경우에 비해서 화학양론적 측면, 유전상수, 산화막의 표면 평탄도 등에서 우수한 산화막이 성장했으며, 특히 비정질 실리콘과 유전체막사이의 계면 특성을 반영하는 산화막의 표면 평탄도가 1/3정도로 획기적으로 줄어들었다. Dielectric thin films for TFT(thin film transistor)s, such as silicon nitride(Si_(3)N_(4)) and silicon oxide(SiO_(2)), are usually deposited at 200 - 300 ℃. In this study, authors have tried to form dielectric films not by deposition but by oxidation with ECR(Electron Cyclotron Resonance) oxygen plasma, to improve the interface properties between the dielectric films and semiconductor films(hydrogenated amorphous silicon(a-Si:H)). The substrate was not intentionally heated during oxidation. The oxidation was performed consecutively without breaking vacuum after the deposition of a-Si:H films on the substrate to prevent the introduction of impurities. In this study, especially pulse mode of microwave power has been firstly tried during ECR oxygen plasma formation. Compared with the case of the continuous wave mode, the oxidation with the pulsed ECR results in higher quality silicon oxide(SiO_(x)) films in terms of stoichiometry of bonding, dielectric constants and surface roughness. Especially the surface roughness of the pulsed ECR oxide films dramatically decreased to one-third of that of the continuous wave mode cases.

Aspergillus niger KCTC6134에 의한 phytase생산에 미치는 탄소원과 질산원의 영향

이승철,황용일,이대희 Institute of Genetic Engineering Changwon National 1997 Gene and Protein Vol.1 No.1

In order to maximize the production of phytase from Aspergillus niger KCTC6134, souse of factors influencing both phytase production and mycelial growth were investigated in shake-flask cultures. The optimal production condition of phytase by each concentration of the optimal carbon and nitrogen sources was examined. The optimal production condition of phytase was obtained with 10% soluble starch 3% glucose. and 0.8% KNO₃at 28℃. The time course of phytase production showed 5.0-fold increase, which correspond to the maximum of a mycelial growth and compare with the basal medium used.

Carbonyl 화합물에 대한 Trimethyl-Silylcyanide의 첨가 반응

한완수,박철영,이일규 中央大學校 自然科學硏究所 1988 自然科學硏究所 論文集 Vol.2 No.-

Trimethylsilylcyanide is found to be a good reagent for the formation fo trimethylsilylcyanohydrin ethers from the direct reaction with carbonyl compounds. To obtain organic cyanoderivatives, trimethylsilylcyanide was addes to vbarious carbonyl compounds (acetaldehyde, acetone, cyclohexanone, propiophenone, benzophenone) in the presence of Lewis acid catalysts at room temperature. Addition of small amounts of Lewis acid catalysts to the reactions increased the yields of trimethylsilylcyanide carbonyl addition products. The results of these reactions indicated that the yields in trimethylsilycyanide addition reaction to the highly hindered carbonyl compounds were affected by the nature of catalysts employed, and increased as below. AlCl₃>SnCl₄≫ZnCl₂

구강에서 채취한 혐기성 세균에 대한 서양산 고추냉이(Horseradish, Armoracia rusticana) 뿌리 추출물의 항균효과

장용걸,박호원,신일식,이주현,서현우 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.2

서양산 고추냉이 (Horseradish, Armoracia rusticana)의 주성분인 allylisothiocyanate(AIT)는 각종 세균에 대한 살균 효과로 주목받고 있다. 이전 연구들을 통해 구강내 다양한 세균 및 진균류에 대한 항균성이 입증되었으나 근단내 병소를 유발하는 혐기성 세균에 대한 연구는 미진한 실정이다. 본 연구에서는 사람의 근단 병소에서 직접 분리한 E. faecalis와 F. nucleatum에 대한 서양산 고추냉이 뿌리 추출물의 항균활성을 표준균주와 비교해보고 이를 대표적인 항균제인 클로르헥시딘과 비교하여 다음과 같은 결론을 얻었다. 1. 서양산 고추냉이 뿌리 추출물은 E. faecalis 임상 분리균주에 대하여 표준균주와 같거나 약간 높은 농도에서 항균효과를 나타냈고, 625.0~1,250.0 μg/ml의 농도에서 클로르헥시딘 (7.8~15.6 μg/ml)과 대등한 항균효과를 가지는 것으로 나타났다. 2. 서양산 고추냉이 뿌리 추출물은 F. nucleatum 임상 분리균주에 대하여 표준균주와 같거나 약간 높은 농도에서 항균효과를 나타냈고, 78.1~312.5 μg/ml의 농도에서 클로르헥사딘 (7.8~15.6 μg/ml)과 대등한 항균효과를 가지는 것으로 나타났다. 이번 연구로 표준균주 뿐만 아니라 구강에서 직접 분리한 혐기성 세균에 대한 서양산 고추냉이 뿌리 추출물의 항균성을 확인할 수 있었고, 추후 근관 세척제나 소독제로 서양산 고추냉이 뿌리 추출물을 이용할 수 있는 가능성을 보여주었다. Objective : The aim of this study was to determine the antimicrobical effect of horseradish root extracts against Enterococcus faecalis and Fusobacterium nucleatum isolated from oral cavity compared with reference strain, and compared with that of chlorhexidine. Method : Horseradish root extracts and chlorhexidine were sequentially diluted and tested against anaerobes(E. faecalis, F. nucleatum) isolated from children's oral cavity. The microbes were anaerobically incubated and the minimum inhibitory concentration(MIC) and minimum bactericidal concentration(MBC) were detected. Results: 1. Horseradish root extracts showed antimicrobial effect against E. faecalis isolated strain at same or slightly higher concentration compared with MIC of reference strain. 2. 625.0~1.250.0 ㎍/ml horseradish root extracts showed similar antimicrobial effect with chlorhexidine(7.8~15.6 ㎍/ml). 3. Horseradish root extracts showed antimicrobial effect against F. nucleatum isolated strain at same or slightly higher concentration compared with MIC of reference strain. 4. 78.1~312.5 ㎍/ml horseradish root extracts showed similar antimicrobial effect with chlorhexidine(7.8~15.6 ㎍/ml). Conclusions : The results of this study confirm that horseradish root extracts has antimicrobial effect against anaerobes isolated from oral cavity as well as reference strain. And we found the potential of horseradish root extracts as a canal irrigant or disinfectant.

흰쥐 치아 재식 후 치수 치유 양상의 조직학적 관찰

고은진,정한성,김의성,정일영,이승종 大韓齒科保存學會 2010 Restorative Dentistry & Endodontics Vol.35 No.4

본 연구의 목적은 흰 쥐 (rat) 를 이용하여 미성숙 단계의 치아를 발치 후 즉시 재식 하였을 때 나타나는 치수의 치유 양상을 조직학적으로 관찰하고자 하는 것이다. 생후 4주된 암컷 Sprague-Dawley 계 흰쥐의 상악 우측 제1대 구치를 발거 후 원래의 치조골와 내로 위치시켰다. 재식 후 3일째부터 국소적으로 치수 내 염증 소견이 관찰되었으나, 치근 부위에서는 이미 치수의 재혈관화 및 치유가 진행되고 있는 소견이 관찰되었다. 재식 후 5일째 부터는 odontoblast-like cell이 관찰되기 시작하였다. 삼차 상아질의 형성은 재식 후 1주째 부터 관찰되기 시작하였으며, 2주째부터는 확실히 관찰할 수 있었다. Odontoblast-like cell 및 삼차상아질 형성은 4주째 까지도 계속 관찰되었다. 재식 후 4주째에는 bone-like tissue 및 cementum-like tissue이 형성되었음을 관찰하였다. 본 실험을 통하여 흰 쥐 치아 재식시 석회화 과정은 초기에는 삼차상아질 침착에 의해서 진행되나, 시간이 경과하면서 점차 bone-like tissue 또는 cementum-like tissue가 차지하는 비율이 증가하는 것을 관찰하였다. The objective of this study was to observe the histology of dental pulp healing after tooth replantation in rats. The maxillary right first molars of 4-week-old rat were extracted. and then the teeth were repositioned in the original socket. At 3 days after replantation. there was localized inflammatory reaction. But, pulp revasculization and healing had already begun in the root area. At 5 days after replantation. odonto blast-like cells were observed. Tertiary dentin deposition was observed beneath the pulp-dentin border from 1 week after replantation. And tertiary dentin was increased at 2 weeks after replantation. The presence of odontoblast-like cells and the formation of tertiary dentin were continued to 4 weeks after replantation. At 4 weeks after replantation. the deposition of bone-like tissues and cementum-like tissues was observed. This results show that there is a possibility of pulp healing after tooth replantation in rats and the mineralization of tooth can progress. The mineralization of tooth after replantation was initially occurred by the deposition of tertiary dentin. but as time passed. the deposition of bone-like tissues and cementum-like tissues was begun and increased.

성장기 흰쥐에서 단백질 장기간 알코올 투여가 인슐린 분비능 및 감수성에 미치는 영향

윤용석,허갑범,이현철,임승길,김경래,송영득,안철우,차봉수,이해일,성제경 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.1

Background: This investigation was performed to examine the combined effects of protein malnutrition and chronic moderate amount of alcohol intake on insulin secretory capacity and sensitivity in growing rats. Methods: Weanling 4-week-old male Sprague-Dawley rats were fed low protein [5%, (wt/wt)] or control (C, 20%) diet from 4 to 12 weeks and alcohol (5 g/kg/d) or saline gavage from 8 to 12 weeks. All rats were divided into the 4 groups according to different diet protocols: group I (protein-deficient alcohol rats), group II (protein-deficient saline rats), group III (protein-sufficient alcohol rats), and group IV (protein-sufficient saline or control rats). At the age of 12 weeks, we determined the insulin secretory capacity and sensitivity in the 4 different diet groups. Results: The results are summarized as following; 1. Normal weight gain was nearly completely arrested in protein-deficient rats compared to control rats. In protein-sufficient rats, chronic alcohol intake decreased body weight gain. Pancreatic weight adjusted with body weight was not different among the 4 groups, but epididymal fat weight adjusted with body weight was decreased in group II compared to group IV. 2. Intraperitoneal glucose tolerance was improved in group I compared to the other groups. Insulin responses to glucose challenge were markedly decreased in group II compared to group IV, but not in group I. 3. Glucose disposal rate during euglycemic clamp test was diminished in group II compared to group IV, but there were no differences between group I and group IV. Glycogen synthase activities of skeletal muscle after 2 hour hyperinsulinemic state were not different among the 4 groups. 4. There were no differences of reserved insulin content of whole pancreas adjusted with pancreas weight among the 4 groups. 5. In light microscopic findings of pancreatic islets, sizes of islets, islet cells and nuclei were decreased in protein-deficient rats compared to control rats. However, the sizes of islet cells and nuclei were further decreased in group II compared to group I. Conclusion: These results suggest that impaired insulin secretion and decreased insulin sensitivity due to protein malnutrition can be restored by chronic, moderate amount of alcohol intake, but these beneficial effects may not be appeared in protein-sufficient state. Therefore, the chronic alcohol intake differently influences glucose metabolism according to individual nutritional status, and further studies for the effects of alcohol intake in lean diabetic patients are required to extrapolate these results in human.

Injury analysis of patients according to impact patterns involved in pedestrian traffic crashes

Lee, Hee Young,Youk, Hyun,II Lee, Jeong,Kang, Chan Young,Kong, Joon Seok,Sung, Sil,Kang, In Hye,Lee, Jung Hun,Kim, Oh Hyun,Jung, Woo Jin,Lee, Kang Hyun,Youn, Young Han,Park, Jong Chan Informa UK (TaylorFrancis) 2018 Traffic injury prevention Vol.19 No.suppl1