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Aryun Kim(Aryun Kim),Jeonghwan Lee(Jeonghwan Lee),Hansol Moon(Hansol Moon),Chulhan Kim(Chulhan Kim),Min Young Yoo(Min Young Yoo),Woo Yoon Park(Woo Yoon Park),Won Dong Kim(Won Dong Kim),Young-Seok Seo( 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2
Purpose: We aimed to determine whether low-dose radiotherapy (LDRT) is effective in patients with Alzheimer disease (AD). Materials and Methods: We included patients according to the following criteria: probable Alzheimer's dementia according to the New Diagnostic Criteria for Alzheimer’s Disease; confirmation of amyloid plaque deposits on baseline amyloid positron emission tomography (PET); a Korean Mini-Mental State Examination 2nd edition (K-MMSE-2) score of 13–26; and a Global Clinical Dementia Rating (CDR) score of 0.5–2 points. LDRT was performed six times at 0.5 Gy each. Post-treatment cognitive function tests and PET-CT examinations were performed to evaluate efficacy. The medication for AD treatment was maintained throughout the study period. Results: At 6 months after LDRT, neurological improvement was seen in 20% of patients. Patient #2 showed improvement in all domains of the Seoul Neuropsychological Screening Battery II (SNSB-II). Moreover, the K-MMSE-2 and Geriatric Depression Score-Short Form scores improved from 20 to 23 and from 8 to 2, respectively. For patient #3, the CDR score (sum of box score) improved from 1 (4.0) to 1 (3.5) at 3 months follow-up. Moreover, the Z scores for language and related functions, memory, and frontal executive function improved to -2.56, -1.86, and -1.32, respectively at the 6-month follow-up. Two patients complained of mild nausea and mild hair loss during LDRT, which improved after treatment. Conclusion: One of the five patients with AD treated with LDRT experienced a temporary improvement in SNSB-II. LDRT is tolerable in patients with AD. We are currently under follow-up and will conduct cognitive function tests after 12 months after LDRT. A large-scale randomized controlled trial with a longer follow-up period is warranted to determine the effect of LDRT on patients with AD.
Kim, Johanna Inyang,Yun, Je-Yeon,Park, Heyeon,Park, Suk-Young,Ahn, Youngsheen,Lee, Hansol,Kim, Tae-Kwon,Yoon, Sooran,Lee, Young-Joon,Oh, Sohee,Denninger, John W,Kim, Bung-Nyun,Kim, Jeong-Hyun JMIR Publications 2018 Journal of medical Internet research Vol.20 No.10
<P><B>Background</B></P><P>Videoconferencing-based treatments have shown great potential in increasing engagement and compliance by decreasing the barriers of time and distance. In general, employees tend to experience a lot of stress, but find it difficult to visit a clinic during office hours.</P><P><B>Objective</B></P><P>The purpose of this study was to investigate the effectiveness of a mobile videoconference-based intervention for stress reduction and resilience enhancement in employees.</P><P><B>Methods</B></P><P>In total, 81 participants were randomly allocated to one of the three conditions: mobile videoconferencing, in-person, and self-care; of these, 72 completed the study. All participants underwent assessment via self-reported questionnaires before, immediately after, and 1 month after the intervention. Intervention lasted for 4 weeks and consisted of elements of cognitive behavioral therapy, positive psychology, and meditation. Changes in clinical variables regarding stress and resilience across time were compared between treatment conditions.</P><P><B>Results</B></P><P>There were significant condition × time effects on variables measuring perceived stress, resilience, emotional labor, and sleep, demonstrating significantly differential effects across time according to treatment condition. Moreover, there were significant effects of condition on perceived stress and occupational stress. There were no significant differences in any variable between the mobile videoconferencing and in-person conditions at 1 month after the intervention.</P><P><B>Conclusions</B></P><P>Results indicate that both mobile videoconferencing and in-person interventions were comparably effective in decreasing stress and enhancing resilience. Further studies with a larger sample size and a longer follow-up period are warranted to investigate the long-term effect of mobile videoconferencing interventions.</P><P><B>Trial Registration</B></P><P>ClinicalTrials.gov identifier NCT03256682; https://clinicaltrials.gov/ct2/show/NCT03256682 (Archived by WebCite at http://www.webcitation.org/71W77bwnR)</P>
( Seokhwan Kim ),( Hansol Kim ),( Hai-seong Kang ),( Yonghoon Kim ),( Migyeong Kim ),( Hyosun Kwak ),( Sangryeol Ryu ) 한국미생물생명공학회(구 한국산업미생물학회) 2020 Journal of microbiology and biotechnology Vol.30 No.12
The spread of plasmid-mediated colistin resistance has posed a serious threat to public health owing to its effects on the emergence of pandrug-resistant bacteria. In this study, we investigated the prevalence and characteristics of mcr-1-positive Escherichia coli isolated from retail meat samples in Korea. In total, 1,205 E. coli strains were isolated from 3,234 retail meat samples in Korea. All E. coli strains were subjected to antimicrobial susceptibility testing and were examined for the presence of mcr-1 gene. All mcr-1-positive E. coli (n = 10, 0.8%) from retail meat were subjected to pulse-field gel electrophoresis (PFGE) and whole-genome sequencing (WGS). The transferability of mcr-1 gene was determined by conjugation assays. The mcr-1-positive strains exhibited diverse clonal types. Our mcr-1 genes were located in plasmids belonged to the IncI2 (n = 1) and IncX4 (n = 8) types, which were reported to be prevalent in Asia and worldwide, respectively. Most mcr-1 genes from mcr-1-positive strains (9/10) were transferable to the recipient strain and the transfer frequencies ranged from 2.4 × 10<sup>-3</sup> to 9.8 × 10<sup>-6</sup>. Our data suggest that the specific types of plasmid may play an important role in spreading plasmid-mediated colistin resistance in Korea. Furthermore, our findings suggest that the retail meat may be an important tool for disseminating plasmid-mediated colistin resistance.
김재연(Jaeyeon Kim),김혜옥(Hyeok Kim),김건휘(Geon Hwi Kim),김다솔(Dasol Kim),류한솔(Hansol Ryu),박태현(Taehyun Park) Korean Society for Precision Engineering 2020 한국정밀공학회지 Vol.37 No.7
This study reports on the feasibility of applying polymer electrolyte membrane fuel cells (PEMFCs) system to an energy storage system (ESS). We modeled each constituting system to compute the overall efficiency of the ESS. As a result, it was verified that the power plants’ electric powering capability can be curtailed. The amount of reduction is equal to that of 2nd Gori Nuclear Power Plant currently under construction. We calculated that approximately 320.85 L/day · MW of hydrogen is produced on a national scale. Also, Seoul’s demand output power of PEMFC and the requisite area of sites to install the PEMFC system are approximately 236 MW and 59059 m² respectively. This study can contribute to preventing the upsurge of the entire electric powering installed capability. Based on the present technology level, this study diagnoses the use of hydrogen-based ESS which will be introduced in the upcoming hydrogen economy period. Considering the water electrolysis by polymer electrolyte membrane water electrolyzers are currently at the beginning of commercialization and the energy density per mass of hydrogen is exceedingly high, we anticipate that the future of hydrogen base ESS’ effectiveness will reach greater levels than the analysis of this study.
고정형 위상 천이기를 이용한 동일 위상 마이크로파 전력 분배기
김정욱(Jung Ouk Kim),김한솔(Hansol Kim),안보람(Boram An),김수정(Sujeong Kim),김찬호(Chan-Ho Kim),윤원상(Won-Sang Yoon),한상민(Sang-Min Han) 한국전자파학회 2018 한국전자파학회논문지 Vol.29 No.8
본 논문에서는 고정형 위상천이기를 이용한 동위상 급전 평면형 전력분배기 회로를 제안하였다. 정교한 빔 조향을 위한 위상배열안테나의 집적도가 높아짐에 따라, 소자 안테나에 동일한 위상 신호를 공급하기 위해 급전 선로의 길이를 조정하는 기존의 방법에는 공간적 제약이 존재하게 된다. 따라서 평면형 위상천이 기능을 갖는 결함접지구조를 이용하여 인위적인 급전선 길이 조정 없이 소자 안테나에 동일 위상 신호를 공급하는 전력분배기를 설계하였다. 결함접지구조는 선로의 삽입손실을 최소화하고, 위상 천이를 조절할 수 있도록 설계되었으며, 안테나 포트간 격리도와 평면형 구현이 가능한 분배기를 설계 제작하였다. In this paper, a planar equi-phase power divider is proposed using fixed phase shifters. As the integrability of a phased array antenna increases for accurate beam steering, a conventional method to excite equi-phase signals to all element antennas, extending the feedline, has spatial limitations. Therefore, the planar equi-phase power divider is designed using a defected ground structure with a planar phase shift function without intentional feedline extension. The defected ground structure has been considered for a low insertion loss and a controllable phase shift, whereas the power divider has been designed and implemented with a port-to-port isolation and a planar configuration.