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Moon, Hansol,Noh, Woo Chul,Kim, Hyun-Ah,Kim, Eun-Kyu,Park, Ko Woon,Lee, Seung Sook,Choi, Joon Ho,Han, Kyung Woo,Byun, Byung Hyun,Lim, Ilhan,Kim, Byung Il,Choi, Chang Woon,Lim, Sang Moo The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.3
Purpose This study investigates the correlation of retention index (RI) using the dual phase FDG PET/CT scan with the breast cancer biomarkers. Methods A total of 55 patients with breast cancer underwent dual phase FDG PET/CT scans (60 and 120 min after FDG injection) before treatment. SUVmax and SUVmean of the primary breast tumors were measured, then the percent change of SUVmax and SUVmean between the two scans were calculated, and denoted as RImax and RImean, respectively. After the surgical resection of the breast tumor, the status of biomarkers (ER, PR, and HER-2) was evaluated in the postsurgical specimen. Results RImean was significantly higher in ER (-) (median, 16.2; IQR, 10.8-21.0) or HER-2 (+) (median, 16.1; IQR, 10.7-21.6) tumors than in ER (+) tumors (median, 9.9; IQR, 5.5-15.3) or HER-2 (-) tumors (median, 10.5; IQR, 5.5-16.1). However, there were no significant differences of SUVmax or RImax according to the ER or HER-2 status. There were no significant differences of any PET parameters between PR (+) and PR (-) tumors. Based off ROC curve analyses, RImean predicted the ER (+) tumors (AUC, 0.699; p = 0.006), and HER-2 (+) tumors (AUC, 0.674; p = 0.022), but not the PR (+) tumors. However, neither SUVmax nor RImax predicted ER (+), PR (+), or HER-2 (+) tumors. Conclusions Retention index of SUVmean can reflect the ER and HER-2 status of breast cancers. Higher retention index of SUVmean might associate with lower ER expression and higher HER-2 expression.
Aryun Kim(Aryun Kim),Jeonghwan Lee(Jeonghwan Lee),Hansol Moon(Hansol Moon),Chulhan Kim(Chulhan Kim),Min Young Yoo(Min Young Yoo),Woo Yoon Park(Woo Yoon Park),Won Dong Kim(Won Dong Kim),Young-Seok Seo( 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2
Purpose: We aimed to determine whether low-dose radiotherapy (LDRT) is effective in patients with Alzheimer disease (AD). Materials and Methods: We included patients according to the following criteria: probable Alzheimer's dementia according to the New Diagnostic Criteria for Alzheimer’s Disease; confirmation of amyloid plaque deposits on baseline amyloid positron emission tomography (PET); a Korean Mini-Mental State Examination 2nd edition (K-MMSE-2) score of 13–26; and a Global Clinical Dementia Rating (CDR) score of 0.5–2 points. LDRT was performed six times at 0.5 Gy each. Post-treatment cognitive function tests and PET-CT examinations were performed to evaluate efficacy. The medication for AD treatment was maintained throughout the study period. Results: At 6 months after LDRT, neurological improvement was seen in 20% of patients. Patient #2 showed improvement in all domains of the Seoul Neuropsychological Screening Battery II (SNSB-II). Moreover, the K-MMSE-2 and Geriatric Depression Score-Short Form scores improved from 20 to 23 and from 8 to 2, respectively. For patient #3, the CDR score (sum of box score) improved from 1 (4.0) to 1 (3.5) at 3 months follow-up. Moreover, the Z scores for language and related functions, memory, and frontal executive function improved to -2.56, -1.86, and -1.32, respectively at the 6-month follow-up. Two patients complained of mild nausea and mild hair loss during LDRT, which improved after treatment. Conclusion: One of the five patients with AD treated with LDRT experienced a temporary improvement in SNSB-II. LDRT is tolerable in patients with AD. We are currently under follow-up and will conduct cognitive function tests after 12 months after LDRT. A large-scale randomized controlled trial with a longer follow-up period is warranted to determine the effect of LDRT on patients with AD.
실시간 객체 모델을 이용한 내장형 무인항공기 제어시스템의 설계 및 구현
박한솔(Hansol Park),신찬희(Chanhee Shin),김문회(Moon Hae Kim) 한국정보과학회 2006 한국정보과학회 학술발표논문집 Vol.33 No.2A
최근 무인항공기는 정찰임무를 포함하여, 기상관측, 해상관측 등의 여러 임무로 사용되고 있으며, 점점 활용도가 높아지고 있다. 이러한 무인항공기 제어시스템은 과거에 비해 복잡도가 증가했으며, 보다 정밀한 실시간 제어가 요구되고 있다. 이러한 제어시스템을 위한 객체지향 설계방법론은 복잡한 모델에 대한 분석을 보다 빠르게 해주고, 재사용이 가능한 시스템 구축을 가능하게 해 줄 것이다. 이러한 목적을 위해 본 논문에서는 실시간 객체 모델인 TMO모델을 사용하여 시스템을 설계하고, TMO모델을 지원해 주는 리눅스 기반의 미들웨어를 사용하여 무인항공기 제어 시스템을 구현함으로써, 정밀한 실시간 제어시스템에 대한 TMO모델의 적합성을 판단하고, TMO모델 지원 미들웨어의 성능을 평가해 본다.
이수진(Sujin Lee),이한솔(Hansol Lee),문성운(Sungwoon Moon),김진우(Jin Woo Kim) 한국HCI학회 2020 한국HCI학회 학술대회 Vol.2020 No.2
이 논문은 밀레니얼 세대가 다양한 정신질환 진단률이 높아지는 것에 경각심을 느낀 후 정신질환과 감정표현불능증 사이의 유의한 관계를 바탕으로 감정표현불능증을 해소하기 위한 감정인지 강화를 유도하는 A.I. 기반 챗봇 서비스 사례를 소개하고 있다.