http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Ok‐,Hwa,Park, Hyunwoong,Seong, Moon‐,Woo,Cho, Tae‐,Joon,Nishimura, Gen,Superti‐,Furga, Andrea,Unger, Sheila,Ikegawa, Shiro,Choi, In Ho,Song, Hae‐,Ryong,Kim, Hyun Woo Wiley Subscription Services, Inc., A Wiley Company 2011 AMERICAN JOURNAL OF MEDICAL GENETICS PART A Vol.a155 No.11
<P><B>Abstract</B></P><P>Multiple epiphyseal dysplasia (MED) is a genetically heterogeneous group of diseases characterized by variable degrees of epiphyseal abnormality primarily involving the hip and knee joints. The purpose of this study was to investigate the frequency of mutations in individuals with a clinical and radiographic diagnosis of MED and to test the hypothesis that characteristic radiological findings may be helpful in predicting the gene responsible. The radiographs of 74 Korean patients were evaluated by a panel of skeletal dysplasia experts. Six genes known to be associated with MED (<I>COMP</I>, <I>MATN3</I>, <I>COL9A1</I>, <I>COL9A2</I>, <I>COL9A3</I>, and <I>DTDST</I>) were screened by sequencing. Mutations were found in 55 of the 63 patients (87%). <I>MATN3</I> mutations were found in 30 patients (55%), followed by <I>COMP</I> mutations in 23 (41%), and <I>COL9A2</I> and <I>DTDST</I> mutations in one patient (2%) each. Comparisons of radiographic findings in patients with <I>COMP</I> and <I>MATN3</I> mutations showed that albeit marked abnormalities in hip and knee joints were observed in both groups, the degree of involvement and the morphology of dysplastic epiphyses differed markedly. The contour of the pelvic acetabulum, the presence of metaphyseal vertical striations, and/or the brachydactyly of the hand were also found to be highly correlated with the genotypes. The study confirms that <I>MATN3</I> and <I>COMP</I> are the genes most frequently responsible for MED and that subtle radiographic signs may give precious indications on which gene(s) should be prioritized for mutational screening in a given individual. © 2011 Wiley Periodicals, Inc.</P>
Translocation of Annexin I to the Nucleus by Epidermal Growth Factor in A549 Cells
Kim, Seung Wook,Na, Doe Sun,Park, Young Min,Lee, Soo Ok,Rhee, Hae Jin 생화학분자생물학회 1997 BMB Reports Vol.32 No.1
Annexin I (also called lipocortin 1), a 37-kDa member of the annexin family of proteins, has been implicated in the mitogenic signal transduction by epidermal growth factor (EGF). Annexin I is phosphorylated by the EGF signal, however, the role of annexin I in the EGF signal transduction is still unknown. To transduce extracellular signals into the intracellular targets, selective translocation of the signaling molecules to their targets would be necessary. In this study, we examined the subcellular locations of annexin I during EGF signal transduction. Treatment of A549 cells with EGF resulted in the translocation of cytoplasmic annexin I to the nucleus and perinuclear region as determined by Western blot and immunofluorescent staining. The nuclear translocation of annexin I was inhibited by tyrphostin AG 1478 and genistein, the inhibitors of EGF receptor kinase and downstream tyrosine kinases, respectively. Pretreatment of cells with cyclohexamide did not inhibit the nuclear translocation. The results suggest that nuclear translocation of annexin I is controlled by a series of kinase dependent events in the EGF receptor signaling pathway and may be important in tranducing the signals by EGF.
Ok-Chul Jung,Tae Soo No,Hae-Dong Kim,Eun-Kyou Kim 한국항공우주학회 2007 International Journal of Aeronautical and Space Sc Vol.8 No.1
In this paper, a method of station keeping strategy using relative orbital motion and numerical optimization technique is presented for geostationary satellite. Relative position vector with respect to an ideal geostationary orbit is generated using high precision orbit propagation, and compressed in terms of polynomial and trigonometric function. Then, this relative orbit model is combined with optimization scheme to propose a very efficient and flexible method of station keeping planning. Proper selection of objective and constraint functions for optimization can yield a variety of station keeping methods improved over the classical ones. Nonlinear simulation results have been shown to support such concept.
( Hae Ok Byun ),( Young Kyoung Lee ),( Jeong Min Kim ),( Gyesoon Yoon ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.10
Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest. It is commonly believed to underlie organismal aging and age-associated diseases. However, the mechanism by which cellular senescence contributes to aging and age-associated pathologies remains unclear. Recent studies showed that senescent cells exert detrimental effects on the tissue microenvironment, generating pathological facilitators or aggravators. The most significant environmental effector resulting from senescent cells is the senescence-associated secretory phenotype (SASP), which is constituted by a strikingly increased expression and secretion of diverse pro-inflammatory cytokines. Careful investigation into the components of SASPs and their mechanism of action, may improve our understanding of the pathological backgrounds of age-associated diseases. In this review, we focus on the differential expression of SASP-related genes, in addition to SASP components, during the progress of senescence. We also provide a perspective on the possible action mechanisms of SASP components, and potential contributions of SASP-expressing senescent cells, to age-associated pathologies. [BMB Reports 2015; 48(10): 549-558]
Basic phenotyping platform for genetically engineered mouse at KRIBB
Hae Rim Kim,Eun Kyoung Kim,Yong Sub Byun,Kang Ju Seong,Ju Young Lee,Yu Rim Kim,Min Young Lee,Sang Mi Cho,Taek Chang Lee,Hae Jin Lee,Young Ho Kho,Ok Seong Moon,Young Won Seo,Ki Hoon Lee,Hoyoung Ghang,W 한국실험동물학회 2015 한국실험동물학회 학술발표대회 논문집 Vol.2015 No.8