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국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포
이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5
Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)
( Hae Ok Byun ),( Young Kyoung Lee ),( Jeong Min Kim ),( Gyesoon Yoon ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.10
Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest. It is commonly believed to underlie organismal aging and age-associated diseases. However, the mechanism by which cellular senescence contributes to aging and age-associated pathologies remains unclear. Recent studies showed that senescent cells exert detrimental effects on the tissue microenvironment, generating pathological facilitators or aggravators. The most significant environmental effector resulting from senescent cells is the senescence-associated secretory phenotype (SASP), which is constituted by a strikingly increased expression and secretion of diverse pro-inflammatory cytokines. Careful investigation into the components of SASPs and their mechanism of action, may improve our understanding of the pathological backgrounds of age-associated diseases. In this review, we focus on the differential expression of SASP-related genes, in addition to SASP components, during the progress of senescence. We also provide a perspective on the possible action mechanisms of SASP components, and potential contributions of SASP-expressing senescent cells, to age-associated pathologies. [BMB Reports 2015; 48(10): 549-558]
Byun, Hae-Ok,Kim, Hee Young,Lim, Jin J.,Seo, Yong-Hak,Yoon, Gyesoon Wiley Subscription Services, Inc., A Wiley Company 2008 Journal of cellular biochemistry Vol.104 No.5
<P>Mitochondrial complex II defect has recently been implicated in cellular senescence and in the ageing process of which a critical phenotype is retardation and arrest of cellular growth. However, the underlying mechanisms of how complex II defect affects cellular growth, remain unclear. In this study, we investigated the effect of complex II inhibition using a subcytotoxic dose (400 µM) of 2-thenoyltrifluoroacetone (TTFA), a conventional complex II inhibitor, on cell cycle progression. TTFA (400 µM) directly decreased KCN-sensitive cellular respiration rate to 67% of control and disrupted the mitochondrial membrane potential. In contrast to other respiratory inhibitors such as rotenone, antimycin A, and oligomycin, TTFA prolonged the duration of each phase of the cell cycle (G1, S, and G2/M) equally, thereby delaying overall cell cycle progression. This delay was accompanied by a biphasic increase of reactive oxygen species (ROS) and concurrent glutathione oxidation, in addition to a slight decrease in the cellular ATP level. Finally, the delay in cell cycle progression caused by TTFA was proved to be mainly due to ROS overproduction and subsequent oxidative stress, as evidenced by its reversal following pretreatment with antioxidants. Taken together, these results suggest that an overall delay in cell cycle progression due to complex II defects may contribute to ageing and degenerative diseases via inhibition of cellular growth and proliferation without arrest at any specific phase of the cell cycle. J. Cell. Biochem. 104: 1747–1759, 2008. © 2008 Wiley-Liss, Inc.</P>
Byun, Hae-Ok,Lee, Young-Kyoung,Kim, Jeong-Min,Yoon, Gyesoon Korean Society for Biochemistry and Molecular Biol 2016 BMB Reports Vol.49 No.11
Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest. It is commonly believed to underlie organismal aging and age-associated diseases. However, the mechanism by which cellular senescence contributes to aging and age-associated pathologies remains unclear. Recent studies showed that senescent cells exert detrimental effects on the tissue microenvironment, generating pathological facilitators or aggravators. The most significant environmental effector resulting from senescent cells is the senescence-associated secretory phenotype (SASP), which is constituted by a strikingly increased expression and secretion of diverse pro-inflammatory cytokines. Careful investigation into the components of SASPs and their mechanism of action, may improve our understanding of the pathological backgrounds of age-associated diseases. In this review, we focus on the differential expression of SASP-related genes, in addition to SASP components, during the progress of senescence. We also provide a perspective on the possible action mechanisms of SASP components, and potential contributions of SASP-expressing senescent cells, to age-associated pathologies.
Basic phenotyping platform for genetically engineered mouse at KRIBB
Hae Rim Kim,Eun Kyoung Kim,Yong Sub Byun,Kang Ju Seong,Ju Young Lee,Yu Rim Kim,Min Young Lee,Sang Mi Cho,Taek Chang Lee,Hae Jin Lee,Young Ho Kho,Ok Seong Moon,Young Won Seo,Ki Hoon Lee,Hoyoung Ghang,W 한국실험동물학회 2015 한국실험동물학회 학술발표대회 논문집 Vol.2015 No.8
청소년들의 성폭력 개념, 인식 및 대처방법에 대한 지식연구
변미옥 ( Mi-ok Byun ),홍해숙 ( Hae-sook Hong ) 경북대학교 간호과학연구소 2009 경북간호과학지 Vol.13 No.2
To identify the notion, recognition and coping method of sexual assault of adolescents, this study conducted a survey on 1,022 students in 7 districts of T city, from Nov 10 to Dec 12, 2008. For the data analysis, SPSS 14.0 program was used. The study found followings: The notion, recognition and coping method of sexual assault showed a statistically significant difference for grades of respondents. High school students marked the lowest scores in the recognition and coping method of sexual assault. The items that garnered the lowest scores are: in the notion of sexual assault, 'sexual assault occurs by sexual discrimination,' in the recognition of sexual assault, 'Persons who are talking a lot about sex are a person who sexually assaults someone.' and in the coping method of sexual assault, 'after being sexually assaulted, should take a bath and change clothes. The study found that women got higher scores in notion, recognition and coping method than male respondents. Respondents who have both parents and whose parents have higher education showed higher scores in coping method of sexual assault. Also, respondents who contact they mainly saw obscene materials through computer and they were exposed to those materials through computer or TV at home or internet cafe got higher scores in the notion and coping method of sexual assault. There is a static correlation among the notion, recognition and coping method of sexual assault. Those findings suggests that more studies should be ducted on improving knowledge on sexual assault for high school students, propagating the knowledge of obtaining forensic proofs and revealing the relationship between parent factor and knowledge of sexual assault by exposure to obscene materials while students should be provided with sexual assault prevention programs that will be developed based on such more studies. And the study recommends that for making the education for preventing sexual violence effective in reality more follow-up programs are developed and their execution is ensured.