대중화권 주식시장 사이의 동태적 상관관계 분석

둥시융 ( Xi Yong Dong ),윤성민 ( Seong Min Yoon ) 국제지역학회 2015 국제지역연구 Vol.19 No.4

본 연구의 목적은 대중화권 주식시장들 사이의 동태적 상관관계를 DCC-GARCH 모형과 2000년 1월 4일부터 2015년 3월 5일까지 일별 자료를 이용하여 추정하고 그것의 분석결과로부터 정책적 시사점을 얻는 것이다. 본 연구의 실증분석에서 얻은 주요 결과를 요약하면 아래와 같다. 첫째, 상해주식시장과 심천주식시장 사이의 동조화 경향이 가장 강하게 나타나고, 금융위기 전후에 그 경향이 그다지 변하지 않은 것으로 나타났다. 둘째, 홍콩주식시장과 대만 주식시장 사이의 동조화 경향이 상대적으로 크게 나타나고, 금융위기 이후에 그 경향이 더 강화되는 것으로 나타났다. 셋째, 중국 대륙 두 주식시장과 홍콩 및 대만 주식시장 사이의 동조화 경향이 상대적으로 크지는 않지만 글로벌 충격을 거치면서 뚜렷하게 강화되고 있는 것으로 나타났다. 본 연구의 분석결과는 정책 입안자, 국제 투자자 및 자산관리자에 대한 몇 가지 중요한 정책적 시사점을 제공할 수 있다. The purpose of this study is to explore the dynamic correlation among the Greater China stock markets for the period January 4, 2000 to March 5, 2015, and to develop policy implications from the results. From the estimation results of the DCC-GARCH model, we found the synchronization between Shanghai and Shenzhen stock markets was the strongest, and it has not changed much before and after the Global Financial Crisis (GFC). Our second finding is that the synchronization between Hong Kong and Taiwan stock markets was relatively large, and it has become stronger after the GFC. The third finding is that the synchronization between Chinese mainland and Hong Kong stock markets, Chinese mainland and Taiwan stock markets were not relatively large, but they have obviously become stronger through the global impact. The findings of this paper have several important implications for policy makers, international investors and portfolio managers.

The Influence of the Initial Spot Size of a Double Half-Gaussian Hollow Beam on Its Propagation Characteristics in a the Turbulent Atmosphere

Dong Yuan,Li Shu-Tao,Guan Jia-Yin,Zhang Xi-He,Jin Guang-Yong 한국광학회 2016 Current Optics and Photonics Vol.20 No.5

In this paper, by using the Rayleigh-Sommer field theory and the cross-spectral density function, theanalytical expression for the intensity distribution of a double half-Gaussian hollow beam in a turbulentatmosphere is obtained. The influence of the initial spot size of this beam on its propagation propertiesin a turbulent atmosphere is simulated, and the intensity distributions for such beams with different spotsizes are obtained. The results show that the initial spot size has an important influence on the propagationproperties in the near field, while this influence in the far field is very weak.

Biphasic effects of TGFβ1 on BMP9-induced osteogenic differentiation of mesenchymal stem cells

( Rui Dong Li ),( Zhong Liang Deng ),( Ning Hu ),( Xi Liang ),( Bo Liu ),( Jin Yong Luo ),( Liang Chen ),( Liang Jun Yin ),( Xiao Ji Luo ),( Wei Shui ),( Tong Chuan He ),( Wei Huang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.9

We have found that the previously uncharacterized bone morphogenetic protein-9 (BMP9) is one of the most osteogenic factors. However, it is unclear if BMP9 cross-talks with TGFβ1 during osteogenic differentiation. Using the recombinant BMP9 adenovirus, we find that low concentration of rhTGFβ1 synergistically induces alkaline phosphatase activity in BMP9-transduced C3H10T1/2 cells and produces more pronounced matrix mineralization. However, higher concentrations of TGFβ1 inhibit BMP9-induced osteogenic activity. Real-time PCR and Western blotting indicate that BMP9 in combination with low dose of TGFβ1 potentiates the expression of later osteogenic markers osteopontin, osteocalcin and collagen type 1 (COL1a2), while higher concentrations of TGFβ1 decrease the expression of osteopontin and osteocalcin but not COL1a2. Cell cycle analysis reveals that TGFβ1 inhibits C3H10T1/2 proliferation in BMP9-induced osteogenesis and restricts the cells in G0/G1 phase. Our findings strongly suggest that TGFβ1 may exert a biphasic effect on BMP9-induced osteogenic differentiation of mesenchymal stem cells. [BMB Reports 2012; 45(9): 509-514]

Indolyl Alkaloid Derivatives, $N_b-Acetyltryptamine$ and Oxaline from a Marine-Derived Fungus

Li, Yong,Li, Xi-Feng,Kim, Dong-Soo,Choi, Hong-Dae,Son, Byeng-Wha The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.1

Indolyl alkaloids, $N_b-acetyltryptamine$ (1) and the known oxaline (2) have been isolated from the organic extract of the broth of an unidentified fungus collected from the surface of the marine red alga Gracilaria verrucosa. The structure of $N_{b}$-acetyltryptamine (1) was assigned on the basis of comprehensive spectroscopic analyses.s.

Polymorphisms in TYMS for Prediction of Capecitabine-Induced Hand-Foot Syndrome in Chinese Patients with Colorectal Cancer

Si-Qi Dong,Tong-Min Wang,Jiang-Bo Zhang,Yong-Qiao He,Wen-Qiong Xue,Zi-Yi Wu,Da-Wei Yang,Lian-Jing Cao,Jing-Wen Huang,Xi-Zhao Li,Pei-Fen Zhang,Xiao-Hui Zheng,Wei-Hua Jia 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3

Purpose Capecitabine is an extensively used oral prodrug of 5-fluorouracil in treatment of colon cancer and is known to cause hand-foot syndrome (HFS). As the target enzyme for capecitabine, thymidylate synthase (TYMS) plays a key role for 5-fluorouracil metabolism and has been associated with some side effects caused by capecitabine. The aim of our study is to identify the possible genetic predictors of capecitabine-induced HFS (CAP-HFS) in Chinese colorectal cancer patients.Materials and Methods Whole exons of TYMS were sequenced for 288 extreme phenotype HFS patients, including 144 severe or early-onset (first 2 cycles) moderate HFS extreme cases and 144 extreme controls with no reported HFS. The associations between polymorphisms and CAP-HFS were analyzed using logistic regression under an additive model.Results We identified a novel risk mutation (c.1A>G, chr18:657743), was associated with severe HFS in an extreme case who was affected during the first cycle of treatment. Moreover, we identified three new variants, rs3786362, rs699517, rs2790, and two previously reported variants, 5’VNTR 2R/3R and 3′-untranslated region 6-bp ins-del, which were significantly associated with CAP-HFS (p < 0.05). In silico analysis revealed that the effect of these polymorphisms in the TYMS region on the development of HFS might not be restricted solely to the regulation of TYMS expression, but also the TYMS catalytic activity through the indirect effect on ENOSF1 expression.Conclusion This study identified new polymorphisms in TYMS gene significantly associated with CAP-HFS, which may serve as useful genetic predictors for CAP-HFS and help to elucidate the underlying mechanism of HFS.

Apatinib Combined with Local Irradiation Leads to Systemic Tumor Control via Reversal of Immunosuppressive Tumor Microenvironment in Lung Cancer

Li-jun Liang,Chen-xi Hu,Yi-xuan Wen,Xiao-wei Geng,Ting Chen,Guo-qing Gu,Lei Wang,You-you Xia,Yong Liu,Jia-yan Fei,Jie Dong,Feng-hua Zhao,Yiliyar Ahongjiang,Kai-yuan Hui,Xiao-dong Jiang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

Purpose This study aimed to investigate the potential systemic antitumor effects of stereotactic ablative radiotherapy (SABR) and apatinib (a novel vascular endothelial growth factor receptor 2 inhibitor) via reversing the immunosuppressive tumor microenvironment for lung carcinoma. Materials and Methods Lewis lung cancer cells were injected into C57BL/6 mice in the left hindlimb (primary tumor; irradiated) and in the right flank (secondary tumor; nonirradiated). When both tumors grew to the touchable size, mice were randomly divided into eight treatment groups. These groups received normal saline or three distinct doses of apatinib (50 mg/kg, 150 mg/kg, and 200 mg/kg) daily for 7 days, in combination with a single dose of 15 Gy radiotherapy or not to the primary tumor. The further tumor growth/regression of mice were followed and observed. Results For the single 15 Gy modality, tumor growth delay could only be observed at the primary tumor. When combining SABR and apatinib 200 mg/kg, significant retardation of both primary and secondary tumor growth could be observed, indicated an abscopal effect was induced. Mechanism analysis suggested that programmed death-ligand 1 expression increased with SABR was counteract by additional apatinib therapy. Furthermore, when apatinib was combined with SABR, the composition of immune cells could be changed. More importantly, this two-pronged approach evoked tumor antigen–specific immune responses and the mice were resistant to another tumor rechallenge, finally, long-term survival was improved. Conclusion Our results suggested that the tumor microenvironment could be managed with apatinib, which was effective in eliciting an abscopal effect induced by SABR.

만삭전 및 만삭임신에서 산모의 청각을 통한 "뇌 alpha-파 생성 음향" 및 "자연음향" 자극이 태아심박동에 미치는 영향

김문영,이용태,황정혜,박문일,신동열,정경미,장수천 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.8

Background : Recently, the acoustic stimulation test (AST) has been commonly used as an alternative tool for conventional nonstress testing (NST) in antepartum fetal heart rates (FHR) monitoring. The rationale of AST is that FHR are influenced by direct acoustic or vibratory stimulation to the fetus via maternal abdominal wall. However, there are few reports concerning emotional or indirect stimulation in pregnant women may affect on FHR. In this study, we attempted to find the effects of emotional changes of pregnant women on FHR tracings. Patients and Methods : Fifty pregnant women (25 preterm and 25 term pregnancies) were engaged in this study from September 1998 to August 1999. The NST (20-minutes) were done in all patients. After NSTs, $quot;alpha-brain wave induced sound [A]$quot; for 15-minutes and $quot;alpha wave plus natural sounds from the sea or forest [B]$quot; for 15-minutes were given using earphones during FHR monitoring. We used a $quot;MC2 study-α (Daeyang E&C, Korea)$quot; machine for these stimulation. Finally, 50-minutes (20+15+15 minutes) of FHR monitoring records were obtained in each patient. Each FHR data were obtained and analyzed using computerized FHR analysis system (HYFM-II, HUH, Korea). This system calculates the mean baseline FHR, variability of FHR, number of fetal movements, number of FHR accelerations (10sec-10bpm, 15sec-15bpm) and signal loss, automatically in the given time-windows. From each file of 50-minutes FHR testing, three 15-minutes windows (15-minutes of 20-minutes window of NST, 15-minutes of [A], and 15-minutes of [B]) were analyzed for comparison, respectively. Results : There were no significant changes in each FHR variable after maternal hearing of [A] & [B] in preterm pregnancies, although increasing trends were seen. However, the FHR variability were significantly increased after stimulation [A] and [B] in term pregnancies (p=0.04239 & 0.00104), respectively. The number of FHR accelerations (10bpm-10sec) were also significantly increased after maternal hearing of [B] after NST (p=0.04447) in term pregnancies. C omments : There are some effect of maternal hearing, namely emotional change of mother, on FHR variables. We could suppose that mature fetuses in term pregnancies were more sensitive to emotional changes of mother than preterm immature fetuses. These results might be useful in study of $quot;Taekyo$quot; in the field of mind-body medicine in clinical obstetrics. Now we are investigating another studies using various indirect or emotional stimulus to pregnant women using our own FHR analysis software.

Vitamin C Promotes Astrocyte Differentiation Through DNA Hydroxymethylation : DNA Hydroxymethylation of Astrocytic Genes

Kim, Jong-Hwan,Kim, Mirang,He, Xi-Biao,Wulansari, Noviana,Yoon, Byoung-Ha,Bae, Dong-Hyuck,Huh, Nanhyung,Kim, Yong Sung,Lee, Sang-Hun,Kim, Seon-Young Wiley (John WileySons) 2018 Stem Cells Vol.36 No.10

Effect of Dietary Beta-Glucan on the Performance of Broilers and the Quality of Broiler Breast Meat

Moon, Sun Hee,Lee, Inyoung,Feng, Xi,Lee, Hyun Yong,Kim, Jihee,Ahn, Dong Uk Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.3

A total of 400, one day-old commercial broiler chicks were divided into five diet groups (negative control, positive control group with 55 ppm Zn-bacitracin, 15 ppm ${\beta}$-glucan, 30 ppm ${\beta}$-glucan, and 60 ppm ${\beta}$-glucan) and fed for six weeks. Ten broilers were allotted to each of 40 floor pens. Eight floor pens were randomly assigned to one of the 5 diets. Each diet was fed to the broilers for 6 weeks with free access to water and diet. The survival rate, growth rate, feed efficiency, and feed conversion rate of the broilers were calculated. At the end of the feeding trial, the birds were slaughtered, breast muscles deboned, and quality parameters of the breast meat during storage were determined. The high level of dietary ${\beta}$-glucan (60 ppm) showed better feed conversion ratio and survival rate than the negative control. The survival rate of 60 ppm ${\beta}$-glucan-treated group was the same as that of the antibiotic-treated group, which showed the highest survival rate among the treatments. There was no significant difference in carcass yield, water holding capacity, pH, color, and 2-thiobarbituric acid reactive substances values of chicken breast meat among the 5 treatment groups. Supplementation of 60 ppm ${\beta}$-glucan to broiler diet improved the survival rate and feed conversion rate of broilers to the same level as 55 ppm Zn-bacitracin group. The result indicated that use of ${\beta}$-glucan (60 ppm) can be a potential alternative to antibiotics to improve the survival and performance of broilers. However, dietary ${\beta}$-glucan showed no effects on the quality parameters of chicken breast meat.

A Putative Histone Deacetylase Modulates the Biosynthesis of Pestalotiollide B and Conidiation in Pestalotiopsis microspora

( Xue Liang Niu ),( Xiao Ran Hao ),( Zhang Yong Hong ),( Long Fei Chen ),( Xi Yu ),( Xu Dong Zhu ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.5

Fungi of the genus Pestalotiopsis have drawn attention for their capability to produce an array of bioactive secondary metabolites that have potential for drug development. Here, we report the determination of a polyketide derivative compound, pestalotiollide B, in the culture of the saprophytic fungus Pestalotiopsis microspora NK17. Structural information acquired by analyses with a set of spectroscopic and chromatographic techniques suggests that pestalotiollide B has the same skeleton as the penicillide derivatives, dibenzodioxocinones, which are inhibitors of cholesterol ester transfer protein (CETP), and as purpactins A and C’, inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). Strain NK17 can make a fairly high yield of pestalotiollide B (i.e., up to 7.22 mg/l) in a constitutive manner in liquid culture. Moreover, we found that a putative histone deacetylase gene, designated as hid1, played a role in the biosynthesis of pestalotiollide B. In the hid1 null mutant, the yield of pestalotiollide B increased approximately 2-fold to 15.90 mg/l. In contrast, deletion of gene hid1 led to a dramatic decrease of conidia production of the fungus. These results suggest that hid1 is a modulator, concerting secondary metabolism and development such as conidiation in P. microspora. Our work may help with the investigation into the biosynthesis of pestalotiollide B and the development for new CETP and ACAT inhibitors.