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Orthogonal 방법을 통한 Poly(AM-DMDAAC)/MMT 고흡수성나노복합체 제조 연구
Jun Dong Yuan,Ming Zhou,Shuang Qiao Yang,Yong Guo Zhou,Nan Qin,Song Tao He,Dong Lai,Zhong Qiang Xie 한국고분자학회 2014 폴리머 Vol.38 No.1
A novel poly(AM-DMDAAC)/MMT superabsorbent nanocomposites are prepared by radical polymerizationusing ammonium persulfate (APS) and anhydrous sodium sulfite as a free radical initiator and N,N-methylene bisacrylamide(MBA) as a crosslinker. In this paper, an optimization study on the synthesis of superabsorbent nanocompositesis carried out. Orthogonal array experiment indicates that the optimized conditions is acrylamide (AM) content 23 wt%,diallyl dimethyl ammonium chloride (DMDAAAC) content 6 wt%, montmorillonite (MMT) content 4 wt%, initiatorcontent 0.2 wt% and crosslinker content 0.02 wt%. Under the optimization syntheses conditions concluded, the maximumwater absorbency in distilled water is 659.53 g·g-1 and in 2 wt% sodium chloride solution is 116.25 g·g-1. Compared withthe range values of different factors (Rj), the order of significance factors in distilled water is C (MMT) > B (DMDAAC)> A (AM) > D (crosslinker) > E (initiator). MMT is intercalated during polymerization reaction and a nanocompositestructure is formed as shown by TEM analysis and XRD analysis.
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Si-Qi Dong,Tong-Min Wang,Jiang-Bo Zhang,Yong-Qiao He,Wen-Qiong Xue,Zi-Yi Wu,Da-Wei Yang,Lian-Jing Cao,Jing-Wen Huang,Xi-Zhao Li,Pei-Fen Zhang,Xiao-Hui Zheng,Wei-Hua Jia 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3
Purpose Capecitabine is an extensively used oral prodrug of 5-fluorouracil in treatment of colon cancer and is known to cause hand-foot syndrome (HFS). As the target enzyme for capecitabine, thymidylate synthase (TYMS) plays a key role for 5-fluorouracil metabolism and has been associated with some side effects caused by capecitabine. The aim of our study is to identify the possible genetic predictors of capecitabine-induced HFS (CAP-HFS) in Chinese colorectal cancer patients.Materials and Methods Whole exons of TYMS were sequenced for 288 extreme phenotype HFS patients, including 144 severe or early-onset (first 2 cycles) moderate HFS extreme cases and 144 extreme controls with no reported HFS. The associations between polymorphisms and CAP-HFS were analyzed using logistic regression under an additive model.Results We identified a novel risk mutation (c.1A>G, chr18:657743), was associated with severe HFS in an extreme case who was affected during the first cycle of treatment. Moreover, we identified three new variants, rs3786362, rs699517, rs2790, and two previously reported variants, 5’VNTR 2R/3R and 3′-untranslated region 6-bp ins-del, which were significantly associated with CAP-HFS (p < 0.05). In silico analysis revealed that the effect of these polymorphisms in the TYMS region on the development of HFS might not be restricted solely to the regulation of TYMS expression, but also the TYMS catalytic activity through the indirect effect on ENOSF1 expression.Conclusion This study identified new polymorphisms in TYMS gene significantly associated with CAP-HFS, which may serve as useful genetic predictors for CAP-HFS and help to elucidate the underlying mechanism of HFS.
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