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Haiming Jin,Zengjie Zhang,Chengui Wang,Qian Tang,Jianle Wang,Xueqin Bai,Qingqing Wang,Majid Nisar,Naifeng Tian,Quan Wang,Cong Mao,Xiaolei Zhang,Xiangyang Wang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Wound healing is delayed in diabetic patients. Increased apoptosis and endothelial progenitor cell (EPC) dysfunction are implicated in delayed diabetic wound healing. Melatonin, a major secretory product of the pineal gland, promotes diabetic wound healing; however, its mechanism of action remains unclear. Here, EPCs were isolated from the bone marrow of mice. Treatment of EPCs with melatonin alleviated advanced glycation end product (AGE)-induced apoptosis and cellular dysfunction. We further examined autophagy flux after melatonin treatment and found increased light chain 3 (LC3) and p62 protein levels in AGE-treated EPCs. However, lysosome-associated membrane protein 2 expression was decreased, indicating that autophagy flux was impaired in EPCs treated with AGEs. We then evaluated autophagy flux after melatonin treatment and found that melatonin increased the LC3 levels, but attenuated the accumulation of p62, suggesting a stimulatory effect of melatonin on autophagy flux. Blockage of autophagy flux by chloroquine partially abolished the protective effects of melatonin, indicating that autophagy flux is involved in the protective effects of melatonin. Furthermore, we found that the AMPK/mTOR signaling pathway is involved in autophagy flux stimulation by melatonin. An in vivo study also illustrated that melatonin treatment ameliorated impaired wound healing in a streptozotocin-induced diabetic wound healing model. Thus, our study shows that melatonin protects EPCs against apoptosis and dysfunction via autophagy flux stimulation and ameliorates impaired wound healing in vivo, providing insight into its mechanism of action in diabetic wound healing.
Application and Simulation of Distribution Function in Grape Drying Process
Cong Wang 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.10
In order to investigate the influence factors of Weibull distribution function and its application in drying, the drying process of grape slices in different microwave vacuum drying power (330, 460, 590W) and vacuum degree (-50, -70, -90kPa) was taken as the research object, and the Weibull distribution function was used to simulate and analyze its drying kinetic curves, the results showed that the Weibull distribution function was able to simulate microwave vacuum drying process of grape slice well: scaling parameterαwas related with microwave power and vacuum degree, and decreased with the rise of them; the influence of drying variable on the form parameterβwas relatively low. The estimated effective moisture diffusivity coefficient in the dry process was obtained by calculating, its value increased with the rise of microwave power and vacuum degree in the scope from 3.45078×10-7 to 6.74613×10-7m2/s; through Arrhenius equation, the activation energy of drying was calculated respectively 1.34701, 1.49099 and 1.57108 W/g under the vacuum degree of -50, -70 and -90kPa. This study has provided the technical basis for the application of Weibull distribution function in microwave vacuum drying technology of grape slices.
Wang, Cong,Lee, Ji-Hoon,Kim, Nam-Young Wiley Subscription Services, Inc., A Wiley Company 2010 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.52 No.3
<P>In this letter, an advanced SI-GaAs-based manufacturing process is presented for creating high quality, cost effective, and compact size integrated passive devices. Through this advanced process, accurate thin film resistors, high Q spiral inductors, and high yield/breakdown voltage metal-insulator-metal capacitors can be successfully realized. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 618–623, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25018</P>
Conge Tan,Weijun Ding,Wenzhe Feng,Jianguo Wang,Miqu Wang 사단법인약침학회 2010 Journal of Acupuncture & Meridian Studies Vol.3 No.3
The warm needling technique used in traditional Chinese medicine has been shown to be effective in the treatment and prevention of knee osteoarthritis (OA), but the biological mechanisms behind this action have not been well explored. This study investigated the molecular mechanisms behind warm needling using cDNA microarray technology, thus providing further scientific evidence for its efficacy. Ten patients with knee OA of deficiency-cold syndrome were selected for 2 weeks of warm needling treatment. This treatment involved stimulating the selected acupoints using needles with a burning moxa stick on their handle for 40 minutes per session. Pain intensity and accumulated clinical scores of deficiency-cold syndrome were assessed pretreatment and posttreatment using a 40-factor questionnaire of OA with deficiency-cold syndrome. Four patients with the best therapeutic efficacy were selected for cDNA microarray testing. Among the four patients, 41, 246,57 and 70 differentially expressed genes were obtained, with more than 50% of these differentially expressed genes functionally linked to primary, cellular and energy metabolism pathways. This work demonstrates that the molecular mechanism behind warm needling treatment may be associated with the regulation of metabolism-related genes and pathways.
Cong Qi,Liang Sun,Yuxing Wang,Chengchao Wang,Genglin Chen 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.8
Aiming at high working power and heat dissipation of electronic components, this study developed a novel bionic fractal microchannel heat sink with traveling-wave fins based on fractal theory and disk-like tree-like structure. -Al2O3-water nanofluid was chosen as the working fluid instead of water in the microchannel heat sink. Thermohydraulic performance of nanofluids in the bionic fractal microchannel heat sink with traveling-wave fins was simulated numerically, and its comprehensive performance was studied. The main control parameters of this study include the depths of the traveling wave structure (h=0.00005 m, 0.00010m, 0.00015 m, 0.00020 m, 0.00025 m), the eccentricity ratios of the traveling wave structure (e=0, 0.1, 0.2, 0.3, 0.4) and Reynolds numbers (Re=200-1,000). Results indicate that the surface temperature of the microchannel heat sink decreases with Reynolds number and depth of traveling wave structure. The use of traveling ribs at fractal corners can convert the inhomogeneous flow caused by the fractal effect into a stable horizontal channel flow more efficiently, while the temperature uniformity increases with depth and eccentricity ratio. Results also show that the traveling wave structure has the best overall performance when the eccentricity ratio of the traveling wave structure is 0.1 or 0.2, and the depth is 0.00020 m or 0.00025 m.
Cong Weixuan,Li Ning,Wang Jinbin,Kang Ying,Miao Yiling,Xu Chunming,Wang Ziqi,Liu Tongtong,Gong Lei,Liu Bao,Ou Xiufang 한국유전학회 2022 Genes & Genomics Vol.44 No.3
Background: Albeit a relatively stable epigenetic modification, DNA methylation in plants can be repatterned and play important roles in response to biotic and abiotic stresses. However, whether DNA methylation dynamics may contribute to cope with mercury (Hg) stress in plants remains to be fully investigated. Objective: To probe the potential roles of DNA methylation dynamics in coping with Hg stress in rice. Methods: Whole-genome bisulfite sequencing was used to profile the DNA methylation patterns of a rice Hg-resistant line (RHg) selected from a heterozygous mutant of the DNA methyltransferase 1 gene (OsMET1+/-), together with its Hg-sensitive wild-type plants of cv. Nipponbare (Nip) under both normal and Hg stress conditions. Results: Genome-wide locus-specific differential methylation regions (DMRs) were detected between RHg and Nip under normal condition, the predominant DMR patterns were CG hypo-DMRs, CHG hypo-DMRs and CHH hyper-DMRs. In both lines, more hyper- than hypo-DMRs were detected at all three sequence contexts (CG, CHG and CHH) under Hg stress relative to normal condition. Comparison of DNA methylation changes in the two lines under Hg stress indicates that RHg had a more dynamic methylome than the control (Nip). Original DMRs in RHg trended to transform to opposite status (from hyper- to hypo- or vice versa) under Hg stress condition. Gene ontology analysis revealed that Hg-resistance-related DMGs were enriched in diverse biological processes. Conclusions: Our results suggest genome-wide locus-specific DNA methylation repatterning can facilitate rapid acquisition of Hg resistance in rice.
Intravitreal implantable magnetic micropump for on-demand VEGFR-targeted drug delivery
Wang, Cong,Seo, Seung-Jun,Kim, Jin-Seong,Lee, Se-Hee,Jeon, Jae-Kun,Kim, Jae-Woo,Kim, Ki-Hong,Kim, Jong-Ki,Park, Jungyul Elsevier 2018 Journal of controlled release Vol.283 No.-
<P><B>Abstract</B></P> <P>In this paper, we propose an intravitreal implantable magnetic micropump integrated with micro check valve capable of on-demand vascular endothelial growth factor receptor (VEGFR)-targeted drug delivery for the treatment of age-related macular degeneration, diabetic retinopathy and other eye pathologies characterized by ocular neoangiogenesis. Precise on-demand drug release is realized by the deflection of the magnetic membrane assembly according to the external magnetic field, and the membrane assembly consists of a thin elastic polydimethylsiloxane (PDMS) membrane and a cylindrical magnetic nanoparticle-PDMS composite block. Additionally, a micro check valve composed of two PDMS layers was integrated into the micropump to realize a diode-like one-directional drug delivery and prevent undesired drug diffusion. For specifically targeting VEGFR and suppression of VEGF-induced proliferation of microvascular endothelial cells, anti-Flt1 gold nanocomplexes are synthesized. <I>In vitro</I> and <I>in vivo</I> experiments and quantitative analysis are carried out in order to verify our proposed concept: precise drug release control according to the external magnetic field, targeting to microvascular endothelial cells, and efficient and on-demand drug delivery from the proposed micropump to the macular area of rabbit's eye.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Antimicrobial compounds from marine actinomycetes
Cong Wang,Yuanyu Lu,Shugeng Cao 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.7
Marine actinomycetes were the main origin ofmarine natural products in the past 40 years. This review wasto present the sources, structures and antimicrobial activitiesof 313 new natural products from marine actinomycetesreported from 1976 to 2019.