성장기 아동의 single tooth scissors bite의 교정 치료: 증례 보고

김지인,현홍근,김영재,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2011 大韓小兒齒科學會誌 Vol.38 No.4

A scissors bite in the posterior teeth occurs when the upper teeth are positioned totally buccal to the lower teeth in centric occlusion, either unilaterally or bilaterally. This malocclusion can result from either excessive width of the maxilla or deficient width of the mandible, or sometimes combination of the both. Scissors bite, when left untreated without a proper dental intervention, interferes with the normal mandibular growth leading to a state where consequent disharmony in dental arch width evokes occlusal disturbances. Therefore, early preventive orthodontic treatment is necessary in patients with scissors bite. Scissors bite rarely involves anterior and posterior sites concuttently across the dental arch but usually affect single tooth. Even in the single tooth scissors bite cases, more likely to be met in the clinical fields, immediate dental intervention is indicated because continuous occlusal forces that exacerbate the already adverse axis of the posterior teeth. In this case study, patients with single tooth scissors bite, each 7, 14, 12, and 16 years old, were each treated with criss-cross elastic, fixed appliance, removable appliance, and miniscrews. With the proper selection of appliances appropriate to each specific cases, good treatment outcome can be achieved without resulting any side effects. 중심교합위의 상태에서 편측 혹은 양측으로 상악 구치부의 치아가 하악 구치부의 협측으로 위치한 경우를 scissors bite라 고 한다. 이는 상악의 폭경이 크거나 하악의 폭경이 좁은 경우 발생한다. Scissors bite의 경우 방치하게 되면 하악의 성장이 방해받게 되고 그 결과, 악궁 폭경의 부조화가 심해져 저작 장애를 일으킬 수 있으므로 조기 차단 교정이 반드시 필요하다. 실제 임상에서는 여러 치아의 scissors bite보다 최후방 구치 혹은 그 외 하나의 구치만의 single tooth scissors bite(STSB)을 보이는 경우가 많다. 이러한 STSB의 경우도 방치하게 되면 저작력으로 인하여 구치의 각도가 더욱 악화되므로 즉각적인 치료가 필요하다. 본 증례에서는 STSB를 보이는 7세, 14세, 12세, 16세의 환자에게 각각 criss-cross elastic, 고정성 장치, 가철성 장치, miniscrew를 사용하여 치료한 증례를 보고하였다. 각 환자의 증례에 적합한 장치를 잘 선택하여 사용한다면 치아를 정출시키는 등의 부작용을 야기하지 않고 양호한 결과를 얻을 수 있을 것이다

X-관련성 만성육아종성질환의 진단을 위한 PMA-activated NBT 검사

김중곤,조한익,오흥범,김의종,최강원 대한감염학회 1996 감염 Vol.28 No.1

목적 : Activated NBT 검사는 만성육아종성질환을 선별하는 검사이다. 활성제로 PMA를 사용하면 X-linked CGD의 경우 보인자를 감별할 수 있다. 방법 : CGD의 가족력을 부인하는 정상인 30명을 대상으로 PMA activated NBT 슬라이드 검사를 실시하여, 정상대조에서의 formazan 형성율을 보았으며, 동일 검사를 CGD가 강력히 의심되는 환자와 그 가족에 대하여 실시하였다. 결과 : 정상대조 30명 전원에서 98% 이상의 formazan 형성세포가 관찰되었다. 환자에게 실시한 결과 세환자 모두에서 0%의 결과를 보였다. 환자의 어머니에서는 각각 57, 70, 67%의 결과를 보였다. 결론 : 본 연구를 통하여 세 환자는 X-관련성 만성육아종성질환이라는 진단을 내릴 수 있었다. PMA activated NBT 슬라이드 검사는 시행하기가 쉽고 재현성이 좋으므로, 어러 검사실에서 소아기 면역결핍증을 선별하는 검사의 하나로 시행되는게 바람직하다고 사료된다. Background : Chronic granulomatous disease(CGD) is uncommon inherited disorder in which phagocytic cells fail to produce antimicrobial superoxide(O₂) due to NADPH oxidase deficiency. This disease can be easily screened by activated nitroblue tetrazolium(NBT) test. In case of X-linked CGD, carriers also can be detected. Methods : PMA(phorbol myristate acetate) activated NBT test was performed as previously described. Test performance was evaluated in 30 normal persons who denied family history mimicking CGD. Test was also applied to the three strongly suspected cases of CGD. Two of the cases were 12 year old boy and 7 year old boy, who suffered from many infectious diseases since 6 month old and 4 month old, respectively. The other remaining case was 22 year old man who suffered from many infectious diseases since 6 year old, but now relatively in health compared to the other two cases. Results : More than 98% formazan formation was observed in all normal controls. No formazan positive cell was shown in all of the three patients. However, applied to the mothers, the test revealed 57%, 70%, 67% positive cells, respectively. Conclusion:X-linked transmission of CGD could be determined with the results of PMA activated NBT slide test. This test can be easily performed. It would be better to do this test routinely as one of the tests for the screening of the immmunodeficiency syndrome in childhood.

이하선 타액내 Parotid Isoelectric Focusing Variant Protein (PIF)의유전적 다형선상에 관한 연구

한동호,김종열 大韓法醫學會 1993 대한법의학회지 Vol.17 No.2

In order to identify the polymorphism of the parotid isoelectric focusing variant protein(PIF), as an integrating part of systemic study about proteins, this study was conducted. One-hundred and fifty healthy adult Koreans between the ages of 20 and 29 were chosen, and their parotid saliva was collected. The parotid asliva went under isoelectric focusing on a urea-plyacrylamide slab gel(pH 3.5-5.2) for 5 hours. Then, it was stained with Coomasie Brilliant Blue R-250/20% Trichloroacetic acid (TCA) and again was destained with 20% TCA solution. The phenotype frequency and gene frequency of each isoelectric focusing variant protein(PIF) were obtained, and the subjects were divied into the indigenous family name froup and immigrated family name group. The phenotype and gene frequency of each group were compared, and the following results were obtained : 1. The phenotypes of parotid isoelectric focusing variant protein(PIF) observed in paroted saliva of the 150 koreans were PIF(+) in 140 people(93.3%) and PIF(-) in 10 people (6.7%). 2. The gene frequency of PIF?? was 0.742, and that of PIF?? was 0.258. 3. Of the 150 Koreans, the gene frequencies of the indigenous family name group were 0.733 in PIF?? and 0.267 in PIF??; those of the immigrated family name group were 0.796 and 0.234. 4. The gene frequency of the entire Korean group was closer to that of indigenous family name gorup than the immigrated family name group.

혈액에서 분리된 세균의 항생제감수성 : Vitek System을 이용한 최소억제농도측정 Minimal Inhibitory Concentration Determined by Vitek System

김의종,김선주,신보문,박명희,조한익,김상인 대한화학요법학회 1988 대한화학요법학회지 Vol.6 No.1

Minimal inhibitory concentrations of total 148 strains isolated from blood culture at Seoul National University Hospital were determined by Vitek System. 90% MIC of gram-negative bacteria against amikacin was 2-16㎍/㎖, and those against beta-lactams was > 16㎍/㎖ in general, Except Salmonella spp,. 90% MIC against chloramphenicol and tetracycline was >8㎍/㎖. Range of 90% MIC against vancomycin was ≤.5-4㎍/㎖ in case of garm-positive bacteria, except Enterococcus spp. which showed 90% MIC as >16㎍/㎖. Against ampicillin, 90% MIC of Staphylococcus spp. was >16㎍/㎖, but those of Streptococcus spp. was ≤.25-2㎍/㎖. Streptococcus viridans group showed 90%MIC against penicillin as ≤.03㎍/㎖. Susceptibility of gram-negative bacteria was generally 98% against amikacin, and those of gram-positive bacteria was 80% against vancomycin. 34% of Staphylococcus spp. was resistant of oxacillin. These results may be useful for the primary selection and the dosage determination of antibiotics in the treatment of patients with bacteremia.

Kiel Bone이 家兎의 下顎骨 損傷部 治癒에 미치는 影響

金相鎬,卞種秀,李相韓 慶北大學校 齒科大學 1985 慶北齒大論文集 Vol.2 No.1

The purpose of this experimental study was to observe the rate of new bone formation, tissue tolerance and influence in the healing process of bony defect after Kiel Bone graft in the mandible of rabbits. Sixteen hybrid white rabbits were divided into two groups: Control group and experimental group with Kiel Bone graft (1.0㎜ in measured diameter). Each of the experimental and control animals was sacrificed on the 1st, 2nd, 4th, 8th weeks postoperation and mandible was removed. Then the specimens were fixed in the 10% neutral formalin solution for 24 hours and decalcified with nitric acid mixed with formalin (1:9). And then embedded in paraffin, sectioned 6μm thickness and stained H-E stain. The results were as follows: Minimal new bone formation developed by I week after Kiel Bone graft. In control group, new bone formation starts at the 2nd week. At the 4th week, partial resorption of Kiel Bone was noted. The rate and amount of new bone formation were more rapid and abundant in the Kiel Bone graft than control group throughout the eight weeks. There was no foreign body reaction (encapsulation or sloughing) to the grafted Kiel Bone.

프로스타글란딘 E₁ 마이크로에멀젼이 함유된 액상좌제의 제조 및 평가

김정환,이사원,박경미,최한곤,김종국 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-

The purpose of this study is to develop a transurethral liquid suppository containing prostaglandin E_(1)(PGE_(1))-loaded microemulsion, which undergoes a phase transition to gels at body temperature. The effects of oils, ethanol as solvent and HCI as pH-controlling agent on the physicochemical properties of liquid suppositories composed of poloxamer P 407. P 188 and carbopol was investigated. The stability of PGE_(1) and release of PGE_(1) from liquid suppository were evaluated. Oils such as Neobee and soybean oil significantly decreased the gelation temperature but increased the gel strength of liquid suppository due to their strongly binding with the components of liquid suppository base. However, ethanol slightly did the opposite. The pH of liquid suppositories hardly affected the gelation temperature and gel strength due to addition of very small HCI(0.005-0.01%). A liquid suppository [PGE_(1)/P 407/P 188/carbopol/Neobee/ethanol/HCI(0.4/14/14/0.4/7/2/0.005%)], which had the gelation temperature (34.2±0.6℃) and gel strength (31.35±4.37 sec) suitable for liquid sup-pository system, was easily administered and not leak out from the body. About 60% of PGE_(1) was released out within 2h from this formulation. It was shown that the release of PGE_(1) was proportional to the square root of time, indicating that PGE_(1) might be released from the suppository by Fickian diffusion. It was stable at 4℃ for at least 2months. The results suggest that transurethral liquid suppository containing prostaglandin E_(1)-loaded microemulsion is thought to be a con-venient, safe and effective dosage form for PGE_(1). However, it should be further developed as a more convenient and stable dosage form for PGE_(1).

표재성 방광암에서 Bacillus Calmette-Guerin 방광 내 주입요법 : 장기적 추적결과 Long-term Follow up Results

김용웅,왕세환,육승모,한동석,노안식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

To evaluated the results of long-term follow up of superficial bladder cancer patients who were treated with transurethral resection and intravesical BCG therapy. Between April 1989 and December 1997, 65 patients with superficial bladder cancer were treated with TUR-B(Transurethral resection of bladder tumor) and intravesical BCG instillation, and follow-up was performed for 5 years longer, and the mean follow-up duration was 82 months. Of 65 patients, pathologic stage were Ta in 17 cases and T1 in 48 cases and grade were G Ⅰ in 22 cases, G Ⅱ in 35 cases and G Ⅲ in 8 cases. The tumor recurred in 22(33.8%) at the median of 21.8 months and the tumor progressed in 9(13.8%) at the median of 20.8 months. Most of the recurrences and progression were within 3 year(838 and 77%). Progression is more likely in higher grade(G Ⅱ, G Ⅲ) and higher stage(T1). The complete response rate after first and second courses of BCG therapy were 53% and 73% and the 5 and 10 year disease specific survival rates were 89.5 and 78% respectively. The complete response rate after first and second courses of BCG therapywere 53% and 73%. Most of recurrences and progressions were within 3 years of the BCG therapy, but some cases occured after 5 years. Therefore, close long-term follow up is needed.

10~12세 남자아동의 신체조성과 혈중지질성분 비교

김정기,박승한,변재철,김규호,조영주,허용 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

The purpose of this study was to compared blood lipids level in male childrens. Aged are 10-12 years. There are participated in obese, athletes, and general male childrens. We evaluated the underwater weighing body compositions, plasma triglyceride (TG), serum total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol levels. in this study, the underwater weight and body density were highest in athlete group compared other groups. The percent body at was higher in obese children than other groups. Furthermore, plasma TG level was higher in obese children group than the other two groups. Serum TC, LDL-C concentration were higher in obese children group than the other two groups. Also, Serum HDL-C level was high in obese children group compared other two groups.

가토에서 일측 요관 부분 및 완전폐색시 신장과 요관의 조직학적 변화

김상현,김용웅,육승모,한동석,노안식,임재성,김홍식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

This study was designed to clarify histologic changes in the experimental rabbit kidney and ureter after unilateral partial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, the partial obstruction followed by 4 weeks, the complete obstruction followed by 2 weeks, and the complete obstruction followed by 4 weeks. The normal control group was consisted of 5 adult white rabbits. The kidneys and ureters for light microscopy were fixed in 10% neutral formalin, embedded in paraffin and stained with hematoxylin and eosin. Abnormal histologic fingings showed in ipsilateral kidney and ureter of all subgroups(such as dilatation of uriniferous tubule, focal necrosis and desquamation of epithelium, interstitial fibrosis, glomerular congestion, widening of Bowman's space, dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis and interstitial inflammation). These findings were most severe in the group of the complete-obstructed ureter for 4 weeks. No significant changes showed in contralateral ureter of all subgroups. The degree of obstruction was severe and period of obstruction was long, the histological changes in ipsilateral side were severe. Despite of changes in ipsilateral side no abnormal findings showed in contralateral side. We suggest that long term experimental investigation of histologic changes in ipsilateral side and compensatory changes in contralateral side have to be studied.

기체-고체 유동상에서 고체입자의 혼합특성에 관한 실험적 연구

金鍾億,陰漢龍,金聖九 弘益大學校 科學技術硏究所 1997 科學技術硏究論文集 Vol.8 No.-

In the present study, mixing characteristics of solid particles in bubbling fluidized bed have been analyzed in a freely bubbling two-dimensional bed experimentally. Verticall and horizental particles mixing was studied by using heated particles as tracers. The steady-state temperature patterns around a heated wire and transient response to an injected pulse of heated particles were measured. A qualitative study of bubble size, velocity and void fraction in the two -dimensional bed was made by using a high-speed viedo recorder. Through the screen anlaysis of bubble flow it was verified that the size of bubbles increases with the rise of excesive velocity or bed height. Steady state experitments gave the result that the movement of heated particles in beds was more vigorous in higher excessive velocity. In trasient experimet the higher excesive velocity delay time of high temperature particles injected into the bed were the shorter. Dispersion coefficient was found to be increased with grouth of the bubble size and excessive velocity.