COMMUNITY PARTICIPATION IN AND BENEFITS OF TOURISM DEVELOPMENT IN THE TURPAN VALLEY, XINJIANG AUTONOMOUS REGION OF CHINA

Cheng,Soo May,Yang,Li,Dong,Lin 세계문화관광학회 2007 Conference Proceedings Vol.8 No.0

While western scholars such as Jamal and Gertz (1995), Tosun (2005), Fallon and Kriwoken (2003), usually presume that community participation is critical to sustainable tourism development, Chinese scholar Wenjun Li (2006) boldly states that it is possible for a community to achieve benefits of tourism development despite weak involvement in the planning and management of a tourist destination. Our survey of government officials, tourist business operators and residents in seven locations in the World Heritage-listed Turpan Valley in the Xinjiang province found that top-down, government-led participation is necessary and desirable, and does not detract from stakeholders' perception that they are sharing in the benefits of tourism development in the region.

Effects of Mold Growth on Building Materials by Different Environments in Taiwan

An Cheng,Yu Hsin,Wei-Ting Lin 대한토목학회 2014 KSCE Journal of Civil Engineering Vol.18 No.4

The main of study is to investigate the effect of moisture variation and micro-structure on the growth mold at surface of buildingmaterials. The two different water-cement ratio of mortars (w/c = 0.4, 0.6), brick and tiles were used in this study. The mercuryIntrusion Porosity-Meter (MIP) was used to determine the pore distribution of building materials. The moisture variation of materialswas recorded in constant climate chamber (25oC, relative humidity 80%), general indoor environment (28oC, relative humidity 55%)and water damage simulation environment. The results indicated that the pore size and distribution will affect the surface water ratioand moisture content of materials. The surface water ratio of specimen was affected by different environment seriously. The surfacewater ratio was an important factor in mold growth.

Characteristics of Reactively Sputtered Niobium Nitride Thin Films as Diffusion Barriers for Cu Metallization

Cheng-Lin Huang,Chih-Huang Lai,Po-Hao Tsai,Hsing-An Huang,Jing-Cheng Lin,Chiapyng Lee 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.5

NbN films were prepared by radio frequency reactive magnetron sputtering and then employed as diffusion barriers between Cu and Si. The microstructure of the NbN films was an assembly of very small columnar crystallites with a cubic structure. To investigate the properties as diffusion barriers, we performed metallurgical reactions of Cu/NbN0.8/Si, Cu/Nb/Si and Cu/TaN0.7/Si for comparisons. The sheet resistance increased dramatically after annealing above 750°C for Cu/NbN0.80/Si, and above 500°C for both Cu/Nb/Si and Cu/TaN0.7/Si. The interfaces were deteriorated seriously and formation of Cu3Si was observed when the sheet resistance was significantly increased. The diffusion coefficient of Cu in NbN barrier films was estimated by using the change of resistance (ΔRs/Rs %). Compared with TaN0.7, NbN0.8 films possess larger grain size and lower Cu diffusion coefficient. Our results suggest that the NbN film can be used as a diffusion barrier for Cu metallization as compared to the well-known TaN film.

Relaxation Effect of Schisandra Chinensis Lignans on the Isolated Tracheal Smooth Muscle in Rats and Its Mechanism

Cheng-Cheng Lin,Zhi-Ying Xu,Bi-Han Wang,Wenyue Zhuang,Jinghui Sun,He Li,JianGuang Chen,Chunmei Wang 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.8

Schisandra chinensis (S. chinensis) is one of the core drugs used for relieving cough and asthma in traditional Chinese medicine. However, there are few basic studies on the treatment of respiratory diseases with S. chinensis in modern pharmacology, and the material basis and mechanism of its antiasthmatic effect are still unclear. Lignans are the main active components of S. chinensis. The aim of this study was to observe the relaxation effect of S. chinensis lignans (SCL) on the tracheal smooth muscle of rats by in vitro tracheal perfusion experiments, and to explore the mechanism by preincubation with L-type calcium channel blocker verapamil, four potassium channel blockers glibenclamide, tetraethylamine, 4-aminopyridine and barium chloride (BaCl2), β-adrenoceptor blocker propranolol, nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester (L-NAME), and the cyclooxygenase inhibitor indomethacin, respectively. The results showed that SCL (0.25–1.75 mg/mL) reduced the contraction of isolated tracheal smooth muscle induced by acetylcholine, the preincubation with verapamil and glibenclamide could attenuate the relaxation effect, whereas propranolol, 4-aminopyridine, BaCl2, tetraethylamine, L-NAME, and indomethacin had no such effect. These results suggest that SCL has a significant relaxation effect on the isolated tracheal smooth muscle of rats, and the mechanism may be related to the inhibition of extracellular calcium influx and intracellular calcium release from the sarcoplasmic reticulum, as well as the activation of ATP-sensitive potassium channels. These findings may provide a pharmacological basis for the traditional use of S. chinensis to treat asthma.

Thermal Stability, Adhesion and Electrical Studies on (Ti,Zr)Nx Thin Films as Low Resistive Diffusion Barriers between Cu and Si

Cheng-Lin Huang,Chih-Huang Lai,Po-Hao Tsai,Yu-Lin Kuo,Jing-Cheng Lin,Chiapyng Lee 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.3

In this study, we investigated the thermal stability, wettability, adhesion and reliability of (Ti,Zr)Nx films used as the diffusion barrier between Cu and Si. (Ti,Zr)Nx films were prepared by DC reactive magnetron sputtering from a Ti-5 at. % Zr alloy target in N2/Ar gas mixtures. A minimum film resistivity of 59.3 μΩ cm was obtained at an N2/Ar flow ratio of 2.75, which corresponds to the near stoichiometric composition (N/(Ti,Zr) ratio ~0.95). The sheet resistance of Cu/(Ti,Zr)N0.95/Si was not significantly increased until annealing above 750°C, indicating good thermal stability. On the other hand, the adhesion energy between Cu and the (Ti,Zr)Nx film was reduced as the N/Ti ratio was increased. To obtain reliable performance on stress-induced-voiding (SIV) and electromigration (EM) tests, we proposed to use (Ti,Zr)/(Ti,Zr)Nx/(Ti,Zr) tri-layers. We suggest that the interfacial adhesion between barrier and Cu plays an important role in reliability. The proposed tri-layer structure may be a promising candidate for a barrier, as it exhibits excellent reliability without increasing resistance.

Changes in prostate-specific antigen kinetics during androgen-deprivation therapy as a predictor of response to abiraterone in chemonaïve patients with metastatic castration-resistant prostate cancer

Chung-Lin Lee,Ying-Hsu Chang,Chung-Yi Liu,Ming-Li Hsieh,Liang-Kang Huang,Yuan-Cheng Chu,Hung-Cheng Kan,Po-Hung Lin,Kai-Jie Yu,Cheng-Keng Chuang,Chun-Te Wu,See-Tong Pang,I-Hung Shao 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.5

Purpose: Metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis. Abiraterone acetate (AA), enzalutamide, and chemotherapy are first-line treatments for patients with mCRPC. This study examined prognostic factors for AA response in the form of prostate-specific antigen (PSA) kinetics throughout androgen-deprivation therapy (ADT) in chemonaïve patients with mCRPC. Materials and Methods: We retrospectively included data from 34 chemonaïve patients with mCRPC who had received AA at some point between January 2017 and December 2018. We separated patients into two study arms according to the decrease in PSA percentages after use of AA for 3 months. We correlated PSA kinetics parameters with response and compared the two study groups with respect to PSA kinetics. Results: The patients’ median age was 77 years. In the total group of patients, 64% had a response to AA, whereas 35% did not. The ratio of the PSA level at nadir to the level during ADT was significantly higher in the AA-sensitive group (19.78 vs. 1.03, p=0.019). Conclusions: Patients who experienced a dramatic change in PSA level during ADT were more likely to be resistant to AA after progression to mCRPC. Chemotherapy rather than AA might be more suitable as a first-line treatment for these patients.

Hydration of DCPD over sulfonic acid-functionalized SBA-15 catalyst

Yu-Cheng Lin,Yu-Wei Huang,Ku-Hsiang Sung,Tsung-Han Lin,Soofin Cheng 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.44 No.-

Sulfonic acid-functionalized SBA-15 materials (SA-SBA-15) with ordered channeling pores weresynthesized by one-pot co-condensation and used to catalyze the hydration of dicyclopentadiene(DCPD). The target product, cydecanol (DCPD-OH) has been used as a modifier for polyester or alkydresin. Propylsulfonic acid functionalized SBA-15 was found to be more efficient than the silica gelcounterpart or arylsulfonic acid functionalized material in catalyzing DCPD hydration to yield DCPD-OH. The DCPD conversion and DCPD-OH yield increased with the decrease in H2O/DCPD ratio. Optimal DCPDconversion and DCPD-OH selectivity were obtained with the molar composition of DCPD:H2O:H+[1TD$DIF]-catalyst = 1:30:0.1.

Service Design of Community Fruit and Vegetable Smart Vending Machine Based on User Touchpoint

Lin Cheng,Younghwan Pan 한국서비스디자인학회 2023 한국서비스디자인학회 학술대회자료집 Vol.2023 No.1

In this paper, the concept of touchpoint in service design is used to optimize the service progress of the fruit and veg table smart vending machine. According to the behavior of users, the whole use process is divided into four stages: arrival, selection, payment and departure. Through the way of user interview and observation, the touchpoints in the use process are summarized into three types: physical touchpoints, digital touchpoints and interpersonal touchpoints. Then analyze the pain points of user touchpoint. According to the pain points and design objectives, sort out the solution of service design. It is expected to optimize the whole process service according to the analysis results, so as to realize better interaction between people, goods and machines.

Effective Antiviral Activity of the Tyrosine Kinase Inhibitor Sunitinib Malate against Zika Virus

Lin Chen-Sheng,Huang Su-Hua,Yan Bo-Yu,Lai Hsueh-Chou,Lin Cheng-Wen 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.4

Introduction: Zika virus (ZIKV), a mosquito-borne flavivirus, causes the outbreaks of Latin America in 2015 - 2016, with the incidence of neurological complications. Sunitinib malate, an orally bioavailable malate salt of the tyrosine kinase inhibitor, is suggested as a broadspectrum antiviral agent against emerging viruses like severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2. Materials and Methods: This study investigated the antiviral efficacy and antiviral mechanisms of sunitinib malate against ZIKV infection using cytopathic effect reduction, virus yield, and time-of-addition assays. Results: Sunitinib malate concentration-dependently reduced ZIKV-induced cytopathic effect, the expression of viral proteins, and ZIKV yield in supernatant with 50% inhibitory concentration (IC50) value of 0.015 μM, and the selectivity index of greater than 100 against ZIKV infection, respectively. Sunitinib malate had multiple antiviral actions during entry and post-entry stages of ZIKV replication. Sunitinib malate treatment at entry stage significantly reduced the levels of ZIKV RNA replication with the reduction of (+) RNA to (-) RNA ratio and the production of new intracellular infectious particles in infected cells. The treatment at post-entry stage caused a concentration-dependent increase in the levels of ZIKV (+) RNA and (-) RNA in infected cells, along with enlarging the ratio of (+) RNA to (-) RNA, but caused a pointed increase in the titer of intracellular infectious particles by 0.01 and 0.1 μM, and a substantial decrease in the titer of intracellular infectious particles by 1 μM. Conclusion: The study discovered the antiviral actions of sunitinib malate against ZIKV infection, demonstrating a repurposed, host-targeted approach to identify potential antiviral drugs for treating emerging and global viral diseases.

Cross-Strait Detente and Implications for U.S. Arms Sales to Taiwan

( Cheng Yi Lin ) 한국국방연구원 2013 The Korean Journal of Defense Analysis Vol.25 No.3

Cross-Strait detente in the wake of China`s rise presents the United States a greater challenge in selling new, advanced weaponry to Taiwan, owing to the political unpredictability of cross-Strait relations and the insurmountable task of maintaining a military balance across the Taiwan Strait. In contrast to the Bush administration, the Obama administration is more concerned about China`s retaliation against U.S. defense corporations involved in arms sales to Taiwan and the maintenance of Sino-American strategic stability. The United States is faced with warming cross-Strait relations and Taiwan`s unknown political destiny with China, complicating faithful implementation of the Taiwan Relations Act (TRA) by the United States. The rise of China has further constrained U.S. policymakers in their deliberation of arms sales to Taiwan. With the signature of 19 cross-Strait functional agreements and all kinds of interflows, Beijing has some evidence-backed arguments that the United States should cease arms sales to Taiwan in accordance with the August17, 1982 Communique. A policy of actively implementing the TRA and providing Taiwan with the most advanced weapons is becoming harder to implement, but the TRA is not moribund unless Beijing renounces the use of force against Taiwan, or Taipei enters a process of political negotiation leading to final settlement of its status with China.