무통분만시 수막강내 Sufentanil에 첨가된 Bupivacaine의 효과

김수창,최덕환,김지애 대한마취과학회 1999 Korean Journal of Anesthesiology Vol.37 No.6

Background : The combination of a local anesthetic and an opioid has been shown to produce effective epidural labor analgesia. It was reported that the combination of intrathecal opioid and bupivacaine could produce labor analgesia with longer duration and less side effects. This study was done to evaluate the effect of intrathecal bupivacaine mixed with sufentanil for labor analgesia. Methods : Eighty women requesting labor analgesia were randomly assigned to receive intrathecal 10 mcg of sufentanil (S group, n = 40) or 2.5 mg of bupivacaine plus 10 μg of sufentanil (SB group, n = 40) diluted in a total volume of 2.2 ml with normal saline. The analgesia was performed using combined spinal-epidural technique in the lateral position. Visual analogue scales (VAS) for pain, sensory changes to cold, duration of analgesia, motor block, hypotension, fetal heart rate, pruritus, and other side effects were assessed for 30 minutes after intrathecal drug injection. Results : There were no significant differences in he VAS pain scores and sensory levels at 5 minutes after intrathecal drug injection between groups. However, VAS pain scores were significantly lower and sensory levels higher in the SB group at 15 minutes and 30 minutes after intrathecal drug injection. The duration of analgesia provided by intrathecal sufentanil (n = 31) was 103.4 41.1 min, by intrathecal sufentanil plus bupivacaine (n = 29) 113.0 32.1 min (P = 0.30). Motor block assessed by a modified Bromage scale was significantly frequent in the SB group (P< 0.001). Not only adverse effects such as hypotension, fetal bradycardia, pruritus, and nausea, but also satisfaction scores were similar in both groups. Conclusions : The addition of bupivacaine to intrathecal sufentanil produced more frequent motor block and extensive sensory block, but better analgesia. However, duration of analgesia, side effects and satisfaction score did not change. (Korean J Anesthesiol 1999; 37: 1068∼1073)

신장수여자의 수술경과시간에 따른 자기존경감, 희망감, 염려 및 스트레스원의 차이

이 철,김창윤,한오수,박인호,유희정,한덕종 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.2

This study attempted to examine the differences of self - esteem, hopes, concerns and total stress scores of 110 kidney recipients in before(N=32) and fellowing kidney transplantation [1 to 6 months(N=29), 6 to 12 months(N=23), 12 to 36 months(N=26)] and utilizing severity rating scale of 44 potential stressors on a 5-point scale of 110 kidney recipients in before(N=32) and following kidney transplantation operation [1 to 6 months(N=29), 6 to 12 months(N=23), 12 to 24 months(N=15) and 24 to 36 months(N=11)]. On scores of hopes and total stress, pretransplant group exhibited significantly higher scores than three posttransplant recipient groups. But, it was found that there was no significant differences among four transplant kidney recipient groups on the scores of self - esteem and concerns. In the pretransplant group, craving for foods was identified as the most stressful event, on the contrary, changes in friends was identified as the lowest stressful events. In the 1 to 6 months posttransplant group, side effect of medications was identified as the most stressful event, however, loss of contact with dialysis patients was identified as the lowest stressful event. In the 6 to 12 months posttransplant group, cost of medication, changes in body appearance were identified as the most stressful event, on the other hand, managing of medications at home was identified as the lowest stressful event. In the 12 to 24 months posttransplant group, cost of medication and insurance coverage were identified as the most stressful event, but possibility of dying and competence of nursing staff were identified as the lowest stressful event. In the 24 to 36 months posttransplant group, changes of body appearance was identified as the most stressful event, on the contrary, possibility of infection was identified as the lowest stressful event. Insurance coverage was a continuing concern throughout posttransplant period.

The role of hLHX6-HMR as a methylation biomarker for early diagnosis of cervical cancer

정삼일,정동준,김진선,Lisha Yi,구근호,이재혁,이순덕,박진화,BOOGI CHANG,김창환,김창진,이명숙 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

The role of hLHX6-HMR as a methylation biomarker for early diagnosis of cervical cancer

정삼일,정동준,김진선,Lisha Yi,구근호,이재혁,이순덕,박진화,BOOGI CHANG,김창환,김창진,이명숙 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

The Korean Society of Gastroenterology & SIDDS 2020 : Slide Session ;K-UG-23 : Upper GI Tract ; Does Discharge Hemoglobin Affect Outcome of Patients with Acute Non-Variceal Upper Gastrointestinal Bleeding?

( Jae Min Lee ),( Hoon Jai Chun ),( In Kyung Yoo ),( Seung Joo Nam ),( Seung Han Kim ),( Hyuk Soon Choi ),( Eun Sun Kim ),( Bora Keum ),( Yoon Tae Jeen ),( Hong Sik Lee ),( Chang Duck Kim ),( Ho Sang 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Many patients with gastrointestinal bleeding show anemia and usually need red blood cell transfusion. But clinicians are concerned about low hemoglobin affects prognosis and clinical outcome after discharge. This study aimed to assess whether discharge hemoglobin infi uence on outcomes, or not, in patient with acute non-variceal gastrointestinal bleeding. Methods: Retrospective analysis was carried out on patients who had upper gastrointestinal bleeding between January 2011 and December 2012. We analyzed the patients who had lowest hemoglobin below 10 g/dL during hospitalization. Patients with variceal bleeding, stroke, or cardiovascular disease were excluded. We divided the patients into two groups by discharge hemoglobin (Low discharge hemoglobin group; 8 g/dL = hemoglobin and compared clinical outcomes and hemoglobin level changes. Results: A total of 212 patients with upper gastrointestinal bleeding were undergone the endoscopic hemostasis during study periods. One hundred two patients were satisfi ed the inclusion criteria. fifty patients discharged with hemoglobin level under 10 g/dL and fi fty two patients discharged with hemoglobin level over 10 g/dL. Patients in low discharge hemoglobin group showed a lower consumption of pRBC and shorter hospital days than patients in high discharge hemoglobin group. Hemoglobin levelswere not fully recovered at out-patient department until 7 days after discharge. But, most patients showed hemoglobin recovery at 45 days after discharge.Conclusions: In patients with acute gastrointestinal bleeding, discharge hemoglobin between 8 to 10 g/dL was showed favorable outcomes during out-patient department follow-up. It seems to be tolerable level without additional pRBC transfusion. Our result can increase the evidence available to support restrictive transfusion strategies in patients with acute non-variceal upper gastrointestinal bleeding.

2-[(4-Cyanophenyl)amino]-3-chloro-1,4-naphthalenedione(NQ-Y15)의 돌연변이원성

김봉희,정기화,유충규,창동신,이기선,전선덕,소동수,채상호,문창규 한국환경독성학회 2000 환경독성보건학회지 Vol.15 No.4

2-[(4-Cyanophenyl)amino]-3-chloro-1, 4-naphthalenedione (NQ-Y15) was asssayed for its genotoxic potential by using Salmonella typhimurium reversion assay and in vitro chromosome aberration test on Chinese hamster lung cells. In the Ames test, NQ-Y 15 induced his+ revertants of Salmonella typhimurium TA 98 and TA1537, reaching levels twice the negative control values. But, NQ-Y15 induced only his^(+) revertants of Salmonella typhimurium TA1537 more than twice the control values under the condition with metabolic activation system. In the cytogenetic test on chinese hamster lung cells, NQ-Y15 showed significant chromosomal aberrations, but the incidence was significantly reduced in the presence of metabolic activation.

구강내에서 재광화용액 "R"의 법랑질 초기 우식병소에 대한 재광화의 정량적 평가

김명은,정일영,금기연,이찬영,노병덕 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.2

Dental caries is a chronic disease that causes the destruction of tooth structure by the interaction of plaque bacteria, food debris, and saliva. There has been attempts to induce remineralization by supersaturating the intra-oral environment around the surface enamel, where there is incipient caries. In this study, supersaturated remineralized solution "R" was applied to specimens with incipient enamel caries, and the quantitative ananlysis of remineralization was evaluated using microradiography. Thirty subjects volunteered to participate in this study. Removable appliances were constructed for the subjects. and the enamel specimen with incipient caries were embedded in the appliances. The subjects wore the intra-oral appliance for 15 days except while eating and sleeping. The removable appliance were soaked in supersaturated solution "R", saline, or Senstime® to expose the specimen to those solutions three times a day, 5 minutes each time. After 15 days, microradiography was retaken to compare and evaluate remineralization. The results were as the following: 1. The ratio of remineralized area to demineralized area was significantly higher in the supersaturated solution "R" and Senstime® than in the saline (p<0.05) 2. Remineralization in the supersaturated buffer solution "R" occurred in the significantly deeper parts of the tooth, compared to the Senstime® group containing high concentration of fluoride.(p<0.05) As in the above results, the remineralization effect of remineralized buffer solution "R" on incipient enamel caries has been proven. For clinical utilization, further studies on soft tissue reaction and the effect on dentin and cementum are necessary. In conclusion compared to commercially available fluoride solution, remineralization solution "R" showed better remineralization effect on early enamel caries lesion. so it is considered as effecient solution for clinical application

사후장기제공 찬성대학생, 사후장기등록자 및 신장공여자 집단의 심리적 특성

김창윤,한오수,이철,박인호,한덕종,유희정,김헌수 울산대학교 의과대학 1994 울산의대학술지 Vol.3 No.2

This study is composed of three sections : First, questionnaires were administered to 350 university student to investigate attitudes related to organ donation. Three groups(agreed(15.4%, N=54), undecided(76%, N=266), opposed(8.6%, N=30)) were identified. Second, the subjects were composed of 30 students who agreed for organ donation with 30 disagreed students for organ donation and those subjects were administered cognition toward health, anticipatory pain for operation, anticipatory discomfort for operation, Beck Depression Inventory (BDI), Hostility scale, social desirability scale, altruism scale, internal-external control scale, self-esteem scale, death anxiety scale, psychological well-being scale, life satisfaction and affect scale. In comparing difference between the agreed and the disagreed for organ donation, the agreed group exhibited higher scores on social desirability, altruism, psychological well-being than the disagreed group. On the contrary, there were significantly higher scores on anticipatory discomfort for operation and negative affect on the disagreed organ donation group than the a greed group. These results indicated that the agreed group for organ donation was more similar to the real organ donation group than the disagreed group. Third, the subjects were composed of 30 kidney donors, 30 kidney donors, 30 potential donors who signed donor cards and 30 agreed student group for organ donation. In comparing among three groups, kidney donor group showed the highest scores on cognition toward health and life satisfaction variables. Consummated kidney donor and potential donor group showed higher scores on internal control, psychological well-being and positive affect variables than the agreed student group. But on social desirability, self-esteem and affect balance, there was no significant difference among three groups. These results suggested that significant factor in willingness to donate were influenced by social desirability, altruism and self-esteem.

제주도 한우의 번식장해 발생원인과 대책에 관한 연구(제3보) : 난소질환 제주한우에 있어서 hormone 처리가 수태에 미치는 영향

김중계,김승찬,장덕지 제주대학교 농과대학 제주도축산문제연구소 1986 畜産論叢 Vol.1 No.1

Acccrding to the investigation of reproductive status and disorders in Cheju native cattle, the delayrd puberty, fist calving age in heifer, and thealternate year calving cow dric to anrstrus following calving were observed more frequently on this island. This study, therefore. was carried out to investigate the effect of PMS as a method of trenstment for the cows with ovarian hypoplasia and atrophy. For the 15 cows with ovarian hypoplasia, the blood was tested and 40 cows of anestrus due to ovarian hypoplasia and atrophy were selected to treat with PMS. The results obtained were as follows. 1. The blood test indicated that cows of the ovarian hypoplasia appeared to havc lower scriim protein and calcium level than that of normal cow. Espercially abnormality inA/G ratio and Ca/P ratio in Holstein was found. 2. Trensment of PMS into 40 cows with the ovaridn atrophy and hvpoplasia showcd estrus average 6.7 days after the final hormone injection. 3. Total 38 cow were conceived by PMS (100 IU) hormone treatment; 26 cows (64.4%) at the first estrus. It cow (30.6%) at the second estrus and the remainder at the third estrus. 4. The above resolts inkicated that treatment of PMS hormone into cow with ovarion hypoplesia and atrophy was effertive for inducing estrus and conception.

다발성 전이를 보인 췌장의 유두상 고형 상피종 -1예 보고-

김덕환,김윤주,양성은,팽성숙,장희진,서정일 대한병리학회 1996 Journal of Pathology and Translational Medicine Vol.30 No.3