2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

合成 鋼板桁橋의 輪荷重 分配에 關한 硏究

崔乘和 三陟大學校 産業科學技術硏究所 1999 産業科學技術硏究論文集 Vol.4 No.-

보강섬유의 배향이 고분자 복합재료의 물성에 미치는 효과

崔相久,李和雨,洪錫杓 全北大學校 1993 論文集 Vol.35 No.-

The tensile and flexural strength of unsaturated polyester laminated with 20% glass-fiber(volume %) were tested. Those were compared with its abtained from Holister's equation. The strengths of laminated polyester were mainly depended on the properties of interface between fiber and resin than the strengths of material itself. For crossplied laminates, correct strength coincided with Holister's were not abtained, but could be explained by Holister's theory. The fractural strength of orientation angle 0∼5˚ was influenced by shear resistance besides the strength of glass fiber.

ADSL을 위한 전화선로의 특성분석 및 등화기 설계

최성환,전진화,권호열 강원대학교 정보통신연구소 1999 정보통신논문지 Vol.3 No.-

In this paper, we evaluate transmission channel characteristics of telephone cable to be used in general. First, we measured the impedances of open and short circuits in order to obtain the RLCG parameters per unit length of transmission line. And we obtained the frequency-dependent transfer function and propagation constant for transmission line using these values. The channel impulse response is derived from the inverse Fourier of transfer function. We design channel equalizer for ADSL(Asymmetrical Digital Subscriber Line) using the measured impulse response of channel. The results shows that the transfer characteristics decrease sharply according to the length of transmission line. Finally, we verify efficacy of the proposed method by means of simulation.

Aflatoxin-DNA Adduct의 화학합성에 관한 연구

최상경,김성영,강진순,정덕화 경상대학교 유전공학연구소 1993 遺傳工學硏究所報 Vol.12 No.-

Aflatoxin은 세계 여러 곳에서 식품에 오염되어 발견되며 증가하는 인간의 간암발생과 빈번히 역학적으로 관련하여 보고되는 발암물질이다. 이러한 aflatoxin의 발암성 규명에 대한 연구의 일환으로 20㎎ calf thymus DNA와 8㎎ 표준 aflatoxin B₁을 반응시켜 화학적으로 aflatoxin B₁-DNA adduct를 합성하였다. 합성된 aflatoxin B₁-DNA adduct는 산가수분해와 열처리에 의해 거대한 DNA 분자를 절단하였고, immunoaffinity column을 통과시켜 aflatoxin B₁-DNA adduct만 선택적으로 정제한 후 HPLC법으로 정량하였다. 그 결과 반응생성물의 대부분은 aflatoxin B₁-guanine adduct였으며, 그 함량은 aflatoxin B₁으로 5.2㎎이었다. Aflatoxins are highly carcinogenic agents consistantly found as contaminants in human food supplies in many areas of the world and epidemiologically linked to incidence of human liver cancer. To examine the carcinogenic action of aflatoxin B₁,aflatoxin B₁-DNA adducts were chemically synhtesized with the reaction of 20㎎ calf thymus DNA, and 8㎎ standard aflatoxin B₁. Since DNA molecule was too large for analysis, it was fragmented by acid hydrolysis and heat. The fragmented aflatoxin B₁-DNA adducts were selectively concentrated by immunoaffinity column procedure and confirmed by HPLC method. The main component was aflatoxin B₁-guanine adduct, which was quantatively measured as 5.2㎎ aflatoxin B₁.

부적절한 예방화학요법 후 지연 발현된 Plasmodium vivax 말라리아 1 예

최수철,장상필,김상화,서환조,서진태,김구엽 대한내과학회 1998 대한내과학회지 Vol.54 No.3

Malaria is the world's most important parasitic infection. Although it has been erw5cated from temperate zones including Korea, increasing numbers of travellers visit tropical malarious countries and imported malaria becomes important medical problem in the developed countries. In Korea with increasing travellers to malaria-endemic area, the incidence of imported malaria shows rising tendency same as the developed countries. It becomes important to personal general personal protective measures and chemoprophylaxis to trevellers, when employed in appropriate manner, that can be highly effective in preventing malaria. We recently experienced a case of in Plasmodium vivax malaria with delayed manifestations due to inadequate chemoprophylaxis. A 53-year-old woman with history of trevel to East Africa 4 months ago and chief complaint of fever was diagnosed as tertian malaria. She had irregularly taken prophylatic antimalarial during travel and had not taken it after return but should have taken it at least 4 weeks after return.

冬蟲夏草의 抗轉移와 免疫增進에 關한 硏究

최우진,유화승,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

This experimental study was carried out to evaluate the effects of Cordiceps sinensis on the antimetastasis and immune activity. In order to investigate the effect of Cordiceps sinensis, the followings were performed; Cytotoxicity, inhibition of MMP-2 & MMP-9 gene expression, fraction of CD4+, CD8+, CD19+ in splenic cell, the moprphological change of splenic cells, gene expression of IL-12(p35), IL-12(p40), IFN-?? and splenic cell proliferation by CS-E. The results were obtained as follows. 1. CS-E did not present cytotoxic effect on L+14, B16-F10 melanoma cells and HMCB. 2. CS-E inhibited MMP-2 and MMP-9 gene expression more effectively compared with control group. 3. CS-E inhibited invasion of B16-F10 melanoma cells more effectively compared with control group. 4. CS-E helped CD4+, CD8+, CD19+ expression more effectively compared with control group. 5. CS-E activated phagocytic cells in spleen more effectively compared with control group. 6. CS-E helped IL-12(p35), IL-12(p40), IFN-?? gene expression in splenic cell more effectively compared with control group. 7. CS-E activated splenic cell proliferation more effectively compared with control group. From above findings, it is suggested that CS-E is able to inhibit metastasis of cancer and activate immune response system.

만성 간장 질환자에서 뇌 MRI 상의 pallidal index와 생물학적 망간지표들 간의 관련성

최영희,박능화,신정우,김효경,김성률,정태흠,박지강,이헌,유철인,이충렬,이지호,김양호 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.2

목적 : 만성 간장 질환자를 대상으로 T1강조 자기공명영상(MRI)에서 나타나는 담창구 부위의 고신호강도 소견(pallidal index, PI)과 생물학적 망간 지표들 간의 관련성을 알아본다. 방법 : B형간염 바이러스에 의한 간경변증으로 진단 받은 40세 이상의 환자 31명과 정상 대조군 10명을 대상으로 설문조사와 혈액 및 소변검사, 뇌 MRI를 시행하였다. 전체 41명 가운데 검사 전 수혈을 받았던 환자군 9명을 제외하고 전체 32명의 자료를 분석하였다. 망간 축적에 관련된 객관적 지표로서 T1 강조 MRI에서 나타나는 담창구 부위의 고신호강도를 전두부 백색질 신호강도로 나눈 수에 100을 곱하여 구한 PI를 택하였다. 환자군과 대조군 사이의 PI와 망간농도들의 평균을 비교하였다. 여러 변수들과 PI와의 상관성을 보기 위해서는 상관분석을 시행하였다. 결과 : 간장 질환자 22명 가운데 18명(81.8%)에서 뇌 MRI 상 고신호강도가 나타났다. 대조군 10명에서는 아무도 MRI 소견상 고신호강도가 나타나지 않았다. 간장 질환자에서의 평균 PI는 122.62로 대조군의 106.23보다 유의하게 높게 나타났다(p<0.01). 간장 질환자의 전혈에서 망간농도는 2.34㎍/㎗으로 대조군의 1.44㎍/㎗와 비교하여 유의하게 높게 나타났다(p<0.05). 혈장과 소변 내 망간농도는 대조군에서 다소 높게 나타났으나, 통계적으로 유의하지는 않았다. 또한 혈색소, 빌리루빈, AST가 대조군과 환자군 사이에서 유의한 차이가 있었다(p<0.05). 전혈(p=0.489, P<0.01, n=29)과 적혈구(p=0.573, P<0.01, n=22) 내 망간농도와 PI 사이에는 각각 유의한 상관관계가 있었다. 그러나 혈장과 소변 내 망간 농도와 PI와의 상관관계는 통계적으로 유의하지 않았다. 총빌리루빈 또한 PI와 유의한 상관관계를 나타내었다(p=0.509, P<0.01, n=32). 결론 : 전혈 또는 적혈구 내의 망간 농도가 뇌 내 망간 침착으로 인한 T1 강조 MRI상 담창구 부위의 고신호 강도를 잘 반영하는 유용한 지표이다. Objectives: The objectives of this study were to clarify which biological manganese exposure indices reflect the pallidal signal intensities in magnetic resonance imaging (MRI) in liver cirrhotics. Methods: We examined whole blood, plasma, RBC and urinary manganese concentrations, as well as, brain MRI in 22 cirrhotic patients and 10 healthy controls. From MRI scans we calculated the signal intensity of the globus pallidus using the pallidal index (PI), the ratio of the globus pallidus to subcortical frontal white-matter signal intensity in axial T1 -weighted MRl planes multiplied by 100. In addition, we studied the relationships between PI and other measurements. Results: The high signal intensity in the globus pallidus on T1-weighted MRI was observed in 18 (81.8%) patients. There was a significant correlation between whole blood and RBC manganese concentration, and PI on MRI. According to multiple linear regression, whole blood and RBC manganese concentration reflected PI on MRI better the other indices did. Conclusions: Whole blood and RBC manganese concentrations could be useful as biological manganese exposure indices that reflect PI on MRI.

減壓 貯藏中 Tomato果實의 Ribonucleic Acid와 Ribonuclease 活性의 變化

崔相源,崔鍾旭,孫泰華 COLLEGE OF AGRICULTURE KYUNGPOOK NATIONAL UNIVERSI 1984 慶北大農學誌 Vol.2 No.-

The process of ripening and senescence of tomato fruits has been studied in terms of storage temperature and pressure. Ribonucleic acid(RNA) content, Ribonuclease (RNase) activity, RNase properties and electrophoretic pattern of RNase were investigated during the storage. Total RNA content was decreased during ripening and senescence. The decreasing rate was greater at room temperature (R) than at low temperature (L), and under normal atmospheric pressure (NAP) than under sub-atmospheric pressure (SAP). RNase activity was increased during the period of climacteric rise and in accordance with developing color score. RNase activity was obviously higher at R than L, and under NAP than SAP. Consequently, RNase activity of NAP-R treatment was the highest among the treatments. The optimum temperature and pH of RNase activity were 70℃and pH 6.7, respectively. RNase activity was the most stable at pH 5.0 and retained 50% of its activity when treated at 90℃ for 10min. RNase activity was inhibited by cations and, markedly by zinc. Both treatment of NAP-R and SAP-L showed one band of RNase on gel electrophoresis in the early stage of storage. With the lapse of storage, the number of RNase band increased, showed 3 bands in the 7th day of NAP-R treatment and 2 bands in the 34th day of SAP-L treatment.

新羅都城의 展開過程에 관한 都市史的 硏究(1)

최창길,예명해,足立裕司,신상화 대구대학교 과학기술연구소 1998 科學技術硏究 Vol.5 No.3

The conclusion drawn from this study can be summarized as follows. The origin of the Silla Capital Castle can be found from the Guem Sung (Golden Castle) which was built in 37 Hyuk Gu Sae year after the formation of Sa Ro Kook. But the Guem Sung during Sa Ro Kook era was not enough to be a Capital City in it's form and size. It was only a castle for the King. The first real formation of what we call city today was gradually progressed while the construction of the royal regime which brought the cetralization of power. Especially, before Ja Bi Ma Rip Gan Chinese capital castle system did not influence directly to Silla Dynasty. But, after that, they started to name the districts, specified the market place as an ecomonical district, built Buddhist temples, constucted East Distirict, West Distirict, and South Distirct around Wol Sung which is the Capital Castle. By doing this, the formation of ancient city was possible. Na Sung was not there around the King's City, they built San Sung instead. This kind of spacial allocation made outline of Capital Castle. After the unification of ancient Korea which was then divided into three by Koguryu. Beakjae and Silla, construction of the city was influenced by China. They followed the Chinese city system as a model and gradually adopted the model. During King Sun Duk era, Jong Myo and Sa Jil, which came from Chinese ceremonial space was built inside of Capital Castle. This means the completion of the city at that time.