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      • KCI등재

        Mucosal dendritic cells shape mucosal immunity

        장선영,고현정,권미나 생화학분자생물학회 2014 Experimental and molecular medicine Vol.46 No.-

        Dendritic cells (DCs) are key modulators that shape the immune system. In mucosal tissues, DCs act as surveillance systems to sense infection and also function as professional antigen-presenting cells that stimulate the differentiation of naive T and B cells. On the basis of their molecular expression, DCs can be divided into several subsets with unique functions. In this review, we focus on intestinal DC subsets and their function in bridging the innate signaling and adaptive immune systems to maintain the homeostasis of the intestinal immune environment. We also review the current strategies for manipulating mucosal DCs forthe development of efficient mucosal vaccines to protect against infectious diseases.

      • KCI우수등재

        수도권 가구의 주거이동 결정요인 및 특성에 관한 연구

        장선영,오주석,김세용 대한건축학회 2020 대한건축학회논문집 Vol.36 No.5

        The purpose of this study is to identify the background and nature of residential mobility and its influencing factors in Seoul metropolitanarea. Spacial range of this study includes from Seoul to Gyeong-in area(Gyeonggi-do and Incheon). To measure this tendency, this studyestablished hypotheses and two logistic regression models through previous researches and conducted an analysis based on 1,911 and 2,923samples, which experienced inbound and outbound moving between the two areas. This research found that residential mobility from Seoul toGyeong-in and those moving from Gyeong-in to Seoul had some differences in the household, socio-economic, environmental, and housingcharacteristics that affected the moving to each area, as well as the architectural and urban environmental characteristics that affect theQuality of Life(QoL) of the households after the residential mobility was completed. 본 연구는 수도권(서울 및 경인권)의 주거 이동의 배경과 성격을 파악하고 이것에 영향을 미치는 요인을 타진하는데 연구의 목적이 있다. 이를 위해 본 연구는 선행연구 분석을 통해 연구가설 및 로지스틱 회귀분석 평가 모델을 구축하였으며, 서울-경인, 경인-서울지역으로 주거이동을 실시한 각 1,911명과 2,923명의 데이터를 바탕으로 분석을 실시하였다. 분석 결과, 서울에서 경인지역으로 이사하는 가구와 경인에서 서울로 이주에 영향을 미치는 인문, 경제, 사회적 특성에 일부 차이가 있음을 발견할 수 있었으며 이사 완료 후 평가하는 가구주의 삶의 만족에 영향을 미치는 건축·도시 환경에도 차이가 발생하는 것으로 나타났다.

      • KCI등재

        Generalized Toeplitz algebra of a certain non-amenable semigroup

        장선영 대한수학회 2006 대한수학회보 Vol.43 No.2

        We analyze a detailed picture of the algebraic struc-ture ofC-algebras generated by isometric representations of thenon-amenable semigroup P = f0;2;3;:;n;: g.

      • KCI등재

        WIENER-HOPF C*-ALGEBRAS OF STRONGLY PERFORATED SEMIGROUPS

        장선영 대한수학회 2010 대한수학회보 Vol.47 No.6

        If the Wiener-Hopf C*-algebra W(G, M) for a discrete group G with a semigroup M has the uniqueness property, then the structure of it is to some extent independent of the choice of isometries on a Hilbert space. In this paper we show that if the Wiener-Hopf C*-algebra W(G, M) of a partially ordered group G with the positive cone M has the uniqueness property, then (G, M) is weakly unperforated. We also prove that the Wiener-Hopf C*-algebra W(Z, M) of subsemigroup M generating the integer group Z is isomorphic to the Toeplitz algebra, but W(Z, M) does not have the uniqueness property except the case M = N.

      • KCI등재

        Fuzzy stability of a cubic-quartic functional equation: a fixed point approach

        장선영,박춘길,신동윤 대한수학회 2011 대한수학회보 Vol.48 No.3

        Using the fixed point method, we prove the generalized Hyers-Ulam stability of the following cubic-quartic functional equation (0. 1)f(2x+y) + f(2x-y) = 3f(x+y) + f(-x-y) + 3 f(x-y) + f(y-x) + 18f(x) + 6f(-x) - 3f(y) - 3f(-y) in fuzzy Banach spaces.

      • KCI등재

        Correlation between TSH Receptor Antibody Assays and Clinical Manifestations of Graves’ Orbitopathy

        장선영,신동엽,이은직,최영준,이상렬,윤진숙 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.4

        Purpose: To investigate an association between the levels of serum thyroid-stimulating hormone (TSH)-receptor autoantibodies (TRAbs) and Graves’ orbitopathy (GO) activity/severity scores, and compare the performance of three different TRAb assays in assessing the clinical manifestations of GO. Materials and Methods: Cross-sectional study. Medical records of 155 patients diagnosed with GO between January 2008 and December 2010 were reviewed. GO activity was assessed by clinical activity score (CAS) and severity graded with the modified NOSPECS score by a single observer. Serum TRAb was measured by three different methods: 1st generation thyrotropin-binding inhibitor immunoglobulin (TBII) assay (TRAb1st); 3rd generation TBII assay (TRAb3rd); and biological quantitative assay of thyroid-stimulating immunoglobulin (TSI) using Mc4-CHO cells (Mc4-CHO TSI assay). Results were correlated with scores of activity/severity of thyroid eye disease. Results: All three assays (TRAb1st, TRAb3rd, and Mc4-CHO TSI) yielded results that were significantly positively correlated with CAS (β=0.21, 0.21, and 0.46, respectively; p<0.05) and proptosis (β=0.38, 0.34, and 0.33, respectively;p<0.05). Mc4-CHO TSI bioassay results were significantly positively correlated with all GO severity indices (soft tissue involvement, proptosis, extraocular muscle involvement, and total eye score; β=0.31, 0.33, 0.25, and 0.39, respectively;p<0.05). Conclusion: Mc4-CHO TSI bioassay was superior over the two TBIIs in assessing active inflammation and muscle restriction due to GO, whereas TBII assay would be sufficient for evaluation of patients with proptosis.

      • KCI등재

        수잔 쿠퍼(Susan Cooper)의 『그림자의 왕』(King of Shadows)을 활용한 셰익스피어와 미래 고교영어교육

        장선영 한국현대영어영문학회 2022 현대영어영문학 Vol.66 No.4

        This paper aims at exploring the felicitous encounter between English Literature and EFL high school Education by introducing the case of ‘English American Novel’ class for Korean sophomore students in English Education, the College of Education. Most of all, it purposes to show how teaching Shakespeare in EFL high school class can be actualized with a readable text for EFL high school learners, a young adult novel, Susan Cooper’s King of Shadows. The novel well represents Shakespeare, his works, especially, A Midsummer Night’s Dream, sonnet 116, and Elizabethan times. This paper argues that teaching King of Shadows to high school students carries the desirable educational value for future high school English education because of the novel’s comprehensive connection to other school subjects such as history, ethics, psychology, biology, and even, architecture. In order to investigate the proper application of the novel and its benefit resulting from introducing to students, this paper provides the close explication of class procedure―students’ presentation of story line, discussion of issues and topics relevant to the novel, and final presentation of class plan imagined in high school class.

      • KCI등재

        불명열 환자에서 동반된 급성 일과성 근시성 굴절력 변화 1예

        장선영,이현준,정문선,김소영 대한안과학회 2009 대한안과학회지 Vol.50 No.8

        Purpose: To report a case of acute transient myopic shift in a patient with fever of unknown origin. Case summary: A 31-year-old woman without a history of any ophthalmic problems presented with a sudden onset of bilateral blurred vision. She was admitted with the diagnosis of fever of unknown origin (FUO). Ophthalmic examination revealed a visual acuity of 0.06 in the right eye and 0.1 in the left eye. A myopic shift of 3.12 diopters (D) and 2.25D was noted in the right and left eyes, respectively. Retinal folds and choroidal thickening accompanied the myopic shift. On the third day after onset, visual acuity had decreased even more. Myopic shift increased to 4.87D in the right eye and 4.50D in the left eye. At the same time, the depth of the anterior chamber maximally decreased and the thickness of the lens was maximally increased. One week later, the myopic shift was normalized to emmetropia. The depth of the anterior chamber and the thickness of the lens also normalized as the fever subsided. 목적: 불명열 환자에서 동반된 급격한 근시성 굴절력 변화 1예를 경험하여 이를 보고하고자 한다. 증례요약: 안과적 과거력이 없는 31세 여자가 불명열로 치료하던 중 갑자기 발생한 양안의 시력저하를 주소로 안과에 의뢰되었다. 처음 검사에서 나안시력은 우안 0.06, 좌안 0.1이었으며 현성굴절검사에서 우안 -3.12Diopters(D), 좌안 -2.25D의 근시성 굴절이상을 보였다. 안저검사에서 망막 주름, 초음파 검사에서 맥락막 부종의 소견이 동반되었다. Pentacam과 A-scan을 이용하여 전방깊이, 수 정체 두께 및 안축장을 측정하였고 매 검사 시마다 추적 관찰했다. 증상 발생 3일째에 시력은 더욱 감소하였으며 우안-4.87D, 좌안 -4.50D로 근시성 굴절이상이 증가하였고 전방 깊이는 더욱 감소되었고 수정체 두께는 증가되었다. 증상 발생 1주일 후 내과적인 증상 이 호전되면서 굴절이상은 정시화되었고 전방 깊이 및 수정체의 두께도 정상화 되었으며 나안시력은 양안 1.0으로 호전되었다.

      • KCI등재

        기본형 간헐외사시에서 수술 전 단안차폐 후 사시각 측정의 의미

        장선영,이자영,박성희,김소영 대한안과학회 2009 대한안과학회지 Vol.50 No.9

        목적: 기본형 간헐외사시의 수술 전 1시간 단안차폐 후 사시각 측정의 의미를 알아보고자 하였다. 대상과 방법: 기본형 간헐외사시로 수술 받은 환아 중 수술 전 단안차폐검사를 시행한 29명을 대상으로 후향적으로 조사하였다(단안차 폐군). 1시간 단안차폐 후 원거리에서 사시각이 재 측정되었으며 사시각이 증가한 경우 측정된 사시각을 목표로 수술이 시행되었다. 수술 전 단안차폐검사를 하지 않았던 환아 중 대상군과 연령, 성별 및 융합상태가 유사한 29명의 환아를 대조군으로 하였으며 6개월 이상 추적관찰 하였을 때 수술 결과를 비교하였다. 결과: 단안차폐군 29명 중 15명(51.7%)에서 사시각의 증가가 관찰되었으며 융합상태가 나빴던 15명 중 4명(26.7%), 융합상태가 좋았던 14명 중 11명(78.6%)에서 사시각의 증가가 있었다(p<0.05). 수술 성공률은 단안차폐군 79.3%, 대조군 75.9%로 유의한 차이는 없었으나 융합 상태가 좋았던 환아의 수술 성공률은 각각 85.7%, 71.46%로 단안차폐군에서 수술 성공률이 높았으나 통계학적으로 유의하지는 않았다 (p=0.357). 결론: 융합상태가 좋은 기본형 간헐외사시에서 수술 전 단안차폐를 시행하는 것은 잠재되어 있는 사시각을 찾아주어 수술 후에 발생하는 부족교정을 예방하는데 도움을 줄 수 있을 것이다. Purpose: To assess the clinical potential of one‐hour monocular occlusion on preoperative alignment evaluation in basic intermittent exotropia. Methods: Twenty-nine patients with basic intermittent exotropia who were preoperatively examined for one‐hour monocular occlusion were selected (monocular occlusion group). Their records were reviewed retrospectively. The measured angle after one hour of monocular occlusion was used to determine the surgical target angle. The control group consisted of 29 patients whose age, sex and control state were similar to the monocular occlusion group. Measurement of the angle of strabismus was not done in the control group. Surgery was performed for the measured angle at six meters. The results of surgery were used to compare the groups relative to the control state. Results: Fifteen patients (51.7%) had an increase in the distance deviation after one hour of monocular occlusion. Of the patients with good control, 78.6% (11/14) had an increase in the angle of misalignment. Only 26.7% (4/15) of patients with poor control experienced a change in the angle deviation (p<0.05). In all, 79.3% of patients in the study group and 75.9% of those in the control group had a satisfactory surgical outcome. Among the patients with good control, 85.7% of patients who underwent surgery for increased angle had a satisfactory outcome, compared with 71.4% of patients who underwent surgery for initial angle (p=0.375). Conclusions: One-hour monocular occlusion might help to prevent undercorrection after surgical treatment by identifying the hidden deviation, especially in the patients whose control over the distance deviation was good.

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