골절의 절대위험도 평가방법에서 GE Prodigy와 FRAX Tool의 비교분석에 관한 고찰

이화진,이효영,윤종준,이무석,송현석,박세윤,정지욱,Lee, Hwa-Jin,Lee, Hyo-Yeong,Yun, Jong-Jun,Lee, Mu-Seok,Song, Hyeon-Seok,Park, Se-Yun,Jeong, Ji-Uk 대한핵의학기술학회 2009 핵의학 기술 Vol.13 No.3

목적: WHO (world health organization)에서는 골밀도뿐만 아니라 대규모 역학연구에서 정리된 골절의 위험인자 분석을 통하여 10년 내 골절위험도(10-year fracture probability)를 실제적으로 임상에 적용시킬 수 있는 소프트웨어 프로그램인 FRAX Tool (fracture risk assessment)이 2008년에 공개되었다. 본 연구는 기존에 사용하고 있는 GE Prodigy사의 골절위험도평가와 $FRAX^{TM}$를 이용한 골절위험도평가를 비교분석하고자 한다. 검사방법: 본원에 골밀도 검사를 시행한 201명($55{\pm}3.5$세)의 여자를 대상으로 GE Prodigy를 이용하여 Femur를 측정하였다. 측정한 Femoral Neck의 BMD (bone mineral density)를 구하여 GE Prodigy의 T-값과 골절위험인자를 고려하지 않은 $FRAX^{TM}$의 T-값를 사용하여 10년 내 대퇴골 골절위험도와 주요한 골다공증성 골절 위험도를 계산하여 SPSS통계프로그램으로 GE Prodigy의 골절위험도 평가와 $FRAX^{TM}$의 골절위험도 평가를 비교분석하였다. 결과: GE Prodigy의 T-값($-0.52{\pm}0.97$)과 $FRAX^{TM}$의 T-값 ($-1.45{\pm}0.81$)은 통계적으로 유의한 차이가 있었으며(p=0.000), GE Prodigy의 주요한 골다공증성 골절위험도($9.15{\pm}3.71$)와 $FRAX^{TM}$의 주요한 골다공증성 골절위험도($4.87{\pm}1.51$)도 또한 통계적으로 유의한 차이가 있었다(p=0.000). 그리고 GE Prodigy의 10년내 대퇴골 골절위험도($1.56{\pm}1.48$)와 $FRAX^{TM}$의 10년 내 대퇴골골절위험도($0.53{\pm}0.61$)도 통계적으로 유의한 차이를 보였다(p=0.000). 결론: GE Prodigy와 $FRAX^{TM}$에서 측정한 골절의 절대위험도는 통계적으로 유의한 차이를 보였다. 특히 GE Prodigy의 T-값, 주요한 골다공증성 골절위험도, 10년 내 대퇴골 골절위험도가 높게 측정되었다. 향후 $FRAX^{TM}$에 대한 평가 및 적용에 관한 연구가 필요할 것으로 생각된다. Purpose: World Health Organization (WHO) have suggested that an individual's 10-year absolute fracture risk is more reliable than Bone Mineral Density (BMD) measurement as the predictor of osteoporotic fracture. In 2008, Fracture Risk Assessment Tool ($FRAX^{TM}$) was developed by WHO to evaluate fracture risk of patients based on individual's clinical risk factors. The purpose of this study is to offer the comparative analysis of the existing GE prodigy and $FRAX^{TM}$ Tool in Absolute Fracture Risk Assessment Tool. Materials and Methods: 201 women ($55{\pm}3.5$ years) underwent femoral neck BMD measurement using GE Prodigy. The 10-year probability (%) of hip fracture (or a major osteoporosis-related fracture) was estimated using T-scores of GE prodigy and $FRAX^{TM}$. We made a comparative analysis of these data using SPSS (Ver.12). Results: There was a significant difference statistically between T-score ($-0.52{\pm}0.97$) of GE prodigy and T-score ($-1.45{\pm}0.81$) of $FRAX^{TM}$ (r=0.977, p=0.000). Also, there was a significant difference statistically between a major osteoporosis- related fracture ($9.15{\pm}3.71$) of GE prodigy and a major osteoporosis-related fracture ($4.87{\pm}1.51$) of $FRAX^{TM}$ (r=0.909, p=0.000). Moreover, a statistically significant difference was found in the 10-year probability of hip fracture of GE prodigy ($1.56{\pm}1.48$) and of hip fracture ($0.53{\pm}0.61$) of $FRAX^{TM}$ (r=0.905, p=0.000). Conclusions: There was a significant difference statistically between GE prodigy and $FRAX^{TM}$ Tool in Absolute Fracture Risk Assessment Tool. Especially, T-score, a major osteoporosis-related fracture and the 10-year probability of hip fracture that were estimated using GE prodigy tended to show the higher results than one evaluated by $FRAX^{TM}$ Tool. In conclusion, $FRAX^{TM}$ Tool may provide a better tool. The application of $FRAX^{TM}$ Tool as a fracture predictor remains to be clarified.

알루미나-유리 복합체용 글래스의 조성에서 $CeO_2$의 함량변화가 강도에 미치는 영향

이화진,송광엽,강정길,Lee, Hwa-Jin,Song, Kwang-Yeob,Kang, Jeong-Kil 대한치과보철학회 2000 대한치과보철학회지 Vol.38 No.5

Dental ceramics have good aesthetics, biocompatibility, low thermal conductivity, abrasion resistance, and color stability. However poor resistance to fracture and shrinkage during firing process have been limiting factors in their use, particularly in multiunit ceramic restorations. A new method for making all-ceramic crowns that have high strength and low processing shrinkage has been developed and is referred to as the Vita In-Ceram method. This study was performed to investigate the effect of $CeO_2$ addition in borosilicate glasses on the strength of alumina-glass composites. Porous alumina compacts were prepared by slip casting and sintered at $1,100^{\circ}C$ for 2 hours. Dense composites were made by infiltration of molten glass into partially sintered alumina at $1,140^{\circ}C$ for 4 hours. Specimens were polished sequentially from #800 to #2000 diamond disk. and the final surface finishing on the tensile side was received an additional polishing sequence through $1{\mu}m$ diamond paste. Biaxial flexure test was conducted by using ball-on-three-ball method at a crosshead speed of 0.5mm/min. To examine the microstructural aspect of crack propagation in the alumina-glass composites, Vickers-produced indentation crack was made on the tensile surface at a load of 98.0 N and dwell time of 15 sec, and the radial crack patterns were examined by an optical microscope and a scanning electron microscope. The results obtained were summarized as follows; 1. The porosity rates of partially sintered alumina decreased with the rising of firing temperature. 2. The maximum biaxial flexure strength of 423.5MPa in alumina-glass composites was obtained with an addition of 3 mol% $CeO_2$ in glass composition and strength values showed the aspect of decrease with the increase of $CeO_2$ content. 3 The biaxial flexure strength values of alumina-glass composites were decreased with rising the firing temperature. 4. Observation of the fracture surfaces of alumina-glass composites indicated that the enhancement of strength in alumina-glass composites was due to the frictional or geometrical inter-locking of rough fracture surfaces and ligamentary bridging by intact islands of materials left behind the fracture front.

생약의 류코트리엔 $B_4$ 수용체결합 저해작용 검색

이화진,류재하,Lee, Hwa-Jin,Ryu, Jae-Ha 한국생약학회 2000 생약학회지 Vol.31 No.3

Leukotriene $B_4\;(LTB_4)$ is a pro-inflammatory mediator synthesized in myeloid cells from arachidonic acid. Elevated levels of $LTB_4$ have been found in a number of inflammatory diseases and levels are related to disease activity in some of these. Because $LTB_4$ interacts with cells through specific cell surface receptors, $LTB_4$ receptor blockade is the most specific approach to reduce the pathogenic role of $LTB_4$. In order to find $LTB_4$ receptor antagonist from plants, we screened the $LTB_4$ receptor antagonistic activity of the methanol extract and solvent fractions of herbal drugs. The ability of samples to inhibit specific binding of $[^3H]-LTB_4$ to human peripheral neutrophils was used as assay to evaluate the antagonistic activity of plant materials. Among the tested methanol extracts of herbal drugs, Mori Radicis Cortex, Perillae Semen, Armeniacae Semen and Sophorae subprostratae Radix showed potent inhibitory activity above 70% at the concentration of $100\;{mu}g/ml$. The inhibitory activities of $LTB_4$ binding to human neutrophils were evaluated for several solvent fractions at three different concentrations. Especially, hexane soluble fractions of Anemarrhenae Rhizoma and Embeliae Radix, and ethyl acetate soluble fractions of Aristolochiae Fructus, Magnoliae Cortex and Zingiberis Rhizoma crudus showed moderate activity at $25\;{mu}g/ml$. These fractions were promising candidates for the study of the activity-guided chromatographic purification of active compounds. Silica gel column chromatography of hexane soluble fractions of Anemarrhenae Rhizoma and Embeliae Radix gave very active sub-fractions, AA-4 and ES-4, and their inhibition activities of $LTB_4$ binding to human neutrophil at $30\;{mu}g/ml$ were 78% and 62%, respectively. From these results we could anticipate new $LTB_4$ receptor antagonist from herbal drugs, and the block of $LTB_4$ effects may provide beneficial in neutrophil mediated diseases such as inflammation and bronchial asthma.

통원 뇌졸중 환자의 우울 및 가족 지지가 재활 동기에 미치는 영향

이화진,이명선,Lee, Hwa-Jin,Yi, Myung-Sun 한국재활간호학회 2004 재활간호학회지 Vol.7 No.2

Purpose: This study was conducted to identify relationships between depression, family support, and rehabilitation-motivation in patients with cerebrovascular accident. Method: The data were collected from 'S' hospital in Seoul from Feb. 1, 2004 to Apr. 30, 2004. The data were analyzed using a SPSS 10.0 program for descriptive statistics, Pearson correlation coefficients and stepwise multiple regression. Result: The results were as follows: The mean rehabilitation-motivation was 119.89, which was slightly high. The rehabilitation-motivation was influenced by religion, education level, occupation, economic status, treatment fee, duration of hospitalization, level of language ability and ADL. Rehabilitation-motivation has showed correlation with family support (r=.538, p=.000) and depression (r=-.417, p=.000). The variables related to rehabilitation-motivation were identified as family support, level of ADL, occupation, depression, and education level, using stepwise multiple regression. They were accounted for 57% of predictability of the rehabilitation-motivation, with the family support the highest at 29.3%. Conclusion: With increasing post stroke patients in Korea, we need to pay more attention to the rehabilitation of them. This study indicates that health professionals need to focus on the intervention especially in increasing family support and in decreasing depression of the patients with cerebrovascular accident.

HSI와 YIQ의 복합 색상정보를 이용한 차량 번호판 영역 추출

이화진,박형철,전병환,Lee, Hwa-Jin,Park, Hyung-Chul,Jun, Byung-Hwan 한국정보처리학회 2000 정보처리논문지 Vol.7 No.12

본 논문은 자가용과 영업용 차량의 컬러 영상에서 번호판 영역을 찾는 방법에 대한 연구이다. 번호판 영역 추출을 위해 차량 영상에서 번호판 영역은 차종에 따라 일정한 색상을 가지고 있다는 특징을 이용하였다. 본 논문에서는 단일 색상 정보에만 의존하지 않고, HSI 컬러모델의 색상 성분 H와 YIQ 컬러 모델의 색상 성분 Q를 결합하는 방식을 제안한다. 또한 처리 과정의 효율성을 높이기 위하여 입력 영상 전체를 처리하지 않고, 수평 라인별 탐색을 통해 번호판의 높이 구간을 찾도록 한다. H 성분과 Q 성분을 각각 사용한 경우와 두 색상 성분을 결합하여 추출한 경우를 비교 실험한 결과, H 성분에만 의존한 경우는 53.6%, Q 성분에만 의존한 경우는 82.1%, 결합 색상 성분에 의한 경우에는 94.6%의 추출률을 보였다. This paper describes a method that extracts the region of car-licence plates in color images of private and commercial cars. To extract car-licence plates, we use the feature that car-licence plate regions have regular colors according to the kinds of cars. In this paper, we propose the method that combines H component of HSI color model and Q component of YIQ color model. To improve efficiency of the process, we cxplore lines ill a car image by a regular interval in a bottom-up style. As a result, the extraction rates by only H-component. only by Q- component. and by combined Hand Q, are 53.6%, 82.1%, and 94.6% respectively.

개체군 생존력 분석을 이용한 여우복원사업 방사 전략

이화진 ( Hwa Jin Lee ),이배근 ( Bae Keun Lee ),권구희 ( Gu Hui Kwon ),정철운 ( Chul Un Chung ) 한국환경생태학회 2013 한국환경생태학회지 Vol.27 No.4

The red fox (Vulpes vulpes), listed as a Class I endangered species by the Ministry of Environment of Korea, has been considered to be extinct in South Korea since the 1980s, and an intensive restoration project has been underway in Sobaeksan national park. This study was carried out to develop a suitable model for the red fox reintroduction program based on Population viability analysis (PVA) by using the VORTEX program. If 10 animals (5 females and 5 males) were continuously released into the initial zero population every year for 10 years, population growth rate and extinction probability over the next 50 years after the introduction of the population were 0.018±0.204 and 0.354, respectively; the maximum population size was 116.34 at the 16th year after the first release, and a reduction rate of 1.22 every year from the 17th year was inferred. We found that additional releases would be needed from the 17th year after the initial release to maintain a positive growth rate and to prevent the extinction of the released red foxes, and releasing more than 12 individuals every year would be needed for the long-term, continuous existence of red foxes. By contrast, if fewer than 6 red fox individuals were released the extinction probability over the next 50 years was more than 80%. To maintain the minimum population growth rate, the release of more than 8 individuals were needed for positive population growth. The population growth rate was more stable when 10 animals in the change of their sex rate every year from the set value were released as the female-to- male sex ratio of 6:4 rather than 1:1. However, if the female-biased sex ratio was increased by more than 7:3, a negative population growth was expected. The occurrence rate of roadkill and poaching are important factors in the red fox restoration project. The extinction probability was decreased to 30% if each factor was decreased to 3% based on the standard baseline; however, if each factor was increased to more than 3%, an extinction rate of about 90% was reached over the next 50 years.

논문 : 신체적, 정신적 발달 지연 및 불임인 환자에 있어서 성염색체 이상

이화진 ( Lee Hwa Jin ),고희정 ( Go Hui Jeong ),오선경 ( O Seon Gyeong ),천대우 ( Cheon Dae U ),서창석 ( Seo Chang Seog ),김석현 ( Kim Seog Hyeon ),문신용 ( Mun Sin Yong ) 서울대학교 인구의학연구소 2002 人口醫學硏究論集 Vol.15 No.-

노장(老莊)의 미학사상에서 보는 한국춤의 심미관조(審美觀照) 고찰

이화진 ( Hwa Jin Lee ) 大韓舞踊學會 2013 대한무용학회논문집 Vol.71 No.3

This study looks at the organic relationships the among various characteristics that form the aesthetics philosophy of Korean dance and the main concepts of Lao-tzu and Chuang-tzu, namely ``principle``, ``natural inaction``, ``supreme beauty supreme delight``, and ``unity of the nature and human.``

현대문학 : 윤흥길 성장소설의 세계와 의미

이화진 ( Hwa Jin Lee ) 반교어문학회 2011 泮橋語文硏究 Vol.0 No.31

한국소설사에서 성장소설은 그다지 주목을 받지 못한 편이다. 성장소설이 지극히 사소설적인 경향을 보이고 있으며, 따라서 문학의 특징인 객관적 상관물로서의 자족성을 담지하지 못하다는 해석이 그 이유이다. 그럼에도 불구하고 성장소설은 우리 삶의 커다란 변화과정을 정치하게 반영하고 있는 소설유형이라는 점은 의미가 크다. 성장소설에서 ``성장``은 ``교양``, ``형성``, ``입사``의 여러 다층적인 개념을 내포하고 있는데, 본고에서는 성장이 유년에서 성인으로 성숙해가는 변화과정이라는 제한적 의미를 극복하고 성장소설이 함의하고 있는 다의성에 주목하고자 한다. 이에 성장소설의 서술전략을 살피고, 그 의미를 해석해내고자 한다. 윤흥길의 성장소설의 세계는 병, 죽음 탐색을 통한 자기발견에 주목하고 있으며, 또한 유년화자에 내면화되어 있는 이데올로기에 주목한다. 그리고 마지막으로 반성적 자아를 통해 고백과 치유로서의 글쓰기를 시도하고 자기 주체성을 정립하고자 하는 의미를 밝힌다. 이로써 성장소설이 미성숙 상태의 체험소설에 머무르지 않고 문학적 자립성을 갖춘 유의미한 소설유형임을 밝힌다. In the history of Korean novels, growth novels have not been spotlighted much. It is because growth novels tend to be extremely private and cannot contain the national sentimentality as objective correlative, which is a characteristic of literature. Nevertheless, it is meaningful that growth novels carefully describe the process of big changes of our lives. In growth novels, ``growth`` is a multidimensional concept implying ``general education``, ``development``, and ``employment``, and this study focused on the polysemy of growth novels to overcome the limited meaning that growth is only the process of maturation from childhood to adulthood. The purpose of this study was to discuss the narrative strategy of growth novels and interpret its meaning. First, it was clarified that Yoon, Heung Gil`s observational perspective of narrators in childhood is a strategic tool to acquire objectivity. Second, the novels` complex structure was analyzed to focus on the public discourse of young narrators. Third, the author`s intention to establish subjectivity through self-reflective ego was interpreted. Through this process, this study concluded that growth novels form an independent genre of literature, not experiential novels in immaturity.

공법분야 투고논문 : 탈북여성의 중국체류 경험을 통해본 출산 및 양육에 관한 권리 침해와 대응 행위

이화진 ( Hwa Jin Lee ) 한양대학교 법학연구소 2013 법학논총 Vol.30 No.1

The purpose of this study is to consider human rights issues and changes in behaviors of women defectors from North Korea from their experiences of childbirth and parenting in China. Human rights issues and relevant behaviors can be summarized as follows. Interviewees has experienced the issue of human rights has been raised in lives illegal aliens in China; run away and hide with her baby, separate from her child and compulsory abortions due to forcibly deported to North Korea. Human rights abuses in married lives is discrimination and disregard by her husband`s family due to the purchased marriage. In such situation, the women decide birth in a risk, escape to South Korea for security who her baby and herself, and examine and reflection herself about relationship with her child in South Korea. The significant findings of this study can be seizes reflection women and independent, not just the victims. In addition, this study can be supply the broad understanding of structured experiences and response methods on human rights issues about motherhood, broad understanding women defectors from North Korea.