도인승기탕에 의한 당뇨병성 혈관장애 개선효과

이윤정,김언국,김혜윰,윤정주,이소민,이용표,이건목,강대길,이호섭,Lee, Yun Jung,Kim, Eon Kuk,Kim, Hye Yoom,Yoon, Jung Joo,Lee, So Min,Lee, Yong-Pyo,Lee, Geon Mok,Kang, Dae Gill,Lee, Ho Sub 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1

Objectives : Diabetes mellitus is the leading cause for vascular complications such as atherosclerosis. The present study is to investigate whether Doinseunggi-tang (DST) improves diabetic vascular dysfunction in type II diabetes. Methods : The db/db mice were treated with high fat/high cholesterol diet and DST (200 mg/kg/day) for 8 weeks. Results : DST significantly lowered blood glucose and systolic blood pressure. In addition, DST also markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol, whereas increased the HDL-cholesterol. Vascular relaxation of aortic rings by acetylcholine or SNP was ameliorated by DST in a dose-dependent manner. Damage of vascular intima and hypertrophic of media was improved by DST. Immunohistological study revealed that DST attenuated the increase of ICAM-1, VCAM-1, and ET-1 expression in thoracic aorta. Conclusions : Taken together, DST suppressed hyperglycemia and diabetic vascular dysfunction in type II db/db mice. The present data suggests that Doinseunggi-tang may be prevent a development of diabetic atherosclerosis.

고지혈증 동물모델에서 홍삼과 천마 혼합투여에 의한 혈관 염증 개선연구

이윤정,김혜윰,윤정주,이소민,고정현,이호섭,최경민,강대길,Lee, Yun-Jung,Kim, Hye-Yoom,Yoon, Jung-Joo,Lee, So-Min,Kho, Joung-Hyun,Lee, Ho-Sub,Choi, Kyung-Min,Kang, Dae-Gill 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.1

Objectives : This experimental study was designed to investigate the inhibitory effects of combination with Korean red ginseng and Gastrodia rhizoma on vascular dysfunction in high-fat/cholesterol diet-induced hyperlipidemia. Methods : Sprague-Dawley rats were fed with 7.5% cocoa butter and 1.25% cholesterol for 10 weeks, with Panax ginseng (PG), and mixtures of Panax ginseng and Gastrodia rhizoma (PGM), respectively. Results : Chronic treatment with PG and PGM significantly decreased body weight. The aortic expression of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin were markedly increased in hyperlipidemia rats. Interestingly, PGM significantly decreased cell adhesion molecules expression. However, there was no significant decrease in PG group. In addition, PG and PGM group inhibited high-fat/cholesterol diet-induced cytokine such as monocyte chemoattractant protein (MCP-1) mRNA expression. Furthermore, PG and PGM group significantly decreased c-reactive protein protein (CRP) level. Especially, PGM significantly accentuated the decrease of MCP-1 mRNA expression and CRP level. Conclusions : the present study provides an evidence that combination with Panax ginseng and Gastrodia rhizoma enhances anti-vascular protective effects through suppression of vascular inflammation in hyperlipidemic rats.

Salmonella typhimurium 에서 무산소 환경 유도유전자들에 대한 조절유전자들의 특성 및 클로닝

이윤정,방일수,이인수,이영록,박용근 ( Yun Joung Lee,Iel Soo Bang,In Soo Lee,Yung Nok Lee,Yong Keun Park ) 한국환경생물학회 1993 환경생물 : 환경생물학회지 Vol.11 No.2

New regulatory loci which participate in the anaerobic environment inducible gene(ani) expression in Salmonella typhimurium were identified. These regulators (oxr) showed negative regulatory effect on the anaerobiosis inducible operon fusions of this organism in aerobic environment (oxr 107 and oxr 108 to ani 2001, oxr 109 to ani 2007). They were identified as the trans-acting regulators, and increased β-galactosidase activity of ani-lacZ fusion strains up to about 10-240 fold in aerobic environment. By using the library of S. typhimurium chromosomal DNA, two negative regulators (oxr 101 and oxr 109) were cloned. The insert fragment of each clone, pPK32 for oxr 101 and pPK33 to oxr 109 were 7.8Kb and 9.3Kb, respectively. The recombinant plasmid pPK32 didn`t complement the mutation effect of oxr 101 on minimal media but rich media, pPK33 complemented the mutation effect of oxr 109 on both minimal and rich media.

전자코와 GC/MS를 이용한 포도 품종별 저장 조건에 따른 휘발성 향기 성분 연구

이윤정,이기택,Lee, Yun-Jeung,Lee, Ki-Teak 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.7

품종에 따른 포도를 이용하여 3일 동안 $4^{\circ}C$와 실온에 각각 저장함에 따라 변화하는 전체적인 향의 패턴을 전자코를 통하여 분석하였고 SPME-GC/MS 분석 결과를 통하여 휘발성분을 분리 동정하였다. 대표적인 포도의 주요 휘발 성분은 alcohols, esters, acids, terpenes 등으로 GC/MS 분석 결과 butanoic acid/ethyl ester와 1-hexanol, hexanoic acid/ethyl ester, phenylethyl alcohol 등이 주요 성분으로 동정되었다. 캠벨은 다른 품종에 비해 다양한 휘발 성분이 동정되었고 레드글로브와 머루 품종에서는 1-hexanol, 2-decene, 8-methyl-(z)/1-dodecanol 등을 제외한 나머지 휘발 성분은 거의 나타나지 않았다. 또한 전자코를 이용하여 휘발성 향기성분 패턴 분석결과 $4^{\circ}C$와 실온 저장한 시료의 제 1주성분 값의 기여율은 각각 99.30, 99.36%로 품종에 따라 구분이 가능하였다. $4^{\circ}C$ 저장 시 저장 기간에 따른 제 1주성분 값의 변화 범위는 실온에서 저장한 것에 비해 적었음을 확인할 수 있었다. Volatile flavor compounds of 4 grape species (Campbell, Sheridan, Red globe, and Meoru) were identified during 3-day storage at either $4^{\circ}C$ or room temperature. Each sample was analyzed by solid-phase micro-extraction (SPME) method combined with gas chromatography-mass spectrometry. Also electronic nose composed of 12 different metal oxide sensors was used to differentiate flavors of grapes. Sensitivities (delta $R_{gas}/R_{air}$) of sensors from electronic nose were obtained by principal component analysis (PCA). Proportion of the first principal component was 99.30% at $4^{\circ}C$ and 99.36% at room temperature, respectively. In our result, flavor patterns of grape can be differentiated according to the storage period. The major volatile flavor compounds were 1-hexanol, hexanoic acid and its ethyl ester, and phenylethyl alcohol with the presence of butanoic acid and its ethyl ester, acetic acid, benzeneacetic acid and its ethyl ester.

근·현대사 이후 한국인의 최다 선호 일반의약품의 추이에 대한 연대별 분석 및 종합적 의의에 대한 평가

이윤정,강태진,임성실,Lee, Yun Jeong,Kang, Tae Jin,Lim, Sung Cil 대한약학회 2016 약학회지 Vol.60 No.3

Over-the-counter (OTC) drugs refer to medicines that are generally safe when used according to the product label. We aimed to assess and reflect upon changes in perception of health and health-related demands by decades in Korea according to the consumption and sales trends of OTC drugs. This study was conducted by literature search on the production and sale rankings of OTC drug market in Korea. Changes in the OTC drug market were analyzed and organized by decades to evaluate changes in drug demands and the influence of national and societal factors. There was a specific trend in the most popular drugs by decades. In the 1950s, drugs of top necessity were antibiotics and helminthics. In the 1960s, the pharmaceutical industry quickly grew and invigorators, such as Bacchus$^{(R)}$, Alps$^{(R)}$, Aronamin$^{(R)}$, were top manufactured drugs. Popularity of these invigorating drinks and vitamin products continued until the 1990s. In 1990s, sales of topical nonsteroidal anti-inflammatory drugs (Ketotop Plaster$^{(R)}$, Trast Patch$^{(R)}$), and in 2000s, gum disease medicine (Insadol$^{(R)}$) and liver and intestine supplement (Ursa$^{(R)}$) were prominent. However, after the separation of prescribing and dispensing in 2000, the sales of OTC drugs decreased dramatically from 58.7% of the total market share in 1990s to 39.6% in 2000 and this trend has continued. In 2012, thirteen OTC drugs were allowed to be sold in convenience stores, and as the sales of health functional foods have been expanding beyond pharmacies, sales of invigorators and nutritional supplements in pharmacies have continued to decrease. As government's drug expenditure will continue to grow, reclassification of OTC drugs based on established safety information and deliberate team efforts on continued development of OTC drugs to meet the health demands of Koreans are required by the healthcare professionals, pharmaceutical industries, and the government.

의류학 전공 대학생들의 패션디자인 독창성에 대한 자기효능감 연구

이윤정,Salusso, Carol J.,Lee, Jaeil 한국패션디자인학회 2016 한국패션디자인학회지 Vol.16 No.1

본 연구는 앨버트 밴듀라(Albert Bandura)의 자기효능감 이론에 근거하여 의류학 전공 대학생들의 패션디자인 독창성에 대한 자기효능감 수준을 알아보고 이에 대한 선행요인들, 즉, 과거 성과, 대리 경험, 언어적 설득, 생리적 피드백과 인구통계적 특성의 영향을 알아보는 것을 목적으로 하였다. 의류학 전공 대학생들의 창의성과 윤리성을 고양시키기 위해서는, 학생들이 창의적 과정을 적극적으로 추구하면서 동시에 윤리적인 결정을 내릴 수 있도록 충분히 높은 자기효능감을 갖도록 하는 것이 중요하다. 따라서 학생들의 패션디자인 독창성에 대한 자기효능감에 영향을 미치는 것으로 선행연구에서 제시된 변수들의 영향을 알아보고자 하였다. 이를 위하여 전국의 의류학 관련 학과에서 패션디자인 과제를 수행해 본 경험이 있는 학생들을 대상으로 설문조사를 실시하였고, 총 174부를 분석하였다. 패션디자인 독창성에 대한 자기효능감에 대한 선행요인으로 과거 성과, 대리 경험, 언어적 설득, 생리적 피드백 및 인구통계적 특성의 효과를 알아보기 위하여 단계적 회귀분석을 실시하였다. 첫 번째 단계에서는 과거 성과, 대리 경험, 언어적 설득, 생리적 피드백을 독립변수로 투입하였으며, 두 번째 단계에서는 인구통계적 특성을 독립변수로 추가 투입하였다. 그 결과 첫 단계에서는 과거 성과, 대리 경험, 생리적 피드백이 유의한 패션디자인 독창성에 대한 자기효능감에 대해 유의한 효과를 갖는 것으로 나타났다. 즉, 과거에 창의적·윤리적 패션디자인을 수행한 경험이 있거나, 다른 사람이 이러한 작업을 하는 것을 지켜본 경험이 있는 경우, 그리고 이러한 작업에 대한 스트레스를 적게 받는 경우 패션디자인 독창성에 대한 자기효능감이 높은 것으로 나타났다. 이러한 경향은 두 번째 단계에서 인구통계적 특성을 통제하였을 때에도 변화가 없었다. 단계 2에서 추가 투입된 인구통계적 특성 중에서는 성별만이 유의한 효과를 가졌는데, 여성보다 남성이 패션디자인 독창성에 대한 자기효능감이 높은 것으로 나타났다. 연구의 결과에 근거하여 대학의 교육자들이 학생들을 지도하는 데 도움을 주기 위한 교육적 함의가 제시되었다. The purpose of this study was to examine the influences of performance outcomes, oral persuasion, vicarious experience, and physiological feedback on fashion design and merchandising students’ creativity and ethical fashion design self-efficacy, based on Bandura’s theory. In order to foster both creativity and ethics among apparel design and merchandising students in higher education, it is essential to encourage students to have sufficiently high self-efficacy to make sound ethical decisions while actively pursuing their creative processes. South Korean college students majoring in fashion design and merchandising from ten different universities were surveyed through an online survey website. A total of 174 questionnaires were collected. Stepwise regression was used to analyze the data. On the first stage, creativity and ethical fashion design self-efficacy was regressed on performance outcomes, oral persuasion, vicarious experience, and physiological feedback. On the second stage, the dependent variable was regressed on demographic characteristics including age, gender, residence, and subjective social status in addition to the four precedent variables entered on the first stage. The results showed that performance outcomes and vicarious experience are positively correlated with self-efficacy and physiological feedback is negatively correlated with self-efficacy, even when the effects of demographic characteristics were controlled for. Among the demographic variables that were added on the second stage, only gender had significantly positive relationship with self-efficacy. Specifically, men showed higher creativity and ethical fashion design self-efficacy than women. Educational implications were suggested based on the results for the educators at a higher education level.

당김줄을 이용한 소아 열상 환부의 쉽고 빠른 발사 방법

이윤정,이경석,김준식,김남균,Lee, Yoon-Jung,Lee, Kyung-Suk,Kim, Jun-Sik,Kim, Nam-Gyun 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.2

Purpose: Except for continuous suture in skin layer, stitching out in facial laceration, we have to hold each knots up and cut the knots by No. 11 blade or small scissors. However, we often have difficulty in stitching out the knots on children who do not cooperate well. Therefore we introduce an easy and fast stitch out method of pediatric lacerations. Methods: From January to May 2009, we studied 15 pediatric patients (mean age 5.6 years old) who had facial laceration on face or underwent any surgery on operation room. For easy stitch out, we left the one string of the first knot long enough to extend at the opposite end of laceration site. And then the extended string was fixed to skin using Steri-strip. Next we do simple interrupted suture including the extended traction nylon string inside the knot. Through this method, we can stitch out all knots simply by lifting up the traction nylon needless to hold the each knot one by one. Results: Until stitching out, the traction nylon was just right position and there was no normal tissue injury during stitch out all knots. Patients were satisfied with the short stitch out time. Conclusion: By using the traction nylon on pediatric laceration suture, we can stitch out all the knots with no normal tissue injury in less time.

건강가정지원센터의 교육사업 담당 건강가정사의 직무와 역량에 관한 연구

이윤정,Lee, Yoon-Jung 한국가족자원경영학회 2008 가족자원경영과 정책 Vol.12 No.4

The aims of this article were to examine the basic law, contents and concept of educational program for healthy family and provide the jobs and competency of healthy family supporter for educational work. The research objects were 53 healthy family supporters for educational work inclusive of full-time and part-time position. They was analyzed through the survey. The process of research consisted of two parts. One was to suggest their jobs and requirements, the other were to offer their core competency and area for improvement. First, the jobs of healthy family supporters for educational work were the planning and valuation of program. The requirements for the performance of their duties are having a bachelor's degree or a master's degree, career for 1-3years, and a certificate of qualification of healthy family supporters, social worker and family counselor. Second, their competencies were the understanding of education for family life, management for healthy family support center, planning and valuation of educational program, a theory of counsel, community networking, ability of documentation, sociality, communication skill, the ability of solving the problem, the adaptation of various environments, receptiveness, positiveness and so on.

2016 양계산업 현황과 과제 - 14/15 HPAI 발생과 예방대책

이윤정,Lee, Yun-Jeong 대한양계협회 2016 월간 양계 Vol.48 No.2

건물 에너지 분석의 개념과 활용

이윤정,김상훈,전준용,Lee, Yun-Jeong,Kim, Sang-Hun,Jeon, Jun-Yong 한국건설관리학회 2012 한국건설관리학회 논문집 Vol.13 No.3