밖에서 본 한국의 민주화와 경제발전

吳淇昌 한림대학교 아시아문화연구소 1990 아시아문화 Vol.- No.6

소프트웨어 개발 생산성과 품질 향상를 위한 어플리케이션 프레임워크 구현방안(J2EE 기반 Data Access Logic 자동 생성 기술 중심 )

오기창,김삼남,최광준 한국정보기술응용학회 2005 한국정보기술응용학회학술대회 Vol.2005 No.1

후기발병 양측성 의미변이원발진행실어증 환자에서 보인 비대칭 아밀로이드 국소침착 소견의 해석 및 진단 접근

오기창,박정주,용영복,김보영,김지은 대한신경과학회 2023 대한신경과학회지 Vol.41 No.2

Semantic variant primary progressive aphasia (svPPA), a well-known subtype of the frontotemporal dementia often shows peculiar clinical features and structural neuroimage findings. To strengthen the accuracy of a clinical diagnosis, amyloid positron emission tomography-computed tomography (PET-CT) might be helpful. However, in patients with late-onset svPPA, an admixture of the various neuropathology would interfere with diagnostic approach. Herein, we report a case of late-onset bilateral svPPA showing a regional amyloid deposition on PET-CT scan.

양성 단일 갑상선 결절의 갑상선 호르몬 억제요법

김순호,오기창,추진호,임중규,조형철,조장현,허진득 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.1

Background: Clinically apparent thyroid nodule is a very common disease in adults. Patients are often treated with thyroxine in order to reduce the size of the nodule, but the efficacy of thyroxine-suppressive therapy with thyroxine remains uncertain. We investigated the efficacy of thyroxine-suppressive therapy and the hormonal characteristics during thyroxine therapy to find out whether such measurement could be used to determine the effectiveness of this therapy in patients with benign solitary thyroid nodule proved by aspiration biopsy. Methods: In this study, 54 patients were randomly assigned to receive L-thyroxine(Group I, n=24) or placebo(GroupII, n=30) for 1 year. High resolution ultrasonography(10MHz) was used to measure the size of the nodules at six month intervals. Thyroid hormones and thyroglobulin assay and FNA(fine needle aspiration) was done at the same time. The dose of thyroxine was 200ug/day. Patients were followed at 6 month intervals. Results: The results were as follows: 1) 13(54.1%) out of 24 Group I patients after adequate TSH suppression had a statistically significant reduction of nodule size and before-to-after nodule volume ratios were significantly different between the Group I and Group II patients. 2) In the responders among Group I patients, the before-to-after therapy ratio of the nodule volume was not related to the pretreatment nodule size, thyroid hormones and thyroglobulin levels. Conclusion: Thus we concluded that an adequate suppressive dose of L-thyroxine significantly altered the volume of the benign solitary thyroid nodules 12 months later. ( J Kor Soc Endocrinol 12:45-52, 1997)

한의사 의료기기 사용과 관련된 판례 및 기존 연구 분석과 경향 변화

박정수,오기창,권상혁,추홍민,김정상,Park, Jeongsu,Oh, Kichang,Kwon, Sanghyuk,Chu, Hongmin,Kim, Jungsang 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.6

Objectives: The aim of this study was to examine the debate on the use of medical devices between Western Medicine and Korean Medicine, as this is one of the greatest conflicts in Korea's medical profession. Judicial precedents and interpretations of authority serve as regulations because medical affairs law states that Korean Medicine practices are ambiguous. Method: We conducted a search in the Korean RISS, OASIS, and DBPIA databases using several keywords associated with medical devices, Korean Medicine, and Korean Medicine Doctors. The search period was until November 5 2021. The retrieved papers were classified according to the selection and exclusion criteria by checking the title, abstract, and text. For precedents, searches were done regarding comprehensive legal information, etc., and in the case of non-disclosure precedents, we requested access to the precedents by web-court requests. Results: A total of 80 documents were found as a result of the search, and 13 publications were included in the study. The selected publications were classified and analyzed by this research team into Korean medicine, Western medicine, and legal or state agency research. In the existing literature and judgments, the arguments that played a major role changed depending on the time the judgment was made. "Social conventions", "curriculum", "academic principles", and "health and hygiene dangers" were the key arguments. Conclusions: Further studies will be needed that can comprehensively arrange the existing literature and clinical results, and continuous study will be needed to verify that the use of medical devices by Korean medicine doctors is helpful for prognosis and accurate treatment of their patients.

위암에서 내시경적 초음파단층술의 유용성에 대한 평가

김명원,박홍배,여향순,오기창,강명원,조장현,조형철,추진호,김원석 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.1

Background: Endoscopic Ultrasonography(EUS), a combination of endoscopy and ultrasonography is one of the most useful tools for diagnosis of digestive system diseases. EUS is useful in staging the primary tumor invasion and regional lymph node metastasis because of its ability to image the gut wall and adjacent structures in unique detail. We performed a study preoperatively for assessing the accuracy and limitation of EUS in gastric carcinoma. Methods: In 75 patients(Male 54, Female 21, Mean age 62.3 years) with a gastric carcinoma confirmed by endoscopic biopsy, we performed EUS preoperatively. The results were compared with the postoperative histopathologic staging. Results: 1) In assessing the depth of tumor invasion, EUS accuracy on depth of invasion was 76.0% and overstaging and understaging were 14.7% and 9.3%, respectively. 2) In assessing the lymph node metastasis, the accuracy rate of EUS was 65.3%. A rate of false-positive diagnosis was 27.3%, and a rate of false-negative diagnosis was 24.5%. 3) In assessing the incidence of lymph node metastasis for each T stage, the involve rate was 10.5% in pT1, 36.4% in pT2, 95.7% in pT3, 100% in pT4. Conclusions: EUS is the most accurate diagnostic methods presently available to determine tumor infiltration depth and lymph node metastasis.

그레이브스병에 있어서 항갑상선제와 티록신 병합요법의 효과

조장현(Jang Hyun Cho),오기창(Ki Chang Oh),김명원(Myung Won Kim),김원석(Won Seok Kim),추진호(Jin Ho Choo),조형철(Hyung Cheol Cho),김순호(Soon Ho Kim),임중규(Joong Kyu Lim),허진득(Jin Duk Huh) 대한내과학회 1998 대한내과학회지 Vol.54 No.2

N/A Objectives: It was recently reported that the administration of T during antithyroid drug(ATD) therapy resulted in a significant decrease of antibodies to TSH receptors as well as the rate of recurrence of active Graves' disease following discontinuance of ATD treatment. But, there is still controversy whether combination therapy is efficient. Therefore, the present study was undertaken to evaluate the effect of T4 administration of patient with Graves' disease who were being treated with ATD. Methods: We studied 56 patients received methimazole(MMI) alone(Group 1) and 48 patients received methimazole plus T4(Group 2). They are diagnosed active Graves' disease at department of internal medicine, Kwang ju Christian Hospital from January, 1994 to December, 1995. AU the patients were treated initially with 30mg of methimazole daily for one month after then, in the Group 1(methimazole alone), the dose of methimazole was adjusted as necessary to achieve normal serum concentrations of T3, T4, and TSH. The patients of Group 2(methimazole plus T4) continue to receive the combination of T4 at a dose of 100 μg daily. Simultaneously, we estimated the serum concentratio n of T3, T4, TSH and Thyroid-stimulating immunoglob ulin(TSI) antibody at every three months. Results : We obtained the following result. In the group 1, mean TSI values were 50.1%(first visit), 30.6%(6months), and 24.7%(1year). And, in the group 2 mean TSI values were 51.8%(first visit), 33.6%(6months), and 22.7% (1year). After 6 months of discontinuing of therapy, the recurrence rate was no significant difference in the two groups (the recurrence rate were 55.4%, 50.0%, respectively P>0.05). Conclusion : These results suggest that T4 administration in combination with MMI therapy have no significant effect in a decrease in levels of TSH receptors antibodies and recurrence rate within 6 months discontinuing MMI therapy as compared with MMI treatment alone.

경피경간적 담도내시경을 이용한 거대 총담관결석의 전기수압쇄석술과 Endocoil 삽입

김명원,박홍배,여향순,오기창,강명원,조장현,조형철,추진호,김원석 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.5

Background/Aims: Electrohydraulic lithotrypsy(EHL) under cholangioscopic control has been performed for difficult bile duct stones. The percutaneous transhepatic approach is technically easy and useful in diagnosis and treatment of bile duct obstruction and stones. Biliary stenting with self expanding metal stent is gaining increasingly wider acceptance as a palliative treatment of bile duct obstruction. Methods: Between Sep. 1994 and Sep. 1996, EHL under choledochoscopy by percutaneous transhepatic approach was performed in 30 cases(Male: 13, Female: 17). After PTBD with 7F pig tail catheter, the percutaneous transhepatic passage was dilated over guide wire with dilaters of increasing size up to 16Fr in 3-Sdays. In one week, after fistula had been estabilished, choledochoscopy was performed. Results: (1) Mean age was 61.3 years. Mean stone number was 2.5. And mean stone size was 1.6 x 2.3 cm. (2) Com.plete removal of the stone was achieved in all patients(100%). (3) There were no serious complications. (4) In six cases, Endocoils were implanted with successful decompression of obstructions and simultaneous removal of biliary stones located at both side of stricutre. Conclusions: Percutaneous transhepatic choledochoscopy is easy and safe and assists in the diagnosis and treatment of biliary stricture and the management of difficult CBD stone.

당뇨병과 뇌졸중 병력을 모두 가진 급성 뇌경색 환자에서 증상 발생 3-4.5시간대 정맥내혈전용해술의 안전성 및 효과

김보영,이지성,박홍균,용영복,오기창,박정주,조용진,강규식,이수주,김재국,차재관,김대현,배희준,박태환,박상순,이경복,이준,이병철,이민우,김준태,최강호,김동억,최재철,신동익,권지현,김욱주,손성일,홍정호,박형종,장성화,박광열,이상화,박종무,홍근식 대한신경과학회 2023 대한신경과학회지 Vol.41 No.2

Background: For acute ischemic stroke (AIS) patients with history of prior stroke (PS) and diabetes mellitus (DM), intravenous recombinant tissue plasminogen activator (IV-tPA) therapy in the 3- to 4.5-hour window is off-label in Korea. This study aimed to assess the safety and efficacy of IV-tPA in these patients. Methods: Using data from a prospective multicenter stroke registry between January 2009 and March 2021, we identified AIS patients who received IV-tPA in the 3- to 4.5-hour window, and compared the outcomes of symptomatic intracranial hemorrhage (SICH), 3-month mortality, 3-month modified Rankin Scale (mRS) score 0-1 and 3-month mRS distribution between patients with both PS and DM (PS/DM, n=56) versus those with neither PS nor DM, or with only one (non-PS/DM, n=927). Results: The PS/DM group versus the non-PS/DM group was more likely to have a prior disability, hypertension, hyperlipidemia, coronary heart disease and less likely to have atrial fibrillation. The PS/DM and the non-PS/DM groups had comparable rates of SICH (0% vs. 1.7%; p>0.999) and 3-month mortality (10.7% vs. 10.2%; p=0.9112). The rate of 3-month mRS 0-1 was non-significantly lower in the PS/DM group than in the non-PS/DM group (30.4% vs. 40.7%; adjusted odds ratio [95% confidence interval], 0.81 [0.41-1.59]). Conclusions: In the 3- to 4.5-hour window, AIS patients with PS/DM, as compared to those with non-PS/DM, might benefit less from IV-tPA. However, given the similar risks of SICH and mortality, IV-tPA in the late time window could be considered in patients with both PS and DM.

경피경간적 담도내시경법에 의한 폐쇄성 담도질환의 진단 및 치료

김명원,박홍배,여향순,추진호,조형철,조장현,김원석,오기창,강명원,임연근 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.1

Background/Aims: Obstructive jaundice is developed from the cholangiocarcinoma, biiliary tract stone, biliary benign stricture and pancreatic head cancer and is rapidly progress to cholangitis or sepsis. So early decompression, accurate diagnosis and treatment are very important. Percutaneous transhepatic choledocoscopy(PTCS) and endoscopic retrograde choledocoscopy(ERCS) have been used for evaluation of the obstructive jaundice. We performed, through the PTCS, electrohydraulic lithotripsy(EHL) for biliary tract stone rernoval, biopsy for diagnosis of biliary stric and self expandible metalic coil stent(EndocoilTM stent, Instent Co.) insertion on biliary stricture to evaluate the usefullness of PTCS in patients with obstructive jaundice. Methods: Between Auguest 1994 and September 1995, PTCS was performed in 37 patients with obstructive jaundice. First, percutaneous transhepatic biliary drainage(PTBD) with 7Fr. drainage tube was done. Three days later, we exchainged the 7Fr. drainage tube with 16Fr.. Seven days later, through the PTCS, we performed EHL, biopsy and EndocoilTM stent insertion. Results: 1) Stones were removed completely and patients were imprcaved clinically after PTCS with EHL in 17 patients with biliary tract stone. During one year, anyone of these patients were not recurred. 2) Biopsy was done in 13 patients with biliary stricture and then 7 patients were confirmed as CBD cancer. 3) EndocoilTM insertion was performed in 22 patients with biliary stricture. In one patient, EndocoilTM iltsertion was failed due to too lowerly inserted. During one year, only 4 patients developed biliary tract obstruction. Conclusion: These resuts suggest that, through the PTCS, EHL of biliary tract stones, biopsy and EndocoilTM stent insertion on biliary stricture are very useful method for biliary tract decompressiom, accurate diagnosis and treatment of patients with obstructive jaundice.