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양상인,이승진,박하영,이상호,장춘곤,이완석,신영희,김정주,이석용 대한약학회 2003 약학회지 Vol.47 No.2
Due to its profound intestinal first-pass metabolism, oral eperisone hydrochloride produces a very low bioavailability and a very short muscle relaxant activity. To improve the efficacy and compliance of eperisone, we designed a new dosage form, the transdermal patch and evaluated the muscle relaxant effects of this patch in rats. The muscle relaxant activity was assessed by measurement of forelimb grip strength and hanging test in rats. The transdermal patch of eperisone hydrochloride showed significant muscle relaxant activity at 0.5, 1.5 and 3 cm$^2$/200 g rat (1.39, 4.17 and 8.33 mg of eperisone hydrochloride/kg, respectively) in a dose-dependent manner and the effects were lasted over 24 hours. The oral eperisone hydrochloride showed significant activity at 12.5, 25 and 50 mg/kg in a dose-dependent manner but the activity was within 1 or 2 hours after administration. These results suggest that the eperisone hydrochloride is absorbed efficiently from transdermal patch and the patch can exert potent and long-lasting muscle relaxant activity. This transdermal patch will increase the efficacy and compliance in the clinical use of eperisone hydrochloride.
양상열,김영철,노종범 한국공업화학회 2001 한국공업화학회 연구논문 초록집 Vol.2001 No.-
EMC는 현재 반도체소자의 봉지제로 사용 중 반도체소자에서 발생되는 열을 제거하며, 반도체 칩과 와이어를 물리적 및 환경적 위험으로부터 보호하는 목적으로 사용하고 있다. 최근 들어 반도체소자의 고밀도 및 소형화에 따라 여러 이종재료가 갖는 열팽창계수 및 단위면적 당 발생하는 열량을 최소화 하기위해 무기재료의 충전밀도를 높게 사용하고 있다. 그러나 무기충전제의 함량이 높아짐에 따라 조성물의 점도가 높아져 성형이 어려워지는 문제점을 갖게되고 이러한 문제점을 해결하기 위해서 수지, 충전제 및 첨가제 등의 조성물을 고르게 분산시키는 방법의 하나로 혼합 및 혼련 방법을 기계적으로 극대화시키고 있다. 이러한 분산 과정 중 무기충전제로서 요구되는 특성 즉, 기계적 강도, 수지의 경화시 수반되는 체적변화, 전기재료로서 요구되는 특성 등이 떨어져 EMC 봉지제로서 성능저하를 야기 시키고 있다. 따라서 본 연구에서는 기계적 혼합공정에서 일어날 수 있는 무기충전제 입자의 파쇄와, 이로인하여 발생되는 EMC의 물성변화와, 최적조건을 조사하여 보았다.
소양인 중풍환자에 병발된 불면증에 양격산화탕(凉膈散火湯)을 투여한 증례(症例)
양상묵,김달래,김혁,Yang, Sang-Mook,Kim, Dal-Rae,Kim, Hyuk 사상체질의학회 2002 사상체질의학회지 Vol.14 No.3
Insomnia is a temporary or continuous condition in which one has difficulty sleeping, due to physical impediments or physical problems. Because insomnia does harms to a labor power or imposes mental and physical burden on a patient, we should pay attention to this disease. This case is about a patient who was 62 years old man with a chronic insomnia since 1996, inspite of no past history about psychical disease. He had sufferred from a cerebral infarction and hypertension since March. 2002. and was hospitalized in Sangji University korean medicine hospital, 25. June. 2002. This patient had been treated by herb-med, Yanggyuksanhwatang for 4 weeks and showed an improvement. This paper describes the process and contents about the patient was cured.
상태공간 모델에 기반한 가변속 냉동시스템의 SMC 설계
양상원(Sang Won Yang),김준기(Jun Gi Kim),정석권(Seok Kwon Jeong) 대한설비공학회 2019 대한설비공학회 학술발표대회논문집 Vol.2019 No.11
In this paper, SMC (Sliding Mode Control) based on a state-space model is described for robust temperature control of a variable speed refrigeration system (VSRS). A state-space model of VSRS inevitably includes many uncertainties in the model during the linearization process and parameter identification. In addition, various disturbances such as heat load and noise through temperature sensors are added to the system during its operation. That makes satisfactory temperature control difficult. To solve this problem, SMC that is less dependent on parameters of the target system is designed in the form of servo system. The validity of the proposed SMC is proved by comparing robustness of it with conventional PI controller through computer simulations of the actual VSRS.
양상일(Yang Sang Ill),진우정(Jin Woo Geong),신효근(Shin Hyo Keun),김오환(Kim Oh Hwan) 대한구강악안면외과학회 1987 대한구강악안면외과학회지 Vol.13 No.2
We had studied on the 36 cases of head and neck malignant tumor which visited Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Chon Buk National University from Jan. 1984 to Sep. 1987. The Study method was according to histopathological classification and from a statistical to sex, age, chief complaint, location, stage, and treatment method choice. The obtained results were as follows: 1. Oral cancer was most common between age of 51 and 60 years old and the average age of oral cancer was 55.08. 2. Sexual incidence in oral cancer was 88.9% in male and 11.1% in female. 3. Most frequently chief complaint was pain (52.8%). 4. Squamous cell carcinoma was the most common oral cancer (77.8%). 5. The predominant location of oral cancer was gingiva (29%). 6. The most common stage in TNM classification method was stage Ⅳ (61.1%). 7. Treatment was performed mostly by combination therapy of the chemotherapy and surgical treatment.