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        헤파린 표면처리된 국산화 혈관우회도관의 개발

        선경,기동,백광제,이혜원,최종원,김승철,김택진,이승열,김광택,김형묵,이인성,Sun, Kyung,Park, Ki-Dong,Baik, Kwang-Je,Lee, Hye-Won,Choi, Jong-Won,Kim, Seung-Chol,Kim, Taik-Jin,Lee, Seung-Yeol,Kim, Kwang-Taek,Kim, Hyoung-Mook,Lee, In-Su 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.2

        배경: 흉부대동맥 수술에 사용하는 헤파린 우회도관의 국산화를 위해, 헤파린 표면처리기법 중 물리분산법을 이용하여 제작한 우회도관의 동물실험을 통해 혈전저항성 및 안정성을 증명하고자 하였다. 대상 및 방법: 성견 21마리(17.5∼25 kg)를 대상으로 하행흉부대동맥 우회모델을 만들었다. 사용한 우회도관의 종류에 따라 무처리 우회도관군(CONTROL; n=3), 무처리 우회도관 및 전신 헤파린 처치군(HEPARIN; n=6), Gott 헤파린 우회도관군(GOTT; n=6), 국산 헤파린 우회도관군(KIST; n=6)로 분류하였다. 관찰지표는 말초혈액검사, 혈액응고검사, 신장 및 간기능검사, 표면전자현미경 소견 등이었다. 각 지표는 우회도관의 원위부 대동맥 혈액에서 검사하여 우회 전과 우회 후 2시간 째의 군내 변화와군간 차이를 비교하였다. 결과: 모든 관찰지표의 우회 전 기초치는 군간에 차이가 없었다. 말초혈액검사 중 혈소판치는 HEPARIN군과 GOTT군에서 유의하게 높아졌으나(p<0.05) 군간 차이는 유의하지 않았다. 기타 혈구세포의 변화는 각 군에서 군내변화와 군간차이가 유의하지 않았다. Activated clotting time, activated partial thromboplastin time, thrombin time은 HEPARIN군에서 현저히 증가하였고(p<0.05) 군간차이도 유의하였다(p<0.005). Prothrombin time은 GOTT군에서 유의하게 증가하였으나(p<0.05) 군간차이는 없었다. Fibrinogen은 각 군에서 군내변화와 군간차이가 유의하지 않았다. Antithrombin III는 HEPARIN군과 KIST군에서 유의하게 감소하였고(p<0.05) 군간차이도 유의하였다(p<0.05). Protein C는 HEPARIN군에서 유의하게 감소하였으나(p<0.05) 군간차이는 없었다. Blood urea nitrogen은 HEPARIN군과 KIST군에서 유의하게 증가하였으나(p<0.05) 군간차이는 없었다. Creatinine, aspartate aminotransferase, alanine aminotransferase는 각 군에서 군내변화와 군간차이가 유의하지 않았다. 표면전자현미경 소견에서 혈소판 및 혈구세포 응집정도는 CONTROL군이 가장 심했고, HEPARIN군은 GOTT군이나 KIST군에 비해 많았다. 결론: 이상의 결과에서 전신 헤파린 처치(HEPARIN)는 출혈경향을 증가시키면서 이물질 표면의 응고반응을 효과적으로 차단하지 못하는 반면, 헤파린 표면처리된 우회도관(GOTT & KIST)의 경우는 출혈경향 없이 표면의 응고반응을 충분히 억제하였다. 또한 국산(KIST) 헤파린 우회도관은 상용화된 외국산(GOTT)과 동등한 항혈전 성능을 보였다. Background: This study was designed to develop a Korean version of the heparin-coated vascular bypass shunt by using a physical dispersing technique. The safety and effectiveness of the thrombo-resistant shunt were tested in experimental animals. Material and Method: A bypass shunt model was constructed on the descending thoracic aorta of 21 adult mongrel dogs(17.5-25 kg). The animals were divided into groups of no-treatment(CONTROL group; n=3), no-treatment with systemic heparinization(HEPARIN group; n=6), Gott heparin shunt (GOTT group; n=6), or Korean heparin shunt(KIST group; n=6). Parameters observed were complete blood cell counts, coagulation profiles, kidney and liver function(BUN/Cr and AST/ ALT), and surface scanning electron microscope(SSEM) findings. Blood was sampled from the aortic blood distal to the shunt and was compared before the bypass and at 2 hours after the bypass. Result: There were no differences between the groups before the bypass. At bypass 2 hours, platelet level increased in the HEPARIN and GOTT groups(p<0.05), but there were no differences between the groups. Changes in other blood cell counts were insignificant between the groups. Activated clotting time, activated partial thromboplastin time, and thrombin time were prolonged in the HEPARIN group(p<0.05) and differences between the groups were significant(p<0.005). Prothrombin time increased in the GOTT group(p<0.05) without having any differences between the groups. Changes in fibrinogen level were insignificant between the groups. Antithrombin III levels were increased in the HEPARIN and KIST groups(p<0.05), and the inter-group differences were also significant(p<0.05). Protein C level decreased in the HEPARIN group(p<0.05) without having any differences between the groups. BUN levels increased in all groups, especially in the HEPARIN and KIST groups(p<0.05), but there were no differences between the groups. Changes of Cr, AST, and ALT levels were insignificant between the groups. SSEM findings revealed severe aggregation of platelets and other cellular elements in the CONTROL group, and the HEPARIN group showed more adherence of the cellular elements than the GOTT or KIST group. Conclusion: Above results show that the heparin-coated bypass shunts(either GOTT or KIST) can suppress thrombus formation on the surface without inducing bleeding tendencies, while systemic heparinization(HEPARIN) may not be able to block activation of the coagulation system on the surface in contact with foreign materials but increases the bleeding tendencies. We also conclude that the thrombo-resistant effects of the Korean version of heparin shunt(KIST) are similar to those of the commercialized heparin shunt(GOTT).

      • KCI등재

        조선 세종대 『사리영응기』 편찬과 왕실불사의 전통

        박선경(Park, Sun-kyung) 동국역사문화연구소 2019 동국사학 Vol.67 No.-

        본 연구는 세종 30년 내불당 불사를 『사리영응기』의 내용을 통해 검토하였다. 내불당 불사에 대해 세종 개인의 신앙에 의한 것이라고 치부하기보다 국초 국가의기틀을 마련하고 정비해 나가는 국왕으로서 세종의 의도를 파악하고자 하였다. 조선 초기 공적 영역에서 불교는 축소되어 갔지만 왕권과 왕실의 위상 강화를 위한불교의 역할 또한 무시할 수 없었다. 세종이 그린 왕실과 불교의 관계를 검토하는데 있어 『사리영응기』는 중요한 자료가 된다. 내불당 불사는 세종의 기획 하에 진행되었으며 『사리영응기』의 편찬은 내불당불사의 마지막 단계였다. 세종은 김수온 등에게 『사리영응기』를 편찬하게 하고 이를 유사에 명하여 금속활자 본으로 간행하게 하였다. 내불당 조영과 경찬법회 사리이적을 기록한 『사리영응기』는 왕실의 불사를 현창하기 위해 편찬된 것이다. 세종은 불사에서 담당자 배치 또한 치밀하게 준비하였다. 각각의 업무에 전문인력을 배치하고 대군들에게 총감독하게 하였다. 또한 장중하고 신성한 불상 이운 행렬의 중심에는 왕실 구성원들이 배치되었으며 세종은 신곡을 지어 불상을 불당에 안치할 때 연주하도록 하였다. 왕실 구성원을 왕실불사 전면에 내세운 것은 세종의 의도와 관련 깊다. 세종은 대군들을 동원하여 왕실불사를 설행하는 전례를 세자에게 남김으로써 왕실 구성원이 불사에 참여할 수 있는 전통과 안정적인 환경에서 왕실불사가 지속적으로 이루어질 수 있는 기반을 마련하였다. 끝으로 내불당 법회에서 연출된 ‘사리이적’을 두 가지 측면에서 살펴보았다. 하나는 세종이 사리가 지니는 상징성을 명확하게 인지하였고, 이를 통해 왕실의 권위를 높이고자 하였다는 사실이다. 또 다른 측면은 세종이 태조의 전례를 답습하여 사리이적을 연출하였고, 이로 인해 끊어졌던 사리이적의 전통이 후대에 다시 이어질 수 있는 발판이 마련된 것이다. 이를 계승하는 모습을 문종에게서도 볼 수 있었다. This study was reviewed through Sariyeongeunggi of Buddhist Projects of Naebuldang at 30th year of King Sejong(1448). It was done to understand King Sejong’s intention to establishing and maintaining the foundation of a nation as a king rather than to be treated by King Sejong’s personal faith of Buddhist Projects of Naehuldang. King Sejong had Kim, Su-Ohn compile Sariyeongeunggi and this was published in Printed with Metal Type by commanding it as national organization. Compiling Sariyeongeunggi was considered as a tool to promote the authority of royal family under plan of King Sejong. King Sejong also closely prepared the person in charge. He arranged an expert in each work and had the princes from the legal queen supervise it. And the royal family members were appointed in middle of the moving parade of spectacle and sacred statue of the Buddha. He excluded the successor to him from the Buddhist Services of Naebuldang. He thought out a plan not to be criticized by bureaucrats who studied Confucianism and for the royal family to traditionally participate in the Buddhist Projects by delivering the manual to him to conduct the Buddhist Services. Finally ‘miracles of sarira incarnation’ emerged from Gyeongchanhoe Buddhist ritual of Naebuldang clearly recognized the sarira that King Sejong followed as a symbol come from the ancient royal family and King Sejong aimed at enhancing royal authority through it. He got foothold to pass down the tradition of Buddhist Projects that was cut off for imitating the precedent of King TaeJo to descendants. We could see the succession of this from the era of King Moonjong.

      • KCI등재
      • Stellar surface gravity extracted from Wilson-Bappu effect

        박선경,강원석,이정은,이상각,Park, Sun-Kyung,Kang, Wonseok,Lee, Jeong-Eun,Lee, Sang-Gak 한국천문학회 2012 天文學會報 Vol.37 No.2

        Wilson and Bappu (1957) found a significant relationship (WBR) between the absolute magnitude ($M_v$) and the width of the Ca II K emission line (W) for late type stars. In this study, we revisit the WBR to claim that WBR can be an excellent indicator of stellar surface gravity. We analyze 95 high-resolution spectra of G, K and M type stars obtained with UVES and BOES. WBR found in this work is $M_v$=34.22-18.34logW. In addition, stellar atmospheric parameters ($T_{eff}$, logg, [Fe/H], ${\xi}_{tur}$) are determined with the MOOG code and the Kurucz ATLAS9 model grids for G and K type stars. For M type stars, the method of Belle et al. (1999) is used to derive effective temperature which shows good agreement with other methods. Using the derived $T_{eff}$ and the measured logW,we find the relationship between logg and [logW, logT]; ${\log}g-_{fit}=-25.051-5.527{\log}W+10.254{\log}T_{eff}$. This relation can be applied to estimate the surface gravity of M type stars, which is difficult to be determined by other methods.

      • KCI등재

        입원환자의 의료질 향상(QI)을 위한 입원생활 안내문의 효과

        박선경 ( Sun Kyung Park ),한상숙 ( Sang Sook Han ),백승남 ( Seung Nam Paik ) 경희대학교 동서간호학연구소 2004 동서간호학연구지 Vol.9 No.1

        Purpose: This study has been conducted as a quality improvement activity in order to confirm the assessment of patients, their guardians and nurses by providing them with a Life in Hospital Guide. Method: Nursing with Life in Hospital Guide provision was conducted at an University Hospital with patients admitted within 5 days or less and their guardians, a control group of 375 persons and a comparison group of 372 persons, and the data have been collected from the 26th of May to the 10th of October 2003. A Life in Hospital Guide, in the form of a leaflet, that contained useful information such as meals, facilities, car parking, documents, linen products etc, was used. The collected data have been analysed using SPSS windows programme 11.0 for percentage, χ2-test, and t-test. Result: The comparison group who were provided with a Life in Hospital Guide will know better about the articulars needed to live in hospital than the control group who were not,`` the average of the comparison group (4.04) was higher than the control group (3.04), which is a significant difference (t=-27.06, p=.000). Conclusion: As a results of this study, it was confirmed that life in hospital guidance through a leaflet each as a quality improvement activity, are effective.

      • 한국 NGO의 현황과 과제

        박선경 ( Sun Kyung Park ),김영미 ( Young Mi Kim ) 상명대학교 사회과학연구소 2005 社會科學硏究 Vol.20 No.-

        한국의 NGO는 지난 10여 년 간 세계 그 어느 곳에서도 찾아보기 어려울 정도로 괄목할만한 급성장을 이룩하여 국가부문이나 시장부문과 더불어 한 사회를 구성하는 중요 핵심영역으로 등장하여 사회의 전 영역에 걸쳐 막대한 영향력을 행사하고 있다. 그러나 공식적인 기구를 대치할 만큼 조직적, 신뢰적, 그리고 전문적인 단체로 성장하고 있지는 못한 것으로 평가되고 있다. 가장 큰 요인은 서구의 NGO에 비하여 그 역사가 짧고 등장배경 또한 역사적·문화적으로 특이한 경험을 갖고 있다는 것이다. 따라서 NGO의 건전한 발전방안으로 N시민의 참여 유도, 독립된 재정 확보, 민주적인 의사결정구조, 전문성을 갖춘 인적자원의 확보, 명확한 목표와 프로그램, 비정파적인 NGO 등을 제시할 수 있지만 가장 중요한 것은 건강한 시민 정신이다. 시민들의 자발적인 직접참여를 통해 형성되는 새로운 정체성, 규범, 연대는 이른바 시민권력의 초석을 제공한다. 그리고 이는 대의민주주의 약점을 보완하여 참여 민주주의의 부활을 의미한다.

      • KCI등재
      • KCI등재

        후삼국시기 선승들의 활동지역과 정치적 배경

        박선경(Park, Sun-kyung) 한국역사연구회 2016 역사와 현실 Vol.- No.101

        Previous studies of Zen Buddhist sects from the Later Three Dynasties period mostly focused their efforts upon determining the intentions of the Goryeo royal family which supported them, or how other sects in other areas were supported by various supporting factions. Thanks to these studies, the Zen priests’ social influence as well as the development process of individual Buddhist sects have been clarified. But a new approach to all sects would be more preferable in creating a bigger picture. Examined in this article is the political nature of regions which housed certain Zen Buddhist sects, in order to determine certain characteristics shared by individual areas where Zen Buddhist priests operated, as such examination would help us have a wider view of the entire Zen Buddhist community, more so than just continuing to study individual sects and factions of this period. There was a period in which all three “Later” dynasties were firmly established, and there was a period in which Goryeo and Hu-Baekje fought with each other to gain dominance over Shilla. During the former period, it should be noted that Zen Buddhist priests who had been connected with the kings were moving to areas such as the Nakdong-gang, Nam’han-gang and Seomjin-gang river basins, which were all strategically important areas that would have allowed leaders of all three dynasties to not only maintain but also expand their own ranges of influence. Then in case of the latter period, the Zen Buddhist priests are mostly spotted in northern parts of the Gyeongsang Buk-do province and also the Habcheon area. It seems like as the competition over Shilla continued, these areas turned into an active war zone. Fierce face-offs ironically forced this region to remain neutral or pro-Shilla. Zen Buddhist priests in this region refrained from forming an active relationship with the kings, and seem to have chosen to instead monitor the situation closely. Later when Goryeo rose as ultimately victorious, they formed a relationship with founder king Taejo.

      • KCI등재

        모야모야질환을 동반한 산모 9예의 임상적 고찰

        박선경 ( Sun Kyung Park ),현민경 ( Min Kyung Hyun ),차경희 ( Kyung Hee Cha ),심재윤 ( Jae Yoon Shim ),원혜성 ( Hye Sung Won ),이필량 ( Pil Ryang Lee ),김암 ( Ahm Kim ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.11

        To describe the clinical manifestations and to establish the management of pregnancy and delivery in pregnant patients with Moyamoya disease. We identified nine women with Moyamoya disease. Six of these patients underwent cesarean section. General anesthesia was administered to only one patient, while epidural or combined spinal-epidural anesthesia was used for the others. The patient diagnosed during pregnancy was epidural anesthesia used for vaginal delivery and two patients diagnosed during post-delivery were delivered vaginally without anesthesia. Three patients showed pregnancy-related complications: intracranial hemorrhage, severe pre-eclampsia, and stroke. Five patients had term delivery, and four had pre-term delivery. The babies were healthy and had no complications. As blood pressure control is the most important factor for the pregnant women with Moyamoya disease, we recommend a spinal or epidural anesthesia in order to reduce the potential complications. Management of the patient`s underlying disease is also crucial.

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