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1990 년대 한국 성인에서 역류성 식도염의 유병률 변화
정성애(Sung Ae Jung),정훈용(Hwoon Yong Jung),김기락(Ki Rhack Kim),민영일(Young Il Min) 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.2
N/A Backgroud/Aims: The prevalence of reflux esophagitis has been considered to be low in Korea, but recent studies suggested that it has been increasing. The prevalence also is generally thought to be less in Korea compared to that in western countries. Methods: Data was collected from the leading medical journals published in Korea dealing with the prevalence of reflux esophagitis for last 10 years between 1990 and 1999 and annual reports of Health Promotion Center in Asan Medical Center of 1997 to 1999. Results: The prevalence was occupied 1.3% in the early period of 1990's, 5.3% in the middle and 7.2% in the late period in symptomatic group and 2.7%, 3.2% and 5.8% in asymptomatic group. The prevalence was reported 5.4% in 1997, 5.3% in 1998 and 7.0% in 1999 in asymptomatic group of annual report of Health Promotion Center in Asan Medical Center. Associated conditions in reflux esophagitis were hiatal hernia, alcohol consumption, smoking and obesity suggesting as risk factors. Conclusions: The prevalence of reflux esophagitis in Korea has increased in last 10 years of 1990' s but is still lower than that in the western countries. Continuous increase in the prevalence of reflux esophagitis in Korea is predictable and it leads to a greater concern for accurate diagnosis and rapid treatment of symptoms. (Korean Journal of Gastrointestinal Motility 2001;7:161-167 )
손정민(Jeoung Min Son),양석균(Suk Kyun Yang),명승재(Seung Jae Myung),김영민(Young Min Kim),김희철(Hee Cheol Kim),유창식(Chang Sik Yu),김진천(Jin Cheon Kim),김기락(Ki Rhack Kim),정훈용(Hwoon Yong Jung),홍원선(Weon Seon Hong),김진호(Ji 대한내과학회 2001 대한내과학회지 Vol.60 No.5
N/A Background : In Korea, the incidence of ulcerative colitis has been very low, but there are few pidemiologic studies about ulcerative colitis. The aim of the present study is to obtain basic epidemiologic information about the diagnostic course of ulcerative colitis in Korea. Methods : The diagnostic course and methods of 150 patients with ulcerative colitis were analyzed by standard questionnaire and interview. Results : The median time between the onset of symptoms and diagnosis was 5 months (2 weeks-10 years). The initial diagnosis made at the institution first visited was ulcerative colitis in 31.3%, hemorrhoid in 16.7%, dysentery in 8.7%, irritable bowel syndrome in 9.3%, enteritis in 12.0%, and others in 22.0%. The diagnostic rate of ulcerative colitis among institutions was 13.0% in clinics (14/108), 28.6% in hospitals (8/28), 47.9% in general hospitals (23/48), and 83.3% in academic medical centers (105/126). Among 39 patients who have received both barium study and endoscopic evaluation at the time of diagnosis at Asan Medical Center, the overall sensitivity of barium study was 76.9% (30/39) (p=0.001). Depending on the extent of the disease, the diagnostic sensitivity of barium study was 50.0% in proctitis (5/10), 69.2% in left-sided colitis (9/13), and 100% in extensive colitis (16/16).
안만수(Man Su Ahn),송문희(Moon Hee Song),박영환(Young Hwan Park),박주상(Ju Sang Park),이상수(Sang Soo Lee),김기락(Ki Rhack Kim),유은실(Eun Sil Yu),서동완(Dong Wan Seo),이성구(Sung Koo Lee),김명환(Myung Hwan Kim),민영일(Young Il Min) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.5
Bile duct hamartomas are rare benign malformations of the biliary tract. It is usually discovered as occasional findings at autopsy. It may be confused with metastatic lesions of the liver or may rarely be found in association with cholangiocarcinoma. We report a case of 64-year-old woman who showed multiple small low attenuated lesions in both lobes of the liver on CT scan. Clinically, it was hard to differentiate them from metastatic lesions in the liver. Multiple bile duct hamartomas were histologically confirmed with liver needle biopsy. We report this case with a review of literature. (Korean J Gastroenterol 2001;38:385-388)
서동대(Dong Dae Seo),이윤정(Yun Jung Lee),박일권(Il Gwon Park),이현주(Hyun Ju Lee),박성제(Seong Je Park),표승일(Seung Il Pyo),윤길숙(Kil Sook Yun),서동완(Dong Wan Seo),이성구(Sung Koo Lee),김명환(Myung Hwan Kim),김기락(Ki Rhack Kim) 대한소화기학회 2001 대한소화기학회지 Vol.37 No.5
Endometriosis is defined as the presence of endometrial tissue outside the uterus. We experienced 51-year-old woman with symptom of epigastric pain and sign of a palpable mass on the left quadrant abdomen. A cystic mass in the tail area of the pancreas was found on CT scan and was removed surgically. It was a cystic mass originated from the mesentery and separated from the pancreas. It was diagnosed as endometrial cyst histopathologically. (Korean J Gastroenterol 2001;37:389-391)
김명환,이성구,주영민,서동완,민영일,김지연,강호형,김기락,이영미 대한소화기학회 2001 대한소화기학회지 Vol.38 No.5
Background/Aims: High-osmolar ionic contrast media are used in ERCP over the world even though low-osmolar nonionic contrast media are mainly selected for intravascular enhancement due to low incidence of side effect. The purpose of this study was to compare cholangiocytotoxicity of the two contrast media which had the same amounts of iodine. Methods: High-osmolar ionic meglumine-ioxithalamte and low-osmolar nonionic iopromide were used. The canine gallbladdder epithelial cells were exposed to the two contrast media with different iodine concentration and osmolality for 2 days. Cell number, S-phase fraction, aneuploidy and supernatant LDH activities were estimated everyday. Results: The cell growth inhibition was more severely affected by ioxithalamte than iopromide (p$lt;0.05) and had a tendency to depend on the osmolality of contrast mixtures. The S-phase fraction was concordant with cell growth. The aneuploidy was more commonly detected in cells exposed to ioxithalamte mixtures. Conclusions: High-osmolar ionic contrast media used in ERCP induce more severe cytotoxicity of gallbladder epithelial cell than low-osmolar nonionic contrast media.
단클론성 유무가 저등급 위점막연관림프조직형 림프종의 임상양상 및 제균요법 후 초기 조직학적 관해에 미치는 영향
김진호,홍원선,민영일,정훈용,명승재,강경훈,김기락,허주령,최승목,심용희,이숭한,양석군 대한소화기학회 2001 대한소화기학회지 Vol.37 No.4
Background/Aims: There has been little description about the clinical significance of B-cell monoclonality in primary low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. We investigated the effects of B-cell monoclonality on early response to Helicobacter pylori (H. pylori) eradication therapy in patients with H. pylori-positive low-grade gastric MALT lymphoma. Methods: Twenty-nine patients with H. pylori-positive low-grade gastric MALT lymphoma were consecutively enrolled. We performed diagnostic tests including esophagogastroduodenoscopy (EGD), endoscopic ultrasonography and CT scan for the patients. PCR with PAGE was used to analyse the patterns of immunoglobulin heavy chain gene rearrangement. All 29 patients received H. pylori-eradication therapy. They were then followed up at regular intervals by EGD with biopsy. Results: Fifty-five percent (16/29) showed a single band in PAGE after PCR, suggesting a monoclonal proliferation of B-cell lineage. Regardless of B-cell monoclonality, there was no difference in histologic regression rates after 3 months of eradication therapy. However, the MALT lymphomas with B-cell monoclonality showed more ulcerous lesions (p$lt;0.01) and deeper infiltration of tumor into gastric wall (p$lt;0.05) than those without B-cell monoclonality. Conclusions: These results suggest that PCR-based B-cell monoclonality may not affect early therapeutic response to H. pylori-eradication therapy in gastric MALT lymphoma in spite of the more aggressive histologic morphology.