VP-16으로 성공적으로 치료된 위 Kaposi 육종 1예

양웅석,송근암,조몽,이재승,송철수,김형욱,김영민,이수봉,김태오,이성훈 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.4

The skin is an uncommon site of distant metastasis from any internal malignancy, and the incidence of metastatic skin lesions as the first symptom of disease is only 0.8% in patients with all systemic malignancies. Furthermore, cutaneous metastasis from adenocarcinoma of the stomach has been found to be extremely rare. A 35-year-old female patient was admitted due to multiple cutaneous nodules in her chest, abdomen, and back. A gastroendoscopic examination and biopsy was made according to the results of skin pathologic findings. Stomach and skin biopsy results revealed a signet ring cell type of adenocarcinoma. A case of gastric adenocarcinoma in which metastatic skin nodules appeared as the first sign of disease, is here in reported with a review of related literature.

A comparison of survival outcome of open, total laparoscopic and laparoscopy-assisted vaginal radical hysterectomy in patients with early cervical cancer of stage IB2

( Sul Lee ),( Hyung Joon Yoon ),( Eun Hye Jeon ),( Juseok Yang ),( Yong Jung Song ),( Hyun Jin Roh ),( Sang Hun Lee ),( Byung Su Kwon ),( Ki Hyung Kim ),( Dong Soo Suh ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: The aim of this study is to evaluate oncologic outcomes of total abdominal radical hysterectomy (TARH), total laparoscopic radical hysterectomy (TLRH) and laparoscopic-assisted radical vaginal hysterectomy (LARVH) in early cervical cancer patients (stage IB2-3, tumor size≥2cm), analyzing the risk factors that may affect the clinical results. Methods: A total of 756 patients underwent radical hysterectomy between 2000 and 2019 from three university hospitals (Pusan National University Hospital, Yang-san Pusan National University Hospital, Ulsan University Hospital) were enrolled. Among them, 172 patients with stage IB2-3 were analyzed retrospectively. Results: Seventy-seven patients were treated with TARH, and 95 were managed via minimally invasive surgery (MIS), consisting of 35 with TLRH and 60 with LARVH. TARH group had better disease five-year disease free survival (DFS) and overall survival (OS) compared with MIS group (86.4% vs. 73.4 for DFS and 91.7 vs. 82.2 for OS), but not statistically significant in both (p=0.058 for DFS and p=0.119 for OS). When TARH and the LARVH group were compared, both five-year DFS and OS were not significant different (86.4 vs 82.2%; p=0.288 for DFS and 91.7 vs 84.4%; p=0.206 for OS). However, when TARH and the TLRH group were compared, TLRH group had significantly worse five-year DFS than TARH (86.4 vs 54.5%; p=0.008), but five-year OS was not significant different (91.7 vs 77.5%; p=0.127). Multivariate analysis showed that LN metastasis and TLRH surgical approaches were an independent prognostic factor for DFS in IB2-3 cervical cancers. Conclusion: Our findings provided the evidence that TLRH surgical approach was associated with worse DFS in IB2-3 cervical cancers but that of LARVH was not. Such results may have important implications of colpotomy method for MIS in cervical cancer.

Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

여성의 性회복을 위한 연구 방안

이양자,이영수 동의대학교 2004 인간과 문화 연구 Vol.- No.9

우묵사스레피(Eurya emarginata)의 플라보노이드 화합물의 분리 및 동정

양홍철,박수영,강희경,이남호 제주대학교 생명과학연구소 2001 제주생명과학연구 Vol.4 No.-

The extracts of Eurya emarginata showed inhibitory effect on the growth of HL-60 leukemia cells. So, 80% methanol(MeOH) extract of its leaves was partitioned to hexane, ethyl acetate, n-butanol and residual water fractions. The ethyl acetate fraction, which showed desirable activities, was further purified using SiO2 column chromatography(CC) followed by reverse phase silica gel CC, then another normal CC to give fraction 4-1-8 as a pure compound. The compound 4-1-8 was analyzed by NMR spectrometry using 1H, 13C, DEPT, HMQC and HMBC spectra, and finally proved to be well-known flavono glycoside, Quercitrin.

불평형을 고려한 절삭력 모델에 관한 연구

양완석,이수훈 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.1

This paper is on a new cutting force model which includes the force caused by unbalance. The cutting forces under the different additional masses are measured with the spindle speed changed. The model is justified through correlation between simulation and experimental result.

우유 중 Antibiotic Residues 검출과 살균처리에 따른 영향

양철영,이수한 서울보건대학 1995 서울보건대학 부설 한국보건과학연구소 논문집 Vol.1 No.1

국내에서 널리 사용되고 있는 세균 발육 억제 물질 검출 시험의 일종인 dye지시약으로 2,3,5-triphenyltetrazolium chloride을 이용한 방법과 속성 검출 시험 방법인 pnzym kit를 이용한 방법으로 원유, 시유의 항생물질 검출성, 시험방법간의 검출능 비교와 살균처리에 의한 영향을 고찰한 내용은 다음과 같다. TTC 시험에 의한 원유 중의 항생물질 검출성은 3개 시험구 60시료에서 평균 25.00%의 양성율을 나타내고, 평균 시험 소요시간은 198.25분이었고, penzym 시험에 의한 양성율은 43.33%이고 소요시간은 31.35분으로 필요로 하였다. 시유 및 가공유 중의 검출성은 15시료의 TTC시험에 의한 경우 13.33%의 양성율과 penzym시험의 경우 46.66%의 양성율을 나타내고 있다. TTC시험방법에서 penicillin G는 0.03IU/ml, cloxacillin은 1.0×10^(-10)g/ml, oxacillin, ampicillin 및 sulfamethazine은 1.0×10^(-15)g/ml까지 검출이 가능하였으며 penzym 시험방법에서는 penicillin G는 0.001IU/ml, oxacillin, cloxacillin, sulfamethazine은 1.0×10^(-15)g/ml, ampicillin은 1.0×10^(-11)g/ml까지 검출성을 보였다. 100℃이내의 살균온도와 유지시간에서는 항생물질의 농도와 검출성의 차이가 발생하지 아니하였다. penzym 검출시험 방법은 특이성, 신속성, 간편성 및 재현성이 있음을 실험결과에서 나타내었다. By 2,3,5-triphenyltetrazolium-2H-chloride test method(TIC) and penzym test method, antibiotic residues in raw milk and city milk was detected, and we compared penzym test with TIC test for antibiotic detection, and we investigated the effect of holding treatment(LTLT, HTST) of various antibiotics added in 12% skim milk. The results obtained are summarized as follows; In case of raw milk, inhibitor positive were 25.00% and 43.33% of 60sample by TIC test and penzym test, and experimental require times was 198.25 minutes and 31.35 minutes, respectively. In case of market milk, inhibitor positive were 13.33% and 46.66% of 15 sample by TIC test and penzym test. The concentration of detected antibiotics by TIC test of penicillinG and cloxacillin were 0.03IU/ml and 1.0×10^(-10)g/ml, oxacillin, ampicillin and sulfamethazine were 1.0×10^(-15)g/ml. The concentration of detected antibiotics by penzym test of pencillin G and ampicillin were 0.00lIU/ml and 1.0×10^(-11)g/ml, oxacillin, cloxoacillin and sulfamethazine were 1.0×10^(-15)g/ml. The antibiotic residues were no changed on the less than l00℃ of heat temperature by TIC reduction test and penzym test. This study showed various merit such as specificity, fastness, simple handling by penzym test.

만성 정신분열증 음성증상에 대한 Mianserin 효과

이정태,서상원,유태열,박원명,김광수,전양환 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.2

This study was designed to examine the mianserin effects on the negative symptoms of chronic schizophrenia. The chronic schizophrenics(N=14) diagnosed by DSM-Ⅲ-R, who were treated at the Catholic University St. Mary Hospital from March 1, 1993 to August 31, 1995, were divided into two groups. One group was composed of 7 patients who were treated with a single classical antipsychotic agent(monotherapy group, MG), and another was composed of 7 patients treated with combined medications(combined therapy group, CG), including classical antipsychotics plus fixed dose of mianserin 30 ㎎/day at bed time. Symptoms were evaluated by BPRS(Brief Psychiatric Rating Scale) and PANSS(Positive and Negatve Syndome Scale) biweekly for 6 weeks, i.e., total 4 times(at baseline, at 2 weeks, at 4 weeks, and at 6 weeks). The results were as follows : 1) Assessed by PANSS, the negative symptoms of CG were statistically significantly improved more than those of MG at 2 weeks, at 4 weeks, and at 6 weeks. 2) Assessed by PANSS, the positive symptoms of CG were not statistically different from those of MG. In both of CG and MG, there was no difference of the positive symptoms across time intervals. 3) Assessed by PANSS, the total symptoms of CG were statistically significantly improved more than those of MG at 2 weeks, at 4 weeks, and at 6 weeks. But, assessed by BPRS, the total symptoms of CG were not statistically different from those of MG. 4) Assessed by PANSS, the general psychopathology symptoms of CG were not statistically different from those of MG. In CG, the general psychopathology stmptoms at 6 weeks were statistically significantly improved more than those of baseline. In summary, mianserin, when combined with classical antipsychotic agent, appears to be effective in diminishing negative symptoms of chronic schizophrenic patients. However, it did not influence positive symptoms.

의과대학생의 자연최면경험과 최면유도점수의 상관관계

이정태,최윤정,전양환,성양숙,박원명,김광수,유태열 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.5

목 적 : 저자들은 자연최면경험과 최면감수성간의 관계를 알아보기 위하여 자연최면점수와 최면유도 척도로 얻은 최면유도점수 및 유도점수와의 관계를 알아보고, MBTI(Myers-Briggs Type Inventory)의 성격유형과 이들의 상호관련성을 알아보려고 하였다. 방 법 : 가톨릭대학교 의과대학에 재학중인 63명의 의대생들을 대상으로 하여 자연최면경험에 대한 설문지와 MBTI를 작성하게 하고 최면유도척도로 최면을 유도하면서 최면유도점수와 유도점수를 얻었다. 결 과 : 1) 자연최면점수와 유도점수 사이에서 양의 상관관계가 있었고, 최면유도점수와 유도점수 사이에도 양의 상관관계가 있었다. 2) 자연최면점수와 최면유도점수 사이에서는 통계적으로 유의한 상관관계가 없었다. 3) MBTI의 각 성격유형들은 최면유도점수와 유도점수 사이에서 양의 상관관계가 있는 것으로 나타났다. 4) 외향형과 사고형의 성격유형은 자연최면점수와 최면유도점수에서 각각 양의 상관관계가 있었고, 자연최면점수와 유도점수 사이에서도 양의 상관관계가 있었다. 5) 직관형과 판단형은 자연최면점수와 유도점수 사이에서 각각 양의 상관관계를 보였다. 결 론 : 자연최면점수는 유도점수와 상관관계가 있었다. MBTI의 외향형과 사고형에서는 자연최면경험이 많을수록 최면유도가 잘 된다는 것을 시사하였다. Objective : We attempted to investigate the relation between naturally occurring hypnotic experiences and hypnotizability. We examined the correlations among hypnotic induction profile scores, natural hypnotic scores, induction scores and MBTI personality types. Methods : Sixty-three medical students completed NHQ(natural hypnotic questionnaire) developed from a list of naturally occuring hypnotic-like experiences and MBTI(Myers-Briggs Type Inventory). HIP(Hypnotic Induction Profile) was also administered to all the subjects. HIP score and IND(induction score) were obtained. Results : 1) The NHS(natural hypnotic score) was significantly correlated with IND in all the subjects. The IND also showed significant correlation with HIP score. 2) There was no significant correlation between NHS and HIP scores. 3) HIP scores were positively correlated with induction scores in all types of MBTI. 4) Natural hypnotic scores were positively correlated with HIP scores and induction scores in introvert and thinking types. 5) There were positive correlations between natural hypnotic scores and induction scores in intuition and judgment types. Conclusion : The natural hypnotic scores were correlated with induction scores. It is suggested that the more the naturally-occurring hypnotic experience is experienced, the better the hypnotic induction is induced in introvert and thinking types of MBTI personality types.

만성 부비동염에서 섬모운동과 전산화 단층촬영에서의 상악동 점막비후의 상관관계

민양기,전상준,이재서,이철회,이강수,윤자복,이원진,박광석 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7