Tropane Spirohydantoin들의 합성 및 구조분석

정대일,이도훈,송주현,이용균,최순규,박유미,한정태 동아대학교 환경문제연구소 2006 硏究報告 Vol.28 No.1

The tropane ring system is an important substructure in a number of natural products and synthetic compounds of biological and medicinal importance. As a result of the significance of the tropane ring system, the purpose of this study is the synthesis of anticonvulsant compounds of new s tructure anticipated anticonvulsant activity. After we first synthesized the various N-substituted nortropinone derivatives, we prepared new nortropane alkaloids and nortropinone derivatives. Substantially, we tried several experiments to optimize reaction condition. The tropane spirohydantoins 17, 18, 19, 20, 21 were respectively synthesized by the treatment of corresponding N-substituted nortropinone with potassium cyanide and ammonium carbonate.

쇼크 업소버의 소음 발생 요인과 진동감쇠 특성에 관한 연구

박태원,신귀수,이기형,김경모,정인성 한국산업안전학회 1998 한국안전학회지 Vol.13 No.4

Shock absorber has a great influence on the performance of the vehicle(ride comfort, manipulation, noise, vibration, turning, stability). Therefore, in this study we consider theoretically about general damper, variable damping oil damper, the control of vehicle Characteristics for the suspension, and undesirable phenomenon. And we measured the vibration/noise characteristics of shack absorber for the real car experimentation, strain change, and noise characteristics of shock absorber using experimental equipment. The study of domestic company and research institute on the vehicle shock absorber is active, but that of basis is not. So we think that they should be accomplished actively. Therefore, this paper will develop theoretical system on the vibration/noise characteristics of shock absorber by theoretical consideration and experimental result analysis of dynamic characteristics of shock absorber that were accomplished in this study. Then we will use it as the optimistic design data for shock absorber development.

최대운동시 항산화제 투여와 운동처지가 대사 및 근피로도에 미치는 영향

정성태,정덕조,전태원,최명동,이왕록 한국운동과학회 2000 운동과학 Vol.9 No.1

최대운동시 항산화제 투여와 운동처치가 대사 및 근피로도에 미치는 영향. 운동과학, 제 9권 제 1호. (137)-(148), 2000. 본 연구는 6주간의 항산화제 투여와 운동처치가 대사반응 및 하지근육의 근 피로도에 미치는 영향을 규명하는 것이었다. 본 연구의 목적을 달성하기 위하여 중학교 학생 27명을 대상으로 6주간의 항산화제 투여(비타민 E+C, 위약)와 운동처치(처치집단, 통제집단)를 실시하였다. 이상의 연구 절차를 통해 얻은 연구결과는 다음과 같다. 첫째, 6주간의 항산화제 투여(비타민 E+C, 위약)와 운동처치(처치집단, 통제집단)를 실시한 후, 각 집단간 운동지속시간을 비교한 결과는 항산화제를 투여한 집단에서 위약을 투여한 집단에 비해서 통계적으로 유의한 차이를 나타내었다(P<0.05). 둘째, 6주간의 합산화제 투여(비타민 E+C, 위약)와 운동처치(처치집단, 통제집단)를 실시한 후, 각 집단간 최대산소섭취량을 비교한 결과는 항산화제를 투여한 집단에서 위약을 투여한 집단에 비해서 통계적으로 유의한 차이를 나타내었다(P<0.05). 세째, 6주간의 항산화제투여(비타민 E+C, 위약)와 운동처치(처치집단, 통제집단)를 실시한 후, 각 집단간 근피로도(평균파워주파수)을 비교하였다. 각 집단간 평균파워주파수는 통계적으로 유의한 차이는 없었다. 이상의 결론을 종합해보면, 항산화 비타민 복합섭취는 운동수행력에 있어서 약간의 효과가 있는 것으로 나타났으나, 좀 더 정확한 결론을 내리기 위해서는 세포수준에서의 세일한 측정과 연구가 더 필요할 것이라고 제안한다.

확률론적 안전성평가를 위한 일반 기기 신뢰도 데이타 베이스 구축 절차와 적용

김길유,김태운,정원대,황미정,임태진 한국산업안전학회 1997 한국안전학회지 Vol.12 No.4

건설중이거나 기기 이력이 부족한 원자력 발전소에 대한 확률론적 안전성평가에 사용되는 일반 기기 신뢰도 데이타를 기 개발된 일반 데이타 및 발전소 데이타를 취합하여 구한다. 이를 위해 본 논문에서 사용한 계산 Code는 모수적 선험적 베이지안 방떱에 근거하여 3단계 베이지안 방법으로 한국원자력연구소에서 개발한 MPRDP Code이다. 일반 자교원에서 주로 자료를 취합하였으므로 각 문헌들 사이에 존재할 수 있는 종속성을 고려하여 Code에서 처리하였다. 본 논문에서는 결과로 얻어진 기기 신뢰도 자료표의 일부분을 보여준다. This paper presents the development procedure and application of the generic component reliability data base considering the dependency among dependent generic compendia in NPPs (Nuclear Power Plants) PSA (Probabilistic Safety Assessment) under construction or without operating history. We use MPRDP (Multi-Purpose Reliability Data Processor) code developed in KAERI (Korea Atomic Energy Research Institute) based on a PEB (Parametric Empirical Bayesian) procedure to estimate the reliability. The employed model in this study accounts for the relative credibility as well as the dependency among generic estimates. Numerical examples and the part of summarized reliability data table are provided as the application.

당뇨병 환자에서 발생한 감염증의 임상적 고찰

김형길,이상용,안혜진,박찬근,방규태,정동균,최조영 대한당뇨병학회 1990 Diabetes and Metabolism Journal Vol.14 No.2

Staged development of long-lived T-cell receptor αβ T_H17 resident memory T-cell population to <i>Candida albicans</i> after skin infection

Park, Chang Ook,Fu, Xiujun,Jiang, Xiaodong,Pan, Youdong,Teague, Jessica E.,Collins, Nicholas,Tian, Tian,O'Malley, John T.,Emerson, Ryan O.,Kim, Ji Hye,Jung, Yookyung,Watanabe, Rei,Fuhlbrigge, Robert C Elsevier 2018 The Journal of allergy and clinical immunology Vol.142 No.2

<P><B>Background</B></P> <P> <I>Candida albicans</I> is a dimorphic fungus to which human subjects are exposed early in life, and by adulthood, it is part of the mycobiome of skin and other tissues. Neonatal skin lacks resident memory T (T<SUB>RM</SUB>) cells, but in adults the <I>C albicans</I> skin test is a surrogate for immunocompetence. Young adult mice raised under specific pathogen-free conditions are naive to <I>C albicans</I> and have been shown recently to have an immune system resembling that of neonatal human subjects.</P> <P><B>Objective</B></P> <P>We studied the evolution of the adaptive cutaneous immune response to <I>Candida</I> species.</P> <P><B>Methods</B></P> <P>We examined both human skin T cells and the <I>de novo</I> and memory immune responses in a mouse model of <I>C albicans</I> skin infection.</P> <P><B>Results</B></P> <P>In mice the initial IL-17–producing cells after <I>C albicans</I> infection were dermal γδ T cells, but by day 7, αβ T<SUB>H</SUB>17 effector T cells were predominant. By day 30, the majority of <I>C albicans</I>–reactive IL-17–producing T cells were CD4 T<SUB>RM</SUB> cells. Intravital microscopy showed that CD4 effector T cells were recruited to the site of primary infection and were highly motile 10 days after infection. Between 30 and 90 days after infection, these CD4 T cells became increasingly sessile, acquired expression of CD69 and CD103, and localized to the papillary dermis. These established T<SUB>RM</SUB> cells produced IL-17 on challenge, whereas motile migratory memory T cells did not. T<SUB>RM</SUB> cells rapidly clear an infectious challenge with <I>C albicans</I> more effectively than recirculating T cells, although both populations participate. We found that in normal human skin IL-17–producing CD4<SUP>+</SUP> T<SUB>RM</SUB> cells that responded to <I>C albicans</I> in an MHC class II–restricted fashion could be identified readily.</P> <P><B>Conclusions</B></P> <P>These studies demonstrate that <I>C albicans</I> infection of skin preferentially generates CD4<SUP>+</SUP> IL-17–producing T<SUB>RM</SUB> cells, which mediate durable protective immunity.</P>

한우 사골, 꼬리, 우족 및 잡뼈 추출물의 이화학적 특성

이진규(J. K. Lee),정지택(J. T. Jeong),최정석(J. S. Choi1),정명옥(M. O. Jung),최양일(Y. I. Choi) 충북대학교 동물생명과학연구소 2017 동물생명과학연구 Vol.9 No.-

This study was conducted to investigate the physico-chemical characteristics of various bone extracts in Hanwoo cattle. The experimental materials are as follows; T1(Shank bone extract), T2(Tail extract), T3(Beef feet extract), and T4(The other bones extract). In the proximate composition, the T1 and T2 showed higher moisture and fat contents than those of T3 and T4(p<0.05), and the T3 had the highest protein content among the bone extracts(p<0.05). The quality properties including salinity, sugar content, turbidity and yellowness(b*) values were significantly higher in the T3 than the other bone extracts(p<0.05). However, the pH value of T3 was significantly lower than the other bone extracts. In the mineral contents, calcium contents of bone extracts were 36.33-48.57mg/kg, and the content of phosphorus was the lowest in T1(4.62mg/kg) and T2(19.88mg/kg) was the highest(p<0.05). Contents of sodium and potassium were the highest in T3(215.83mg/kg) and T2(54.59mg/kg), while the content of magnesium was the lowest in T3(12.28mg/kg). In conclusion, these results could be suggested to be the basis information for processed meat extract products industry in korea using Hanwoo bone extract.

Seroprevalence of Toxoplasma gondii and Trichinella spiralis infections in wild boars (Sus scrofa) in Korea

Kang, S.W.,Doan, H.T.T.,Noh, J.H.,Choe, S.E.,Yoo, M.S.,Kim, Y.H.,Reddy, K.E.,Nguyen, T.T.D.,Van Quyen, D.,Nguyen, L.T.K.,Kweon, C.H.,Jung, S.C. Elsevier 2013 Parasitology international Vol.62 No.6

Toxoplasma gondii and Trichinella spiralis are important zoonotic pathogens with worldwide distributions. In Korea, several outbreaks of human toxoplasmosis and trichinellosis due to the consumption of infected wild animals have been reported. The purpose of this study was to determine the seroprevalence of T. gondii and T. spiralis infections in wild boars killed in Korea from December 2009 to October 2011. A total of 521 wild boars hunted in eight provinces were examined for antibodies to T. gondii and T. spiralis by using commercial ELISA kits. Overall, 25.1% of serum samples from individual boars were seropositive for T. gondii and 1.7% were seropositive for T. spiralis. Seropositive for T. gondii was found in the boars in all the eight provinces investigated and for T. spiralis in four provinces. This is the first report on the seroprevalence of T. gondii and T. spiralis infections in wild boars in Korea. The consumption of undercooked wild boar meat may expose humans to a high risk of infection.

T-Type Calcium Channels Are Required to Maintain Viability of Neural Progenitor Cells

Kim, Ji-Woon,Oh, Hyun Ah,Lee, Sung Hoon,Kim, Ki Chan,Eun, Pyung Hwa,Ko, Mee Jung,Gonzales, Edson Luck T.,Seung, Hana,Kim, Seonmin,Bahn, Geon Ho,Shin, Chan Young The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.5

T-type calcium channels are low voltage-activated calcium channels that evoke small and transient calcium currents. Recently, T-type calcium channels have been implicated in neurodevelopmental disorders such as autism spectrum disorder and neural tube defects. However, their function during embryonic development is largely unknown. Here, we investigated the function and expression of T-type calcium channels in embryonic neural progenitor cells (NPCs). First, we compared the expression of T-type calcium channel subtypes (CaV3.1, 3.2, and 3.3) in NPCs and differentiated neural cells (neurons and astrocytes). We detected all subtypes in neurons but not in astrocytes. In NPCs, CaV3.1 was the dominant subtype, whereas CaV3.2 was weakly expressed, and CaV3.3 was not detected. Next, we determined CaV3.1 expression levels in the cortex during early brain development. Expression levels of CaV3.1 in the embryonic period were transiently decreased during the perinatal period and increased at postnatal day 11. We then pharmacologically blocked T-type calcium channels to determine the effects in neuronal cells. The blockade of T-type calcium channels reduced cell viability, and induced apoptotic cell death in NPCs but not in differentiated astrocytes. Furthermore, blocking T-type calcium channels rapidly reduced AKT-phosphorylation (Ser473) and $GSK3{\beta}$-phosphorylation (Ser9). Our results suggest that T-type calcium channels play essential roles in maintaining NPC viability, and T-type calcium channel blockers are toxic to embryonic neural cells, and may potentially be responsible for neurodevelopmental disorders.

T-Type Calcium Channels Are Required to Maintain Viability of Neural Progenitor Cells

( Ji-woon Kim ),( Hyun Ah Oh ),( Sung Hoon Lee ),( Ki Chan Kim ),( Pyung Hwa Eun ),( Mee Jung Ko ),( Edson Luck T. Gonzales ),( Hana Seung ),( Seonmin Kim ),( Geon Ho Bahn ),( Chan Young Shin ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.5

T-type calcium channels are low voltage-activated calcium channels that evoke small and transient calcium currents. Recently, T-type calcium channels have been implicated in neurodevelopmental disorders such as autism spectrum disorder and neural tube defects. However, their function during embryonic development is largely unknown. Here, we investigated the function and expression of T-type calcium channels in embryonic neural progenitor cells (NPCs). First, we compared the expression of T-type calcium channel subtypes (CaV3.1, 3.2, and 3.3) in NPCs and differentiated neural cells (neurons and astrocytes). We detected all subtypes in neurons but not in astrocytes. In NPCs, CaV3.1 was the dominant subtype, whereas CaV3.2 was weakly expressed, and CaV3.3 was not detected. Next, we determined CaV3.1 expression levels in the cortex during early brain development. Expression levels of CaV3.1 in the embryonic period were transiently decreased during the perinatal period and increased at postnatal day 11. We then pharmacologically blocked T-type calcium channels to determine the effects in neuronal cells. The blockade of T-type calcium channels reduced cell viability, and induced apoptotic cell death in NPCs but not in differentiated astrocytes. Furthermore, blocking T-type calcium channels rapidly reduced AKT-phosphorylation (Ser473) and GSK3β-phosphorylation (Ser9). Our results suggest that T-type calcium channels play essential roles in maintaining NPC viability, and T-type calcium channel blockers are toxic to embryonic neural cells, and may potentially be responsible for neurodevelopmental disorders.