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진홍률,양상권,최영석 충북대학교 의과대학 충북대학교 의학연구소 1999 忠北醫大學術誌 Vol.9 No.2
비성형수술에 삽입하는 사용물로는 자가연골이 가장 이상적이지만 필요한 만큼의 충분한 양을 얻기가 힘들고, 수술시간이 길어지며, 흡수가 일어날 수 있다는 단점이 있다. 이러한 단점을 극복할 수 있는 이종이식물 중에서 고어텍스는 최근에 개발되어 사용이 점차 증가하고 있는 추세이지만 아직까지 고어텍스의 임상적 효용성에 대한 보고는 드물다. 저자들은 고어텍스를 5명의 융비술 환자에서 사용하였는데 3명은 연골과 같이, 2명은 고어텍스 단독으로 사용하였다. 이 중 1명에서 감염이 발생하여 고어텍스를 제거하고 늑연골을 이용하여 융비술을 다시 시행하였고 나머지 4명은 모두 만족스러운 결과를 얻었다. 평균 20개월의 추적관찰에서 이식물의 이동이나 탈출, 피부의 손상 등의 큰 부작용이 없어 고어텍스가 비성형, 특히 융비술에 유용하다고 판단되어 관련문헌 고찰과 함께 보고하는 바이다. Though autogenous cartilage remains the ideal graft material in nasal surgery, situations exist where an alternative or an additional grafting material is needed. Gore-Tex is one of most recently developed alloplastic material and has been widely used for rhinoplasty. But there are few reports about the clinical efficacy of this material in rhinoplasty. The authors used Gore-Tex as a nasal implant in 5 cases of augmentation rhinoplasty. In three patients, the Gore-Tex was used with septal or conchal cartilages because the cartilages were not enough for the needed augmentation. In one patient, the implant was removed due to postoperative infection and subsequent augmentation was done with autogenous rib catilage after infection control. During average 20 months of follow-up, complications such as absorption, mobilization, or extrusion of the implant and thinning of the nasal skin were not found. All patients were satisfied with the surgical results. From these results, Gore-Tex can be considered as an effective material in augmentation rhinoplasty when autogenous material is not available or is not sufficient for the proper augmentation.
柳忠烈,梁慶嬉,李相遠,金仁洙 釜山大學校 師範大學 1996 교사교육연구 Vol.33 No.-
Tectonic investigation is very important to understand the seismic environments. Many strong seismic activities are found to be closely related with pre-existed discontinuous planes of the crust, such as faults. Here we describe an example of the Quaternary faults occurring in the vicinity of the Ulsan fault near Ipshil-ri, Oedong-up, Ky o ∨ ngju city to enlight a seismic activity evaluation. This fault is thought to be the contact boundary between the Cretaceous to early Tertiary granite and andesite, and also cut the Quaternary formation which unconformably overlies granite and andesite. General strike of the fault plane is N-S, dipping 70° to the east. Along this fault plane, two different faulting events are distinguished; (1) reverse faulting with up to 5m of displacement in the Quaternary formation, and (2) normal faulting with 50° northerly plunging striation within the Quatenary fault plane. We suggest that these faultings are related to the WNW-ENE compressional tectonic environments during late Quaternary, and to the readjustment of accumulated strains by the pre-compressional tectonic environments. The age of the Quaternary formation is not fully investigated, however, this Quaternary fault is probably one of the active faults which has been rarely described in Korea.
Reconstituting Human Cutaneous Regeneration in Humanized Mice under Endothelial Cell Therapy
Yang, Heung-Mo,Choi, Jong-Jin,Kim, Ha-Na,Yang, Seung Jip,Park, Soon-Jung,Kang, Changhee,Chung, Hyung-Min,Lee, Man Ryul,Kim, Sung Joo,Moon, Sung-Hwan Elsevier 2019 The Journal of investigative dermatology Vol.139 No.3
Clinical application of whole-genome sequencing of solid tumors for precision oncology
Kim Ryul,Kim Seokhwi,Oh Brian Baek-Lok,Yu Woo Sik,Kim Chang Woo,Hur Hoon,Son Sang-Yong,Yang Min Jae,Cho Dae Sung,Ha Taeyang,Heo Subin,Jang Jeon Yeob,Yun Jae Sung,Kwack Kyu-Sung,Kim Jai Keun,Huh Jimi,L 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Genomic alterations in tumors play a pivotal role in determining their clinical trajectory and responsiveness to treatment. Targeted panel sequencing (TPS) has served as a key clinical tool over the past decade, but advancements in sequencing costs and bioinformatics have now made whole-genome sequencing (WGS) a feasible single-assay approach for almost all cancer genomes in clinical settings. This paper reports on the findings of a prospective, single-center study exploring the real-world clinical utility of WGS (tumor and matched normal tissues) and has two primary objectives: (1) assessing actionability for therapeutic options and (2) providing clarity for clinical questions. Of the 120 patients with various solid cancers who were enrolled, 95 (79%) successfully received genomic reports within a median of 11 working days from sampling to reporting. Analysis of these 95 WGS reports revealed that 72% (68/95) yielded clinically relevant insights, with 69% (55/79) pertaining to therapeutic actionability and 81% (13/16) pertaining to clinical clarity. These benefits include the selection of informed therapeutics and/or active clinical trials based on the identification of driver mutations, tumor mutational burden (TMB) and mutational signatures, pathogenic germline variants that warrant genetic counseling, and information helpful for inferring cancer origin. Our findings highlight the potential of WGS as a comprehensive tool in precision oncology and suggests that it should be integrated into routine clinical practice to provide a complete image of the genomic landscape to enable tailored cancer management.