전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

다수의 동일한 입력원을 갖는 ATM Multiplexer의 정확한 셀 손실 확률 분석

최우용,전치혁 한국경영과학회 1995 한국경영과학회 학술대회논문집 Vol.- No.1(2)

We propose a new approach to the calculation of the exact cell loss probability in a shared buffer ATM multiplexer, which is loaded with homogeneous discrete-time ON-OFF sources. Renewal cycles are identified in regard to the state of input sources and the buffer state on each renewal cycle is modelled as a K(shared buffer size)-state Markov chain. We also analyze the behavior of queue build-up at the shared buffer whose distribution together with the steady-state probabilities of the Markov chain leads to the exact cell loss probability. Our approach to obtaining the exact cell loss probability seems to be more efficient than most of other existing ones since our underlying Markov chain has less number of states.

한약수치에 관한 연구(제 9보) : 炒甘草 제법의 표준화 및 규격화(1) Preparing Standardization and Regulation of Stir-Frying Glycyrrhzia root(1)

최혁재,이우정,박성환,송보완,김동현,김남재 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

In this study, We carried out the preparing standardization and regulation of processed Glycyrrhizae Radix(PGR) which have been widely used in oriental medicines. Glycyrrhizae Radix(GR) have been generally prepared by the stir-frying, or mix-frying with honey for purpose of decreasing sweetness and augmenting vitality. Firstly, we tried to standardize PGR prepared by the stir-frying. We purchased 14 kinds of PGR and non-processed GR(NPGR) at oriental physician's offices and oriental pharmacies on a nation scale, respectively. The amounts of dry on loss, water extract, diluted ethanol extract, ether extract, total ash, acid insoluble ash, glycyrrhizin(GL), glycyrrhetic acid(GA) and liquiritin(LQ) of them were examined. The amounts of dray on loss, GL and LQ in commercial PGRs showed remarkable decrease, while GA showed increase as compared with NPGR. In order to standardize preparing method of PGR, the effect of heating time on physico-chemical parameters and biological activities were examined. Physico-chemical parameters such as dry on loss, extract amount, GL and LQ contents in PGRs showed decrease, however, GA was increased with heating time as compared with NPGR. Also, GA obtained form heat-treated GR, was found as an artifact in PGRs. PGR was more effective than NPGR in vitro test of DPPH scavenging effect and TBA-Rs reducing effect. PGR and NPGR showed potent hepatoprotective effect on CCl_(1)-intoxicated rats. Especially, PGR prepared by 80 min of heating was the most effective. Considering these results, the optimal condition for PGR preparation was 150℃ for 80min.

Lowe 증후군 환아의 전신마취를 이용한 치료증례보고

장우혁,이긍호,최영철 大韓小兒齒科學會 2002 大韓小兒齒科學會誌 Vol.29 No.2

Lowe 증후군 또는 안뇌신증후군(oculocerebrorenal syndrome)은 X-염색체와 관련된 유전성 질환으로, 반성열성유전양상을 나타낸다. 선천성 백내장과 녹내장 등의 증상, 근긴장 저하, 건반사감소 등의 근신경계 증상, 신장 기능이상이 가장 특징적인 임상증상이며, 이외에도 정신 지체, 성장지연, 전두부 융기, 가늘고 성긴 모발, 돌출된 귀, 골질환 등이 발생할 수 있다. Lowe증후군 환자는 정신지체로 인해 치과치료시 전신마취하에서의 처치가 요구되나, 대사성 산증, 악성고열의 발생위험과 사용약제의 의한 부작용 등이 위험요소로 작용할 수 있으므로, 필요한 경우 내과 또는 소아과 의료진이 참여된 협진체제 하에서 가능한 짧은 시간 진행되어야 한다. 이러한 치과적 처치의 어려움으로 Lowe증후군 환자에서 치과질환의 예방이 좀더 강조되어야 하며, 이를 위해 보호자의 주위의 적극적 관리가 요구된다. Lowe syndrome, also known as oculocerebrorenal syndrome, is a rare genetic disorder involving eyes, kidney and nervous system, and occurs predominantly in mostly males. The patients with Lowe syndrome are charac-terized with prominent forehead, thin and sparse hair, protruding ears, congenital cataracts, glaucoma, mental retardation, stunted growth, hypotonia, decrease in muscle mass and tendon reflexes, renal tubular dysfunction, and metabolic bone disease. A 6-year-old boy with Lowe syndrome was admitted to our clinic, with multiple caries and a chief complaint of intermittent pain on the left mandibular molar area. Because of difficulty in management of behavior and his medical problem, general anesthesia was performed for dental care. No specific complication was noticed during dental treatment procedure under general anesthesia and also during periodic recall-checks. General anesthesia itself, however, could be a potentially life-threatening procedure due to patient's biomed-ical problems. When a dental procedure under general anesthesia is to required in patient with Lowe syn-drome, it may be advisable being teamed with physicians, and general anesthesia duration should be as short as possible.

ATM 스위치의 쎌 손실율 추정을 위한 Hybrid 시뮬레이션 기법

김지수,최우용,전치혁 한국경영과학회 1996 韓國經營科學會誌 Vol.21 No.3

An ATM switch must deal with various kinds of input sources having different traffic characteristics and it must guarantee very small value of cell loss probability, about 10^-8~10^-12, to deal with loss-sensitive traffics. In order to estimate such a rare event probability with simulation procedure, a variance reduction technique is essential for obtaining an appropriate level of precision with reduced cost. In this paper, we propose a hybrid simulation technique to achieve reduction of variance of cell loss probability estimator, where hybrid means the combination of analytical method and simulation procedure. A discrete time queueing model with multiple input sources and a finite shared buffer is considered, where the arrival process at an input source is governed by an Interrupted Bernoulli Process and the service rate is constant. We deal with heterogeneous input sources as well as homogeneous case. The performance of the proposed hybrid simulation estimator is compared with those of the raw simulation estimator and the importance sampling estimator in terms of variance reduction ratios.

한약수치에 관한 연구(제 8보) : 오수유 탕포법 The Changes of Physico-chemical Parameter and Biological Activities by Processing of Evodia Fruit

박성환,이우정,최혁재,송보완,김동현,김남재 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

We have studied the physico-chemical change and pharmacological transformation of traditional herbal medicines with processing. Evodia fruit (EF) has processed for the purpose of detoxification and reduction of its bitter taste. There are various methods of processing EF in Oriental medicinal references. Among them, we processed EF according to the method of Sang-han theory, the most famous medicinal reference. We processed EF with washing in hot water, and then dried. Processed EFs(PEFs) were prepared according to the above procedure through repetition of 1,3,5 and 7 times respectively. The contents of weight loss, water extract, diluted ethanol extract, ether extract, total ash, acid insoluble ash, alkaloids and limonin in non-processed EF (NPEF) and PEFs were examined. The weight loss, and contents of water extract and dilute ethanol extract in PEF showed decrease in proportion to increase of washing time, while the contents of ether extract, total ash and acid insoluble ash showed little change as compared with those of NPEF. And the content of evodiamine and rutaecarpine was not changed distinctly. However, the content of limonin decreased in the final processed material in proportion to increase of washing times with hot water. And the intense of bitter taste in PEF was also reduced. These results were ascribed to the flowing-out of the water-soluble portion. The biological activities of NPEF and PEF were also investigated. In the test of DPPH scavenging effect, xanthine oxidase inhibition effect and TBA-Rs effect, PEF was more effective than NPEF in vitro. Also, both NPEF and PEF showed potent analgesic and anti-inflammatory effects against in mice. Especially, PEF by 3 times washing with hot water was more effective than other PEFs. From these results, it is considered that PEF should be prepared by 3 times washing with hot water.

부하분산 및 결함허용을 제공하는 CORBA 기반 원격 회의 시스템 설계

성재철,임주혁,장우혁,조찬윤,최항묵 인제대학교 1999 仁濟論叢 Vol.15 No.1

인터넷 및 통신 기술의 발달에 따라 원격 회의 시스템이나 원격 교육, 가상 대학과 같은 응용에 대한 연구가 활발히 진행되고 있다. 이와 판은 시스템에 기존의 중앙 집중 방식을 사용할 경우에는 서버측의 부하가 모두 집중되어 전체 시스템에 영향을 미치게 될 수 있으므로 분산 시스템을 이용한 연구가 활발히 진행되고 있다. 본 논문에서는 이미지나 텍스트-파일과 같은 자료를 필요로 하는 원격 회의 시스템을 설계하고 Factory 객체와 관계형 통합 데이터 베이스를 이용하여 동적 부하 분산과 동적 결함 허용을 제공하는 시스템을 제안한다. As the technigues of the Interned and Communication are developed, the study about its applications such as Remote Conference system, Remote Education and Cyber University are lively progressing. When the centralized method is applied to those kinds of system mentioned above, the load is mostly occurred in the server side anaitcauas bad effect to the whole system. So the Study about an application such as Remote Conference system, Remote Education and Cyber University is considering using the distributed system. In this paper I would like design a Remote Conference System is soogetled, which needs sub data like images, text files and givers dynamic load balance and dynamic fault tolerance using Factory object and Relational Integrated Data Base.

종골 골절 치료에 있어서의 전산화 단층 촬영의 유용성

김학준,하권익,윤정로,심재익,김택선,김영배,이우승,최재혁 대한골절학회 2003 대한골절학회지 Vol.16 No.4

History, Classes and Mechanism of MonocIonal Antibodies as Cancer Therapeutics

Woo-Hyuck Choi and Sang Kyum Kim 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

Monoclonal antibodies (mAbs) for use as therapeutics for various diseases, especially cancer, have been extensively investigated and developed in recent decades. Since the first appearance of murine mAbs which are of fulIy murine structure, several antibody formats such as chimeric, humanized, and ones comprising fully human structure have been presented consecutively. These advances were mainly stemmed from the efforts to mitigate the immunogenic potential of this category of drug. Owing to their long half-life and versatility in ef-fecter functions, IgG1 is most frequently selected for the backbone of therapeutic mAbs. Among the various ef-feclor functions by which IgG exert their designated role as therapeutics, antibody-dependent cellular cytotoxicity is commonly utilized to take care of tumorigenesis by virtue of its effectiveness in killing cancer cells‘ Recently, approaches to strengthen power of native rnAbs have been developed, which include conjugation of antibody with various effector molecules and antibodies armed with moieties targeting more than one epitopes. Several mole-cules specifically overexpressed in tumorigenic state, such as ErbB family proteins, VEGF, cytotoxic T Iympho-cyte-associated antigen 4, CD20, have been targeted by various successful therapeutic rnAbs. While mAbs have lots of advantages compared to small molecules as therapeutics, they are readily immunogenic which lead them to lose activity or induce hypersensitivity reactions. With several novel formats or modifications other than original immunoglobulin structure, mAbs are still evolving and expanding their roles as anti-cancer therapeutics

Antigenicity of HM10760 in Guinea Pigs

Choi, Woo-Hyuck,Lee, Sung-Hak,Lee, Mi-Chael,Chung, Moon-Ku,Kwon, Se-Chang,Lee, Gwan-Sun,Han, Jae-Yong,Koh, Woo-Suk Korean Society of ToxicologyKorea Environmental Mu 2005 Toxicological Research Vol.21 No.3

HM10760 is a recombinant human erythropoietin that has beer developed as a drug for anemia. In this study, antigenic potential of HM10760 was examined by active systemic anaphylaxis in guinea pigs and passive cutaneous anaphylaxis in a guinea pig-guinea pig system. HM10760 was subcutaneously administered at 0, 2, and $20{\mu}g/kg$ and also as a suspension with adjuvant ($20{\mu}g/kg$ + FCA). Ovalbumin as a suspension with adjuvant was administered to induce positive control responses. In the active systemic anaphylaxis test, no symptoms except rubbing or licking nose and urination that were considered as physiological phenomena were observed at $0{\mu}g/kg$. Four of 5 animals at $2{\mu}g/kg$ and all the 5 animals at $20{\mu}g/kg$ showed cyanosis and lying on side. All animals in the adjuvant mixture group showed relatively mild symptoms such as rubbing or licking nose, urination, and evacuation. In the passive cutaneous anaphylaxis test, 0/5, 3/5, and 5/5 serum samples from the animals immunized with 0, 2, and $20{\mu}g/kg$, respectively, showed positive reactions against HM10760. All 5 sera collected from the animals immunized with an adjuvant mixture contained HM10760-specific antibodies. These results suggest HM10760 have antigenicity in guinea pigs.