Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

Effects of Chungkookjang Extract on Growth Hormone Secretion from GH3 Mouse Pituitary Cell and Growth Hormone Receptor Signaling Pathway

Sun Il Choi(최선일),Ji Eun Kim(김지은),In Sik Hwang(황인식),Hye Ryun Lee(이혜련),Young Ju Lee(이영주),Hong Joo Son(손홍주),Dong Seob Kim(김동섭),Kyu Min Park(박규민),Dae Youn Hwang(황대연) 한국생명과학회 2012 생명과학회지 Vol.22 No.9

뇌하수체 전엽에서 성장호르몬의 생산과 분비는 세포의 분열과 분화 그리고 이동을 조절하는 몇 가지 천연물질에 의해 유도된다. 따라서 발효과정을 통해 제조된 청국장이 성장호르몬의 대사에 미치는 영향을 평가하기 위하여 성장호르몬 분비능과 반응성을 뇌하수체 세포와 성장호르몬 표적세포에서 관찰하였다. 6가지 종류의 콩 품종으로 제조된 청국장 추출물 중에서, 대원, 대풍, 태광의 3종류 청국장 추출물은 5 mg/ml 농도에서 GH3 세포로부터 성장호르몬의 분비를 촉진하였다. 비록 세포 생존능은 이러한 추출물에 의해 유의적인 변화가 유도되지 않았으나, 성장호르몬의 분비량은 청국장 추출물의 농도에 의존적으로 증가하였다. 또한 성장호르몬의 표적 기관으로부터 유래된 MG63과 HepG2 세포는 GH3로부터 수집된 조건적 배양액에 의해 유의적으로 활성화되었다. 또한 이러한 세포에서 STAT5 발현은 대원 청국장 추출물을 처리 후, 15분 혹은 30분부터 세포질에서 유의적으로 증가하였으며, p-STAT5는 핵에서 30분 혹은 60분부터 증가하였다. 따라서 이러한 결과는 3가지 종류의 청국장 추출물은 성장호르몬의 분비를 촉진시키며, 청국장의 조건적 배양액은 성장호르몬 표적세포에서 신호전달을 유도함을 제시하고 있다. The production and secretion of growth hormone (GH) in the anterior pituitary gland can be induced by several natural products to control cell proliferation, differentiation, and migration. To investigate whether Chungkookjang (CKJ) produced by the fermentation process affects GH-related metabolism, the secretion and the response of GH were observed in pituitary cells and GH target cells. Among six CKJs manufactured by different strains of glycine max, only three CKJs, including Daewon (DW), Daepung (DP), and Taegwang (TG), induced GH secretion from GH3 cells at 5.0 mg/ml concentration. There were no significant changes detected in the viability of any of the cells treated with these CKJs. In addition, the increase in GH secretion from the GH3 cells was dependent on the concentration of the three types of CKJs. The proliferation of cell lines, including MG63 and HepG2 cells, that originated from those derived from the GH target organs was significantly activated by treatment with the GH-containing conditional medium (GCM) harvested from the three CKJ-treated GH3 cells, although their induction rate was different from each other. In these cells, p-STAT5 was maximally translocated into the nucleus of MG63 cells 30 min after DW treatment, while it was translocated in HepG2 cells at 60 min. These results suggest that these three types of CKJ could enhance the secretion of GH, as well as the GCM-derived response, in the two target organs.

Effects of a High-Intensity Interval Physical Exercise Program on Cognition, Physical Performance, and Electroencephalogram Patterns in Korean Elderly People: A Pilot Study

Lee Sun Min,Choi Muncheong,전병오,Sun Kyunghwa,Kim Ki Sub,Kang Seung Wan,Song Hong-Sun,Moon So Young 대한치매학회 2022 Dementia and Neurocognitive Disorders Vol.21 No.3

Background and Purpose: The effects of high-intensity interval training (HIIT) interventions on functional brain changes in older adults remain unclear. This preliminary study aimed to explore the effect of physical exercise intervention (PEI), including HIIT, on cognitive function, physical performance, and electroencephalogram patterns in Korean elderly people. Methods: We enrolled six non-dementia participants aged >65 years from a community health center. PEI was conducted at the community health center for 4 weeks, three times/week, and 50 min/day. PEI, including HIIT, involved aerobic exercise, resistance training (muscle strength), flexibility, and balance. Wilcoxon signed rank test was used for data analysis. Results: After the PEI, there was improvement in the 30-second sit-to-stand test result (16.2±7.0 times vs. 24.8±5.5 times, p=0.027), 2-minute stationary march result (98.3±27.2 times vs. 143.7±36.9 times, p=0.027), T-wall response time (104.2±55.8 seconds vs.71.0±19.4 seconds, p=0.028), memory score (89.6±21.6 vs. 111.0±19.1, p=0.028), executive function score (33.3±5.3 vs. 37.0±5.1, p=0.046), and total Literacy Independent Cognitive Assessment score (214.6±30.6 vs. 241.6±22.8, p=0.028). Electroencephalography demonstrated that the beta power in the frontal region was increased, while the theta power in the temporal region was decreased (all p<0.05). Conclusions: Our HIIT PEI program effectively improved cognitive function, physical fitness, and electroencephalographic markers in elderly individuals; thus, it could be beneficial for improving functional brain activity in this population.

적외선 체열촬영을 이용한 온천요법에 관한 임상적 연구

이정민 ( Jung Min Lee ),뱍인선 ( In Sun Park ),안택원 ( Taek Won Ahn ),홍서영 ( Seo Young Hong ) 한방재활의학과학회 2012 한방재활의학과학회지 Vol.22 No.1

Objectives :The purpose of this study was to investigate the influence of balneotherapy on the changes of DITI(digital infrared thermal imaging). Methods :This study was carried out on 27 patients. They went through balneotherapy with high pressure under water shower(15 min.) and whole body bathing in neutral or hot water between 32 to 40 ℃(15 min.). DITI was measured at before and after the treatment. And then the data was analyzed. Results :1. In cold hypersensitivity of hands group, temperature on PC8 rose and difference between LU4 and PC8 decreased(p<0.05)(Fig. 1, Table Ⅱ). 2. In cold hypersensitivity of feet group, temperature on LR3 rose and difference between ST32 and LR3 decreased(p<0.05)(Fig. 2, Table Ⅱ). 3. In shangrexiahanzheng(上熱下寒證) group, there were no significant changes on CV17, CV6 and difference between CV17 and CV6(Fig. 3, Table Ⅱ). Conclusions :These results demonstrated that balneotherapy has clinical effects on cold hypersensitivity of hands and feet. And further studies are required to apply the balneotherapy in order to cure various diseases in the future.

NO(Nitric Oxide)에 의한 이자의 외분비 조절작용

한유미,김병무,민본홍,박인선 대한해부학회 2000 Anatomy & Cell Biology Vol.33 No.5

장중첩증을 동반한 맹장 지방종 1예

홍의실,나병규,김민옥,유일영,채지영,채희복,윤세진,이상전,송형근,박길선,정현용 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

대장 지방종은 주로 우측 결장에 호발하고 특히 회맹판 부위와 맹장 부위에 호발한다. 또한 50~60대에 빈도가 높고 증상이 있는 환자에서 장중첩증이 높게는 40~50%에서 보고되고 있어 성인 장중첩증의 원인으로 중요한 비중을 차지한다. 특히 성인 장중첩증 및 장폐쇄의 중요 원인인 악성 종양과 임상 양상이 유사하여 감별진단이 중요하다. 저자들은 반복적인 복통을 주소로 내원한 환자에서 맹장의 4×5㎝의 점막하 지방종이 말단 회장부위와 반복적인 장중첩중이 발생했던 1례를 부분 절제술로 치료하여 양호한 임상 경과를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Lipomas are one of the most common benign nonepithelial tumors of the colon which are often detected incidentally by radiologic investigation or on operation. These tumors are usually without specific symptoms. Colonic lipomas occur most often in the right colon, particularly in the ileocecal valve and the cecum. Most patients are asymptomatic. but tumors larger than 2 cm tend to produce a change in bowel habit. abdominal pain. rectorrhagia and complications including luminal obstruction or intestinal intussusception. Diagnosis can be made by colonoscopy abdominal CT. MRI, or barium enema. We report a case of lipoma of the cecum that originated in the submucosa and presented as a intussusception in a 50-year-old woman with a brief review of the literature.

中學 科學敎育의 探究學習에 대한 評價問項 開發 (Ⅱ)

閔庚德,楊洪準,李善行,鄭遠佑,이병교,金裕漢,羅長薰 경북대학교 과학교육연구소 1985 科學敎育硏究誌 Vol.9 No.-

This study was accomplished to develope the evaluation items for inquiry learning in the 2nd grade Middle School Science for the consecutive study of the evaluation items for inquiry learning in the 1st grade Middle School Science(U-Hang Ki et al, 1984). In this study, paper and pencil test items and performance test items are made by analyzing the abilities of inquiry according to the contents and four basic experiments from each unit in the 2nd grade Middle school science. These evaluation items were applied to tke five classes of the 2nd grade of middle school to test their validity. It is desirable that performance test schuld be used for the evaluation for the abilities of inquiry which can not be evaluated by paper and pencil test. In the evaluation methods of performance test, tester evaluation, peer evaluation and self-evaluation can be applied to the science class in a multi-student class. In higher grade, however tester evaluation is more desirable than peer and self evaluation. It is found that peer evaluation and self-evaluation make possible the perfect study by feedback.

수질감시를 위한 조류의 형광성과 DO변화의 금속독성 평가

閔善泓 三陟大學校 2001 論文集 Vol.34 No.2

Ecotoxicological pollutants are monitored by biological monitoring system combining or substituting physical chemical and mechanical system in waste water discharge monitoring for the river water quality control and water supply monitoring for purification of water. In spite of many studies on development of water quality auto-monitoring to solve these problems, informations about selection of test species, test conditions, and ecotoicological characteristics are not enough to apply to practical monitoring. In this study, Selenastrum capricornutum is recommended to water quality monitoring species and the standardized test methods and conditions are proposed. Using Chlorella fusca, Chlorella sacchrophila, Scenedesmus basiliensis, Scenedesmus qua-dricauda, Selenastrum capricornutum, Microcystis aeruginosa and Anabaena flos-aquae fluorescence responses by metal toxicity are analyzed to prove the sensitivity. Fluorescence response of S. capricornutum is the most stable among examined algae. Toxic response is sensitive at low algal concentration, stable and sensitive between algal con-centration 20 and 150.

산화구리 촉매담지 세라믹 캔들필터를 이용한 NO 제거

홍민선,문수호,이재춘,이동섭 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.3

The CuO/3Al₂O₃ㆍ2Si0₂ catalyst impregnated ceramic candle filters for nitrogen oxides removal were prepared by porous mullite(3Al₂O₃ㆍ2Si0₂) support and CuO catalyst deposited on this support to achieve uniformly dispersed CuO deposition, which arc impregnated into the pores of available alumino-silicate ceramic candle filter. The CuO/3Al₂O₃ㆍ2Si0₂ catalyst impregnated ceramic candle filters were characterized by XRD, BET, air permeability, pore size, SEM and catalytic tests in the reduction of NOx by NH₃. The observed effects of CuO/3Al₂O₃ㆍ2Si0₂ impregnated ceramic candle tilters in SCR reaction arc as follows: (1) when the content of CuO catalyst increased further, activity of NO increased. (2) NO conversion at first increased with temperature and then decreased at high temperatures (above 400℃), possibly due to the occurrence of the ammonia oxidation reaction. (3) In pilot plant test for 3 months, NO conversion was greater than 90%.

질소산화물 제거를 위한 디스크형 바나디아 촉매담지 세라믹필터의 특성

홍민선,문수호,이재춘,이동섭 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.4

The performance of disk-type catalytic fillers impregnated by TiO₂ or TiO₂-3Al₂O₃ㆍ2SiO₂ supports and V₂O_(5), catalyst was evaluated for selective catalytic reduction (SCR) of NO with ammonia as a reductant. XRD, FT-IR, BET and SEM were used to characterize the catalytic filters prepared in this work. Optimal V₂O_(5) loading and reaction temperature for V₂O_(5)/TiO₂ catalytic filters were 3~6wt.% and 350~400℃ at GHSV 14.300hr-¹ in the presence of oxygen, respectively. With increasing the V₂O_(5) loading from 0.5 to 6 wt.%, NO conversion increased from 24 to 96% at 400℃ and 14.300 hr-¹, and maintained at 80% over in the V₂O_(5) loading range of 3~6 wt.% and then dropped at V₂O_(5) loading of 7wt.% over. In comparing V₂O_(5)/TiO₂ and V₂O_(5)/TiO₂-3Al₂O₃ㆍ2SiO₂ catalytic fillers, which have same 3 wt.% V₂O_(5) loading, the V₂O_(5)/TiO₂-3Al₂O₃ㆍ2SiO₂ catalytic filter showed higher activity than V₂O_(5)/TiO₂ catalytic filter, but higher differential pressure drops owing to its low air permeability.