심근경색의 위험인자로서 Thrombomodulin유전자변이의 의의

박현영,김영미,권혁문,지선하,조승연,정남식,심원흠,장양수 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

지루각화증과 유사한 임상양상을 보인 색소성 Bowen 병 1예

조유경,김미연,박영민,김형옥,안성열 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.3

Pigmented Bowen's disease is characterized by microscopically increased melanin pigment in the epidermis and/or papillary dermis in addition to the typical findings of Bowen's disease. Pigmented Bowen's disease is often confused clinically with pigmented lesions, such as seborrheic keratosis, melanocytic nevus, pigmented basal cell cacinoma and superficial spreading melanoma. A 74-year-old man presented with a black hyperkeratotic nodule ovrlying a solitary dark brownish patch on the scalp, this was clinically diagnosed as seborrheic keratosis. Histopathologic examination revealed pigmented Bowen's disease. We, herein, report an unusual case of pigmented Bowen's disease, which is the first reported case to have occurred on the scalp and to clinically resemble seborreic keratosis. (Korean J Dermatol 2004;42(3):381~383)

고등어 및 정어리 선어의 휘발성성분

조우진,김훈,정연정,이영미,정은정,차용준 창원대학교 생활과학연구소 2002 생활과학연구 Vol.- No.6

This study was conducted to identify volatile compounds, associating with quality deterioration, which may play roles as indicators for quality assessment in fresh mackerel and sardine. Volatile compounds were analyzed by liquid liquid continuous extraction(LLCE)/GC/MSD methods. A total of 83 and 81 volatile compounds were detected in fresh mackerel and sardine, respectively, and these compounds were mainly composed of aldehydes(12 in raw mackerel, 11 in raw sardine), ketones(7, 4), alcohols(15, 14), esters(1, 3), aromatic compounds(13, 15), terpenes(5, 7), S-containing compounds(2, 2), hydrocarbons(13, 11) and miscellaneous compounds(2, 1). Most of compounds including carbonyls, alcohols, aromatic compounds and hydrocarbons were derived from lipid oxidation, and some compounds were detected from microbial degradation. It was supposed that LLCE method was proper to seek indicators for quality assessment in fresh mackerel and sardine, because of various volatile compounds derived from nonthermal lipid oxidation.

Mycobacterium abscessus에 의한 피부감염증 1예

조재훈,김미연,박영민,김형옥 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.4

We report a case of cutaneous Mycobacterium abscessus infection in a 30-year-old woman who had two, tender, erythematous subcutaneous nodules on the upper extremitiy. A skin biopsy specimen revealed a neutrophilic and histiocytic lobular, with septal panniculitis as well as some acid-fast bacilli in the dermis. The culture from a tissue specimen on Ogawa media for 7 days, yielded reaction. The patient was treated with incision and drainage, followed by administration of proper antibiotics. After 2 months the skin lesions were resolved without recurrence. (Korean J Dermatol 2004;42(4):512~515)

영아에서 수포 및 농포성 병변을 보인 과면역글로블린 E 증후군 1예

조재훈,김미연,박영민,김형옥 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.1

The hyper-IgE syndrome is characterized by marked elevated levels of IgE, recurrent cutaneous and systemic staphylococcal infections, peripheral eosinophilia and defective neutrophil chemotaxis. The characteristic cutaneous findings of hyper-IgE syndrome have been reported as an eczematous or atopic dermatitis-like eruption with multiple skin abscesses, whereas the initial presentation of hyper-IgE syndrome in infancy as a papulopustular or vesicular eruption. We report a case of hyper-IgE syndrome featuring a vesiculopustular eruption in infancy. A 15-month-old baby presented with recurrent vesiculopustules on the face and hands. The biopsy specimen revealed eosinophilic spongiotic dermatitis with an eosinophil-predominant perivascular lymphocytic infiltration. These findings might lead to an earlier recognition of hyper-IgE syndrome and an institution of appropriate treatment. (Korean J Dermatol 2004;42(1):108~110)

마우스에서 조합시험법에 의한 고려홍삼의 생식발생독성 평가

김미라, 박동선, 장자영, 신선희, 이예은, 백인정, 연정민, 이세라 , 남상섭, 황방연, 노재섭, 김순선, 조대현, 남상윤, 이범준, 김윤배, 윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

徐渭曲論探析

趙美娟 韓國外國語大學校 外國學綜合硏究센터 中國硏究所 2004 中國硏究 Vol.33 No.-

This article examined Xu Wei drama theory and its significance in Chinese literature, in particular, in Chinese southern play. Xu Wei was a Ming Dynasty writer, who excelled in a wide range of art fields such as poetry, calligraphy, essays. painting and so on. He underwent all sorts of miserable hardships throughout his life, accordingly, his works showed his queer character and behavior as the major feature and style of his works. It can be said that Xu Weis Drama theory is a prominent work in the thriving field of drama in the middle and late of Ming Dynasty. Nam-Sa-Se-Rok written by Xu Wei is a sole work regarding Chinese southern play in the Ancient Chinese Drama history. This work has been regarded as an important study in the Chinese southern play, since, for the first time, it drew attention to the Chinese southern play and explained a critical aspect of drama theory. Xu Wei explored the area of the Chinese southern play that had have been neglected by men noble of birth in Ming Dynasty. In those days, drama had a tendency to set a high value on poetry and prose, elegance and gentleness. However, Xu Weis deep and critical views regarding drama broke down this tendency of the drama in Ming Dyanasty. Based on the ancient philosophy and literary thoughts, Xu Weis drama theory was gradually developed and accomplished. In the area of philosophy ideas, Xu Weis drama theory was influenced by Wang Yang Myung thoughts, Buddhology, Taoism. In the area of literature thoughts, Xu Wei accepted literature notions and views of the conservatism and Dan-song-Pa that placed high value on private citizen works in the middle of Ming Dynasty. Mainly, Xu Weis drama theory can be found in Nam-Sa-Su-Rok and in this work, Xu Wei explained the history of Nam-Hui and how it had have been developed in those days. Moreover, focusing on Nam-Hui, Xu Wei broadly dealt with the crucial problems founded in the field of the drama theory. Xu Weis drama theory can be categorized into four studies: the study of its origin and development; the study of truth; the study of nai¨ve emotion and the study of rythem. Free from the traditional notions, Xu Wei studied the Particular features and rules in writing drama, and examined the forms and changes of drama works as well. These Xu Weis artistic behaviours had have been influencing a lot of drama theorists. Accordingly, it can be said that a lot of drama theories were driven from the view of Xu Weis drama theory. In this sense, it is obvious that Xu Weis drama theory had have been influencing significantly upon Chinese drama theory.

위선암에서 p53, MMP-2 및 TIMP-2의 표출

황호현,김의한,오미혜,조현득,양승하 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Gastric adenocarcinoma is the most common malignant tumor in Korea. Many oncogens have been found in malignant tumor cells. Among these oncogene, MMP-2 and TIMP-2 show important role in invasivness and metastasis of malignant tumor cells. P53 is regulator of cellular proliferation, and the over expression of p53 relate to malignant transformation and prognosis. To evaluate the expression of MMP-2, TIMP-2, and p53 according to histopathologic features and the relation between these antigens and prognosis in gastric adenocarcinoma, we have performed immune staining, using mouse anti-MMP-2, mouse anti-p53, and mouse anti-TIMP-2 for 91 cases. The results were as follows; 1) The expression rates of MMP-2, TIMP-2, and p53 in gastric adenocacinoma were 58.2%, 57.1%, and 49.5%, respectively. 2) MMP-2 and TIMP-2 in gastric adenocarcinoma showed reverse correlation.(p<0.001) 3) MMP-2 showed more higher expression rates in intesinal type and sell differentiated form of gastric adenocarcinoma, and in cases showing more deeper invasion and metastasis to lymph nodes in advanced carcinoma. 4) TIMP-2 in advanced carcinoma showed more lower expression rates in cases showing more deeper invasion and metastasis to lymph nodes. 5) MMP-2 expression and TIMP-2 non-expression showed more higher frequency in intestinal type of gastric adenocarcinoma and in cases showing more deeper invasion depth in advanced carcinoma. 6) p53 in advanced carcinoma showed more higher expression rates in cases more deeper invasion and metastasis to lymph nodes. Above results indicated that MMP-2 and TIMP-2 in gastric adenocarcinoma shows reverse correlation, and may be show reverse relation according to progression, type, invasion depth, and metastasis to lymph node. The expression of p53 may be related to metastasis to lymph nodes and degree of depth in advanced carcinoma.

Brine Shrimp Bioassay를 이용한 해양생물의 세포독성검색

손병화,조용진,이대령,노연숙,이선미,최홍대 동의대학교 기초과학연구소 1994 基礎科學硏究論文集 Vol.4 No.1

As a part of chemical study on the bioactive metabolites from marine organisms, we have investigated cytotoxicity using brine shrimp bioassay for each solvent fractions of the marine algae(12 species), marine sponges(3 species), coelenterates(2 species), echinoderms(4 species), marine molluscs(17 species), and ascidians(2 species), respectively. As the results, chloroform extract of Stichopus japonicus (LC_50 : 274 ㎍/ml), ethyl acetate extract of Anthocidaris crassispina(LC_50 : 121 ㎍/ml), n-butanol extract of Undaria pinnatifida (LC_50 : 178 ㎍/ml), and water extract of Thais clavigera (LC_50 : 61 ㎍/ml), displayed the most significant cytotoxic activity against brine shrimp. Among the marine organisms tested, echinoderms and marine molluscs were thought to be the most active Phylums on screening of new bioactive compounds.

급성 신우신염이 선행된 Escherichia coli 농흉 1예

차치운,조준형,김미진,오윤정,연재우,이성규,오미정,채지영,김수연 대한감염학회 2009 감염과 화학요법 Vol.41 No.5

We experienced a case of acute pyelonephritis which progressed to Escherichia coli bacteremia and later complicated by empyema in a 65-year-old female. She was successfully treated with intravenous antibiotic therapy and percutaneous drainage of empyema.