Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer

Hye-Kyung Jung,Chung Hyun Tae,Hye Ah Lee,Ko Eun Lee,Chang Mo Moon,Seong Eun Kim,Ju Young Seoh,Joo-Ho Lee 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3

Background/AimsPost-operative weight loss in patients with gastric cancer lead to a poor quality of life and long-term survival. This study aims to evaluate the effects of gut regulatory hormones on post-operative weight loss in patients with subtotal gastrectomy for gastric cancer. MethodsThis prospective study was conducted for 12 months post-surgery in 14 controls and 13 gastrectomy patients who underwent subtotal gastrectomy for gastric cancer. Serum plasma ghrelin, glucagon-like peptide-1, gastric inhibitory peptide-1, peptide YY, insulin, and homeostatic model assessment for insulin resistance responses to a standardized test meal were recorded at multiple time points before and after gastrectomy at 4 and 12 months. ResultsThe mean weight difference between the pre-operative state and the 4-month period was significantly reduced to 6.6 kg (P = 0.032), but significant weight reduction was not observed from 4 months to 12 months. The plasma levels of glucagon-like peptide-1, gastric inhibitory peptide-1, and peptide YY were significantly increased 4 months postoperatively compared to the pre-operative state (all P = 0.035); however, pre-operative levels and relative changes over a period of 0-4 months of hormones were not correlated with body weight changes. Only the pre-operative ghrelin at peak had a negative correlation with changes in weight reduction in the 4 months after surgery (ρ = −0.8, P = 0.024). ConclusionsSignificant weight reduction was common after subtotal gastrectomy for gastric cancer with a negative correlation pre-operative plasma ghrelin levels. Incretin hormones are modestly but significantly increased after subtotal gastrectomy; however, these changes did not affect the weight changes.

레진 표면처리제가 열가소성 의치상 레진과 자가중합형 이장 레진 간의 결합강도에 미치는 여향

정창모,문태성 大韓齒科器材學會 2001 대한치과재료학회지 Vol.28 No.4

The introduction of several thermoplastic polymers was intended to overcome the disadvantages of methacrylate denture base resins. Existing dentures often require denture base relines to improve the fit against the tissue bearing mucosa because of gradual changes of underlying bone structure. Chair-side reline that used autopolymerizing acrylic resin is not only convenient but inexpensive means to improve the fit and function of denture bases. However, it is not known whether the differences in chemical composition of resin surface primers affect the bonding strengths between chair-side reline resin and thermoplastic denture base resin. This study evaluated two kinds of primers(exclusive primer recommended by manufacture of thermoplastic resin and primer supplied with chair-side reline resin) to determined their effect on the bond strengths of a chair-side reline resin to two different thermoplastic denture base resins(polycarbonate and polyacetal resin) by use of a three-point transverse flexural strength test. In both polycarbonate and polyacetal resin, each exclusive resin surface primer resulted in higher bond strength than chair-side reline resin primer(p<0.05). Bond strengths of polycarbonate with chair-side reline resin were higher than those of polyacetal resin, despite the type of resin surface primer(p<0.05).

다발성 골수종으로 이행한 단일형질세포종 1예

정재용,모성환,기장도,문철호,김창욱,전용준,박유환,정춘해,오윤경 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

Thiabendazole에 衣한 腸內線?의 驅?實驗

金鍾煥,朴柄宰,文昌模,蘇鎭琸 中央醫學社 1941 中央醫學 Vol.10 No.2

Clinical trials of Thiabendazole(HK-8642) suspension upon 62 cases included 37 ascaris infestations, 34 trichiural infestations, 23 hook worm. infestations and 6 Trichostrongylus orientalis infestations were reported, and they were medicated with Thiabendazole approximately 50 mg/kg body weight. 1. 56.8% negative conversion rate among ascaris infestations, 11.4% among trichiural infestations, 26.1% among hook worm cases and 66.7% of 'T. orientalis cases were observed at 10 days after the medication of Thiabendazole respectively. 2. The reduction rates of E.P.G. (egg per gram) were 84.4% in ascaris cases, 34.4 in trichiural cases, 31.5% in hook worm cases and 73. 3% in T. orientalis cases. 3. The side effects were observed 33 cases(84.6%)out of 39 cases and the main symptoms were dizzeness(51%), nausea(41%) headache(41%), fever(24%), and vomiting(21%) No abnormal :laboratory findings in hematology, in blood chemistry and in urinalysis among 5 cases who were medicated.

IL-10 Plays a Pivotal Role in Tamoxifen-Induced Spasmolytic Polypeptide-Expressing Metaplasia in Gastric Mucosa

( Chansu Lee ),( Hyuk Lee ),( Seo Yun Hwang ),( Chang Mo Moon ),( Sung Noh Hong ) 대한간학회 2017 Gut and Liver Vol.11 No.6

Background/Aims: Gastric cancer evolves in the pathologic mucosal milieu, and its development is characterized by both the loss of acid-secreting parietal cells and mucosal cell metaplasia, called spasmolytic polypeptide-expressing metaplasia (SPEM). Cytokines, such as interleukin (IL)-10, IL-1β, and IL-6, play a key role in gastric carcinogenesis. However, changes in the cytokine profile of SPEM have not been evaluated. Methods: To induce SPEM in mouse stomachs, C57BL/6 mice were intraperitoneally injected with tamoxifen and sacrificed at 3, 10, and 21 days after treatment. RNA-sequencing (RNA-seq) and a multiplex bead array were used to measure cytokines in the stomachs of tamoxifen-treated/control mice. Results: The administration of tamoxifen led to the rapid development and histological normalization of SPEM 3 and 10 days after administration, respectively. RNA-seq revealed that the expression of IL-10 was decreased 3 days after tamoxifen administration. The multiplex assay identified a significant decline in IL-10 levels 3 days after tamoxifen treatment (58.38±34.44 pg/mL vs 94.09±4.98 pg/mL, p=0.031), which normalized at 10 and 21 days after tamoxifen treatment. Immunofluorescence staining confirmed that IL-10 expression was markedly decreased at the time of SPEM development and subsequently returned to normal, accompanied by a reversal in histologic changes. Conclusions: IL-10 may play a pivotal role in the tamoxifen-induced acute development of gastric SPEM. (Gut Liver 2017;11:789-797)

Poster Session : PS 0850 ; Upper GI Tract : Gastric Sarcoidosis Accompanied with Non-Specifi c Lymphadenopathy

( Sohyeon Hong ),( Min Sun Ryu ),( Kwang Jin Woo ),( Jeong Mi Lee ),( Heywon Yoon ),( Chunghyun Tae ),( Chang Mo Moon ),( Seongeun Kim ),( Hyekyung Jung ),( Sungae Jung ),( Kinam Shim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Gastric sarcoidosis is a rare disease accounting for 0.1-0.9 % of all sarcoidosis. We report our experience with a patient with lung and stomach sarcoidosis accompanied by an enlarged abdominal lymph nodes. A sixty-year-old female patient visited our hospital with an abnormal chest x-ray. The patient has no smoking history and no noticeable medical history. There were no fever, cough, dyspnea, nor weight changes. Physical examination showed clear breathing sound and no palpable lymph node. The chest x-ray showed reticular opacity in the right lower lung zone and chest computed tomography indicated that it was an interstitial thickening in the right middle and right lower lobes. A soft tissue density nodule, 9 mm in diameter, neighboring inferior pulmonary vein was also found. Furthermore, multiple enlarged lymph nodes were observed in the left gastric vessel area, which could be suspected as metastatic lymphadenopathy of intra-abdominal malignancy. Abdominal computed tomography showed that the enlarged lymph node spanned over left gastric area, splenic artery area, greater omentum, and gastro-colic trunk, with no mass or thickening in the walls of the stomach. Esophagogastroduodenoscopy revealed a satellite-shaped shallow whitish discoloration accompanied by mucosal irregularity in the anterior wall side of lower body and mucosal depression in the greater curvature side of lower body. Biopsies on both lesions showed chronic active gastritis with foreign-body type granuloma and Sydney grade 1 Helicobacter pylori. Laparoscopic biopsy on intra-abdominal lymph node was conducted. It was negative in mycobacterium tuberculosis and non-tuberculous mycobacterium, confi rming multiple well-formed non-caseating granulomas, satisfying our diagnosis as sarcoidosis. The patient was prescribes with methylprednisolone and follow-up CT 6 months after treatment indicated signifi cant improvement.

Deep Resequencing of Ulcerative Colitis-Associated Genes Identifies Novel Variants in Candidate Genes in the Korean Population

Moon, Chang Mo,Kim, Seung Won,Ahn, Jae Bum,Ma, Hyun Woo,Che, Xiumei,Kim, Tae Il,Kim, Won Ho,Cheon, Jae Hee Oxford University Press 2018 Inflammatory bowel diseases Vol.24 No.8

Poster Session : PS 0880 ; Lower GI Tract : Clinical Factors and Disease Course Associated with Diagnostic Delay in Korean Patients with Crohn`s Disease; Results from the Connect Study

( Chang Mo Moon ),( Sung Ae Jung ),( Seong Eun Kim ),( Byong Duk Ye ),( Jae Hee Cheon ),( You Sun Kim ),( Young Ho Kim ),( Joo Sung Kim ),( Dong Soo Han ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Crohn`s disease (CD) is the chronic and disabling inflammatory disorder of the gastrointestinal tract over time. Diagnostic delay frequently occurs in CD patients due to its unspecific clinical symptoms and inappropriate diagnostic accuracies. However, Diagnostic delay and its related clinical factors remain elusive. Thus, this study aimed to identify clinical factors associated with diagnostic delay and to evaluate the impact of diagnostic delay on clinical course in a Korean CD cohort. Methods: We conducted a retrospective multicenter analysis of a total of 1,306 CD patients registered in the Crohn`s disease clinical network and cohort (CONNECT) study in Korea. Diagnostic delay was defined as the time period from consulting a physician for specific symptoms to establishment of CD diagnosis. Results: The mean period of diagnostic delay was 16.1 ± 32.3 months. In multivariate analysis, female gender, concomitant upper gastrointestinal (UGI) disease, penetrating disease behavior at diagnosis were significantly associated with long diagnostic delay (> 12 months) (p < 0.05). When analyzed the association of clinical variables with the risk of CD-related abdominal surgery, there was no significant difference among diagnostic delay groups. In contrast, diagnostic delay (> 18 months) was independently predictive of further development of intestinal stenosis (hazard ratio [HR], 1.42; 95% confidence interval [CI], 1.11 to 1.83; p = 0.006) and internal fistula (HR, 1.39; 95% CI, 1.03 to 1.89; p = 0.033). Conclusions: Diagnostic delay occurs in a considerable number of Korean CD patients and female gender, UGI involvement, and penetrating disease behavior are related to the diagnostic delay. Diagnostic delay is significantly associated with an increased risk of CD-related complications such as intestinal stenosis and internal fistula.

Fecal Microbiota Transplantation beyond Clostridioides Difficile Infection

Chang Mo Moon,Sung Noh Hong 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.2

Obesity is becoming increasingly prevalent worldwide, and its metabolic sequelae lead to a significant burden on healthcareresources. Options for the management of obesity include lifestyle modification, pharmacological treatment, surgery, and endoscopicWith advancing analytical methods for gut microbes, many studies have been conducted, revealing that gut microbes cause variousdiseases, including gastrointestinal and non-gastrointestinal diseases. Accordingly, studies have been actively conducted to analyzethe effects on the prevention and treatment of these diseases through changes in intestinal microbes and control of dysbiosis. Fecalmicrobiota transplantation (FMT) is an effort and is currently being applied to Clostridioides difficile treatment in Korea. Manystudies have demonstrated the application of FMT in inflammatory bowel disease, irritable bowel syndrome, non-alcoholic fattyliver disease, metabolic syndrome, obesity, and diabetes. With further studies and accumulation of evidence, FMT could help treatpresently untreatable diseases in clinical practice.

다한증환자의 흉부교감신경절단술시 양측 손바닥의 온도변화

이헌재,김대식,문승철,구원모,양진영,이건,임창영,박정현,Lee, Hyeon-Jae,Kim, Dae-Sik,Moon, Seung-Cheol,Koo, Won-Mo,Yang, Jin-Young,Lee, Gun,Lim, Chang-Young,Park, Chung-Hyun 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.5

Background: Thoracoscopic T2 sympathicotomy is an effective method for the treatment of palmar hyperhidrosis. Not only are the symptoms of hyperhidrosis abolished but also the temperature of the ipsilateral palm is elevated due to the sympatholytic vasodilation after the completion of the sympathicotomy on the first side. However little is known about the temperature changes in the contralateral palm. This study was performed to evaluate the changes in both palmar temperatures during the thoracoscopic T2 sympathicotomy for palmar hyperhidrosis. Material and Method: Thoracoscopic T2 sympathicotomy was performed in 15 patients with primary palmar hyperhidrosis. Surface temperatures of both palms were monitored continuously and were recorded simultaneously during the 7 different stages of the operation. Result: When T2 sympathicotomy was performed on the first(left) side, an ipsilateral increase with a contralateral decrease of temperature was observed. The difference in the temperature of both palms was greatest just before the sympathicotomy on the contralateral(right) side(Lt. 34.6$\pm$0.9$^{\circ}C$ vs. Rt. 31.6$\pm$1.3$^{\circ}C$, P<0.0001). After the sympathicotomy on the second(right) side, temperature of the right palm was elevated. The difference in the temperature of both palms was abolished at the end of the operation(Lt.34.7$\pm$0.9$^{\circ}C$ vs. Rt.34.4$\pm$1.$0^{\circ}C$, P=0.415). Conclusion: When T2 sympathicotomy was performed on the first side, an ipsilateral palmar temperature increased due to the sympatholytic vasodilation. However contralateral palmar temperature decreased due to a vasoconstriction. Although the mechanism of vasoconstriction is still unknown, it is postulated that there may be a cross- inhibitory effect by the post-ganglionic neurons innervating blood vessels of the palm. 배경: 흉강경을 이용한 T2 교감신경절단술은 수장부다한증의 효과적인 치료법이다. 교감신경을 절단하면 다한증 증상이 소실되는 것은 물론 피하혈관의 확장으로 동측 손바닥 온도가 올라간다. 그러나 반대측 손바닥의 온도 변화에 대해서는 밝혀진 바가 적다. 저자들은 수장부다한증 환자에서 교감신경절단술 과정에 나타나는 양측 손바닥 온도의 변화양상을 알아보고자 하였다. 대상 및 방법: 일차성 수장부다한증 환자 15명에서 T2 교감신경절단술을 시행하였다. 수술중 양측 손바닥에 피부온도감지패취를 부착하여 손바닥의 온도를 관찰기록하였다. 결과: 먼저 좌측 2번 흉부교감신경을 절단하자 동측 손바닥의 온도는 상승하고 반대측 손바닥의 온도는 감소하였다. 두 손바닥의 온도차는 우측 교감신경절단전에 가장 컸으며(좌측 34.6$\pm$0.9 $^{\circ}C$, 우측 31.6$\pm$1.3$^{\circ}C$, P < 0.0001) 반대쪽(우측) 교감신경을 절단하자 감소하였던 우측 손바닥의 온도가 상승하여 수술종료시 두 손바닥의 온도차가 없어졌다(좌측 34.7$\pm$1.0 $^{\circ}C$, 우측 34.4$\pm$1.0 $^{\circ}C$, P=0.415). 결론: 수장부 다한증에서 교감신경절단술을 시행할 때는 상지에 분포하는 교감신경이 정확히 차단되었는가를 확인하는 것이 중요하다. 이를 위해서 수술중 손바닥 피부온도를 측정하여 온도상승을 확인한다. 반대측 손바닥 온도가 감소하는 기전인 혈관수축에는 교차억제효과(Cross inhibitory effect)가 관계될 것으로 생각되며 향후 이에 대한 많은 연구가 이루어져야 할 것으로 생각된다.