How Do South Korean People View the US and Chinese National Influence?: Is Soft Power Zero-Sum?

Zhao, Xiaoyu Center for Asian Public Opinion ResearchCollaborat 2017 Asian journal for public opinion research Vol.5 No.1

This paper addresses the zero-sum of soft power against the backdrop of the rise of China and the relative "decline" of America. It attempts to find out that whether the "decline" of America's soft power is caused by the rise of China's soft power, and whether China's rise could guarantee with certainty the growth of soft power. In light of the particularity of South Korea, that is, its economy relies on China and its security relies on the US, this paper chooses South Korea as the entry point for the study. Based on the Pew data from a South Korean opinion poll, this paper conducts bivariate correlation and binary logistic regression respectively, to explore the existence of zero-sum "competitions" between China's and America's soft power.

How Do South Korean People View the US and Chinese National Influence?: Is Soft Power Zero-Sum?

Xiaoyu Zhao 충남대학교 아시아여론연구소 2017 Asian journal for public opinion research Vol.5 No.1

This paper addresses the zero-sum of soft power against the backdrop of the rise of China and the relative “decline” of America. It attempts to find out that whether the “decline” of America’s soft power is caused by the rise of China’s soft power, and whether China’s rise could guarantee with certainty the growth of soft power. In light of the particularity of South Korea, that is, its economy relies on China and its security relies on the US, this paper chooses South Korea as the entry point for the study. Based on the Pew data from a South Korean opinion poll, this paper conducts bivariate correlation and binary logistic regression respectively, to explore the existence of zero-sum “competitions” between China’s and America’s soft power.

Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion

Zhao Jingyi,Li Bingyan,Ren Yongxia,Liang Tiansong,Wang Juan,Zhai Suna,Zhang Xiqian,Zhou Pengcheng,Zhang Xiangxian,Pan Yuanyuan,Gao Fangfang,Zhang Sulan,Li Liming,Yang Yongqiang,Deng Xiaoyu,Li Xiaole,C 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Compelling evidence has indicated the vital role of lysine-specific demethylase 4 A (KDM4A), hypoxia-inducible factor-1α (HIF1α) and the mechanistic target of rapamycin (mTOR) signaling pathway in nasopharyngeal carcinoma (NPC). Therefore, we aimed to investigate whether KDM4A affects NPC progression by regulating the HIF1α/DDIT4/mTOR signaling pathway. First, NPC and adjacent tissue samples were collected, and KDM4A protein expression was examined by immunohistochemistry. Then, the interactions among KDM4A, HIF1α and DDIT4 were assessed. Gain- and loss-of-function approaches were used to alter KDM4A, HIF1α and DDIT4 expression in NPC cells. The mechanism of KDM4A in NPC was evaluated both in vivo and in vitro via RT-qPCR, Western blot analysis, MTT assay, Transwell assay, flow cytometry and tumor formation experiments. KDM4A, HIF1α, and DDIT4 were highly expressed in NPC tissues and cells. Mechanistically, KDM4A inhibited the enrichment of histone H3 lysine 9 trimethylation (H3K9me3) in the HIF1α promoter region and thus inhibited the methylation of HIF1α to promote HIF1α expression, thus upregulating DDIT4 and activating the mTOR signaling pathway. Overexpression of KDM4A, HIF1α, or DDIT4 or activation of the mTOR signaling pathway promoted SUNE1 cell proliferation, migration, and invasion but inhibited apoptosis. KDM4A silencing blocked the mTOR signaling pathway by inhibiting the HIF1α/DDIT4 axis to inhibit the growth of SUNE1 cells in vivo. Collectively, KDM4A silencing could inhibit NPC progression by blocking the activation of the HIF1α/DDIT4/mTOR signaling pathway by increasing H3K9me3, highlighting a promising therapeutic target for NPC.

Pseudolaric Acid B Inhibits Proliferation, Invasion and Epithelial-to-Mesenchymal Transition in Human Pancreatic Cancer Cell

Xiaoyu Li,Xianzhi Zhao,Wen Song,Zibin Tian,Lin Yang,Qinghui Niu,Qi Zhang,Man Xie,Bin Zhou,Yonghong Xu,Jun Wu,Cuiping Zhang 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.1

Purpose: This study was aimed to investigate the effect of pseudolaric acid B (PAB) on proliferation, invasion and epithelial-to-mesenchymal transition (EMT) in pancreatic cancer cells and to explore the possible mechanism. Materials and Methods: The pancreatic cancer cell line SW1990 was cultured and treated with PAB dose- and time-dependent manners. Cell proliferation and invasion ability were measured by MTT assay and Matrigel/Transwell test, respectively. Semi-quantitative real-time polymerase chain reaction and Western blotting were conducted to detect the expression of EMT markers and the key molecules. Finally, nude mice subcutaneous transplantation tumor model was used to confirm the therapy efficacy of PAB. Results: PAB could inhibit SW1990 cell proliferation and invasion in time- and dose-dependent manners. Vimentin, fibronectin, N-cadherin, Snail, Slug, YAP, TEAD1, and Survivin were down-regulated (p<0.01), while E-cadherin, caspase-9, MST1, and pYAP were up-regulated (p<0.05). Combined PAB and gemcitabine treatment markedly restricted the tumor growth compared with gencitabin or PAB alone groups. Conclusion: PAB could inhibit the proliferation and invasion ability of pancreatic cancer cells through activating Hippo-YAP pathway and inhibiting the process of EMT.

Identification of a Novel CSNK2A1-PDGFRB Fusion Gene in a Patient with Myeloid Neoplasm with Eosinophilia

Xiaoyu Xu,Qiongyu Lu,Zheng Wang,Ping Cai,Zhao Zeng,Ling Zhang,Man Wang,Liang Ma,Changgeng Ruan,Suning Chen 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3

Platelet-derived growth factor receptor beta (PDGFRB) rearrangements play an important role in the pathogenesis of eosinophilia-associated myeloid/lymphoid neoplasms. Up to now, more than 70 PDGFRB fusions have been identified. Here, a novel PDGFRB fusion gene CSNK2A1-PDGFRB has been identified in myeloproliferative neoplasm (MPN) with eosinophilia by RNA-sequencing, which has been verified by reverse transcription polymerase chain reaction and Sanger sequencing. The new PDGFRB fusion partner gene CSNK2A1 encoded one of the two catalytic subunit of casein kinase II (CK2). To our knowledge, this is the first report on the involvement of CSNK2A1 in fusion genes, especially fusion with another kinase PDGFRB in MPN. In addition, the CSNK2A1-PDGFRB fusion retained the entire kinase domain of PDGFRB and response to imatinib at low concentration. The patient with CSNK2A1-PDGFRB was sensitive to imatinib treatment and acquired sustained complete remission.

Protective efficacy of a novel multivalent vaccine in the prevention of diarrhea induced by enterotoxigenic Escherichia coli in a murine model

Hong Zhao,Yongping Xu,Gen Li,Xin Liu,Xiaoyu Li,Lili Wang 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.1

Background: Enterotoxigenic Escherichia coli (ETEC) infection is a primary cause of livestock diarrhea. Therefore, effective vaccines are needed to reduce the incidence of ETEC infection. Objectives: Our study aimed to develop a multivalent ETEC vaccine targeting major virulence factors of ETEC, including enterotoxins and fimbriae. Methods: SLS (STa-LTB-STb) recombinant enterotoxin and fimbriae proteins (F4, F5, F6, F18, and F41) were prepared to develop a multivalent vaccine. A total of 65 mice were immunized subcutaneously by vaccines and phosphate-buffered saline (PBS). The levels of specific immunoglobulin G (IgG) and pro-inflammatory cytokines were determined at 0, 7, 14 and 21 days post-vaccination (dpv). A challenge test with a lethal dose of ETEC was performed, and the survival rate of the mice in each group was recorded. Feces and intestine washes were collected to measure the concentrations of secretory immunoglobulin A (sIgA). Results: Anti-SLS and anti-fimbriae-specific IgG in serums of antigen-vaccinated mice were significantly higher than those of the control group. Immunization with the SLS enterotoxin and multivalent vaccine increased interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) concentrations. Compared to diarrheal symptoms and 100% death of mice in the control group, mice inoculated with the multivalent vaccine showed an 80% survival rate without any symptom of diarrhea, while SLS and fimbriae vaccinated groups showed 60 and 70% survival rates, respectively. Conclusions: Both SLS and fimbriae proteins can serve as vaccine antigens, and the combination of these two antigens can elicit stronger immune responses. The results suggest that the multivalent vaccine can be successfully used for preventing ETEC in important livestock.

Chemical Constituents from Mussaenda Pubescens

Weimin Zhao,Rensheng Xu,Guowei Qin,Xican Tang,Xiaoyu Li 한국생약학회 1995 Natural Product Sciences Vol.1 No.1

A new triterpenoid saponin named Mussaendoside F(1), along with five known compounds (2-6) were isolated from aerial part of Mussaenda pubescens.

CD44 Antibody-Conjugated Gold Nanostars as SERS Probes for Distinguishing Cancer Cells (A549 Cells, H1229 Cells) from Normal Cells (ATII Cells)

Hang Zhao,Xiaowei Cao,Man Wang,Lin Tao,Xiaoyu Pan,Chunwei Yuan,Weiping Qian 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.3

In this paper, we report a novel antibody conjugated gold nanostars (AuNSs) as surface-enhanced Raman spectroscopy (SERS) probes for distinguishing cancer cells (A549 cells, H1229 cells) from normal cells (ATII cells). In such a probe, bovine serum albumin (BSA) was served as the protective agent and stabilizing agent, 4-mercaptobenzoic acid (4-MBA) was used as the Raman reporter to generate SERS signals as well as the conjugation agent for attaching CD44 antibody (anti-CD44) molecules to AuNSs, where anti-CD44 could effectively target to CD44 protein overexpressed cells. All the results of the experiments con¯rmed that more SERS probes have been targeted to cancer cells (A549 cells and H1229 cells) than that of normal cells (ATII cells) under the same condition. The anti-CD44 SERS probes hold a potential application in distinguishing cancer cells from normal cells with high sensitivity and good biocompatibility.

N-doped porous carbon encapsulated MnFe2O4 nanoparticles as advanced anodes for Li-ion batteries

Taolin Zhao,Xinlei Zhang,Zezheng Liu,Qingyuan Gu,Xiaoyu Jin,Saihu Xie,Shuai Liu 대한금속·재료학회 2024 ELECTRONIC MATERIALS LETTERS Vol.20 No.3

Transition metal oxide MnFe 2 O 4 is considered a promising anode material for Li-ion batteries owing to its high theoreticalspecifi c capacity. However, this material has two bottleneck problems, i.e., poor conductivity and serious volume expansionduring cycling. In this work, MnFe 2 O 4 nanoparticles were successfully encapsulated in the matrix of N-doped porouscarbon via a sol–gel method. As a result, the N-doped carbon matrix enhances the electronic conductivity of the composites. The special porous structure increases the contact area between the electrode material and the electrolyte and facilitates therapid infi ltration of the electrolyte. At a calcination temperature of 400 °C, the MnFe 2 O 4 /C composite shows a high initialdischarge specifi c capacity of 1207.0 mAh g −1 at 0.2 A g −1 and retains a reversible specifi c capacity of 1100.1 mAh g −1after 200 cycles. The simple design of metal oxide nanomaterials encapsulated in N-doped porous carbon provides a newdirection for improving the electrochemical performance of electrode materials for Li-ion batteries.

Therapeutic responses to chemotherapy or immunotherapy by molecular subtype in bladder cancer patients: A meta-analysis and systematic review

Shunde Wang,Xiaoyu Yuan,Zhongjie Shen,Jiaming Zhao,Baishu Zheng,Junyong Zhang,Chengguo Ge 대한비뇨의학회 2023 Investigative and Clinical Urology Vol.64 No.3

To systematically evaluate the differences in therapeutic response to chemotherapy or immunotherapy between different molecular subtypes of bladder cancer (BC). A comprehensive literature search was performed up to December 2021. Consensus clusters 1 (CC1), CC2 and CC3 molecular subtypes were used to perform meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the therapeutic response by fix-effect modeling. Eight studies involving 1,463 patients were included. For immunotherapy, CC3 showed the highest response rate (CC1 vs. CC3: OR=0.52, 95% CI=0.34–0.78, p=0.002; CC2 vs. CC3: OR=0.42, 95% CI=0.28-0.62, p<0.001), which was mainly reflected in the highest response rate to atezolizumab (CC1 vs. CC3: OR=0.47, 95% CI=0.29–0.75, p=0.002; CC2 vs. CC3: OR=0.38, 95% CI=0.24–0.59, p<0.001). For chemotherapy, CC3 had the lowest response rate to the overall chemotherapy (CC1 vs. CC3: OR=2.05, 95% CI=1.23–3.41, p=0.006; CC2 vs. CC3: OR=2.48, 95% CI=1.50–4.10, p<0.001). Compared with CC2, CC3 responded poorly to both neo-adjuvant chemotherapy (NAC) (OR=1.93, 95% CI=1.09–3.41, p=0.020) and chemoradiation therapy (CRT) (OR=6.07, 95% CI=1.87–19.71, p<0.001). Compared with CC1, CC3 only showed a poorer response to CRT (OR=4.53, 95% CI=1.26–16.27, p=0.020), and no difference in NAC. Our study suggested that molecular classifications are important predictors of cancer treatment outcomes of BC patients and could identify subgroup patients who are most likely to benefit from specific cancer treatments.