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- 저자 : Zhang Peng (검색결과 1,068 건)
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Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.
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Terahertz Characteristics of Hydroxygraphene Based on Microfluidic Technology
Boyan Zhang,Siyu Qian,Bo Peng,Bo Su,Zhuang Peng,Hailin Cui,Shengbo Zhang,Cunlin Zhang 한국광학회 2023 Current Optics and Photonics Vol.7 No.4
Hydroxygraphene as a kind of functionalized graphene has important applications in composite, photoelectric and biological materials. In the present study, THz and microfluidic technologies were implemented to study the THz transmission characteristics of hydroxygraphene with different concentrations and residence times in magnetic and electric fields. The results show that the THz transmission intensity decreases with the increase in sample concentration and duration of an applied electric field, while it increases by staying longer in the magnetic field. The phenomenon is analyzed and explained in terms of hydrogen bond, conductivity and scattering characteristics. The results establish a foundation for future research on the THz absorption characteristics of liquid graphene based on microfluidic technology in different external environments. It also provides technical support for the application and development of graphene in THz devices.
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Peng Zhang 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.8
Traditional Photovoltaic (PV) mathematical models have advantage of high accuracy, but its characteristics are multi-parameters and non-linear, which makes it difficult to be solved. Obviously, these are not suitable for engineering design since it requires both complexity and accuracy. In this paper, a simplified precision engineering PV mathematical model is proposed based on analysis of double diode PV cells mathematical model, and also gives a parameter calculation method based on Newton-Raphson method. Four different kinds of PV materials and variable resistance parameter characteristics are separately tested under different irradiance and temperature conditions. The results show that the proposed model can quickly and accurately reflect the PV model I-V and P-V characteristics, which has good versatility and sensitivity, and provides strong support for PV system related research.
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PEGylated Fmoc–Amino Acid Conjugates as Effective Nanocarriers for Improved Drug Delivery
Zhang, Peng,Huang, Yixian,Kwon, Yong Tae,Li, Song American Chemical Society 2015 Molecular pharmaceutics Vol.12 No.5
<P>A structure activity relationship (SAR) study was conducted using a series of PEGylated Fmoc-amino acid conjugates (PFA) as a simple model to gain more insight into carrier drug interaction. Among the eight PEG(2000)-Fmoc conjugates with different neighboring structures of Fmoc motif, PEG(2000)-Fmoc-Lys (Cbz) (PFA(2))-based nanomicelles exhibited the smallest particle size distribution, lowest critical micelle concentration (CMC) value, and highest loading capacity with paclitaxel (PTX). These biophysical properties were largely attributed to the strengthened carrier carrier and carrier drug interaction, including pi-pi stacking, hydrophobic, and hydrogen bonding interaction, as confirmed by fluorescence quenching and C-13 NMR study. In vitro and in vivo evaluation further demonstrated the effectiveness of PFA(2) as a nanocarrier for efficient delivery of PTX to achieve improved antitumor activity. Importantly, PFA(2) was also effective in formulating eight other model drugs of diverse structures, indicating a broad application potential. This work may shed insights into the molecular basis for the structural optimization of nanocarriers for improved delivery efficacy.</P>
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The Admissible Multiperiod Mean Variance Portfolio Selection Problem with Cardinality Constraints
Peng Zhang,Bing Li 대한산업공학회 2017 Industrial Engineeering & Management Systems Vol.16 No.1
Uncertain factors in finical markets make the prediction of future returns and risk of asset much difficult. In this paper, a model,assuming the admissible errors on expected returns and risks of assets, assisted in the multiperiod mean variance portfolio selection problem is built. The model considers transaction costs, upper bound on borrowing risk-free asset constraints, cardinality constraints and threshold constraints. Cardinality constraints limit the number of assets to be held in an efficient portfolio. At the same time, threshold constraints limit the amount of capital to be invested in each stock and prevent very small investments in any stock. Because of these limitations, the proposed model is a mix integer dynamic optimization problem with path dependence. The forward dynamic programming method is designed to obtain the optimal portfolio strategy. Finally, to evaluate the model, our result of a meaning example is compared to the terminal wealth under different constraints.
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Fracture behavior of fly ash concrete containing silica fume
Peng Zhang,Ji-Xiang Gao,Xiao-Bing Dai,Tian-Hang Zhang,Juan Wang 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.59 No.2
Effect of silica fume on fresh properties, compressive strength at 28 days and fracture behavior of fly ash concrete composite were studied in this paper. Test results indicated that the fluidity and flowability of fly ash concrete composites decreased and fly ash concrete composite are more cohesive and appear to be sticky with the addition of silica fume. Addition of silica fume was very effective in improving the compressive strength at 28 days of fly ash concrete composite, and the compressive strength of fly ash concrete composite has a trend of increase with the increase of silica fume content. Results also indicated that all the fracture parameters of effective crack length, fracture toughness, fracture energy, the critical crack opening displacement and the maximum crack opening displacement of fly ash concrete composite decreased with the addition of silica fume. When the content of silica fume increased from 3% to 12%, these fracture parameters decreased gradually with the increase of silica fume content. Furthermore, silica fume had great effect on the relational curves of the three-point bending beam specimen. As the silica fume content increased from 3% to 12%, the areas surrounded by the three relational curves and the axes were becoming smaller and smaller, which indicated that the capability of concrete composite containing fly ash to resist crack propagation was becoming weaker and weaker.
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PENG AN,FANG ZUO,XINHUA LI,YUANPENG WU,JUNHUA ZHANG,ZHAOHUI ZHENG,XIAOBIN DING,YUXING PENG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.6
A biomimetic and facile approach for integrating Fe3O4 and Au with polydopamine (PDA) was proposed to construct gold-coated Fe3O4 nanoparticles (Fe3O4@Au–PDA) with a core–shell structure by coupling in situ reduction with a seed-mediated method in aqueous solution at room temperature. The morphology, structure and composition of the core–shell structured Fe3O4@Au–PDA nanoparticles were characterized by transmission electron microscopy (TEM), X-ray powder diffraction (XRD) and X-ray photoelectron spectrometry (XPS). The formation process of Au shell was assessed using a UV-Vis spectrophotometer. More importantly, according to investigating changes in PDA molecules by Fourier transform infrared spectroscopy (FTIR) and in preparation process of the zeta-potential data of nanoparticles, the mechanism of core–shell structure formation was proposed. Firstly, PDA-coated Fe3O4 are obtained using dopamine (DA) self-polymerization to form thin and surface-adherent PDA films onto the surface of a Fe3O4 "core". Then, Au seeds are attached on the surface of PDA-coated Fe3O4 via electrostatic interaction in order to serve as nucleation centers catalyzing the reduction of Au3+ to Au0 by the catechol groups in PDA. Accompanied by the deposition of Au, PDA films transfer from the surface of Fe3O4 to that of Au as stabilizing agent. In order to confirm the reasonableness of this mechanism, two verification experiments were conducted. The presence of PDA on the surface of Fe3O4@Au–PDA nanoparticles was confirmed by the finding that glycine or ethylenediamine could be grafted onto Fe3O4@Au–PDA nanoparticles through Schiff base reaction. In addition, Fe3O4@Au–DA nanoparticles, in which DA was substituted for PDA, were prepared using the same method as that for Fe3O4@Au–PDA nanoparticles and characterized by UV-Vis, TEM and FTIR. The results validated that DA possesses multiple functions of attaching Au seeds as well as acting as both reductant and stabilizing agent, the same functions as those of PDA.
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Zhang Fei,Peng Wuxun,Wang Tao,Zhang Jian,Dong Wentao,Wang Chuan,Xie Zhihong,Luo Hong,Liu Gang 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Bone marrow mesenchymal stem cells (BMSCs) have been used in the treatment of early steroid-induced osteonecrosis of the femoral head (SONFH). However, the hypoxic microenvironment in the osteonecrotic area leads to hypoxia-induced apoptosis of transplanted BMSCs, which limits their efficacy. Therefore, approaches that inhibit hypoxia-induced apoptosis of BMSCs are promising for augmenting the efficacy of BMSC transplantation. Our present study found that under hypoxia, the expression of the long noncoding RNA (Lnc) transmembrane protein 235 (Tmem235) was downregulated, the expression of Bcl-2-associated X protein was upregulated, the expression of B-cell lymphoma-2 protein was downregulated, and the apoptotic rate of BMSCs was over 70%. However, overexpression of Lnc Tmem235 reversed hypoxia-induced apoptosis of BMSCs and promoted their survival. These results demonstrated that Lnc Tmem235 effectively inhibited hypoxia-induced apoptosis of BMSCs. Mechanistically, we found that Lnc Tmem235 exhibited competitive binding to miR-34a-3p compared with BIRC5 mRNA, which is an inhibitor of apoptosis; this competitive binding relieved the silencing effect of miR-34a-3p on BIRC5 mRNA to ultimately inhibit hypoxia-induced apoptosis of BMSCs by promoting the expression of BIRC5. Furthermore, we cocultured BMSCs overexpressing Lnc Tmem235 with xenogeneic antigen-extracted cancellous bone to construct tissue-engineered bone to repair a model of early SONFH in vivo. The results showed that overexpression of Lnc Tmem235 effectively reduced apoptosis of BMSCs in the hypoxic microenvironment of osteonecrosis and improved the effect of BMSC transplantation. Taken together, our findings show that Lnc Tmem235 inhibited hypoxia-induced apoptosis of BMSCs by regulating the miR-34a-3p/BIRC5 axis, thus improving the transplantation efficacy of BMSCs for treating early SONFH.
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