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Youliang, Ren,Jin, Yang,Jinghui, Zhang,Xiao, Yang,Lei, Shi,Dajing, Guo,Yuanyi, Zheng,Haitao, Ran,Zhongliang, Deng,Lei, Chu Techno-Press 2022 Advances in nano research Vol.13 No.6
Due to its biofilm formation and colonization of the osteocyte-lacuno canalicular network (OLCN), Staphylococcus aureus (S.aureus) implant-associated bone infection (SIABI) is difficult to cure thoroughly, and may occur recurrently subsequently after a long period dormant. It is essential to explore an alternative therapeutic strategy that can eradicate the pathogens in the infected foci. To address this, the polymethylmethacrylate (PMMA) bone cement and Fe3O4 nanoparticles compound cylinder were developed as implants based on their size and mechanical properties for the alternative magnetic field (AMF) induced thermal ablation, The PMMA mixed with optimized 2% Fe<sub>3</sub>O<sub>4</sub> nanoparticles showed an excellent antibacterial efficacy in vitro. It was evaluated by the CFU, CT scan and histopathological staining on a rabbit 1-stage transtibial screw model. The results showed that on week 7, the CFU of infected soft tissue and implants, and the white blood cells (WBCs) of the PMMA+2% Fe<sub>3</sub>O<sub>4</sub>+AMF group decreased significantly from their controls (p<0.05). PMMA+2% Fe<sub>3</sub>O<sub>4</sub>+AMF group did not observe bone resorption, periosteal reaction, and infectious reactive bone formation by CT images. Further histopathological H&E and Gram Staining confirmed there was no obvious inflammatory cell infiltration, neither pathogens residue nor noticeably burn damage around the infected screw channel in the PMMA+2% Fe<sub>3</sub>O<sub>4</sub>+AMF group. Further investigation of nanoparticle distributions in bone marrow medullary and vital organs of heart, liver, spleen, lung, and kidney. There were no significantly extra Fe<sub>3</sub>O<sub>4</sub> nanoparticles were observed in the medullary cavity and all vital organs either. In the current study, PMMA+2% Fe<sub>3</sub>O<sub>4</sub>+AMF shows promising therapeutic potential for SIABI by providing excellent mechanical support, and promising efficacy of eradicating the residual pathogenic bacteria in bone infected lesions.
Kim, Sung Won,Oh, Chang Whan,Williams, Ian S.,Rubatto, Daniela,Ryu, In-Chang,Rajesh, V.J.,Kim, Cheong-Bin,Guo, Jinghui,Zhai, Mingguo Elsevier 2006 Lithos Vol.92 No.3
<P><B>Abstract</B></P><P>Petrological analysis, zircon trace element analysis and SHRIMP zircon U–Pb dating of retrogressed eclogite and garnet granulite from Bibong, Hongseong area, SW Gyeonggi Massif, South Korea provide compelling evidence for Triassic (231.4±3.3 Ma) high-pressure (HP) eclogite facies (M1) metamorphisms at a peak pressure–temperature (<I>P</I>–<I>T</I>) of ca. 16.5–20.0kb and 775–850°C. This was followed by isothermal decompression (ITD), with a sharp decrease in pressure from 20 to 10kb and a slight temperature rise from eclogite facies (M1) to granulite facies (M2), followed by uplift and cooling. Granitic orthogneiss surrounding the Baekdong garnet granulite and the ophiolite-related ultramafic lenticular body near Bibong records evidence for a later Silurian (418±8Ma) intermediate high-pressure (IHP) granulite facies metamorphism and a prograde <I>P</I>–<I>T</I> path with peak <I>P</I>–<I>T</I> conditions of ca. 13.5kb and 800°C. K–Ar ages of biotite from garnet granulites, amphibolites, and granitic orthogneisses in and around the Bibong metabasite lenticular body are 208–219Ma, recording cooling to about 310°C after the Early Triassic metamorphic peak. Neoproterozoic zircon cores in the retrogressed eclogite and granitic orthogneiss provide evidence that the protoliths of these rocks were ∼800 and ∼900Ma old, respectively, similar to the ages of tectonic episodes in the Central Orogenic Belt of China. This, and the evidence for Triassic HP/UHP metamorphism in both China and Korea, is consistent with a regional tectonic link within Northeast Asia from the time of Rodinia amalgamation to Triassic continent–continent collision between the North and South China Blocks, and with an eastward extension of the Dabie–Sulu suture zone into the Hongseong area of South Korea.</P>