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      • KCI등재

        완전탈구된 치아의 지연 재석

        한유리,최형준,이제호,최병재 大韓小兒齒科學會 2002 大韓小兒齒科學會誌 Vol.29 No.4

        완전탈구된 치아의 치료법은 재식술을 들 수 있는데, 이는 치조와에서 이탈된 치아를 가능한 빠른 시간 내에 재식립하는 술식이다. 일반적으로 재식술의 성공여부는 치수와 치주인대 손상의 정도, 치아상실 시부터 치조와 내로 재식될 때까지의 경과시간, 탈구된 치아의 보관 상태, 치근의 발육 정도 등에 좌우된다. 그 중 치아상실 시부터 재식까지의 경과시간이 특히 중요한데, 일반적으로 30분 이내에 재식을 시행한 경우에는 90%이상의 성공률을 보인 반면 30분에서 90분 사이에서는 43%, 90분 이상 경과 시에는 7%의 성공률을 보인다고 알려져 있다. 본 증례는 완전탈구 후 오랜 시간이 지연되어 재식을 시행하였으나 치근유착을 통해 비교적 양호한 임상적 결과를 얻었다. 이러한 치료로 결국은 치아의 손실이 일어날지라도, 이것은 환자 및 보호자의 사고에 따른 충격을 감소시켜주고, 자체로 공간 유지장치로서의 기능을 할 수 있으며, 발치에 따른 치조골의 흡수를 늦추는 한편, 적극적인 보철치료를 위한 시간을 벌어줄 수 있을 것으로 사료된다. Replantation may be treatment choice for a completely avulsed tooth caused by traumatic injury. The outcome of replantation depends on the following factors: minimal damage to pulp and periodontal membrane the length of time the avulsed tooth was out of the mouth, how the tooth was stored the level of root formation, etc. The time from the act of avulsion of the tooth to the actual replantation is especially important. Generally, when replanted within 30 minutes, more than 90% of cases succeed but when the time is between 30 to 90minutes 43% and greater than 90 minutes 7%. This is a case of a replanted tooth with relatively good prognois by ankylosis though there was a great time lapse since the tooth was avulsed. Though such treatment lead to loss of the tooth in case of children or adolescents this treatment is meaningful because it may earn time until any definitive therapy functionally stimulate the alveolar bone to retain its hight for a better prognosis for future treatment and act as space maintainer

      • DeSOx/DeNOx 효율 개선을 위한 펄스 코로나 방전하에서 기체미립자 전환반응의 적용

        김동주,최유리,김교선 江原大學校 産業技術硏究所 1998 産業技術硏究 Vol.18 No.-

        In this paper, we investigated the post-combustion removal of nitrogen oxide(N0?) and sulfur oxide(S0?) which is based on the gas to particle conversion process by the pulsed corona discharge. Under normal pressure, the pulsed corona discharge produces the energetic free electrons which dissociate gas molecules to form the active radicals. These radicals cause the chemical reactions that convert SO? and NO? into acid mists and these mists react with NH? to form solid particles. Those particles can be removed from the gas stream by conventional devices such as electrostatic precipitator or bag filter. The reactor geometry was coaxial with an inner wire discharge electrode and an outer ground electrode wrapped on a glass tube. The simulated flue gas with SO? and NO? by adding NH? and H?O in the gas stream. We also measured the rmoval efficiency of SO? and NO? in a cylinder type corona discharge reactor and obtained more than 90% of removal efficiency in these experimental conditions. The effects of process variables such as the inlet concentrations of SO?, NH? asnd H?O, residence time, pulse frequencies and applied voltages were investigated.

      • KCI등재

        학령전기 아동의 글씨 쓰기에 영향을 미치는 요인에 관한 연구

        김원진,왕군철,김두리,최인영,허진아,최유정,장문영 대한감각통합치료학회 2011 대한감각통합치료학회지 Vol.9 No.1

        목적 : 학령전기 아동의 글씨 쓰기 명료도 및 속도와 지각-운동 기술의 상관관계를 확인하고, 글씨 쓰기에 가장 영 향을 주는 요인을 알아보고자 하였다. 연구방법 : 덴버 발달 선별 검사를 통하여 정상 발달로 선별된 23명의 학령 전기 아동(평균 연령=68.61개월, SD=2.04)을 대상으로 글씨 쓰기 명료도 및 속도 측정을 위하여 한글 자모 쓰기 검사지를 사용하여 자음과 모음을 쓰도록 하였다. 시지각과 시각-운동 통합 수행 능력 측정을 위하여 시지각 발달 검사를 사용하였고, 소운동 협응 수행 능력 측정을 위하여 Grooved pegboard test를 사용하였다. 결과 : 글씨 쓰기 명료도와 전반적인 시지각, 비운동성 시지각, 시각-운동 통합, 우세손 소동작 협응의 상관관계는 없었으며, 글씨 쓰기의 속도는 전반적 시지각과 우세손 소동작 협응 항목에서 유의한 상관관계를 보였다. 회귀 분 석 결과 글씨 쓰기 속도에 가장 큰 영향을 주는 요인은 전반적 시지각 항목이었다. 결론 : 만 5~6세 학령 전기 아동의 전반적 시지각 능력의 발달을 향상시키기 위한 중재를 제공하는 것이 글씨 쓰기 의 속도 능력을 향상 시킬 수 있다는 것을 알 수 있다. Objective : This study investigated the relationships of handwriting legibility and perceptual-motor skills, and handwriting speed and perceptual-motor skills. And identified the predictors that most affect the handwriting of preschool children. Methods : Twenty-three typically developing preschool aged children (mean age: 68.61 months, SD=2.04) were selected through the Korean-Denver Developmental Screening Test-2(K-DDST-2). The children were tested with regard to handwriting legibility, visual perception, visual-motor integration and fine-motor coordination. Results : First, a significant relationship was not found among handwriting legibility, visual perception, visualmotor integration and fine-motor coordination. Second, a significant relationship was found among handwriting speed, visual perception and fine-motor coordination. Third, stepwise multiple regression analyses showed that general visual perception were significant predictors for handwriting speed. Conclusion : Occupational therapists should evaluate children's visual perception levels utilizing a standardized test, and focus on general visual perception in order to improve handwriting skill(speed). Also, occupational therapists are expected to play an important role in the management and treatment of children's handwriting skills.

      • KCI등재

        Therapeutic Effects of Microbubbles Added to Combined High-Intensity Focused Ultrasound and Chemotherapy in a Pancreatic Cancer Xenograft Model

        Yu, Mi Hye,Lee, Jae Young,Kim, Hae Ri,Kim, Bo Ram,Park, Eun-Joo,Kim, Hoe Suk,Han, Joon Koo,Choi, Byung Ihn The Korean Society of Radiology 2016 KOREAN JOURNAL OF RADIOLOGY Vol.17 No.5

        <P><B>Objective</B></P><P>To investigate whether high-intensity focused ultrasound (HIFU) combined with microbubbles enhances the therapeutic effects of chemotherapy.</P><P><B>Materials and Methods</B></P><P>A pancreatic cancer xenograft model was established using BALB/c nude mice and luciferase-expressing human pancreatic cancer cells. Mice were randomly assigned to five groups according to treatment: control (n = 10), gemcitabine alone (GEM; n = 12), HIFU with microbubbles (HIFU + MB, n = 11), combined HIFU and gemcitabine (HIGEM; n = 12), and HIGEM + MB (n = 13). After three weekly treatments, apoptosis rates were evaluated using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay in two mice per group. Tumor volume and bioluminescence were monitored using high-resolution 3D ultrasound imaging and <I>in vivo</I> bioluminescence imaging for eight weeks in the remaining mice.</P><P><B>Results</B></P><P>The HIGEM + MB group showed significantly higher apoptosis rates than the other groups (<I>p</I> < 0.05) and exhibited the slowest tumor growth. From week 5, the tumor-volume-ratio relative to the baseline tumor volume was significantly lower in the HIGEM + MB group than in the control, GEM, and HIFU + MB groups (<I>p</I> < 0.05). Despite visible distinction, the HIGEM and HIGEM + MB groups showed no significant differences.</P><P><B>Conclusion</B></P><P>High-intensity focused ultrasound combined with microbubbles enhances the therapeutic effects of gemcitabine chemotherapy in a pancreatic cancer xenograft model.</P>

      • Extract of <i>Rhus verniciflua</i> stokes protects against renal ischemia-reperfusion injury by enhancing Nrf2-mediated induction of antioxidant enzymes

        Choi, Du Ri,Jeong, Ji Heun,Yu, Kwang-Sik,Lee, Nam-Seob,Jeong, Young-Gil,Kim, Do Kyung,Na, Chun Soo,Na, Dae Seung,Hwang, Won Min,Han, Seung-Yun D.A. Spandidos 2018 Experimental and therapeutic medicine Vol.15 No.4

        <P>Ischemia-reperfusion injury (IRI) may cause acute kidney disease (AKD) by mediating the oxidative stress-induced apoptosis of parenchymal cells. The extract of <I>Rhus verniciflua</I> Stokes (RVS) is used as a traditional herbal medicine as it exhibits anti-oxidant, anti-apoptotic and anti-inflammatory properties. Therefore, the current study investigated the therapeutic effect and the underlying mechanism of RVS on IRI-induced AKD <I>in vivo</I> and <I>in vitro</I>. The current study assessed the effects of RVS on a mouse model of renal IRI and in hypoxic human renal tubular epithelial HK-2 cells. The results demonstrated that the IRI-induced elevation of blood urea nitrogen, serum creatinine and lactate dehydrogenase was significantly attenuated by the intraoral administration of RVS (20 mg/kg/day) for 14 days prior to surgery. It was demonstrated that IRI surgery induced histological damage and cellular apoptosis in renal parenchyma, which were attenuated by pretreatment with RVS. Furthermore, in HK-2 cells incubated with 300 µM CoCl<SUB>2</SUB> to induce chemical hypoxia, it was demonstrated that RVS treatment significantly inhibited cell death and the production of reactive oxygen species (ROS). Furthermore, RVS treatment upregulated the levels of endogenous antioxidant enzymes, including heme oxygenase-1 and catalase, as well as their upstream regulator nuclear factor erythroid 2-related factor 2, in HK-2 cells. Taken together, these results suggested that the intraoral administration of RVS induces a therapeutic effect on IRI-induced AKD. These effects are at least partly due to the attenuation of ROS production via upregulation of the antioxidant defense system in renal tubular cells.</P>

      • SCISCIESCOPUS

        Exercise-induced downbeat nystagmus in a Korean family with a nonsense mutation in CACNA1A.

        Choi, Jae-Hwan,Seo, Jae-Deuk,Choi, Yu Ri,Kim, Min-Ji,Shin, Jin-Hong,Kim, Ji Soo,Choi, Kwang-Dong Springer-Verlag Italia 2015 NEUROLOGICAL SCIENCES Vol.36 No.8

        <P>Episodic ataxia type 2 (EA2) is characterized by recurrent attacks of vertigo and ataxia lasting hours triggered by emotional stress or exercise. Although interictal horizontal gaze-evoked nystagmus and rebound nystagmus are commonly observed in patients with EA2, the nystagmus has been rarely reported during the vertigo attack. To better describe exercise-induced nystagmus in EA2, four affected members from three generations of a Korean family with EA2 received full neurological and neuro-otological evaluations. Vertigo was provoked in the proband with running for 10?min to record eye movements during the vertigo attack. We performed a polymerase chain reaction-based direct sequence analysis of all coding regions of CACNA1A in all participants. The four affected members had a history of exertional vertigo, imbalance, childhood epilepsy, headache, and paresthesia. The provocation induced severe vertigo and imbalance lasting several hours, and oculography documented pure downbeat nystagmus during the attack. Genetic analyses identified a nonsense mutation in exon 23 which has been registered in dbSNP as a pathogenic allele (c.3832C>T, p.R1278X) in all the affected members. Ictal downbeat nystagmus in the studied family indicates cerebellar dysfunction during the vertigo attack in EA2. In patients with episodic vertigo and ataxia, the observation of exercise-induced nystagmus would provide a clue for EA2.</P>

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