Reducing Body Fat with platycodon grandiflorum Using lactobacillus rhamnosus HK-9 Fermentation on C57BL/6 Mice

Yu-Hua Huang,Da-Woon Jung,Sun-Hyuk Im,Jeong Eun Ban,Yoon-Hee Choi,Il-Jun Kang 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

在類型學視野下考察漢韓語趨向範疇表達的異同點

황옥화 ( Yu Hua Huang ) 중국어문연구회 2007 中國語文論叢 Vol.0 No.35

한어화한국어(漢語和韓國語)"V상(上)오르다"류비교연구(類比較硏究)

황옥화 ( Yu Hua Huang ) 中國語文硏究會 2008 中國語文論叢 Vol.0 No.39

韓國學生漢語趨向補語的習得特點及偏誤分析

黃玉花(Huang, Yu-hua) 한국중국어교육학회 2007 중국어교육과연구 Vol.5 No.-

The inaccuracy of preposition zai appeared when Korean students learn Chinese can be divided into five kinds: the false use of zai in existential sentence, the false use of zai when the location words work as subject or attribute, the generalization of verbs when zai+location words are after predicate, the omission of zai in frame preposition, and omission or redundancy of direction words in frame preposition. The inaccuracy of preposition dui appeared when Korean students learn Chinese can be divided into four kinds: the confused use of preposition dui and gei, dui and xiang, the false use of dui, the redundancy of dui, and the inaccuracy of dui......lai shuo in frame preposition. There are two emphasis and difficulty points for Korean students to learn Chinese preposition zai: one is the present and absent of zai in the sentence of zai+location words, and the other is the present and absent of direction words in frame preposition structure. There are three emphasis and difficulty points to learn Chinese preposition dui, the first is the distinguish of dui and its similar words gei and xiang, the second is the present and absent of dui, and the last one is the present and absent of lai shuo/lai jiang in frame preposition.

中国朝鲜民族双语教育研究

黃玉花(Huang Yu Hua) 가천대학교 아시아문화연구소 2000 아시아문화연구 Vol.4 No.-

본 논문은 중국 조선족 학생들이 중국어 동사학습을 통하여 어음, 의미, 문법 세 갈래 각도로부터 동사오류를 분석하였고 진일보로 중간언어 이론을 이용하여 목구어와 목적어 차원에서 그 오류의 주요한 원인을 해석하였다. 그 원인을 구체적으로 말하면: ① 조선어고유동사의 의미의 영향, ② 조선어 품사의 전환 혹은 겸용의 영향, ③ 조선어 상황어와 중심단어사이 결합의 영향, ④ 조선어의 고유결합의 영향, ⑤ 중국어 동사 특유한 의미의 영향, ⑥ 한어 동의동사(近義動詞)의 상호영향, ⑦ 동사 그 어떤 문법기능의 유추(類推)의 영향, ⑧ 중국어 고유결합의 영향 등 8가지이다. 이는 중국 조선족 중국어 어휘교수에 지도적인 역할에 도움이 될 것이다. In this paper, 5 types of verb errors produced in Chinese language learning of Korean nationality in China were analyzed from pronunciation, meaning and grammar, and the causes of error production were explained from knowledge of mother tongue and target language with interlanguage theory. The principal causes were as follows: (1) the interference of meaning of Korean intrinsic verbs; (2) the influences of conversion or multiplicity in parts of speech in Korean language; (3) influences developed from structure of adverb and verb of Korean language; (4) interference with habitual use of mother tongue; (5) interference come from intrinsic meaning of Chinese verb; (6) interaction between synonyms of verbs; (7) outroutine analogization in some grammar function of verbs; and (8) Chinese habitual collocation. The results mentioned above provide guiding tactics for second language vocabulary teaching among Chinese Korean nationality.

이온화 에너지를 조사한 수입 오렌지의 유전독성학적 안전성 평가

황옥화(Yu-Hua Huang),정다운(Da-Woon Jung),강일준(Il-Jun Kang) 한국식품영양과학회 2014 한국식품영양과학회지 Vol.43 No.6

본 연구에서는 방사선 조사 오렌지의 수입 가능성이 높아짐에 따라 이들의 안전성을 검토할 목적으로 0.5, 1 kGy 감마선 조사 수입 오렌지의 복귀돌연변이 시험, 소핵 및 염색체 이상시험의 유전독성학적 안전성 평가를 수행하였다. S.Typhimurium TA98, TA100, TA1535 및 TA1537에 대한 감마선 조사 수입 오렌지(0.5, 1 kGy)의 복귀변이 집락수를 조사한 결과, 대사활성계 도입 및 부재 시 0.625~10 mg/plate의 범위에서 복귀변이 집락수의 농도 의존적인 증가 혹은 감소를 보이지 않았다. 포유류 배양세포를 이용한 염색체이상시험에서 0.5, 1 kGy 감마선 조사 수입 오렌지는 1.25~10 mg/mL의 시험적용 용량에서 염색체이상 유발능이 5% 미만이어서 염색체이상을 유발하지 않는 것으로 나타났다. 설치류 망상적혈구를 이용한 소핵형성 시험을 수행한 결과, 시험적용 용량인 250~2,000 mg/kg의 범위에서 0.5, 1 kGy 감마선 조사 수입 오렌지는 소핵을 가진 망상적혈구의 출현율이 음성대조군과 유의한 차이를 나타내지 않아 소핵을 유발하지 않음을 확인하였다. 이상의 결과, 0.5, 1 kGy 감마선 조사 수입 오렌지는 본 시험조건에서 유전독성이 없는 것으로 나타났다. This study was carried out to evaluate the genotoxicity of imported oranges irradiated with ionizing energy (0.5 and 1 kGy). In bacterial reversion assays with Salmonella Typhimurium TA98, TA100, TA1535, and TA1537, imported oranges irradiated with ionizing energy (0.5 and 1 kGy) showed no significant increase in the number of revertant colonies in both the absence and presence of the S9 metabolic activation system. In chromosomal aberration tests with Chinese hamster ovary (CHO) cells, imported oranges irradiated with ionizing energy (0.5 and 1 kGy) showed no increase in the frequency of chromosomal aberrations. In in vivo mouse micronucleus assay, imported oranges irradiated with ionizing energy (0.5 and 1 kGy) showed no increase in the frequency of polychromatic erythrocytes with micronucleus. These results indicate that imported oranges irradiated with ionizing energy (0.5 and 1 kGy) showed no genotoxic effects under these experimental conditions.

Efficacy and Safety of 12 Weeks of Daclatasvir, Asunaprevir Plus Ribavirin for the Treatment of HCV Genotype 1b Infection without Baseline NS5A Resistance-Associated Variants (DARING)-Interim Report

( Ming-lung Yu ),( Chao-hung Hung ),( Yi-hsiang Huang ),( Cheng-yuan Peng ),( Chun-yen Lin ),( Pin-nan Cheng ),( Rong-nan Chien ),( Shih-jer Hsu ),( Chen-hua Liu ),( Jee-fu Huang ),( Chung-feng Huang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The current study aims to elucidate the treatment efficacy (defined as undetectable HCV RNA throughout 12 weeks of post-treatment follow-up, SVR12) and safety DCV/ASV plus ribavirin for 12 weeks in HCV-1b patients without NS5A RAS. Methods: This is a single-arm, open-label phase 2 study. Seventy directly acting antivirals (DAA)-naïve HCV-1b patients without L31/Y93 RAS are planned to receive daclatasvir (60 mg/ day) and asunaprevir (100 mg twice daily) plus weight-based ribavirin (1000-1200 mg/day) for 12 weeks. After treatment they were followed up for 12 weeks. Results: As of 31 Oct 2017, 58 eligible patients are allocated to treatment, with a mean age of 59.3 years and female predominance (67.2%, 39/58). The mean HCV RNA was 5.87+0.77 log10 IU/mL; 23 patients (39.7 %) had significant hepatic fibrosis (>F2). In the modified intention-to-treat analysis, the rate of undetectable HCV at week 1, week 2, week 4, week 8 and endof- treatment was 25 % (14/56), 84.8 % (39/46), 100 % (46/46), 100 % (38/38) and 100 % (27/27), respectively. Undetectable HCV RNA were observed in all of the patients with HCV RNA assessable 4 weeks (SVR4, 18/18) and 12 weeks (SVR12, 12/12) post treatment. None of the 18 patients who completed the 12-week treatment experienced relapse during post-treatment follow-up. The most common adverse event was fatigue (78.3 %), followed by pruritus (65.2 %) and dizziness (52.2 %), of which were considered as ribavirin related. None of the participating subjects withdrew treatment or follow-up throughout the trial peroid. Three serious adverse events were reported which included urosepsis, appendicitis and left ureteral stone. All were unrelated to the investigating drugs. Conclusions: 12 weeks of DCV/ASV plus ribavirin was highly effective and safe in HCV-1b patients without NS5A RAS in the interim analysis. The satisfactory results would be anticipated in the full patient set.

Who Wants Checks and Balances? Endogeneity of the Balancing Perspective

Yu, Eric Chen-Hua,Huang, Chi,Hsiao, Yi-Ching Center for Asian Public Opinion ResearchCollaborat 2015 Asian journal for public opinion research Vol.2 No.3

The premise of the intentional model of split-ticket voting is that some voters split their tickets simply because they prefer divided government and believe in constant "checks and balances." This article examines whether this premise stands firm in an emerging democracy like Taiwan. That is, by using survey data in Taiwan, we explore whether one's attitude toward divided or unified government is "real." We hypothesize that a citizen's attitude toward "checks and balances" is subject to change, and conditional on whether her preferred party is in power. Specifically, we speculate that a citizen would tend to hold the balancing perspective or favor divided government, if her preferred party is in opposition. However, if her preferred party becomes the ruling party, she would be more likely to oppose (hold) the balancing (non-balancing) perspective or favor unified government. We then utilize panel survey data embedded in Taiwan's Election and Democratization Studies (TEDS) to verify our hypothesis.

Association Between VDR Polymorphisms and Breast Cancer: An Updated and Comparative Meta-analysis of Crude and Adjusted Odd Ratios

Huang, Qian-Qian,Liao, Yu-Yi,Ye, Xiao-Hua,Fu, Jin-Jian,Chen, Si-Dong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

There is a lot of debate on the relationship between vitamin D receptor polymorphisms and risk of breast cancer. Herein, we quantitatively analyzed the published case-control studies on this relationship by meta-analysis, performing a bibliographic search from Pubmed and CNKI up to July 31, 2013. The included case-control studies for Fok1, Bsm1, Taq1, Apa1, Cdx2 and Poly-A were 16, 19, 20, 10, 4, 6, respectively. Crude and adjusted odd ratios and 95% confidence intervals were calculated to present and compare the strength of any associations. The results of combined analyses indicated that Fok1, Bsm1, Apa1, Cdx2 and Poly-A were not significantly associated with the risk of breast cancer. In contrast, the tt genotype of Taq1 was a modest risk factor for breast cancer development (tt vs. TT: OR = 1.21, 95% CI: 1.01-1.44). To further confirm the above results, adjusted effects for the six polymorphisms were pooled based on adjusted ORs reported in the original studies. Adjusted ORs of Fok1, Apa1, Cdx2 and Poly-A were similar to the crude ORs. However, Bsm1 and Taq1 showed inconsistent results. For Bsm1, OR for BB vs. bb was 0.85, 95% CI: 0.74-0.98; for Taq1, OR for tt vs. TT was 1.03, 95% CI: 0.92-1.15, and not associated with risk. Subgroup analyses for crude ORs showed some association between Bsm1, Taq1 and breast cancer in Caucasians only, but for adjusted ORs, no associations were found. This meta-analysis suggests that the roles that Fok1, Apa1, Cdx2 and Poly-A polymorphisms play in breast cancer risk are negligible, with Bsm1 and Taq1 as possible exceptions. To be conservative, we still assumed that they may play a modest role in determining breast cancer risk. Further studies are needed to validate our findings.

中國朝鮮民族雙語敎育硏究

黃玉花 韓國 暻園大學校 아시아文化硏究所 中國 中央民族大學 韓國文化硏究所 2000 亞細亞文化硏究 Vol.4 No.-

본 논문은 중국 조선족 학생들이 중국어 동사학습을 통하여 어음, 의미, 문법 세 갈래 각도로부터 동사오류를 분석하였고 진일보로 중간언어 이론을 이용하여 모국어와 목적어 차원에서 그 오류의 주요한 원인을 해석하였다. 그 원인을 구체적으로 말하면: ① 조선어고유동사의 의미의 영향, ② 조선어 품사의 전환 혹은 겸용의 영향, ③ 조선어 상황어와 중심단어사이 결합의 영향, ④ 조선어의 고유결합의 영향, ⑤ 중국어 동사 특유한 의미의 영향, ⑥ 한어 동의동사(近義動詞)의 상호영향, ⑦ 동사 그 어떤 문법기능의 유추(類推)의 영향, ⑧ 중국어 고유결합의 영향 등 8가지이다. 이는 중국 조선족 중국어 어휘교수에 지도적인 역할에 도움이 될 것이다. In this paper, 5 types of verb errors produced in Chinese language learning of Korean nationality in China were analyzed from pronunciation, meaning and grammar, and the causes of error production were explained from knowledge of mother tongue and target language with interlanguage theory. The principal causes were as follows: (1) the interference of meaning of Korean intrinsic verbs; (2) the influences of conversion or multiplicity in parts of speech in Korean language; (3) influences developed from structure of adverb and verb of Korean language; (4) interference with habitual use of mother tongue; (5) interference come from intrinsic meaning of Chinese verb; (6) interaction between synonyms of verbs; (7) outroutine analogization in some grammar function of verbs; and (8) Chinese habitual collocation. The results mentioned above provide guiding tactics for second language vocabulary teaching among Chinese Korean nationality.