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( Yu Jeong Chun ),( Seung-kook Sohn ),( Hye Kyung Song ),( Song Mi Lee ),( Young Hoon Youn ),( Seung Min Lee ),( Hyo Jin Park ) 한국임상영양학회 2015 Clinical Nutrition Research Vol.4 No.2
This study aimed to examine the associations between intakes of various nutrients and food groups and colorectal cancer risk in a case-control study among Koreans aged 20 to 80 years. A total of 150 new cases and 116 controls were recruited with subjects’ informed consent. Dietary data were collected using the food frequency questionnaire developed and validated by the Korea Centers for Disease Control and Prevention. Multivariate logistic regression models were used to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for colorectal cancer incidence. High intakes of total lipid (ORT3 vs T1 = 4.15, 95% CI: 1.33-12.96, p for trend = 0.034), saturated fatty acid (ORT3 vs T1 = 2.96, 95% CI: 1.24-7.04, p for trend = 0.016) and monounsaturated fatty acid (ORT3 vs T1 = 3.04, 95% CI: 1.23-7.54, p for trend = 0.018) were significantly associated with increased incidence of colorectal cancer. High dietary fiber (ORT3 vs T1 = 0.22, 95% CI: 0.08-0.56, p for trend = 0.002) and vitamin C (ORT3 vs T1 = 0.38, 95% CI: 0.14-1.05, p for trend = 0.021) intakes were significantly associated with reduced colorectal cancer incidence. From the food group analysis, bread (ORT3 vs T1 = 2.26, 95% CI: 0.96-5.33, p for trend = 0.031), red meat (ORT3 vs T1 = 7.33, 95% CI: 2.98-18.06, p for trend < 0.001), milk·dairy product (ORT3 vs T1 = 2.42, 95% CI: 1.10-5.31, p for trend = 0.071) and beverage (ORT3 vs T1 = 3.17, 95% CI: 1.35-7.48, p for trend = 0.002) intakes were positively associated with colorectal cancer risk. On the other hand, high intake of traditional rice cake (ORT3 vs T1 = 0.35, 95% CI: 0.14-0.86, p for trend = 0.024) was linked with lower colorectal cancer incidence. In conclusion, eating a diet high in total lipid, saturated fatty acids and monounsaturated fatty acids is associated with higher incidence of colorectal cancer, whereas a diet high in dietary fiber and vitamin C was found to lower the incidence in Korean adults. Interestingly high traditional rice cake consumption is associated inversely with colorectal cancer incidence, warranting a future study.
The protective effects of BMSA1 and BMSA5-1-1 proteins against Babesia microti infection
Yu-Chun Cai,Chun Li Yang,Peng Song,Muxin Chen,Jia-Xu Chen 대한기생충학ㆍ열대의학회 2024 The Korean Journal of Parasitology Vol.62 No.1
The intracellular parasite Babesia microti is among the most significant species causinghuman babesiosis and is an emerging threat to human health worldwide. Unravelling thepathogenic molecular mechanisms of babesiosis is crucial in developing new diagnosticand preventive methods. This study assessed how priming with B. microti surface antigen1 (BHSA 1) and seroreactive antigen 5-1-1 (BHSA 5-1-1) mediate protection against B. microti infection. The results showed that 500 µg/ml rBMSA1 and rBMSA5-1-1 partiallyinhibited the invasion of B. microti in vitro by 42.0±3.0%, and 48.0±2.1%, respectively. Blood smears revealed that peak infection at 7 days post-infection (dpi) was 19.6%,24.7%, and 46.7% in the rBMSA1, rBmSA5-1-1, compared to the control groups (healthymice infected with B. microti only), respectively. Routine blood tests showed higher whiteblood cell, red blood cell counts, and haemoglobin levels in the 2 groups (BMSA1 andBMSA5 5-1-1) than in the infection control group at 0–28 dpi. Moreover, the 2 groups hadhigher serum interferon-γ, tumor necrosis factor-α and Interleukin-17A levels, and lowerIL-10 levels than the infection control group throughout the study. These 2 potential vaccine candidate proteins partially inhibit in vitro and in vivo B. microti infection and enhancehost immunological response against B. microti infection.
송재천 ( Jae Chun Song ),김상겸 ( Sang Kyum Kim ),김익성 ( Eak Seong Kim ),정인수 ( In Su Jung ),송영구 ( Young Goo Song ),유정식 ( Jeong Sik Yu ),박효진 ( Hyo Jin Park ) 대한소화기학회 2008 대한소화기학회지 Vol.52 No.4
We experienced a rare case of colonic cryptococcosis in an apparently immunocompetent individual. A 27-year-old woman admitted our hospital for intermittent melena. Initial abdominal CT scan revealed a mass lesion obstructing most of the lumen in ascending colon. Colonoscopy showed huge ulcerofungating mass in proximal ascending colon. Colonoscopic biopsy was performed and pathologic diagnosis was made as colonic cryptococcosis with positive PAS stain. Laboratory test evaluating immune status and bone marrow examination was normal. The patient was treated with intravenous amphotericin B for four weeks and six months of oral fluconazole afterwards. Follow-up abdominal CT scan and colonoscopy were taken at four weeks and seven months after the beginning of treatment. On completion of intravenous amphotericin B treatment, the mass lesion was decreased in abdominal CT and colonoscopy. After seven months, abdominal CT and colonoscopy showed near-complete resolution of the colonic lesion so the treatment ended. Cryptococcosis in a healthy individual is a rare disease and there have been only several sporadic case reports on pulmonary or central nervous system involvement. Hence, we report a case of colonic cryptococcosis in an apparently immunocompetent individual. (Korean J Gastroenterol 2008;52:255-260)
Hai-Xia Li,Yan Ma,Yu-Xiao Yan,Xin-Ke Zhai,Meng-Yu Xin,Tian Wang,Dong-Cao Xu,Yu-Tong Song,Chun-Dong Song,Cheng-Xue Pan 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.6
Background: Caveolin-1, the scaffolding protein of cholesterol-rich invaginations, plays an important rolein store-operated Ca2þ influx and its phosphorylation at Tyr14 (p-caveolin-1) is vital to mobilize protectionagainst myocardial ischemia (MI) injury. SOCE, comprising STIM1, ORAI1 and TRPC1, contributesto intracellular Ca2þ ([Ca2þ]i) accumulation in cardiomyocytes. The purified extract of steamed Panaxginseng (EPG) attenuated [Ca2þ]i overload against MI injury. Thus, the aim of this study was to investigatethe possibility of EPG affecting p-caveolin-1 to further mediate SOCE/[Ca2þ]i against MI injury in neonatalrat cardiomyocytes and a rat model. Methods: PP2, an inhibitor of p-caveolin-1, was used. Cell viability, [Ca2þ]i concentration were analyzedin cardiomyocytes. In rats, myocardial infarct size, pathological damages, apoptosis and cardiac fibrosiswere evaluated, p-caveolin-1 and STIM1 were detected by immunofluorescence, and the levels ofcaveolin-1, STIM1, ORAI1 and TRPC1 were determined by RT-PCR and Western blot. And, release of LDH,cTnI and BNP was measured. Results: EPG, ginsenosides accounting for 57.96%, suppressed release of LDH, cTnI and BNP, and protectedcardiomyocytes by inhibiting Ca2þ influx. And, EPG significantly relieved myocardial infarct size, cardiacapoptosis, fibrosis, and ultrastructure abnormality. Moreover, EPG negatively regulated SOCE viaincreasing p-caveolin-1 protein, decreasing ORAI1 mRNA and protein levels of ORAI1, TRPC1 and STIM1. More importantly, inhibition of the p-caveolin-1 significantly suppressed all of the above cardioprotectionof EPG. Conclusions: Caveolin-1 phosphorylation is involved in the protective effects of EPG against MI injury viaincreasing p-caveolin-1 to negatively regulate SOCE/[Ca2þ]i.
Yu-jin Song,Hye-young Jin,Chung-hee Lee,Yun-chang Jeon,Chun-hee Nam 한국인간·식물·환경학회 2017 인간식물환경학회지 Vol.20 No.3
This study was conducted to analyze the relationship between planted plants and immigration plants by monitoring the wildflower garden constructed at Seoul Samgaksan Elementary School. The results of this study are as follows: First, plants planted in the garden 32 taxa, except for weakened only 1 taxa (Clematis patens), the remaining plants maintained or increased their populations. Among maintained Plants, that did not volume growth were 6 taxa and volume growth on the spot were 5 taxa. 15 taxa were spread around the planting area and 5 taxa spread sporadically to unpredictable areas other than the planting area. Although most of the planted plants show good growth, no special management is required, but Lonicera japonica needs the density management that cuts off the stem in the early spring and 5 sporadically spreading taxa, the planting intent of garden is attenuated, so remove the root when new leaves come out in spring. Second, the total number of plants transferred after 2 years of wildflower garden constructed were 83 taxa total, which is 2.6 times that of planted plants. The seed disseminule form was analyzed as 52% barochory, 27% anemochory&hydrochory, 16% autochory and 5% zoochory. Also about 43% of the transferred plants were estimated to been imported from soil seed bank. Third, we classified immigration plants into largely native plants and naturalized plants. The native plants were transferred to more than naturalized plants: 65 native plants, 1 cultivated plants and 17 (22%) naturalized plants. The results of the monitoring of the rooftop garden ‘Choroktteul’ in Seoul City Hall showed that there were differences in the type and number of the immigration plants depending on the distance and quality of the surrounding greenery. Fourth, the management method of immigration plants is divided into three categories: elimination, transplantation, and utilization. The 39 taxa were selected for the elimination: Invasive alien plants among naturalized plants, fast spreading plants, plants that expand sideways with rhizomes, and plants that interfere with the growth of planted plants: grow to over 1 meter in height and climbing plant. The elimination period should be dry, clear, windy day, remove the root without any residue. The transplanted plants are 18 taxa, tree, plants not suitable for habitat, and in elementary school textbooks. It is a group of 26 taxa which are used in the garden: for landscape that plants have ornamental values (flowers, leaves, and autumn colors etc.) but do not attenuate the intent of the garden, and for groundcover that plants have low plant height and fast spread. It is also possible to prevent immigration plants when you are mulching or planting plants densely populated areas when making a garden.
Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model
Chun Hua Piao,Yan Jing Fan,Thi Van Nguyen,Zhen Nan Yu,Hee Soon Shin,Chang Ho Song,Ok Hee Chai 대한체질인류학회 2021 대한체질인류학회지 Vol.34 No.2
Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi on ovalbumin (OVA)-induced mouse asthma model. In this study, we examined the effect of F. amomi on OVA-induced asthma by analyzing Th1/Th2 cytokine production, histopathologic changes, and focusing on the NF-κB signaling. Oral administration of F. amomi reduced the number of inflammatory cells especially eosinophils and improved airway and pulmonary inflammation in the lungs of OVA-challenged mice. In addition, F. amomi significantly downregulated the overproduction of tumor necrosis factor-α, IL-1β, IL-4, IL-5 and the levels of OVA-specific both IgE and IgG1 and increased the secretion of interferon-γ and OVA-specific IgG2a. Moreover, F. amomi suppressed the increase of total NF-κB level and the phosphorylation of IκB-α and NF-κB by OVA. F. amomi may have therapeutic effect for allergic asthma by modulating Th1/Th2 cytokine imbalance and inhibiting NF-κB signaling activation.