Caveolin-1 mediates the utilization of extracellular proteins for survival in refractory gastric cancer

Hwang Nahee,Yoon Bo Kyung,Chun Kyu-Hye,Kim Hyeonhui,Lee Yoseob,Kim Jae-Won,Jeon Hyeonuk,Kim Tae-Hyun,Kim Mi-Young,Fang Sungsoon,Cheong Jae-Ho,Kim Jae-woo 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Despite advances in cancer therapy, the clinical outcome of patients with gastric cancer remains poor, largely due to tumor heterogeneity. Thus, finding a hidden vulnerability of clinically refractory subtypes of gastric cancer is crucial. Here, we report that chemoresistant gastric cancer cells rely heavily on endocytosis, facilitated by caveolin-1, for survival. caveolin-1 was highly upregulated in the most malignant stem-like/EMT/mesenchymal (SEM)-type gastric cancer cells, allowing caveolin-1-mediated endocytosis and utilization of extracellular proteins via lysosomal degradation. Downregulation of caveolin-1 alone was sufficient to induce cell death in SEM-type gastric cancer cells, emphasizing its importance as a survival mechanism. Consistently, chloroquine, a lysosomal inhibitor, successfully blocked caveolin-1-mediated endocytosis, leading to the marked suppression of tumor growth in chemorefractory gastric cancer cells in vitro, including patient-derived organoids, and in vivo. Together, our findings suggest that caveolin-1-mediated endocytosis is a key metabolic pathway for gastric cancer survival and a potential therapeutic target.

R&D Trends Monitoring through Scanning Public R&D Investments: The Case of Information & Communication Technology (ICT) in Meteorology and Climatology

Yoseob Heo,Hyunwoo Kim,Jungjoon Kim,Jongseok Kang 아시아기술혁신학회 2016 Asian Journal of Innovation and Policy Vol.5 No.3

Public R&D investment information has diverse implications for researching R&D trends. Also, as it is important for the establishment of R&D policy to grasp the current situation and trends of R&D to improve science and technology level, science and technology information service system, such as NTIS (National Science & Technology Information Service), is operated at a national level in most countries. However, since the data forms provided by current NTIS are raw data, it is necessary to develop the R&D performance indicator or to use additional scientometric methods by analyzing scientific papers or scientific R&D project information for grasping R&D trends or analyzing R&D task results. Thus, this study applied public R&D investment information to investigate and monitor R&D trends in the field of information & communication technology (ICT) of meteorology and climatology by using NTIS data of Korea and NSF (National Science Foundation) data of USA.

Awareness Toward Child Abuse of Parents With the Elementary School Students

Yoseob Kim,Inn-Jee Park,Taehoon Kim 한국콘텐츠학회 2013 International Journal of Contents Vol.9 No.3

Awareness Toward Child Abuse of Parents With the Elementary School Students

Kim, Yoseob,Park, Inn-Jee,Kim, Taehoon The Korea Contents Association 2013 International Journal of Contents Vol.9 No.3

The purpose of the present study was to investigate the degree of awareness toward child abuse behaviors, causes of child abuse, and the necessity of the parent education for child abuse prevention in the parents of elementary school students. Four hundred fifty parents of elementary school students participated for this study. The results were as follows. First, the parents generally were aware of emotional abuse and physical abuse, but not aware of neglect. In the comparison, according to parental education level and family income, highly educated parents and high-income parents were more aware of both emotional abuse and neglect. Second, most of the parents agreed on the causes of child abuse presented in the survey except the cause of having an unexpected child. Third, most parents agreed on the necessity of parent education programs for child abuse prevention. The discussion for the results and strategies for child abuse prevention was provided.

특수교사의 인식을 통하여 본 학습장애 학생 전환교육의 중요도와 실행정도 및 개선방안

김요섭(Kim, Yoseob) 이화여자대학교 특수교육연구소 2016 특수교육 Vol.15 No.3

연구목적: 본 연구의 목적은 특수교사의 인식을 통하여 일반 고등학교에 재학 중인 학습장애 학생을 위한 전환교육의 영역별 중요도와 실행정도, 그리고 실행하는 데 있어서 문제점과 개선방안을 파악해 보고자 하는 것이었다. 연구방법: 이를 위해 경상남도 및 울산광역시 일반 고등학교에서 학습장애 학생을 교육하는 특수교사 62명을 대상으로 설문조사를 실시하였다. 연구결과: 첫째, 특수교사들은 학습장애 학생 전환교육 영역의 중요도에 있어서 제시된 영역별 내용 전체를 ‘중요하다’와 ‘매우 중요하다’의 사이 수준으로 인식하고 있었으며, 실행정도에서는 ‘보통’과 ‘잘하고 있다’의 중간정도로 평가하여 ‘잘하고 있다’라고 해석하기에는 부족한 수준이었다. 둘째, 전환교육 영역의 중요도와 실행정도의 차이를 비교한 결과를 보면 모든 영역에 있어서 중요도에 비해 실행정도는 현저하게 낮은 것으로 조사되었다. 셋째, 학습장애 학생 전환교육 실행 시 문제점으로 비율이 높게 지적된 것은 지역사회 관련기관이나 업체의 연계 및 협조 부족, 학습장애 학생 장애인 복지카드 미소지로 인한 취업의 어려움, 지역 업체의 학습장애인 취업에 대한 부정적 인식, 학습장애 학생의 취업의욕 부족, 학교 내의 전환교육 관련 시설이나 설비 부족, 부모나 가족의 협조부족 순으로 나타났다. 넷째, 이러한 문제점을 해결하기 위한 방안으로는 지역사회 업체나 취업관련 기관과 연계 및 협력체계 구축 강화가 가장 비율이 높았으며, 다음은 학습장애 학생 장애인 복지카드 미소지로 인한 취업의 불이익 문제 해결, 전환 혹은 직업교육 전담인력 배치, 현장중심 전환교육 및 프로그램 개발 및 실시, 전환교육지원센터 증가 및 활성화와 전문인력 배치 등이 상대적으로 높은 비율로 제시된 방안들이었다. 결론: 본 연구의 결과는 관련 정부기관의 학습장애 학생 전환성과 향상을 위한 노력이나 정책 개발을 위한 기초자료로 활용될 수 있을 것이다. Purpose: This study aimed to investigate the level of importance and implementation, difficulties in implementation, and to suggest directions for improvement, in transition education programs for students with learning disabilities from the viewpoint of special education teachers. Method: Sixty-two special education teachers of students with learning disabilities in Gyeongsangnam-Do and Ulsan Metropolitan City participated in this study; a survey was used to collect data. Results: First, teachers perceived that the transition education program items suggested were either important or very important, but they evaluated the overall implementation level as average or just slightly above average. Second, in a comparison between the overall level of importance and the effectiveness of implementation of transition education programs, teachers responded that the latter was significantly lower than the former. Third, in terms of difficulties in implementing transition education, teachers pointed towards quite a few factors: a lack of cooperation and support from related agencies and local companies, a dearth of employment opportunities for individuals without disability welfare cards, local companies" negative attitudes towards employing people with learning disabilities, students" lack of desire for employment, a lack of facilities and equipment for transition education in schools, and a lack of cooperation from parents. Fourth, concerning major directions for improvement, teachers suggested reinforcement of cooperation and connections with local companies and employment-related agencies, resolution of disadvantages in employment for those without disability welfare cards, employment of transition education specialists in schools, development and implementation of field-centered transition programs, an increase in transition service support centers and transition education special coordinators. Conclusion: It is expected that the government or related agencies will use the results from this study to develop policies to improve transition outcomes for students with learning disabilities.

특수교사를 통해 살펴본 장애학생 상담실태 및 활성화 방안

김요섭(Kim, Yoseob) 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.22

본 연구는 통합교육 상황의 장애학생을 교육하는 특수교사를 대상으로 장애학생 상담실태와 상담관련 인식, 상담 활성화 방해요인 및 상담서비스 활성화 방안을 조사하기 위해 수행되었다. 이를 위해 2019년 6월에서 8월에 걸쳐 경상남도 초·중등학교 특수교사 132명을 대상으로 설문조사를 하였다. 주요 결과는 첫째, 응답자의 대다수가 통합교육 상황의 장애학생 상담의 활성화 정도는 매우 낮으며 일반학생에 비해 상담서비스가 덜 제공되고 있다고 응답하였다. 둘째, 특수교사들이 상담을 의뢰하였거나 상담을 받는 것을 본 적이 있는 장애학생 유형은 지적장애, 정서·행동장애, 학습장애가 대다수였고, 주요 상담주제는 학교생활 적응력 향상, 대인관계기술 향상, 문제행동 수정, 부모/가족과의 갈등, 이성교제 관련문제, 우울/스트레스 해결이었다. 셋째, 대다수의 특수교사들은 장애학생 상담 담당자는 특수교사가 아닌 상담교사/상담사이며, 상담이 장애학생에게 도움이 될 것이라고 응답하였다. 넷째, 장애학생 상담 활성화 방해요인은 상담교사/상담사의 장애학생에 대한 지식/이해 부족, 장애학생의 의사소통/인지능력 부족, 상담교사/상담사의 장애학생은 상담대상이 아니라는 인식, 상담교사/상담사의 업무과다로 인한 장애학생 상담시간의 부족 등이었다. 다섯째, 장애학생 상담의 활성화 방안으로 상담교사/상담사의 장애학생 상담에 대한 인식전환, 장애학생에 대한 이해와 상담역량 강화, 특수교사의 상담교사/상담사와 소통 및 협력강화, 상담교사/상담사의 업무과다 문제해결, 장애학생 담당 전문상담사 양성 및 배치등을 제안하였다. 본 연구에서 도출된 결과를 바탕으로 논의하였으며 추후 연구를 위한 제언을 서술하였다. This study aimed to investigate actual condition, perceptions, barriers, and activation strategies in counseling for students with disabilities in inclusive education via special education teachers. For the purpose, one hundred and thirty-two special education teachers from elementary or secondary schools in Gyeongsangnam-Do participated in this study. A survey was used to collect data over June to August in 2019. The main results were as follows. First, the majority of respondents answered the degree of counseling for students with disabilities was low, and counseling services for those students were less provided than regular students. Second, students provided with counseling in the higher rate were those who have intellectual disabilities, emotional or behavior disorders, learning disabilities, and the main counseling topics were improvement of school adaptation ability, improvement of social skills, behavior modification, and solving problems with parents, depression or stress. Third, majority of the teachers answered counselors are in charge of counseling for students with disabilities, and counseling will be helpful for those students. Fourth, the main barriers to counseling indicated were lack of counselors’ understanding and knowledge for those students, lack of communication or intelligence abilities of those students, counselors’ recognition that students with disabilities are not their clients, lack of counseling time for the students due to counselors’ excessive work. Fifth, activation strategies suggested were change of counselors’ recognition of counseling for students with disabilities, strengthening of counselors’ understanding about, and counseling ability for, students with disabilities, strengthening of cooperation between special education teachers and counselors, increase of counselors in schools, and training and placement of special counselors in charge of students with disabilities. Lastly, discussion based on the results and suggestions for further study were included.

R&D Trends Monitoring through Scanning Public R&D Investments: The Case of Information & Communication Technology (ICT) in Meteorology and Climatology

Heo, Yoseob,Kim, Hyunwoo,Kim, Jungjoon,Kang, Jongseok Asian Society for Innovation and Policy 2016 Asian Journal of Innovation and Policy Vol.5 No.3

Public R&D investment information has diverse implications for researching R&D trends. Also, as it is important for the establishment of R&D policy to grasp the current situation and trends of R&D to improve science and technology level, science and technology information service system, such as NTIS (National Science & Technology Information Service), is operated at a national level in most countries. However, since the data forms provided by current NTIS are raw data, it is necessary to develop the R&D performance indicator or to use additional scientometric methods by analyzing scientific papers or scientific R&D project information for grasping R&D trends or analyzing R&D task results. Thus, this study applied public R&D investment information to investigate and monitor R&D trends in the field of information & communication technology (ICT) of meteorology and climatology by using NTIS data of Korea and NSF (National Science Foundation) data of USA.

장애아동 학대 실태,원인 및 예방방안 연구

김요섭 ( Yoseob Kim ) 인문사회콘텐츠학회 2023 인문사회콘텐츠학회지 Vol.1 No.2

연구 목적: 본 연구의 목적은 최근 3년 동안 조사된 장애아동 학대의 실태를 파악해보고 학대 행위를 유발하는 원인과 다양한 측면에서 예방을 위한 방안을 제시하는 데 있다. 연구 방법: 연구 도구로는 보건복지부에서 2021년부터 2023년까지 발행한 장애인 학대 현황 보고서와 학대원인 분석 및 예방방안을 제시한 선행연구들을 활용하였다. 연구 내용: 첫째, 학대실태를 보면 8개 유형의 장애아동들이 학대를 경험하였으며 피학대 아동의 인원이 매년 증가하였다. 학대유형 가운데는 신체적 학대의 비율이 가장 높았고 학대 행위자는 부모나 친인척이 가장 높은 비율을 차지하였다. 둘째, 학대원인은 아동 자신의 특성, 부모의 문제, 사회환경 및 제도의 측면으로부터 기인하는 것으로 나타났다. 셋째, 학대의 예방방안으로는 아동에게는 자기보호 기술 등 지도, 부모를 위한 예방 교육 프로그램 제공과 다양한 지원, 그리고 사회인식의 변화와 제도의 개선이 필요함을 발견하였다. 결론 및 제언: 우리 사회가 장애아동 학대의 청정지대가 될 때까지 학대 근절을 위한 관심, 학계의 연구와 방안 제시, 정부의 효과적인 정책수립과 집행을 통한 지속적인 노력이 필요하다. This study aimed to investigate the current status of abuse of child with disability in recent three years, its causes and preventive strategies. As the research methods, the report on status of abuse of people with disabilities published from year 2021 to 2023 by Ministry of Health and Welfare, and previous articles were used. In main results, first, eight categories of children suffered from abuse and numbers abused increased every year. Physical abuse showed highest rate among abuse categories and parents/relatives of children was ranked in highest rate in perpetrators of abuse. Second, causes of abuse were due to characteristics of children themselves, problems of parents, and social environment and systems. Third, in preventive strategies, education of self-protection skills for children, education and supports for parents, and change of society and improvement of system were discussed. Lastly, for our society to be clear zone of child abuse, people’s concerns to eradicate abuse, research and suggestions from academic field and effort from government to establish effective policy and practice will be needed.

Neuroscientific Review on Sensory Stimulation Therapy and Virtual Reality for Somatosensory Rehabilitation

Taehoon Kim,Yoseob Kim 한국콘텐츠학회 2010 International Journal of Contents Vol.6 No.1

수학적 직관을 키우는 게임 콘텐츠 개발 방법 연구

김요섭(Kim, Yoseob),우탁(Woo, Tack),주희영(Joo, Heeyoung) 한국게임학회 2013 한국게임학회 논문지 Vol.13 No.6

현재의 최신 교육과정은 창의적인 인재를 육성하는데 중점을 두고 있다. 하지만 학교에서 실제로 진행되고 있는 수학 교육은 창의성과 거리가 먼 주입식 교육으로 진행되어, 수학을 어렵게 여기는 학생들이 늘어나고 있다. 정부는 이러한 상황을 극복하기 위해 '스토리텔링을 활용한 수학 교육'을 제안하였으며, 이에 게임을 활용한 수학 교육이 다방면에서 연구 개발되고 있다. 그러나 현재 대부분의 교육용 기능성게임들은 연역적 체계를 중시하는 현재의 수학 교육을 탈피하지 못하여, 창의성을 기른다는 목표를 이루지 못하고 있다. 이는 기존의 수학 교육용 기능성 게임들이 수학과목에 대한 목표와 수학 교수 학습이론을 깊이 고찰하지 않았기 때문이다. 따라서 본 연구는 기존의 수학교육이 지닌 주입식 교육의 한계를 넘어서기 위해 수학 교수 학습이론인 RME를 기반이론으로 하여 게임 요소를 활용한 수학적 직관 향상을 위한 초등 기하 교육용 게임 콘텐츠를 개발하는 방법론을 제시하고자 한다. Current up-to-date courses of study put emphasis on raising creative students. However, the cramming methods of teaching mathematics in the school seems far from the creativity and the number of students who feels mathematics difficult is increasing. To overcome this situation, the government proposed 'the mathematics education using storytelling', which leads to lots of developments of mathematics using serious game in many areas. However most of the current serious games couldn't do away with the deductive framework of mathematics, which makes it impossible to achieve the purpose of raising creative students. This is because existing mathematics serious games have not deeply contemplated many aspects such as the purpose and theories of teaching and teaching mathematics. Therefore, in order to overcome the limitations of cramming methods in existing mathematics educations, this research proposes the new method of developing serious game contents for elementary geometry that is useful to improve mathematical intuition, based on RME, the theory of teaching/learning mathematics.