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Yin Guo Nan,Kim Do-Kyun,Kang Ji In,Im Yebin,Lee Dong Sun,Han Ah-reum,옥지연,Choi Min-Ji,Kwon Mi-Hye,Limanjaya Anita,Jung Saet-Byel,Yang Jimin,Min Kwang Wook,Yun Jeongwon,Koh Yongjun,Park Jong-Eun,Hwang D 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate hyperglycemia, which causes endothelial dysfunction and peripheral neuropathy, ultimately leading to multiple complications. One prevalent complication is diabetic erectile dysfunction (ED), which is more severe and more resistant to treatment than nondiabetic ED. The serum glycoprotein leucine-rich ɑ-2-glycoprotein 1 (LRG1) is a modulator of TGF-β-mediated angiogenesis and has been proposed as a biomarker for a variety of diseases, including DM. Here, we found that the adhesion GPCR latrophilin-2 (LPHN2) is a TGF-β-independent receptor of LRG1. By interacting with LPHN2, LRG1 promotes both angiogenic and neurotrophic processes in mouse tissue explants under hyperglycemic conditions. Preclinical studies in a diabetic ED mouse model showed that LRG1 administration into the penile tissue, which exhibits significantly increased LPHN2 expression, fully restores erectile function by rescuing vascular and neurological abnormalities. Further investigations revealed that PI3K, AKT, and NF-κB p65 constitute the key intracellular signaling pathway of the LRG1/LPHN2 axis, providing important mechanistic insights into LRG1-mediated angiogenesis and nerve regeneration in DM. Our findings suggest that LRG1 can be a potential new therapeutic option for treating aberrant peripheral blood vessels and neuropathy associated with diabetic complications, such as diabetic ED.
Yin, Guo Nan,Jin, Hai-Rong,Choi, Min-Ji,Limanjaya, Anita,Ghatak, Kalyan,Minh, Nguyen Nhat,Ock, Jiyeon,Kwon, Mi-Hye,Song, Kang-Moon,Park, Heon Joo,Kim, Ho Min,Kwon, Young-Guen,Ryu, Ji-Kan,Suh, Jun-Kyu American Diabetes Association 2018 Diabetes Vol.67 No.6
<P>Penile erection requires well-coordinated interactions between vascular and nervous systems. Penile neurovascular dysfunction is amajor cause of erectile dysfunction (ED) in patients with diabetes, which causes poor response to oral phosphodiesterase-5 inhibitors. Dickkopf2 (DKK2), a Wnt antagonist, is known to promote angiogenesis. Here, using DKK2-Tg mice or DKK2 protein administration, we demonstrate that the overexpression of DKK2 in diabetic mice enhances penile angiogenesis and neural regeneration and restores erectile function. Transcriptome analysis revealed that angiopoietin-1 and angiopoietin-2 are target genes for DKK2. Using an endothelial cell-pericyte co-culture system and ex vivo neurite sprouting assay, we found that DKK2-mediated juxtacrine signaling in pericyte-endothelial cell interactions promotes angiogenesis and neural regeneration through an angiopoietin-1-Tie2 pathway, rescuing erectile function in diabetic mice. The dual angiogenic and neurotrophic effects of DKK2, especially as a therapeutic protein, will open new avenues to treating diabetic ED.</P>
Yin-Nan Li,전종덕 한국항공운항학회 2023 한국항공운항학회지 Vol.31 No.1
The purpose of this study is to analyze the patterns and framework of innovative services through the evaluation of airport passengers on innovation facilities at the airport. This study was carried out based on four concepts of theories: the pursuit of the airport passengers, the perceived innovation, acceptance intentions, and the desire for structuralization. The data were collected from July 5 to 9, 2022, targeting 299 passengers who had used the airport's innovation facility. This paper analyzed the effects of the needs for structured in the relationship between the airport passengers 'pursuit benefits and the accommodation, and the relationship between the airport passengers' mediation effect and the pursuit of the airport passengers and the perceived innovation. As a result, the pursuit of airport passengers has a positive effect on the intention of acceptance and perceived innovation has also a positive effect on the intention of acceptance. These results suggest such an implication that innovative functions at airport should be improved based on the needs of passengers.
Yin-Nan Li,Young Woo Lee 한국항공운항학회 2023 한국항공운항학회지 Vol.31 No.4
This paper calls attention to the central problem of the influence of identifying the determinants of airport duty-free store customers perceived innovativeness, pursuit benefits and value- congruency on the behavioral intention. The data is completed with 307 adults with purchasing experience of airport duty-free store O2O integration service which brings sufficient convenience to consumers. The content analysis results show that the influence factors of innovation characteristics, consumer pursuit benefits and value-congruency affect the behavioral intention in various aspects. The result suggests that we should upgrade the innovate functionality and improve the service quality based on consumer needs. Finally, this study discusses implications for theory and practice, indicates limitations, and concludes with some suggestions for future research.
Role of soluble CD14 in cerebrospinal fluid as a regulator of glial functions
Yin, Guo Nan,Jeon, Hyejin,Lee, Shinrye,Lee, Ho Won,Cho, Je-Yoel,Suk, Kyoungho Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of neuroscience research Vol.87 No.11
<P>Proteomic analysis of cerebrospinal fluid (CSF) samples derived from patients with Alzheimer's disease (AD) or Parkinson's disease (PD) was performed. On the basis of liquid chromatography–tandem mass spectrometry, two-dimensional gel electrophoresis analysis, and Western blot validation, it was found that the level of soluble form of monocyte differentiation antigen CD14 precursor was elevated in CSF from AD or PD patients compared with normal subjects. The soluble CD14 protein and mRNA expression was detected in microglia cells, indicating that microglia may be a cellular source of soluble CD14 in CSF. Next, the role of soluble CD14 in the regulation of glial functions was investigated. Soluble CD14 inhibited lipopolysaccharide (LPS)- or LPS/interferon-gamma-induced nitric oxide production and cell death of microglia and astrocytes. Soluble CD14 suppressed glial neurotoxicity in a coculture of glia/neuroblastoma. In addition, soluble CD14 moderately enhanced phagocytic activity of microglia. These results suggest that microglia-derived soluble CD14 is a candidate CSF biomarker for AD and PD, and the soluble CD14 may inhibit glial activation by interfering with LPS effects. © 2009 Wiley-Liss, Inc.</P>
A biothiols and H 2 O 2 responsive fluorescence probe for selective cancer imaging
Yin Nan,Qin Guixin,Wang Yuting,Tang Jiali,Yao Xin,Xu Qingling 대한화학회 2024 Bulletin of the Korean Chemical Society Vol.45 No.3
Identification of cancer from normal tissues is important for early diagnosis of cancer. Combined detection of multiple tumor markers is important for accurate diagnosis. It is urgent to develop fluorescent probes that are responsive to multiple cancer characterizations for selective cancer imaging. Herein, we designed a novel near‐infrared (NIR) fluorescent probe ( IRAPA ) using a hemi‐cyanine skeleton as fluorophore and 3‐acrylamidopropanoic ester as recognizing unit that is responsive to both oxidative and reductive molecules. IRAPA has faint fluorescence emission as the intramolecular charge transfer (ICT) process is blocked. H 2 O 2 , glutathione (GSH) and cysteine (Cys) can individually induce the hydrolysis of ester bond and give fluorescent NIR IROH . IRAPA shows low cytotoxicity and produces strong fluorescence specifically in cancer cells/tissues. While the normal cells/tissues showed very weak fluorescence. Moreover, IRAPA shows higher differences between cancer and normal cells compared to probes that only response to biothiols or ROS. Identification of cancer from normal tissues is important for early diagnosis of cancer. Combined detection of multiple tumor markers is important for accurate diagnosis. It is urgent to develop fluorescent probes that are responsive to multiple cancer characterizations for selective cancer imaging. Herein, we designed a novel near-infrared (NIR) fluorescent probe (IRAPA) using a hemicyanine skeleton as fluorophore and 3-acrylamidopropanoic ester as recognizing unit that is responsive to both oxidative and reductive molecules. IRAPA has faint fluorescence emission as the intramolecular charge transfer (ICT) process is blocked. H2O2, glutathione (GSH) and cysteine (Cys) can individually induce the hydrolysis of ester bond and give fluorescent NIR IROH. IRAPA shows low cytotoxicity and produces strong fluorescence specifically in cancer cells/tissues. While the normal cells/tissues showed very weak fluorescence. Moreover, IRAPA shows higher differences between cancer and normal cells compared to probes that only response to biothiols or ROS.
Ultrasonic Evaluation of Creep Damage in 316LN Stainless Steel
Yin, Song-Nan,Hwang, Yeong-Tak,Yi, Won Korean Society for Precision Engineering 2007 International Journal of Precision Engineering and Vol.8 No.4
Creep failure of 316LN stainless steel (SS) occurs due to the nucleation and growth of cracks. An investigation was performed to correlate the creep damage with ultrasonic wave speeds and angular frequencies using creep-tested 316LN SS specimens. Ultrasonic wave measurements were made in the direction of and perpendicular to the loading using contact probes with central frequencies of 10, 15, and 20 MHz. We found that the angular frequency and wave speed decreased with increasing creep time to rupture by analyzing the ultrasonic signals from the 15 and 20 MHz probes. Therefore, the creep damage was sensitive to the angular frequency and wave speed of ultrasonic waves.
Yin, Guo Nan,Kim, Woo Jean,Jin, Hai-Rong,Kwon, Mi-Hye,Song, Kang-Moon,Choi, Min Ji,Park, Jin-Mi,Das, Nando Dulal,Kwon, Ki-Dong,Batbold, Dulguun,Kim, Kyu-Won,Ryu, Ji-Kan,Suh, Jun-Kyu Blackwell Pub 2013 The journal of sexual medicine Vol.10 No.6
<P>Radical prostatectomy for prostate cancer can not only induce cavernous nerve injury (CNI) but also result in structural changes in the cavernous tissues. Nerve injury-induced protein 1, Ninjurin-1 (Ninj1), is known to be involved in neuroinflammatory processes and to be related to vascular regression during the embryonic period.</P>