Systemic Inflammatory Biomarkers, Especially Fibrinogen to Albumin Ratio, Predict Prognosis in Patients with Pancreatic Cancer

Lin Fang,Fei-Hu Yan,Chao Liu,Jing Chen,Dan Wang,Chun-Hui Zhang,Chang-Jie Lou,Jie Lian,Yang Yao,Bo-Jun Wang,Rui-Yang Li,Shu-Ling Han,Yi-Bing Bai,Jia-Ni Yang,Zhi-Wei Li,Yan-Qiao Zhang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1

Purpose Systemic inflammatory response is a critical factor that promotes the initiation and metastasis of malignancies including pancreatic cancer (PC). This study was designed to determine and compare the prognostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and fibrinogen-to-albumin ratio (FAR) in resectable PC and locally advanced or metastatic PC. Materials and Methods Three hundred fifty-three patients with resectable PC and 807 patients with locally advan-ced or metastatic PC were recruited in this study. These patients were classified into a training set (n=758) and a validation set (n=402). Kaplan-Meier survival plots and Cox proportional hazards regression models were used to analyze prognosis. Results Overall survival (OS) was significantly better for patients with resectable PC with low preoperative PLR (p=0.048) and MLR (p=0.027). Low FAR, MLR, NLR (p < 0.001), and PLR (p=0.003) were significantly associated with decreased risk of death for locally advanced or metastatic PC patients. FAR (hazard ratio [HR], 1.522; 95% confidential interval [CI], 1.261 to 1.837; p < 0.001) and MLR (HR, 1.248; 95% CI, 1.017 to 1.532; p=0.034) were independent prognostic factors for locally advanced or metastatic PC. Conclusion The prognostic roles of FAR, MLR, NLR, and PLR in resectable PC and locally advanced or metastatic PC were different. FAR showed the most prognostic power in locally advanced or metastatic PC. Low FAR was positively correlated with OS in locally advanced or metastatic PC, which could be used to predict the prognosis.

Commercial Simulation Technology Enables Wideband-CDMA Research and Development

Yi Yuan Chen,Bing Lin,Xiao Jing Lu,Min Ying Sun,Faul Washkewicz,Wei Jun Zhu 대한전자공학회 1998 CDMA International Conference and Exhibition Vol.- No.-

Structure of PVA/gelatin hydrogel beads and adsorption mechanism for advanced Pb(II) removal

Bing Hui,Yi Zhang,Lin Ye 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1

Poly(vinyl alcohol)(PVA)/gelatin hydrogel beads were prepared for Pb2+ removal. The loose network structure formed at high dosage of gelatin resulted in increasing permeability and Pb2+ adsorption capacity. High content of Pb2+ was adsorbed on the surface of hydrogel, which dense structure could hinder Pb2+ to internal diffusion. The Pb2+ adsorption was rapid and spontaneous, and favorable at high temperature and Pb2+ concentration; Langmuir isotherm fits well with the experimental data, indicating homogeneous nature of monolayer adsorption of Pb2+; the adsorption process belonged to the secondorder kinetic model, indicating chemical adsorption with ion-exchange mechanism. Good reusability of the hydrogel was achieved.

Effects of zinc sources and levels of zinc amino acid complex on growth performance, hematological and biochemical parameters in weanling pigs

Zhang, Yi,Ward, Terry Lynn,Ji, Fei,Peng, Chucai,Zhu, Lin,Gong, Limin,Dong, Bing Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.8

Objective: The objective of the study was to investigate the effects of zinc amino acid complex (ZnAA) on growth performance, hematological and biochemical parameters in weanling pigs. Methods: In Exp. 1, a total of 216 Duroc${\times}$Landrace${\times}$Large White weanling pigs were assigned randomly to 6 dietary treatments. Each treatment had 6 replicates (pens) with 6 pigs each. The diets were corn-soybean meal based with supplementation of 0, 20, 40, 80, 120 mg Zn/kg from ZnAA or 40 mg Zn/kg from feed-grade zinc sulfate. The experiment lasted 42 days. In Exp. 2, a total of 180 weanling pigs were assigned randomly to 3 dietary treatments supplemented with 0, 80, or 800 mg Zn/kg from ZnAA. Results: In Exp. 1, pigs fed 40 to 80 mg Zn/kg from ZnAA had higher (p<0.05) average daily gain (ADG) than the unsupplemented group during d 0 to 14. During d 0 to 42, the pigs fed 20 to 120 mg Zn/kg from ZnAA had increased (p<0.05) ADG. Pigs fed 20 to 120 mg/kg Zn from ZnAA had lower feed:gain (p<0.05), increased the activity of serum Cu-Zn superoxide dismutase on d 14, and increased serum Zn levels on d 42 (p<0.05). In Exp. 2, pigs fed diets with 800 mg Zn/kg had increased average daily feed intake during d 15 to 28 (p<0.05) compared to the unsupplemented group. During d 0 to 28, the pigs fed supplemental Zn had increased ADG (p<0.05). On d 14 and d 28, pigs fed supplemental Zn had higher the serum alkaline phosphatase activities (p<0.05). No significant differences were observed in the hematological parameters and organ indices. Conclusion: Supplementation with 20 to 80 mg/kg Zn from ZnAA improved the growth performance in weaned pigs. The piglets can tolerate up to 800 mg/kg Zn from ZnAA with limited potential health effects.

SIZE EFFECT IN THE RELATIONSHIP BETWEEN EQUITY OWNERSHIP STRUCTURE AND CORPORATE PERFORMANCE

J Barry Lin,Bing sheng Yi People&Global Business Association 2003 Global Business and Finance Review Vol.8 No.1

This paper investigates the relationship between firm performance and different kinds of corporate equity ownership-insider ownership. institutional ownership. and blookholder ownership--for a sample of 2,822 publicly listed companies in the United States 1998. There are significant differences between small and large firms in the relationship between ownership structure and firm performance. Specifically. for small firms. institutional ownership has a significant positive effect on firm performance. while blockholding has a negative bur insignificant effect. In contrast. large firms. blockholding has a significant negative effect on firm performance. and institutional ownership has a positive but insignificant effect. It appears that the roles played by these large shareholders are different for small firms vs. large firms. Insider ownership has no significant effect on firm performance. indicating that. on average. firms have endogenously-determined optimal degrees of insider holding.

CORPORATE LEVERAGE AND FUTURE GROWTH: EVIDENCE FROM INDONESIA'S EMERGING CAPITAL MARKET

J Barry Lin,T Chotigeat,Bing sheng Yi People&Global Business Association 2004 Global Business and Finance Review Vol.9 No.2

This study investigates the relationship between leverage and future corporate growth, using a ten-year sample of Indonesian firms. The leverage effect is found to be insignificant for the overall sample, unlike the earlier findings by Lang et al. (1996) for firms in a well-developed market such as the U.S. However, when firms are sorted by size and Tobin's q, only the small low-q firms indicate a statistically significant negative effect of leverage on future corporate growth. This is evidence consistent with the fact that the Indonesian economy has been dominated by large firms which have better access to capital markets, and also that small firms with high growth potential do not suffer from debt-overhang, although small firms with low growth potential do.

Effect of ground ginger on dough and biscuit characteristics and acrylamide content

Huaijie Yang,Lin Li,Yongpo Yin,Bing Li,Xia Zhang,Wenjuan Jiao,Yi Liang 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.5

Effect of different contents of ground ginger[0%, 1%, 3%, 5%, and 7% (w/w)] on flour quality, doughand biscuit characteristic and acrylamide content wereinvestigated. Texture results showed that by adding 1% (w/w) ground ginger, hardness of dough, hardness andchewiness of biscuit decreased, which was beneficial forbiscuit making. Moreover, the L* value of biscuit droppedwhile the a* and b* value rose with the increase of gingercontents, indicating darker, redder and yellower biscuits. Sensory score of biscuits became worse but acrylamidecontent reduced with the addition of ground ginger. Thephenol hydroxyl group of gingerol played a more importantrole in the reaction of formation of acrylamide than the sidechain. Finally, biscuit with 1% ground ginger contentshowed good texture, color and acceptable sensory evaluation,as well as lowering the acrylamide content by 6.2%.

GPS-free Vehicular Localization System Using Roadside Units with Directional Antennas

Ou Chia-Ho,Wu Bing-Yi,Lin Cai 한국통신학회 2019 Journal of communications and networks Vol.21 No.1

The success of dedicated short-range communications(DSRC) applications depends on an accurate knowledge of the positionsof vehicles within the network. At present, vehicle localizationis generally performed using some form of vehicle-mountedglobal positioning system (GPS). However, GPS signals may not bealways available. Various GPS-free vehicle localization techniquesusing the ranging information, the prior knowledge of the vehicle’sposition, or the special hardware have been proposed for enhancingthe performance of traditional GPS-based methods. Differentfrom the previous approaches, we propose a GPS-free vehicle localizationsystem using roadside units (RSUs) with directional antennaswithout specific hardware support on the vehicle and theassumption of the prior knowledge of the vehicle. In the proposedapproach, each vehicle determines its position using the informationcontained within beacon messages transmitted by neighboringRSUs deployed along the road only. The performance of the proposedlocalization scheme is evaluated by ns-2 simulations and iscompared with those of recent GPS-free and GPS-assisted localizationsystems. The simulation results show that the proposed localizationscheme achieves a higher positioning accuracy than theexisting GPS-free and GPS-assisted schemes. The feasibility of theproposed system for practical applications is further investigatedexperimentally. The experimental results for the positioning accuracyare consistent with those obtained from the ns-2 simulations.

Dose-Dense Rituximab-CHOP versus Standard Rituximab-CHOP in Newly Diagnosed Chinese Patients with Diffuse Large B-Cell Lymphoma: A Randomized, Multicenter, Open-Label Phase 3 Trial

Xueying Li,He Huang,Bing Xu,Hongqiang Guo,Yingcheng Lin,Sheng Ye,Jiqun Yi,Wenyu Li,Xiangyuan Wu,Wei Wang,Hongyu Zhang,Derong Xie,Jiewen Peng,Yabing Cao,Xingxiang Pu,Chengcheng Guo,Huangming Hong,Zhao 대한암학회 2019 Cancer Research and Treatment Vol.51 No.3

Purpose Rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone administered every 3 weeks (R-CHOP-21) is the standard care for diffuse large B-cell lymphoma (DLBCL). It is unknown whether the dose-dense R-CHOP (R-CHOP-14) could improve the outcome of the disease in Asian population. Materials and Methods Newly diagnosed DLBCL patients were centrally, randomly assigned (1:1) to receive R-CHOP- 14 or R-CHOP-21. R-CHOP-14 was administered every 2 weeks, and R-CHOP-21 was administered every 3 weeks. Primary end point was disease-free survival (DFS). Secondary end points included overall survival (OS), progression-free survival (PFS), response rate and toxicities. Results Seven hundred and two patients were randomly assigned to receive R-CHOP-14 (n=349) or R-CHOP-21 (n=353). With a median follow-up of 45.6 months, the two groups did not differ significantly in 3-year DFS (79.6% for R-CHOP-14 vs. 83.2% for R-CHOP-21, p=0.311), 3-year OS (77.5% for R-CHOP-14 vs. 77.6% for R-CHOP-21, p=0.903), or 3-year PFS (63.2% for R-CHOP-14 vs. 66.1% for R-CHOP-21, p=0.447). Patients with an International Prognostic Index (IPI) score ! 2 had a poorer prognosis compared to those with an IPI score < 2. Grade 3/4 hematologic and non-hematologic toxicities were manageable and similar between R-CHOP-14 and R-CHOP-21. Conclusion R-CHOP-14 did not improve the outcome of DLBCL compared to R-CHOP-21 in Asian population. With manageable and similar toxicities, both of the two regimens were suitable for Asian DLBCL patients. For high-risk patients with IPI ! 2, new combination regimens based on R-CHOP deserve further investigation to improve efficacy.

Using an Evaluative Criteria Software of Optimal Solutions for Enterprise Products' Sale

Shih-chung liao,Bing Yi Lin 한국유통과학회 2015 유통과학연구 Vol.13 No.4

Purpose - This study focuses on the use of evaluative criteria software for imprecise market information, and product mapping relationships between design parameters and customer requirements. Research design, data, and methodology – This study involved using the product predicted value method, synthesizing design alternatives through a morphological analysis and plan, realizing the synthesis in multi-criteria decision-making (MCDM), and using its searching software capacity to obtain optimal solutions. Results - The establishment of product designs conforms to the customer demand, and promotes the optimization of several designs. In this study, the construction level analytic method and the simple multi attribute comment, or the quantity analytic method are used. Conclusions - This study provides a solution for enterprise products' multi-goals decision-making, because the product design lacks determinism, complexity, risk, conflict, and so on. In addition, the changeable factor renders the entire decision-making process more difficult. It uses Fuzzy deduction and the correlation technology for appraising the feasible method and multi- goals decision-making, to solve situations of the products' multi- goals and limited resources, and assigns resources for the best product design.