A Novel Missense Mutation of Keratin 17 Gene in a Chinese Family with Steatocystoma Multiplex

( Wei Wei Ha ),( Jing Wang ),( Wen Wang ),( Hong Yang Fu ),( Hua Yang Tang ),( Xian Fa Tang ),( Jun Zhu ),( Xian Yong Yin ),( Sen Yang ),( Xue Jun Zhang ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.4

A Novel Intermediate Estimator Based Secure Consensus Control for Multi-agent Systems with Application to Networked Multi-axis Motion Synchronization

Jun-Wei Zhu,Chao-Yang Liang,De-Feng He,Xin Wang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.4

This paper studies the secure consensus control problem of multi-agent systems under DoS attacks onthe sensor, the actuator, and the communication topology. A resilient intermediate estimator based attack tolerantcontrol strategy is proposed. By fully exploiting the hardware redundancies, both of the estimators and the controlprotocols can be reconstructed online according to different DoS attack scenarios. Finally, the experiment results ofthe networked multi-axis motion control system are given to verify the effectiveness of the proposed method.

Biotransformation of Panax ginseng extract by rat intestinal microflora

Wei-Wei Dong,Jinhua Zhao,Fei-Liang Zhong,Wen-Jing Zhu,Jun Jiang,Songquan Wu,Deok-Chun Yang,Donghao Li,Lin-Hu Quan 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.4

Background: In general, after Panax ginseng is administered orally, intestinal microbes play a crucial role in its degradation and metabolization process. Studies on the metabolism of P. ginseng by microflora are important for obtaining a better understanding of their biological effects. Methods: In vitro biotransformation of P. ginseng extract by rat intestinal microflora was investigated at 37C for 24 h, and the simultaneous determination of the metabolites and metabolic profile of P. ginseng saponins by rat intestinal microflora was achieved using LCeMS/MS. Results: A total of seven ginsenosides were detected in the P. ginseng extract, including ginsenosides Rg1, Re, Rf, Rb1, Rc, Rb2, and Rd. In the transformed P. ginseng samples, considerable amounts of deglycosylated metabolite compound K and Rh1 were detected. In addition, minimal amounts of deglycosylated metabolites (ginsenosides Rg2, F1, F2, Rg3, and protopanaxatriol-type ginsenosides) and untransformed ginsenosides Re, Rg1, and Rd were detected at 24 h. The results indicated that the primary metabolites are compound K and Rh1, and the protopanaxadiol-type ginsenosides were more easily metabolized than protopanaxatriol-type ginsenosides. Conclusion: This is the first report of the identification and quantification of the metabolism and metabolic profile of P. ginseng extract in rat intestinal microflora using LCeMS/MS. The current study provided new insights for studying the metabolism and active metabolites of P. ginseng.

Fault-tolerant Control for Linear System Under Sensor Saturation Constraint

Jun-Wei Zhu,Qiao-Qian Zhou,Jianming Xu,Jian-Wei Dong 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1

An observer-based fault-tolerant control method is proposed for a linear system with sensor saturationconstraint. Considering the linear system with simultaneous actuator faults and sensor faults, the sensor saturation would bring the output measurement error of the system, which would result in the estimation performancedegradation. Firstly, the intermediate estimator is modified to estimate the system states and fault signals at thesimultaneous time, and the fault-tolerant controller is designed based on the estimation to compensate the effectof actuator faults effectively. Through Lyapunov stability analysis, the sufficient conditions are obtained to ensurethe states of closed-loop system to be uniformly ultimately bounded. The effect of sensor saturation error can besuppressed by adjusting some specified parameters directly without introducing any performance index. Finally, theeffectiveness and superiority of the proposed method are verified by a simulation example

A Model Transfer Learning Based Fault Diagnosis Method for Chemical Processes With Small Samples

Jun-Wei Zhu,Bo Wang,Xin Wang 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.12

Traditional fault diagnosis methods relies on sufficient fault samples, but it is unrealistic since the fault is a low possibility event in real industrial scenes. To address the above issue, this paper proposed a fault diagnosis method for chemical processes with small samples. First, a data self-generating-based transfer learning (DSGTL) method is presented to expand the fault samples. The characteristic of fault data is learned by adversarial relation and transferred to the generated data. Moreover, a model-based transfer learning strategy is adopted to improve the robustness of the proposed method to the quality of generated data. Second, the sample reconstruction-based convolutional neural network (SR-CNN) is proposed which adaptively extracts features from both spatial domain and time domain and identifies the fault type of industrial process with small samples. Finally, the experimental result of the Tennessee Eastman (TE) process proves the validity and the feasibility of the proposed method.

Biotransformation of Panax ginseng extract by rat intestinal microflora: identification and quantification of metabolites using liquid chromatography-tandem mass spectrometry

Dong, Wei-Wei,Zhao, Jinhua,Zhong, Fei-Liang,Zhu, Wen-Jing,Jiang, Jun,Wu, Songquan,Yang, Deok-Chun,Li, Donghao,Quan, Lin-Hu The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.4

Background: In general, after Panax ginseng is administered orally, intestinal microbes play a crucial role in its degradation and metabolization process. Studies on the metabolism of P. ginseng by microflora are important for obtaining a better understanding of their biological effects. Methods: In vitro biotransformation of P. ginseng extract by rat intestinal microflora was investigated at $37^{\circ}C$ for 24 h, and the simultaneous determination of the metabolites and metabolic profile of P. ginseng saponins by rat intestinal microflora was achieved using LC-MS/MS. Results: A total of seven ginsenosides were detected in the P. ginseng extract, including ginsenosides Rg1, Re, Rf, Rb1, Rc, Rb2, and Rd. In the transformed P. ginseng samples, considerable amounts of deglycosylated metabolite compound K and Rh1 were detected. In addition, minimal amounts of deglycosylated metabolites (ginsenosides Rg2, F1, F2, Rg3, and protopanaxatriol-type ginsenosides) and untransformed ginsenosides Re, Rg1, and Rd were detected at 24 h. The results indicated that the primary metabolites are compound K and Rh1, and the protopanaxadiol-type ginsenosides were more easily metabolized than protopanaxatriol-type ginsenosides. Conclusion: This is the first report of the identification and quantification of the metabolism and metabolic profile of P. ginseng extract in rat intestinal microflora using LC-MS/MS. The current study provided new insights for studying the metabolism and active metabolites of P. ginseng.

Proanthocyanidins accelerate the germination of cucumber (Cucumis sativus L.) seeds

Li-jun Zhu,Xing-guang Deng,Li-juan Zou,Jun-qiang Wu,Da-wei Zhang,Honghui Lin 한국식물학회 2016 Journal of Plant Biology Vol.59 No.2

Proanthocyanidins (PAs) are the end products of the flavonoid biosynthetic pathway in many seeds, but their biological function is rarely unknown during seed germination. In the present study, we observed that PAs pretreatment accelerated cucumber seeds germination with maximum efficiency at 0.15% by measuring germination percentage and radical length. Using inhibitors of abscisic acid (ABA), gibberellins (GA) and alternative oxidase (AOX) and H2O2 scavenger pretreatment and gene expression analysis, we found that the accelerated effect of 0.15% PAs on seed germination was due to the decreased ABA biogenesis and enhanced GA production. ROS are induced by PAs pretreatment. Then, the enhanced ROS contributed to GA and ethylene accumulation and ABA decrease in seeds. Moreover, the improvement of GA was involved in the further induction of antioxidant enzymes activities. Therefore, our findings uncover a novel role of PAs in seed germination and clarify the relationships between ROS, ABA, GA and ethylene during seed germination.

Celastrol, produced by Tripterygium wilfordii Hook F. enhances defense response in cucumber seedlings against diverse environmental stresses

Li-jun Zhu,Xing-guang Deng,Li-juan Zou,Peng-xu Li,Jun-qiang Wu,Da-wei Zhang,Honghui Lin 한국식물학회 2017 Journal of Plant Biology Vol.60 No.1

Celastrol is an active triterpenoid compound isolated from Tripterygium wilfordii Hook F.. Many reports have highlighted that celastrol is an effective, safe and desirable approach to the treatment of cancers. However, their biological function during environmental stresses in plants is rarely reported. In the present study, the effects of celastrol on the tolerance against high light (HL), polyethylene glycol (PEG) and cold stress in cucumber (Cucumis sativus L.) were investigated. Celastrol pretreatment could enhance cucumber seedlings stress tolerance at a concentration of 1 μg ml–1. The results showed that pretreatment with 1 μg ml–1 celastrol clearly induced the activities of antioxidative enzymes, which subsequently alleviated stress-induced oxidative damage in plant cells. We also provided evidence that celastrol upregulated ABA biosynthetic gene NCED2 expression and ABA accumulation in cucumber seedlings, which resulted to the enhanced tolerance in response to environmental stresses. Furthermore, the celastrol-pretreated seedlings showed less photosystem damaged caused by the stress conditions, when compared with the control. Therefore, our findings provide a novel role of celastrol in plant against environmental stresses and indicate that the celastrol-induced activities of antioxidative enzymes and ABA content might contribute to the stress tolerance.

Effect of temperature on the development of Echinothrips americanus Morgan (Thysanoptera: Thripidae) with special reference to the number of generations

Liang Zhu,Ze-Hua Wang,Ya-Jun Gong,Li-Jun Cao,Shu-Jun Wei 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.4

The thrips Echinothrips americanus Morgan (Thysanoptera: Thripidae) was recently reported in China. The effect of temperature on its development was investigated and the potential area of further dispersal was predicted by estimation of its generations in China. First instar larvae developed to adults on green peppers Capsicum anuum at all constant temperatures (16, 19, 22, 25, 28, 31 and 34 °C) except for 34 °C, at which they developed only as far as the second instar. The percentage surviving of immature stages were not significantly different at the other six temperatures (range 32.10%–52.72%). The developmental times from egg to adult ranged from 11.68 to 45.13 days and were negatively correlated with temperature. There were significant differences between male and female immature stages in their developmental time at 22 °C and 25 °C. Regression analysis indicated that both the Lactin and linear models could describe the relationship between developmental rate and temperature for immature stages but a slightly higher coefficient of determination was obtained with the Lactin model. The high-temperature threshold and the optimum temperature for development were 32.04 °C and 31.79 °C, respectively, estimated by the Lactin model. The low-temperature threshold for development was 11.35 °C and thermal constant was 229.76 degree-days for immature stages, estimated by the linear model. The models predicted that E. americanus could have produced 8–10 generations per year under field conditions in Beijing (N39°56′, E116°17′) and Yangling (N34°12′, E108°7′) from 2002 to 2012. The potential risk posed by E. americanus to crops in different regions of China was discussed.

Improving the electrical performance of HfInZnO-TFTs by introducing a thin ITO interlayer

Jun Li,Xing-Wei Ding,Jianhua Zhang,Wen-Qing Zhu,Xue-Yin Jiang,Zhi-Lin Zhang 한국물리학회 2014 Current Applied Physics Vol.14 No.8

We have fabricated hafniumeindiumezinc-oxide (HfInZnO) thin film transistors (TFT) with indiumetinoxide (ITO) interlayer. Compared with conventional HfInZnO-TFT, the electrical performance and bias stability of HfInZnO-TFTs with ITO interlayer are improved. HfInZnO-TFT with 4-nm-thick ITO interlayer shows a high mobility of 7.2 cm2/V s, a low threshold voltage of 0.13 V and a better bias stability. The performance enhancement is attributed to a decrease in interface trap state and an increase in carrier concentration. It suggests that introducing ITO interlayer at the ALD Al2O3/HfInZnO interface is an effective way to improve the electrical performance and bias stability.