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Incidence and case fatality of acute myocardial infarction in Korea, 2011-2020
Yeeun Seo,Jenny Moon,Hyeok-Hee Lee,Hyeon Chang Kim,Fumie Kaneko,Sojung Shin,Eunji Kim,Jang-Whan Bae,Byeong-Keuk Kim,Seung Jun Lee,Min Kim,Hokyou Lee 한국역학회 2024 Epidemiology and Health Vol.46 No.-
OBJECTIVES: Cardiovascular diseases are a leading cause of mortality worldwide, and acute myocardial infarction (AMI) is particularly fatal condition. We evaluated the incidence and case fatality rates of AMI in Korea from 2011 to 2020. METHODS: We utilized data from the National Health Insurance Services to calculate crude, age-standardized, and age-specific incidence rates, along with 30-day and 1-year case fatality rates, of AMI from 2011 to 2020. Age-standardized incidence rates were determined using direct standardization to the 2005 population. RESULTS: The crude incidence rate of AMI per 100,000 person-years consistently increased from 44.7 in 2011 to 68.3 in 2019, before decreasing slightly to 66.2 in 2020. The age-standardized incidence rate of AMI displayed a 19% rise from 2011 to 2019, followed by a slight decline in 2020. The increasing trend for AMI incidence was more pronounced in males than in females. Both 30-day and 1-year case fatality rates remained stable among younger individuals but showed a decrease among older individuals. There was a minor surge in case fatality in 2020, particularly among recurrent AMI cases. CONCLUSIONS: Over the past decade, the AMI incidence rate in Korea has consistently increased, with a slight downturn in 2020. The case fatality rate has remained relatively stable except for a minor increase in 2020. This study provides data for continuous surveillance, the implementation of targeted interventions, and the advancement of research aimed at AMI in Korea.
Park, Subin,Lee, Yeeun,Jun, Jin Yong Elsevier/North Holland Biomedical Press 2017 Psychiatry research Vol.257 No.-
<P><B>Abstract</B></P> <P>North Korean adolescent defectors experience adaptation difficulties along with a wide range of psychosocial problems, but no study has yet examined their Internet addiction symptoms. We compared early traumatic experiences, self-esteem, negative cognition, and Internet addiction symptoms, as well as the relationships between these variables, between North Korean adolescent defectors and South Korean adolescents. Fifty-six North Korean adolescent defectors and 112 age- and sex- matched South Korean adolescents participated. The analyses examined the relationship between traumatic experiences and Internet addiction symptoms, with negative automatic thoughts or low self-esteem as mediators of these relations. North Korean adolescent defectors tended to have higher levels of negative automatic thoughts and more severe Internet addiction symptoms, as well as better self-esteem, than did South Korean adolescents. Furthermore, only among North Korean adolescent defectors, traumatic experiences were positively associated with Internet addition symptoms via increasing negative automatic thoughts. North Korean adolescent defectors are more susceptible to Internet addiction, negative cognitions, and early traumatic experiences compared to South Korean adolescents. However, the cross-sectional design of this study precludes consideration of the causality of these relationships. Interventions aiming to correct negative cognitions and increase self-esteem may be helpful for North Korean adolescent defectors with problematic Internet use.</P> <P><B>Highlights</B></P> <P> <UL> <LI> North Korean adolescent defectors had higher trauma and Internet addiction (IA). </LI> <LI> North Korean defectors also had greater self-esteem and negative automatic thoughts. </LI> <LI> Self-esteem and negative thoughts were mediators in the relation of trauma and IA. </LI> <LI> Country of origin (North vs. South Korea) moderated the mediating effects. </LI> </UL> </P>
Lactobacillus plantarum BHN-LAB 33에 의한 천궁 발효 추출물의 항산화 활성 증대 효과 평가
정수진(Su Jin Jeong),김병혁(Byung-Hyuk Kim),이준형(Jun-Hyeong Lee),박예은(YeEun Park),김중규(Jung-Gyu Kim),권기석(Gi-Seok Kwon),이중복(Jung-Bok Lee) 한국식품영양과학회 2019 한국식품영양과학회지 Vol.48 No.10
천궁(Cnidium officinale Makino, Umbelliferae)은 중국의 특산종으로 한국, 중국, 일본에서 재배되고 있다. 천궁은 한국에서 전통의학으로 사용되어 왔으며, 통증, 염증, 생리 장애, 혈압 저하제 및 항비타민 결핍 질환에 효과가 있다고 알려져 있다. 본 연구는 유산균 발효를 통한 천궁과 발효하지 않은 천궁의 항산화 활성과 총 폴리페놀 및 총 플라보노이드 함량을 비교하고자 하였다. 발효한 천궁의 활성은 DPPH 라디칼 소거 활성에서 1.7배 증가하였다. 또한 ABTS 라디칼 소거 활성, SOD 유사활성, 총 폴리페놀, 총 플라보노이드 함량도 소폭 증가하였다. 이러한 결과는 기능성 식품 개발을 위한 유산균으로 발효한 천궁의 항산화능을 확인하고 기능성 식품 또는 화장품 소재로의 개발에 필요한 기초 자료를 제공하고자 하였다. Cnidium officinale Makino (Umbelliferae) is an endemic species in China that has been cultivated in Korea, China, and Japan. C. officinale is used as traditional medicine in Asia because of its effects on pain, inflammation, menstrual disturbance, blood pressure depressant, and anti-vitamin deficiency disease. This study compared the antioxidant activity, total polyphenol, and total flavonoid content of fermented C. officinale with lactic acid bacteria and non-fermented C. officinale. The activity of the fermented C. officinale was increased, as illustrated by the 1.7 fold increase in 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity. In addition, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity, and superoxide dismutase, total polyphenol, and total flavonoid contents were increased slightly. These results provide the basic data needed to understand the biological activities of fermented C. officinale for the development of functional foods and biological materials.
Lactobacillus plantarum BHN-LAB 33의 생물전환공정을 통한 방풍 발효 추출물의 항산화 활성 및 미백 활성 증대 효과
김병혁(Byung-Hyuk Kim),장종옥(Jong-Ok Jang),이준형(Jun-Hyeong Lee),박예은(YeEun Park),김중규(Jung-Gyu Kim),윤여초(Yeo-Cho Yoon),정수진(Su Jin Jeong),권기석(Gi-Seok Kwon),이중복(Jung-Bok Lee) 한국생명과학회 2019 생명과학회지 Vol.29 No.11
방풍의 화합물은 동양 전통 의학에서 사용되고 있는 식물로 항염증, 비염, 미백, 아토피, 항알레르기 및 각종 피부질환에 사용되고 있다. 본 연구는 한국 전통발효식품에서 분리된 Lactobacillus plantarum BHN-LAB 33를 이용해 발효한 방풍 추출물의 항산화 효과를 조사하였다. L. plantarum BHN-LAB 33 발효는 37℃에서 3일간 발효하였으며, 발효하지 않은 방풍 추출물에 비해 L. plantarum BHN-LAB 33 발효 방풍 추출물에서 총 폴리페놀 함량은 약 14%, 총 플라보노이드 함량은 약 09% 증가된 것을 확인하였다. 또한, SOD 유사활성능, DPPH radical 소거활성능과 ABTS radical 소거활성능, 환원력은 각각 약 70%, 80%, 45% 및 39% 항산화능이 증가하는 것을 확인하였다. 또한, tyrosinase 저해 활성은 44% 증가되는 것을 확인하였다. 이 결과를 통해 L. plantarum BHN-LAB 33을 이용한 생물전환을 통한 방풍 발효 추출물의 항산화능 증대에 효과적인 것을 확인하였다. 또한, 생물전환기술은 생리활성을 증대시키기 위한 매우 유용한 기술임을 확인하였으며, 생물전환기법을 통한 기능성 식품소재 및 화장품 소재 개발 및 응용이 가능할 것으로 기대된다. Saposhnikovia has been used as a traditional medicinal herb in Asia because of the reported anti-inflammatory, anti-allergic rhinitis, pro-whitening, anti-atopy, anti-allergy, and anti-dermatopathy effects of the phytochemical compounds it contains. In this study, we investigated the antioxidant effects of a Saposhnikovia extract after fermentation by Lactobacillus plantarum BHN-LAB 33. Saposhnikovia powder was inoculated with L. plantarum BHN-LAB 33 and fermented at 37℃ for 72 hr. After fermentation, the total polyphenol content of the Saposhnikovia extract increased by about 14%, and the total flavonoid content increased by about 9%. The superoxide dismutase-like activities, DPPH radical scavenging, ABTS radical scavenging, reducing power activity, and tyrosinase inhibition activity also increased after fermentation by approximately 70%, 80%, 45%, 39%, and 44%, respectively. The results confirmed that fermentation of a Saposhnikovia extract by L. plantarum BHN-LAB 33 is an effective way to increase the antioxidant effects of the extract. The bioconversion process investigated in this study may have the potential to produce phytochemical-enriched natural antioxidant agents with high added value from Saposhnikovia matrices. These results can also be applied to the development of improved foods and cosmetic materials.
혐기성 조건에서 유산균에 의한 Daidzin의 생물 전환
김병혁(Byung-Hyuk Kim),정수진(Su Jin Jeong),이준형(Jun-Hyeong Lee),박예은(YeEun Park),김중규(Jung-Gyu Kim),천정윤(Jung-Yoon Cheon),황학수(Hak-Soo Hwang),이중복(Jung-Bok Lee) 한국식품영양과학회 2020 한국식품영양과학회지 Vol.49 No.2
식물체 내 이소플라본은 만성질환, 암, 골다공증 및 폐경증후군 예방에 잠재적인 역할을 한다고 보고되었다. 칡의 주요 성분인 식물성 이소플라본인 daidzin은 인체에 흡수가 어려운 배당체 형태로 생체이용률을 높이기 위해서는 β-glucosidase에 의한 가수분해를 통해 증진할 수 있다. 또한, 장내 미생물을 이용한 생물 전환을 통해 이소플라본의 생물학적 활성을 증진할 수 있다. 본 연구는 한국 전통식품 ‘김치’로부터 분리한 젖산균을 확보하였으며, daidzein의 생물학적 생물 전환 활성을 HPLC로 평가하였다. L. rhamnosus BHNLAB 76 및 젖산 박테리아 혼합배양 시료의 혐기성 배양을 통한 daidzein의 생물 전환은 각각 약 25.5%와 30.0%로 확인하였다. 또한, 혼합배양에 의한 daidzein으로 생물 전환능은 5.47 mg/L/h로 L. rhamnosus BHN-LAB 76에 의한 생물 전환능 4.38 mg/L/h보다 높은 것을 확인하였다. 위 결과를 통해 혼합배양에 의한 생물 전환이 단독 미생물보다 매우 높으며, 이를 발효 식품 및 기능성물질을 생산하는 probiotic 소재로 활용에 더욱 유리함을 확인하였다. The potential role of plant isoflavone in preventing chronic diseases, such as cancer, osteoporosis, and post-menopausal syndrome, has been reported. The daidzin of puerarin is comprised mainly of un-absorbable and biologically inactive glycosides. The bio-availability of glucosides is increased by hydrolysis using β-glucosidase. In addition, intestinal microorganisms can enhance biological activity through the bio-conversion of isoflavone as a glycoside. In this study, lactic acid bacteria were obtained from the traditional Korean food, ‘Kimchi’, and the isoflavone- transforming activity was determined from the production of daidzein measured by HPLC. Lactobacillus rhamnosus BHN-LAB 76 and the lactic acid, bacterial mixed culture converted approximately 25.5% and 30.0% of daidzin to daidzein under the anaerobic conditions, respectively. In addition, the rate of daidzin bioconversion to daidzein (5.47 mg/L/h) with the mixed culture was much higher than the rate of daidzin bioconversion to daidzein (4.38 mg/L/h) by L. rhamnosus BHN-LAB 76. As a result, the rate of daidzin bio-conversion to daidzein by the mixed culture was very high compared to the sole micro-organisms. Therefore, the mixed culture might be useful as a probiotic culture in the manufacture of fermentation foods and functional materials.
Lactobacillus rhamnosus BHN-LAB 76로 발효한 흰목이버섯(Tremella fuciformis Berk) 추출물의 항비만 및 항당뇨 효과
윤여초 ( Yeo-cho Yoon ),김병혁 ( Byung-hyuk Kim ),김중규 ( Jung-gyu Kim ),이준형 ( Jun-hyeong Lee ),박예은 ( Yeeun Park ),박혜숙 ( Hye-suk Park ),황학수 ( Hak-soo Hwang ),권기석 ( Gi-seok Kwon ),이중복 ( Jung-bok Lee ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 한국미생물·생명공학회지 Vol.47 No.3
흰목이버섯(Tremella fuciformis Berk.; TF)은 흰목이과에 속하는 버섯으로 한국, 중국 및 열대지방에 분포한다. 흰목이버섯은 아시아 전통 의학에서 고혈압, 노화, 암 및 동맥 경화를 예방하는 것으로 알려져 있다. 본 연구는 L. rhamnosus BHN-LAB 76로 발효된 흰목이버섯 추출물의 항 당뇨 효능에 대해 조사하였다. 그 결과, 발효된 흰목이버섯 추출물은 발효하지 않은 추출물에 비해 α-glucosidase 저해 활성을 증가시키고, 3T3-L1 전지방 세포에서의 지방세포 분화 유도를 통한 지방구 생성을 억제하는 것을 확인하였다. 이러한 발효된 흰목이버섯은 지방 및 세포 분화 유도에 관여한다고 알려진 AMPK, Akt의 유전자 발현을 촉진하고, JNK의 발현을 억제하는 것을 통해 지방생성억제 및 항 당뇨 활성이 증가됨을 확인하였다. 따라서 L. rhamnosus BHN-LAB 76으로 발효한 흰목이버섯 추출물은 항비만 및 항당뇨 기능성 소재 및 식품 개발로의 활용이 가능할 수 있음을 제안한다. White jelly fungus (Tremella fuciformis Berk; TF) has been used as a traditional medicine in Asia; it is known to prevent hypertension, aging, cancer, and arteriosclerosis. This study aimed to investigate the anti-diabetic effects of fermented Tremella fuciformis Berk (FTF) ethanol extracts fermented with L. rhamnosus BHN-LAB 76. We show that FTF increases the α-glucosidase inhibitory activity and suppress the adipogenesis of 3T3-L1 adipocytes. These inhibitory effects of FTF are accompanied by the regulation of the phosphorylation of AMPK, JNK, and Akt. These data demonstrate that FTF not only inhibits adipogenesis by affecting the adipogenic signaling, but also increases the anti-diabetic effects by regulating the insulin signaling pathway. Therefore, we suggest that the FTF can be used for developing functional food and cosmetics materials.